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3. 发明专利

AU637701B2 IMMUNODIAGNOSTIC ASSAY FOR RHEUMATOID ARTHRITIS 未知
公开(公告)号：AU637701B2
公开(公告)日：1993-06-03
申请号：AU7737091
申请日：1991-05-27
申请人： BRITISH TECHNOLOGY GROUP LIMITED
发明人： DENIS RAYMOND STANWORTH , IAN VICTOR LEWIN , SARITA NAYYAR
IPC分类号： C07K5/10 , C07K7/06 , C07K7/08 , C07K14/00 , C07K16/00 , C07K16/38 , C07K16/42 , C07K19/00 , C12N15/02 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/564
摘要： The assay of rheumatoid arthritis by reference to IgA- alpha 1 antitrypsin complex present in analytes is facilitated by certain novel antibody reagents. These are ligands comprising an antibody domain specific for an antigenic determinant of a complex of human IgA and alpha 1-antitrypsin, this antibody domain being substantially non reactive with free human IgA and free human alpha 1-antitrypsin. Monoclonal antibodies to the naturally occurring IgA- alpha 1AT complex and monoclonal or polyclonal antibodies to a synthetic peptide are preferred. The synthetic peptide in itself part of the invention and preferably has an amino acid sequence: Val-Ser-Val-Val-Met-Ala-Glu-Val-Asp-Gly-Thr-Cys-Tyr (SEQ ID NO:

7. 发明专利

AU636914B2 CHECK VALVES 未知
公开(公告)号：AU636914B2
公开(公告)日：1993-05-13
申请号：AU6404390
申请日：1990-09-05
申请人： BRITISH TECHNOLOGY GROUP LIMITED
发明人： WILLIAM EDWARD WARREN
IPC分类号： B65D83/44 , B65D83/14 , F16K17/36
摘要： PCT No. PCT/GB90/01370 Sec. 371 Date Apr. 30, 1991 Sec. 102(e) Date Apr. 30, 1991 PCT Filed Sep. 5, 1990 PCT Pub. No. WO91/03408 PCT Pub. Date Mar. 21, 1991.A check valve (170) for the discharge passageway of an aerosol dispensing package, comprising: a chamber (171) having inlet and outlet openings (175,174) for in-line connection in the passageway; a dished seat (176) extending across the chamber between the openings with its dished surface facing towards the outlet opening; and a ball (177) housed in the chamber for free movement between substantial sealing engagement with the outlet opening and direct engagement in the seat; the ball being gravitationally engaged in the seat when the chamber is in a generally upright position with the outlet opening uppermost, the seat acting to deflect discharge flow through the chamber around the ball in these last circumstances, and the dished surface being outwardly divergently shaped to cause the ball to roll therefrom under gravity and move to its outlet opening sealing engagement when the chamber is inclined from the upright position by a substantially predetermined angle towards a horizontal disposition.

8. 发明专利

AU635616B2 AEROSOL CARRIERS 未知
公开(公告)号：AU635616B2
公开(公告)日：1993-03-25
申请号：AU7155991
申请日：1991-01-24
申请人： BRITISH TECHNOLOGY GROUP LIMITED
发明人： DAVID GANDERTON , NUHA MOHAMMED KASSEM
IPC分类号： A61K9/72 , A61K9/00 , A61K9/14 , A61K47/26 , A61K47/36
摘要： Pharmaceutical excipients useful in dry powder inhalents comprise particles having a rugosity (measured by air permeametry) of less than 1.75. The use of these carriers increases the amount of drug injested by the patient using a dry powder inhaler. The preferred excipients are crystalline sugars such as lactose which may conveniently be prepared by controlled crystallisation from an aqueous medium.

9. 发明专利

AU634125B2 (DIETHYLAMINO-N-OXIDE) ETHYLAMINO-DIHYDROXYANTHRACENE-9, 10-DIONE DERIVATIVES 未知
公开(公告)号：AU634125B2
公开(公告)日：1993-02-11
申请号：AU6539590
申请日：1990-10-12
申请人： BRITISH TECHNOLOGY GROUP LIMITED
发明人： LAURENCE HYLTON PATTERSON
IPC分类号： A61K31/135 , A61K31/22 , A61P35/00 , C07C225/36 , C07C291/04 , C09B1/515
摘要： PCT No. PCT/GB90/01574 Sec. 371 Date Apr. 10, 1991 Sec. 102(e) Date Apr. 10, 1991 PCT Filed Oct. 12, 1990.Compounds of formula (I) (I) in which R1, R2, R3 and R4 are each separately selected from hydrogen, X, NH-A-NHR and NH-A-N(O)R'R'' wherein X is hydroxy, halogeno, amino, C1-4 alkoxy or C2-8 alkanoyloxy, A is a C2-4 alkylene group with a chain length between NH and NHR or N(O)R'R'' of at least 2 carbon atoms and R, R' and R'' are each separately selected from C1-4 alkyl groups and C2-4 hydroxyalkyl and C2-4 dihydroxyalkyl groups in which the carbon atom attached to the nitrogen atom does not carry a hydroxy group and no carbon atom is substituted by two hydroxy groups, or R' and R'' together are a C2-6 alkylene group which with the nitrogen atom to which R'' and R'' are attached forms a heterocyclic group having 3 to 7 atoms in the ring, but with the proviso that at least one of R1 to R4 is a group NH-A-N(O)R'R'', and physiologically acceptable salts thereof are of value in the treatment of cancer.

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