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1. 发明专利

CA2743572A1 DEVICES, SYSTEMS, METHODS AND TOOLS FOR CONTINUOUS ANALYTE MONITORING 未知
公开(公告)号：CA2743572A1
公开(公告)日：2010-05-27
申请号：CA2743572
申请日：2009-08-19
申请人： ARKAL MEDICAL INC
发明人： JINA ARVIND N , PARMAR ASHOK , CHUA BEELEE , TAMADA JANET , LEE JONATHAN , TIERNEY MICHAEL , KAUR NAVNEET , MAGGINETTI PAUL , DESAI SHASHI
IPC分类号： A61B5/145 , A61B5/157 , G05F1/00
摘要： One aspect of the invention provides an analyte monitor including a sensing volume, an analyte extraction area in contact with the sensing volume adapted to extract an analyte into the sensing volume, and an analyte sensor adapted to detect a concentration of analyte in the sensing volume. The sensing volume is defined by a first face, a second face opposite to the first face, and a thickness equal to the distance between the two faces. The surface area of the first face is about equal to the surface area of the second face and the extraction area is about equal to the surface area of the first and second face of the sensing volume. The analyte sensor includes a working electrode in contact with the sensing volume, the working electrode having a surface area at least as large as the analyte extraction area, and a second electrode in fluid communication with the sensing volume.

2. 发明专利

CA2602259A1 DEVICES, SYSTEMS, METHODS AND TOOLS FOR CONTINUOUS GLUCOSE MONITORING 未知
公开(公告)号：CA2602259A1
公开(公告)日：2006-10-05
申请号：CA2602259
申请日：2006-03-28
申请人： ARKAL MEDICAL INC
发明人： JINA ARVIND N
IPC分类号： G01F1/64 , G01N33/487
摘要： One aspect of the invention provides a glucose monitor having a plurality of tissue piercing elements, each tissue piercing element having a distal opening, a proximal opening and interior space extending between the distal and proximal openings; a sensing area in fluid communication with the proxim al openings of the tissue piercing elements; sensing fluid extending from the sensing area into substantially the entire interior space of the tissue piercing elements; and a glucose sensor adapted to detect a concentration of glucose in the sensing fluid within the sensing area. Another aspect of the invention provides a method of in vivo monitoring of an individual's interstitial fluid glucose concentration including the following steps: inserting distal ends of a plurality of tissue piercing elements through a stratum corneum area of the individual's skin, the tissue piercing elements each having a distal opening, a proximal opening, an interior space extendin g between the distal and proximal openings, and a sensing fluid filling substantially the entire interior space; and sensing a glucose concentration of the sensing fluid.

3. 发明申请

WO2008077147A3 DEVICES, SYSTEMS, METHODS AND TOOLS FOR CONTINUOUS GLUCOSE MONITORING 审中-公开
标题翻译：用于连续葡萄糖监测的装置，系统，方法和工具
公开(公告)号：WO2008077147A3
公开(公告)日：2008-10-16
申请号：PCT/US2007088456
申请日：2007-12-20
申请人： ARKAL MEDICAL INC , JINA ARVIND N
发明人： JINA ARVIND N
IPC分类号： G01F1/64 , G01N33/487
CPC分类号： A61B5/14532 , A61B5/14514 , A61B5/14865
摘要： The present invention includes methods and apparatus for continuous glucose monitoring of a patient. In one aspect a glucose monitor includes a plurality of substantially cylindrical tissue piercing elements adapted to pierce the stratum corneum and enter the epidermis, allowing for the diffusion of glucose from the interstitial fluid into the glucose monitors described herein. In another aspect of the invention, a glucose monitor includes a deformed substrate layer defining a plurality of tissue piercing elements.
摘要翻译：本发明包括用于患者的连续血糖监测的方法和装置。在一个方面，葡萄糖监测器包括适于刺穿角质层并进入表皮的多个基本上圆柱形的组织刺穿元件，从而允许葡萄糖从组织间液扩散到本文所述的葡萄糖监测器中。在本发明的另一方面中，葡萄糖监测器包括限定多个组织穿刺元件的变形的基底层。

