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1. 发明申请

WO2011091412A1 A25 BACTERIOPHAGE LYSIN 审中-公开
公开(公告)号：WO2011091412A1
公开(公告)日：2011-07-28
申请号：PCT/US2011/022383
申请日：2011-01-25
申请人： ALERE SCARBOROUGH, INC. , MERMER, Brion , PALIN, William, J. , TURCOTTE, Nancy
发明人： MERMER, Brion , PALIN, William, J. , TURCOTTE, Nancy
IPC分类号： C12N9/26 , C12Q1/14 , G01N33/50
CPC分类号： G01N33/56944 , C07K14/005 , C12N1/06 , C12N2795/00022 , G01N2469/10 , G01N2800/26
摘要： The invention relates to the identification, sequencing, and isolation of an A25 bacteriophage lysin gene that expresses a protein involved in the lysis of bacterial cells during the phage life cycle. The invention further relates to methods for lysing certain bacteria using lysin, which are useful for example in a diagnostic procedure designed to detect these bacteria.
摘要翻译：本发明涉及在噬菌体生命周期中表达参与细菌细胞裂解的蛋白质的A25噬菌体溶素基因的鉴定，测序和分离。本发明还涉及使用溶素裂解某些细菌的方法，其可用于例如设计用于检测这些细菌的诊断程序。

2. 发明授权

EP1596976B1 CHROMATOGRAPHIC STRIP FOR THE PERFORMANCE OF A GLUCOSE-6-PHOSPHATE DEHYDROGENASE ASSAY 有权
公开(公告)号：EP1596976B1
公开(公告)日：2019-11-13
申请号：EP04714110.6
申请日：2004-02-24
申请人： Alere Scarborough Inc.
发明人： PIASIO, Roger , TURNER, Nathan B.
IPC分类号： G01N33/543 , G01N33/558 , G01N33/52 , B01J20/28 , B01J20/281 , C12Q1/32

3. 发明授权

EP2084528B1 ASSAYS AND DEVICES FOR IDENTIFYING PATHOGENS 有权
标题翻译：试验和设备病原的
公开(公告)号：EP2084528B1
公开(公告)日：2012-08-29
申请号：EP07874224.4
申请日：2007-10-22
申请人： Alere Scarborough, Inc.
发明人： MOORE, Norman, James
IPC分类号： G01N33/53 , G01N33/569
CPC分类号： G01N33/56911 , G01N33/5308

4. 发明授权

US08951532B2 A25 bacteriophage lysin 有权
标题翻译： A25噬菌体溶素
公开(公告)号：US08951532B2
公开(公告)日：2015-02-10
申请号：US13575217
申请日：2011-01-25
申请人： Brion Mermer , William J. Palin , Nancy Turcotte
发明人： Brion Mermer , William J. Palin , Nancy Turcotte
IPC分类号： A01N63/00 , A61K39/00 , A61K39/02 , A61K31/00 , G01N33/569 , C07K14/005 , C12N1/06
CPC分类号： G01N33/56944 , C07K14/005 , C12N1/06 , C12N2795/00022 , G01N2469/10 , G01N2800/26
摘要： The invention relates to the identification, sequencing, and isolation of an A25 bacteriophage lysin gene that expresses a protein involved in the lysis of bacterial cells during the phage life cycle. The invention further relates to methods for lysing certain bacteria using lysin, which are useful for example in a diagnostic procedure designed to detect these bacteria.
摘要翻译：本发明涉及在噬菌体生命周期中表达参与细菌细胞裂解的蛋白质的A25噬菌体溶素基因的鉴定，测序和分离。本发明还涉及使用溶素裂解某些细菌的方法，其可用于例如设计用于检测这些细菌的诊断程序。

