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1. 发明专利

JP2006187295A Promoters for gene expression 有权
标题翻译：促进基因表达
公开(公告)号：JP2006187295A
公开(公告)日：2006-07-20
申请号：JP2006066844
申请日：2006-03-13
申请人： Allelix Biopharmaceuticals Inc , アリリックス・バイオファーマシュウティカルズ・インコーポレイテッド
发明人： LAGOSKY PETER A
IPC分类号： C12N15/00 , C12N15/09 , C07K14/635 , C12N1/21 , C12N15/16 , C12N15/72 , C12P21/02 , C12R1/19
CPC分类号： C12N15/72 , C07K14/635 , C07K2319/00
摘要： PROBLEM TO BE SOLVED: To provide an efficient expression system of protein in bacterial hosts. SOLUTION: Disclosed are a recombinant DNA construct and an expression system in a bacterial host cell such as Escherichia coli comprising a recombinant DNA construct in which the coding region of a protein comprises operably linking with a promoter enabling the expression of the protein in host cells and the promoter comprises a DNA sequence represented by a specific sequence. The host cells are cultured under the condition that the protein is produced, and a recombinant protein may be produced by collecting the protein. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供细菌宿主中蛋白质的有效表达系统。解决方案：公开了一种重组DNA构建体和细菌宿主细胞如大肠杆菌中的表达系统，其包含重组DNA构建体，其中蛋白质的编码区包含可操作地连接于能够使蛋白质表达的启动子宿主细胞和启动子包含由特定序列表示的DNA序列。在产生蛋白质的条件下培养宿主细胞，通过收集蛋白质可以产生重组蛋白质。版权所有（C）2006，JPO＆NCIPI

2. 发明申请

WO1998003547A1 ANTAGONISTS OF INTESTINOTROPHIC GLP-2 PEPTIDES 审中-公开
标题翻译： INTESTINOTROPHIC GLP-2 PEPTIDES的拮抗剂
公开(公告)号：WO1998003547A1
公开(公告)日：1998-01-29
申请号：PCT/CA1997000521
申请日：1997-07-18
申请人： 1149336 ONTARIO INC. , ALLELIX BIOPHARMACEUTICALS INC. , DRUCKER, Daniel, J. , CRIVICI, Anna, E. , SUMNER-SMITH, Martin
发明人： 1149336 ONTARIO INC. , ALLELIX BIOPHARMACEUTICALS INC.
IPC分类号： C07K14/605
CPC分类号： C07K14/605 , A61K38/00 , G01N2333/605 , Y02A50/471
摘要： Antagonists of glucagon-like peptide 2 have been identified. Their effects on the growth of gastrointestinal tissue are described. Its formulation as a pharmaceutical, and its therapeutic and related uses in treating bowel tissue, are described. Also described are methods of identifying antagonists of glucagon-like peptide 2.
摘要翻译：胰高血糖素样肽2的拮抗剂已被鉴定。描述了它们对胃肠组织生长的影响。描述了其作为药物的制剂及其在治疗肠组织中的治疗和相关用途。还描述了鉴定胰高血糖素样肽2的拮抗剂的方法。

3. 发明申请

WO1996038480A1 ANTI-INFLAMMATORY THROMBOSPONDIN-DERIVED PEPTIDES 审中-公开
标题翻译：抗炎炎症血栓形成蛋白衍生肽
公开(公告)号：WO1996038480A1
公开(公告)日：1996-12-05
申请号：PCT/IB1996000537
申请日：1996-06-01
申请人： ALLELIX BIOPHARMACEUTICALS, INC.
发明人： ALLELIX BIOPHARMACEUTICALS, INC. , BEAUBIEN, Beatrice , BURROWES, Clement, E. , YANG, Zhi-Jie
IPC分类号： C07K14/78
CPC分类号： C07K14/78 , A61K38/39
摘要： An anti-inflammatory peptide is provided having the amino acid sequence of the following general formula (I): R1-X1-X2-X3-X4-X5-X6-R2 wherein: X1 and X5 are selected from the group consisting of cysteine and alanine; X2, X3, and X4 are the same or different amino acid residues selected from the group consisting of valine, threonine, serine and arginine; X6 is an amino acid selected from the group consisting of lysine, glycine and arginine; R1 is selected from the group consisting of H, a blocking group, a blocked or an unblocked amino acid residue and the desamino form of said amino acid; and R2 is selected from the group consisting of NH2, a blocking group, a blocked or an unblocked amino acid residue and the carboxyamide or alkylamide form of said amino acid.
摘要翻译：提供具有以下通式（I）的氨基酸序列的抗炎肽：R1-X1-X2-X3-X4-X5-X6-R2其中：X1和X5选自半胱氨酸和丙氨酸; X2，X3和X4是相同或不同的选自缬氨酸，苏氨酸，丝氨酸和精氨酸的氨基酸残基; X6是选自赖氨酸，甘氨酸和精氨酸的氨基酸; R1选自H，封闭基团，封闭或未封闭的氨基酸残基和所述氨基酸的脱氨基形式; 并且R 2选自NH 2，封闭基团，封闭或未封闭的氨基酸残基和所述氨基酸的羧酰胺或烷酰胺形式。