4. 发明申请

WO2008116017A1 CONTINUOUS ANALYTE MONITOR WITH MULTI-POINT SELF-CALIBRATION 审中-公开
标题翻译：具有多点自校准功能的连续分析仪监控
公开(公告)号：WO2008116017A1
公开(公告)日：2008-09-25
申请号：PCT/US2008/057547
申请日：2008-03-19
申请人： ARKAL MEDICAL INC. , JINA, Arvind, N.
发明人： JINA, Arvind, N.
IPC分类号： A61B5/00 , G01N33/487
CPC分类号： A61B5/1495 , A61B5/14514 , A61B5/14532 , A61B5/14865 , A61B5/150022 , A61B5/150358 , A61B5/15061 , A61B5/150717 , A61B5/150809 , A61B5/150816 , A61B5/150824 , A61B5/150854 , A61B5/15087 , A61B5/150969 , A61B5/150984 , A61B5/157 , A61B2560/0223 , G01N27/3271
摘要： Analyte monitors and their methods of use. The analyte monitors include multiple calibration fluids which may have different known concentrations of an analyte, such as glucose. The analyte monitors may also include sensing or washing fluids. The analyte monitors are configured to be calibrated with the multiple calibration fluids to potentially provide a more accurate determination of analyte concentrations. The analyte monitors can be adapted to be self-calibrating with the multiple calibration fluids.
摘要翻译：分析物监测仪及其使用方法。分析物监测器包括多个校准流体，其可以具有不同已知浓度的分析物，例如葡萄糖。分析物监测器还可以包括感测或洗涤流体。分析物监测器被配置为用多个校准流体进行校准，以潜在地提供更精确的分析物浓度的测定。分析物监测器可以适应于使用多个校准流体进行自校准。

5. 发明专利

CA2670020A1 DEVICES, SYSTEMS, METHODS AND TOOLS FOR CONTINUOUS GLUCOSE MONITORING 未知
公开(公告)号：CA2670020A1
公开(公告)日：2008-06-26
申请号：CA2670020
申请日：2007-12-20
申请人： ARKAL MEDICAL INC
发明人： JINA ARVIND N
IPC分类号： G01F1/64 , G01N33/487
摘要： The present invention includes methods and apparatus for continuous gluco se monitoring of a patient. In one aspect a glucose monitor includes a plura lity of substantially cylindrical tissue piercing elements adapted to pierce the stratum corneum and enter the epidermis, allowing for the diffusion of glucose from the interstitial fluid into the glucose monitors described here in. In another aspect of the invention, a glucose monitor includes a deforme d substrate layer defining a plurality of tissue piercing elements.

6. 发明申请

WO2008157255A1 ON-DEMAND ANALYTE MONITOR AND METHOD OF USE 审中-公开
标题翻译：需求分析监测和使用方法
公开(公告)号：WO2008157255A1
公开(公告)日：2008-12-24
申请号：PCT/US2008/066765
申请日：2008-06-12
申请人： ARKAL MEDICAL, INC. , JINA, Arvind, N. , CHUA, Beelee , DESAI, Shashi, P. , KAWDE, Abdel-nasser
发明人： JINA, Arvind, N. , CHUA, Beelee , DESAI, Shashi, P. , KAWDE, Abdel-nasser
IPC分类号： A61B5/00
CPC分类号： A61B5/1495 , A61B5/0002 , A61B5/14514 , A61B5/14532 , A61B5/14546 , A61B5/14865
摘要： An analyte monitor is provided with a sensor unit body configured for mounting on tissue, a sensor configured to detect an analyte in a fluid in the sensing area, an output device configured to communicate a result from the sensor to a user; and a user input device coupled with the sensor and the output device, wherein the monitor is configured to communicate a result to the user through the output device only after the user input device is activated. Systems, sensors and methods associated with the monitor are also disclosed.
摘要翻译：分析物监视器设置有被配置为安装在组织上的传感器单元主体，被配置为检测感测区域中的流体中的分析物的传感器，被配置为将来自传感器的结果传达给用户的输出设备; 以及与传感器和输出设备耦合的用户输入设备，其中监视器被配置为仅在用户输入设备被激活之后通过输出设备将结果传达给用户。还公开了与监视器相关联的系统，传感器和方法。