5. 发明申请

US20130252322A1 DRY CHEMISTRY, LATERAL FLOW-RECONSTITUTED CHROMATOGRAPHIC ENZYME-DRIVEN ASSAYS 审中-公开
标题翻译：干燥化学，侧流式重构色谱酶促测定
公开(公告)号：US20130252322A1
公开(公告)日：2013-09-26
申请号：US13741973
申请日：2013-01-15
申请人： ALERE SCARBOROUGH, INC.
发明人： Roger N. Piasio , Nathan Turner
IPC分类号： G01N21/78
CPC分类号： C12Q1/32 , B01J20/28033 , B01J20/281 , G01N21/78 , G01N33/523 , G01N33/54326 , G01N33/558 , G01N2333/902 , G01N2333/904 , G01N2333/986
摘要： A lateral flow chromatographic assay format for the performance of rapid enzyme-driven assays is described. A combination of components necessary to elicit a specific enzyme reaction, which are either absent from the intended sample or insufficiently present therein to permit completion of the desired reaction, are predeposited as substrate in dry form together with ingredients necessary to produce a desired color upon occurrence of the desired reaction. The strip is equipped with a sample pad placed ahead of the substrate deposit in the flowstream, to which liquid sample is applied. The sample flows from the sample pad into the substrate zone where it immediately reconstitutes the dried ingredients while also intimately mixing with them and reacting with them at the fluid front. The fluid front moves rapidly into the final “read zone” wherein the color developed is read against predetermined color standards for the desired reaction. Pretreatment pads for the sample, as needed, are placed in front of the sample pad in the flow path as appropriate. The assay in the format of the invention is faster and easier to perform than analogous wet chemistry assays.
摘要翻译：描述了用于快速酶驱动测定的侧流色谱测定方法。将引起特定酶反应（其不在预期样品中或不充分存在于其中以允许完成所需反应）所需的组分的组合预先沉积为干燥形式的底物以及在发生时产生所需颜色所需的成分的所需反应。带材上装有样品垫，放置在流动的衬底沉积物的前面，并向其施加液体样品。样品从样品垫流入基底区域，在那里它立即重构干燥的成分，同时与它们充分混合并在流体前面与它们反应。流体前沿快速移动到最终的“读取区域”，其中根据预期的颜色标准读取显色的颜色用于所需的反应。根据需要将样品的预处理垫适当地放置在流路中的样品垫的前面。本发明形式的测定比类似的湿化学测定更快更容易进行。

6. 发明申请

US20140038202A1 ASSAY DETECTION SYSTEMS AND METHODS 审中-公开
标题翻译：测定系统和方法
公开(公告)号：US20140038202A1
公开(公告)日：2014-02-06
申请号：US13960169
申请日：2013-08-06
申请人： Alere Scarborough, Inc.
发明人： Andrew Wheeler , Christopher Turmel
IPC分类号： G01N21/53
CPC分类号： G01N21/534 , G01N21/8483 , G01N2015/0693
摘要： Described herein are methods and devices for detecting one or more targets in a sample using an assay device, optical illumination, and optical detection.
摘要翻译：本文描述了使用测定装置，光学照明和光学检测来检测样品中的一种或多种靶的方法和装置。

7. 发明申请

US20120208202A1 Method for the Reduction of Biological Sampling Errors by Means of Image Processing 审中-公开
标题翻译：通过图像处理减少生物抽样误差的方法
公开(公告)号：US20120208202A1
公开(公告)日：2012-08-16
申请号：US13236038
申请日：2011-09-19
申请人： Andrew Wheeler , Roger N. Piasio , Christopher Turmel
发明人： Andrew Wheeler , Roger N. Piasio , Christopher Turmel
IPC分类号： G01N33/53
CPC分类号： G01N33/543
摘要： The present invention relates to methods and devices for reducing biological sampling errors by means of image processing. Image processing techniques are used to determine the volume of sample added to a device, such as a diagnostic test, and to correct for user error in sampling techniques.
摘要翻译：本发明涉及通过图像处理减少生物抽样误差的方法和装置。图像处理技术用于确定添加到设备的样本的体积，如诊断测试，并纠正采样技术中的用户错误。