4. 发明申请

WO1996033218A1 ANTI-HAEMORRHAGIC PEPTIDES 审中-公开
标题翻译：抗高血压肽
公开(公告)号：WO1996033218A1
公开(公告)日：1996-10-24
申请号：PCT/IB1996000358
申请日：1996-04-19
申请人： ALLELIX BIOPHARMACEUTICALS INC.
发明人： ALLELIX BIOPHARMACEUTICALS INC. , BEAUBIEN, Beatrice , BURROWES, Clement, E. , YANG, Zhi-Jie
IPC分类号： C07K14/78
CPC分类号： C07K7/06 , A61K38/08 , A61K38/39 , C07K5/101 , C07K14/78
摘要： An anti-haemorrhagic peptide is provided having the amino acid sequence of the general formula (I): R1-X1-X2-X3-X4-X5-X6-R2 wherein: X1 and X5 are selected from the group consisting of cysteine and alanine; X2, X3, and X4 are the same or different amino acid residues selected from the group consisting of valine, threonine, serine, and arginine; X6 is an amino acid selected from the group consisting of lysine, glycine and arginine; R1 is selected from the group consisting of H, a blocking group, a blocked or an unblocked amino acid residue and the desamino form of said amino acid; and R2 is selected from the group consisting of NH2, a blocking group, a blocked or an unblocked amino acid residue and the carboxyamide or alkylamide form of said amino acid.
摘要翻译：提供了具有通式（I）的氨基酸序列的抗出血肽：R1-X1-X2-X3-X4-X5-X6-R2其中：X1和X5选自半胱氨酸和丙氨酸 ; X2，X3和X4是相同或不同的选自缬氨酸，苏氨酸，丝氨酸和精氨酸的氨基酸残基; X6是选自赖氨酸，甘氨酸和精氨酸的氨基酸; R1选自H，封闭基团，封闭或未封闭的氨基酸残基和所述氨基酸的脱氨基形式; 并且R 2选自NH 2，封闭基团，封闭或未封闭的氨基酸残基和所述氨基酸的羧酰胺或烷酰胺形式。

5. 发明申请

WO1995029926A1 GUANIDINO-SUBSTITUTED COMPOUNDS 审中-公开
标题翻译：官网替代化合物
公开(公告)号：WO1995029926A1
公开(公告)日：1995-11-09
申请号：PCT/CA1995000250
申请日：1995-04-28
申请人： ALLELIX BIOPHARMACEUTICALS INC. , RAKHIT, Sumanas , SLASSI, Abdelmalik
发明人： ALLELIX BIOPHARMACEUTICALS INC.
IPC分类号： C07H15/04
CPC分类号： C07H15/04 , C07C279/16 , C07D211/06 , C07H15/08
摘要： Novel guanidino-substituted compounds are described having general formula (I) or a salt, hydrate or solvate thereof, in which X is selected from C, O, N and S; R1 and R3 are independently -(W)a-(R6)b-Z, wherein a and b are independently 0 or 1; W is NH, O or S; R6 is C1-8alkylene in which one or two non-adjacent, intervening carbon atoms thereof is optionally replaced with nitrogen or oxygen; and Z is H, OH or -NH-C(NH)-NH2; provided that when b is 0 then Z is H; R2 is selected from H and OH; and R4 and R5 are independently C1-8alkylene in which one of the carbon atoms thereof is optionally replaced with nitrogen or oxygen. Compounds in accordance with formula (I) have been found to inhibit HIV replication.
摘要翻译：描述了新的胍基取代的化合物，其具有通式（I）或其盐，水合物或溶剂合物，其中X选自C，O，N和S; R1和R3独立地为 - （W）a-（R6）b-Z，其中a和b独立地为0或1; W是NH，O或S; R6是C1-8亚烷基，其中一个或两个不相邻的中间碳原子任选被氮或氧取代; 并且Z是H，OH或-NH-C（NH）-NH 2; 条件是当b为0时，Z为H; R2选自H和OH; 并且R 4和R 5独立地为C 1-8亚烷基，其中一个碳原子任选被氮或氧取代。已经发现根据式（I）的化合物抑制HIV复制。