7. 发明申请

WO2008077147A2 DEVICES, SYSTEMS, METHODS AND TOOLS FOR CONTINUOUS GLUCOSE MONITORING 审中-公开
标题翻译：用于连续葡萄糖监测的装置，系统，方法和工具
公开(公告)号：WO2008077147A2
公开(公告)日：2008-06-26
申请号：PCT/US2007/088456
申请日：2007-12-20
申请人： ARKAL MEDICAL, INC. , JINA, Arvind, N.
发明人： JINA, Arvind, N.
IPC分类号： A61B5/145
CPC分类号： A61B5/14532 , A61B5/14514 , A61B5/14865
摘要： The present invention includes methods and apparatus for continuous glucose monitoring of a patient. In one aspect a glucose monitor includes a plurality of substantially cylindrical tissue piercing elements adapted to pierce the stratum corneum and enter the epidermis, allowing for the diffusion of glucose from the interstitial fluid into the glucose monitors described herein. In another aspect of the invention, a glucose monitor includes a deformed substrate layer defining a plurality of tissue piercing elements.
摘要翻译：本发明包括用于患者的连续葡萄糖监测的方法和装置。在一个方面，葡萄糖监测器包括多个基本上圆柱形的组织刺穿元件，其适于刺穿角质层并进入表皮，允许将葡萄糖从间质液扩散到本文所述的葡萄糖监测器中。在本发明的另一方面，葡萄糖监测器包括限定多个组织刺穿元件的变形的基底层。

8. 发明专利

CA2661033A1 METHODS AND APPARATUS INCORPORATING A SURFACE PENETRATION DEVICE 未知
公开(公告)号：CA2661033A1
公开(公告)日：2008-03-06
申请号：CA2661033
申请日：2007-08-30
申请人： ARKAL MEDICAL INC
发明人： DESAI SHASHI , KAWDE ABDEL-NASSAR , CHUA BEELEE , JINA ARVIND , PARMAR ASHOK
IPC分类号： A61M5/32
摘要： A surface penetration device, methods of use and methods of manufacture t hereof are provided. The device includes a substrate supporting a tapered el ongate structure extending from and supported by the substrate upper surface . The elongate structure includes a distal portion, a proximal portion suppo rted at the substrate upper surface, a lumen, and a plurality of lumen openi ngs. A cross section of the lumen is asymmetrical and includes a fist defini ng dimension that is larger than a second defining dimension. The lumen exte nds from the lumen openings and through the elongate structures. The lumen o penings are positioned proximal to the elongate structure's distal portion. In one embodiment an array of a plurality of the elongate structures are pro vided. In another embodiment, the elongate structures are microneedles.

9. 发明专利

CA2700556A1 MICRONEEDLE ARRAY WITH DIVERSE NEEDLE CONFIGURATIONS 未知
公开(公告)号：CA2700556A1
公开(公告)日：2009-04-16
申请号：CA2700556
申请日：2008-10-10
申请人： ARKAL MEDICAL INC
发明人： JINA ARVIND N , DESAI SHASHI P , CHUA BEELEE , PARMAR ASHOK
IPC分类号： A61M5/32 , A61B5/00 , A61B10/00 , A61M37/00
摘要： The invention relates to a surface penetration device (100) and an analyte monitor. Embodiments of the surface penetration device include a substrate (6) with first and second surfaces, and first and second tissue piercing elements (2, 2', 102, 102'), the elements differing in configuration, but each associated with the first surface of the substrate. At least some of the tissue piercing elements have a distal (75' ) and a proximal opening and a lumen extending between the openings. The proximal openings are in fluid communication with an opening in the second surface of the substrate. Embodiments of the analyte monitor include the features of the penetration device (502) plus an analyte sensor (512) that detects an analyte in a fluid.

10. 发明公开

EP2059286A2 METHODS AND APPARATUS INCORPORATING A SURFACE PENETRATION DEVICE 审中-公开
标题翻译：方法和设备与表面渗透设备
公开(公告)号：EP2059286A2
公开(公告)日：2009-05-20
申请号：EP07841674.0
申请日：2007-08-30
申请人： Arkal Medical, Inc.
发明人： JINA, Arvind , CHUA, Beelee , DESAI, Shashi , PARMAR, Ashok , KAWDE, Abdel-Nassar
IPC分类号： A61M5/32
CPC分类号： A61B5/14532 , A61B5/14865 , A61M37/0015 , A61M2037/003 , A61M2037/0053
摘要： A surface penetration device, methods of use and methods of manufacture thereof are provided. The device includes a substrate supporting a tapered elongate structure extending from and supported by the substrate upper surface. The elongate structure includes a distal portion, a proximal portion supported at the substrate upper surface, a lumen, and a plurality of lumen openings. A cross section of the lumen is asymmetrical and includes a fist defining dimension that is larger than a second defining dimension. The lumen extends from the lumen openings and through the elongate structures. The lumen openings are positioned proximal to the elongate structure's distal portion. In one embodiment an array of a plurality of the elongate structures are provided. In another embodiment, the elongate structures are microneedles.

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