8. 发明授权

US09989529B2 Method for detection of Legionella bacteria employing purified antigen-specific antibodies 有权
公开(公告)号：US09989529B2
公开(公告)日：2018-06-05
申请号：US14828823
申请日：2015-08-18
申请人： Alere Scarborough, Inc.
发明人： Vladimir A. Koulchin , Norman J. Moore , Elena V. Molokova
IPC分类号： C12Q1/68 , G01N33/569 , C07K16/12 , G01N33/53 , G01N21/78 , G01N21/75 , G01N21/77
CPC分类号： G01N33/56911 , C07K16/126 , G01N21/78 , G01N33/53 , G01N2021/752 , G01N2021/757 , G01N2021/7759 , G01N2400/10 , G01N2469/10
摘要： The present invention involves extracting from Legionella bacteria, particularly L. pneumophila bacteria, an essentially protein-free O-polysaccharide or carbohydrate antigen, coupling this antigen to an activated chromatographic column through a protein space molecule which is first conjugated to the antigen, utilizing the column thus prepared for the affinity purification of raw polyvalent antibodies to the same Legionella bacterium from which the O-polysaccharide or carbohydrate antigen was separated—thereby obtaining antigen-specific antibodies which are useful for the rapid detection of the corresponding Legionella bacterium or its antibody in human bodily fluids such as urine, sputum, blood and the like or in environmental samples suspected of harboring theLegionella bacterium.

9. 发明授权

US09921220B2 Process and materials for the rapid detection of Streptococcus pneumoniae employing purified antigen-specific antibodies 有权
公开(公告)号：US09921220B2
公开(公告)日：2018-03-20
申请号：US15057822
申请日：2016-03-01
申请人： Alere Scarborough, Inc.
发明人： Norman J. Moore , Mary K. Konstantin , Vladimir A. Koulchin , Elena V. Molokova
IPC分类号： G01N33/569 , C07K16/12 , G01N21/78 , G01N21/75 , G01N21/77
CPC分类号： G01N33/56944 , C07K16/1275 , G01N21/78 , G01N2021/752 , G01N2021/757 , G01N2021/7759 , G01N2333/3156 , G01N2400/10 , G01N2469/10
摘要： Disclosed is a cell wall C-polysaccharide antigen of Streptococcus pneumoniae which contains not more than 10% by weight of protein, and preferably less which has been purified with 0.1N Na OH prior to deproteinizing. Also disclosed are polyvalent antibodies raised against Streptococcus pneumoniae which have been affinity purified by passing them over a chromatographic affinity matrix to which is coupled the purified and at least partially deproteinized antigen to render them antigen-specific.

10. 发明授权

US09562901B2 A25 bacteriophage lysin 有权
标题翻译： A25噬菌体溶素
公开(公告)号：US09562901B2
公开(公告)日：2017-02-07
申请号：US14561776
申请日：2014-12-05
申请人： Alere Scarborough, Inc.
发明人： Brion Mermer , William J. Palin , Nancy Turcotte
IPC分类号： C12Q1/00 , C12Q1/68 , G01N33/53 , G01N33/554 , G01N33/569 , C07K14/005 , C12N1/06
CPC分类号： G01N33/56944 , C07K14/005 , C12N1/06 , C12N2795/00022 , G01N2469/10 , G01N2800/26
摘要： The invention relates to the identification, sequencing, and isolation of an A25 bacteriophage lysin gene that expresses a protein involved in the lysis of bacterial cells during the phage life cycle. The invention further relates to methods for lysing certain bacteria using lysin, which are useful for example in a diagnostic procedure designed to detect these bacteria.
摘要翻译：本发明涉及在噬菌体生命周期中表达参与细菌细胞裂解的蛋白质的A25噬菌体溶素基因的鉴定，测序和分离。本发明还涉及使用溶素裂解某些细菌的方法，其可用于例如设计用于检测这些细菌的诊断程序。

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