6. 发明申请

WO1995017508A2 GLUTAMATE RECEPTOR (OR EAA RECEPTOR) POLYNUCLEOTIDES AND THEIR USES 审中-公开
标题翻译：谷氨酸受体（或EAA受体）多核苷酸及其用途
公开(公告)号：WO1995017508A2
公开(公告)日：1995-06-29
申请号：PCT/CA1994000705
申请日：1994-12-21
申请人： ALLELIX BIOPHARMACEUTICALS INC. , KAMBOJ, Rajender , NUTT, Stephen
发明人： ALLELIX BIOPHARMACEUTICALS INC.
IPC分类号： C12N15/12
CPC分类号： C07K14/705
摘要： Human CNS receptor-encoding DNA is provided from which more than one form of the receptor protein, an edited form and an unedited form, is expressed in vivo . The edited and unedited receptor forms are functionally distinct, and appear to be selectively expressed. Thus, a CNS receptor-encoding gene that is subject to such editing has value in screening compounds for potential therapeutic utility.
摘要翻译：提供了人CNS受体编码DNA，其中多于一种形式的受体蛋白，编辑形式和未编辑形式在体内表达。编辑和未编辑的受体形式在功能上是不同的，并且似乎被选择性地表达。因此，经受这种编辑的CNS受体编码基因在筛选化合物中具有潜在的治疗效用。

7. 发明申请

WO1995017207A1 PARATHYROID HORMONE FORMULATION 审中-公开
标题翻译： PARATHYROID HORMONE配方
公开(公告)号：WO1995017207A1
公开(公告)日：1995-06-29
申请号：PCT/CA1994000693
申请日：1994-12-16
申请人： ALLELIX BIOPHARMACEUTICALS INC. , GLAXO CANADA INC.
发明人： ALLELIX BIOPHARMACEUTICALS INC. , GLAXO CANADA INC. , HOLTHUIS, Josephus, Johannes, Maria , MEKKING, Albert , VOETMAN, Alwinus, Antonius
IPC分类号： A61K38/29
CPC分类号： A61K38/29 , A61K9/0019 , A61K9/19 , A61K47/12 , A61K47/26 , Y10S514/97
摘要： Described herein are preparations containing parathyroid hormone that has been stabilized with an excipient and buffering agent. Preferred preparations incorporate human PTH(1-84), mannitol as excipient and citrate as buffering agent, and are incorporated in vials as a freeze-dried powder for reconstitution to treat osteoporosis.
摘要翻译：本文描述了含有已经用赋形剂和缓冲剂稳定的甲状旁腺激素的制剂。优选的制剂包括人PTH（1-84），甘露醇作为赋形剂和柠檬酸盐作为缓冲剂，并且作为冷冻干燥粉末并入小瓶中用于重建以治疗骨质疏松症。

8. 发明申请

WO1995009237A3 EXPRESSION OF HUMAN D4 DOPAMINE RECEPTORS IN STABLE CELL LINES 审中-公开
公开(公告)号：WO1995009237A3
公开(公告)日：1995-04-06
申请号：PCT/CA1994000538
申请日：1994-09-27
申请人： ALLELIX BIOPHARMACEUTICALS INC. , OWOLABI, Joshua , RAMPERSAD, Vikarna , KAMBOJ, Rajender
发明人： ALLELIX BIOPHARMACEUTICALS INC.
IPC分类号： C12N15/12

9. 发明申请

WO1998017278A1 NEUROTROPHIN ANTAGONIST COMPOSITIONS 审中-公开
标题翻译：神经营养拮抗剂组合物
公开(公告)号：WO1998017278A1
公开(公告)日：1998-04-30
申请号：PCT/CA1997000779
申请日：1997-10-20
申请人： ALLELIX BIOPHARMACEUTICALS INC. , TEHIM, Ashok , CHEN, Xiannong
发明人： ALLELIX BIOPHARMACEUTICALS INC.
IPC分类号： A61K31/47
CPC分类号： C07D221/14 , A61K31/473 , A61K31/4738 , C07D401/04 , C07D401/06 , C07D405/06
摘要： A pharmaceutical composition comprising a compound of formula (I) wherein R is selected from, inter alia, alkyl, aryl-loweralkyl, heterocycle-loweralkyl, loweralkyl-carbonate; optionally substituted amino; benzimidaz-2-yl; optionally substituted phenyl; loweralkyl-(R ), (R ) wherein one of R and R is selected from H and loweralkyl and the other is selected from carboxy, carboxy-loweralkyl and loweralkoxycarbonyl; NHCH2CH2OX wherein X represents an in vivo hydrolyzable ester; and R and R are independently selected from H, NO2, halo, di(loweralkyl)amino, cyano, C(O)OH, phenyl-S-, loweralkyl, and Z(O)OR wherein Z is selected from C and S and R is selected from H, loweralkylamino and arylamino; or pharmaceutically acceptable salts or certain in vivo hydrolyzable esters or amides thereof, in an amount effective to inhibit neurotrophin-mediated activity, and a suitable carrier, is described. The compositions are useful to inhibit undesirable neurotrophin-mediated activity such as the neurite outgrowth that occurs in some neurodegenerative disease states.
摘要翻译：一种药物组合物，其包含式（I）化合物，其中R 1特别选自烷基，芳基 - 低级烷基，杂环 - 低级烷基，低级烷基 - 碳酸酯; 任选取代的氨基; benzimidaz -2-基; 任选取代的苯基; 低级烷基 - （R 5），（R 6）其中R 5和R 6中的一个选自H和低级烷基，另一个选自羧基，羧基 - 低级烷基和低级烷氧基羰基; NHCH2CH2OX其中X表示体内可水解的酯; R 2和R 3独立地选自H，NO 2，卤素，二（低级烷基）氨基，氰基，C（O）OH，苯基-S-，低级烷基和Z（O）OR 7 其中Z选自C和S，R 7选自H，低级烷基氨基和芳基氨基; 或其药学上可接受的盐或某些体内可水解的酯或酰胺，以有效抑制神经营养因子介导的活性的量和合适的载体。所述组合物可用于抑制不期望的神经营养因子介导的活性，例如在一些神经变性疾病状态中发生的神经突向外生长。

10. 发明申请

WO1997046525A1 5-ALKOXY-TRYPTAMINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS 5-HT1D RECEPTOR AGONISTS 审中-公开
标题翻译： 5-ALKOXY-TRYPTAMINE衍生物，其制备及其用作5-HT1D受体激动剂
公开(公告)号：WO1997046525A1
公开(公告)日：1997-12-11
申请号：PCT/CA1997000366
申请日：1997-05-28
申请人： ALLELIX BIOPHARMACEUTICALS INC.
发明人： ALLELIX BIOPHARMACEUTICALS INC. , MENG, Qingchang , SLASSI, Abdelmalik , RAKHIT, Sumanas
IPC分类号： C07D209/16
CPC分类号： C07D403/06 , C07D209/14 , C07D403/12 , C07D403/14 , C07D417/12 , C07D417/14
摘要： Novel 5-alkoxy tryptamine derivatives are provided, correponding to general formula (I) wherein n is an integer from 1 - 3; R represents a straight or branched C1-C9 alkylene chain optionally interrupted by a phenylene group; X represents amino, mono(loweralkyl)amino, di(loweralkyl)amino or optionally N-lower alkyl-substituted pyrrolidine; and Y represents optionally substituted phthalimide, benzosulfonimide, naphthosultam, naphthalimide, isoindolone camphorsultam, toluenesulfonamido, N, N'-dicarboxylated guanidino or N-carboxylated amino, each of which is linked to R via a respective N-group thereof. The compounds show selective binding to 5-HT1D receptor subtypes, and have potential pharmaceutical utility in manufacture of migraine-treating drugs.
摘要翻译：提供新的5-烷氧基色胺衍生物，与通式（I）相对应，其中n为1-3的整数; R表示任选被亚苯基中断的直链或支链C 1 -C 9亚烷基链; X表示氨基，单（低级烷基）氨基，二（低级烷基）氨基或任选的N-低级烷基取代的吡咯烷; Y代表任意取代的邻苯二甲酰亚胺，苯并磺酰亚胺，萘磺酰胺，萘二甲酰亚胺，异吲哚酮樟脑磺酸，甲苯磺酰氨基，N，N'-二羧酸胍基或N-羧化氨基，它们各自通过其相应的N-基与R连接。这些化合物显示出与5-HT1D受体亚型的选择性结合，并且在制造偏头痛药物方面具有潜在的药用效用。

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