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1. 发明授权

US11352389B2 Treatment of haematological malignancies 有权
公开(公告)号：US11352389B2
公开(公告)日：2022-06-07
申请号：US16627230
申请日：2018-06-28
申请人： ACADEMISCH ZIEKENHUIS LEIDEN (H.O.D.N. LEIDS UNIVERSITAIR MEDISCH CENTRUM)
发明人： Marieke Griffioen , J. H. Frederik Falkenburg
IPC分类号： C07K7/06 , A61P35/02 , A61K35/17 , A61K35/761 , C07K14/47 , C07K14/725 , C12N15/86 , A61K39/00
摘要： Novel nucleic acid sequences, vectors, modified cells, peptides and pharmaceutical compositions are provided that are useful in the treatment of human subjects having a ΔNPM1 positive haematological malignancy. Corresponding methods and uses are also provided.

2. 发明申请

WO2008143506A1 TEST AND CALIBRATION DEVICE 审中-公开
标题翻译：测试和校准设备
公开(公告)号：WO2008143506A1
公开(公告)日：2008-11-27
申请号：PCT/NL2008/050298
申请日：2008-05-21
申请人： PUBLIEKRECHTEIIJKE RECHTSPERSOON ACADEMISCH ZIEKENHUIS LEIDEN H.O.D.N. LEIDS UNIVERSITAIR MEDISCH CENTRUM , SCHOT, Robert , STERK, Peter Jan , VAN DER PLAS, Dirk Teunis , SLATS, Annelies Margaretha
发明人： SCHOT, Robert , STERK, Peter Jan , VAN DER PLAS, Dirk Teunis , SLATS, Annelies Margaretha
IPC分类号： A61B5/093
CPC分类号： A61B5/085 , A61B5/087
摘要： The invention pertains to a device for testing the lung function in a subject, comprising a pump for providing a gas flow, an actuator for driving said pump, a sensor for determining a flow parameter of said gas flow, and a control unit, operationally coupled to said sensor for receiving at least one flow parameter from said sensor and operationally coupled to said actuator for controlling said actuator, said control unit having a processor and software for calculating a passive inspiration manoeuvre following an active inspiration manoeuvre using said flow parameters.
摘要翻译：本发明涉及一种用于测试受试者的肺功能的装置，包括用于提供气流的泵，用于驱动所述泵的致动器，用于确定所述气流的流量参数的传感器，以及控制单元，到所述传感器，用于从所述传感器接收至少一个流量参数并且可操作地耦合到所述致动器以控制所述致动器，所述控制单元具有处理器和软件，用于使用所述流动参数在主动吸气机动之后计算被动吸气机动。

3. 发明申请

WO2019004831A8 TREATMENT OF HAEMATOLOGICAL MALIGNANCIES 审中-公开
公开(公告)号：WO2019004831A8
公开(公告)日：2019-01-03
申请号：PCT/NL2018/050421
申请日：2018-06-28
申请人： ACADEMISCH ZIEKENHUIS LEIDEN (H.O.D.N. LEIDS UNIVERSITAIR MEDISCH CENTRUM)
发明人： GRIFFIOEN , Marieke , FALKENBURG, J. H. Frederik
IPC分类号： C07K14/725 , C07K14/47 , A61K48/00 , A61K39/00 , A61K2039/5154 , A61K2039/525 , A61K2039/53 , A61K2039/572 , A61K2039/585 , A61K2039/6006 , A61K35/17 , A61K35/761 , A61P35/02 , C07K14/4748 , C07K14/7051 , C07K7/06 , C12N15/86 , C12N2740/10043
摘要： Novel nucleic acid sequences, vectors, modified cells, peptides and pharmaceutical compositions are provided that are useful in the treatment of human subjects having a ΔΝΡΜ 1 positive haematological malignancy. Corresponding methods and uses are also provided.

4. 发明申请

WO2020055247A1 ARTERIOVENOUS GRAFT SYSTEM, ARTERIOVENOUS VALVE DEVICE AND METHOD TO IMPLANT AN ARTERIOVENOUS GRAFT SYSTEM 审中-公开
公开(公告)号：WO2020055247A1
公开(公告)日：2020-03-19
申请号：PCT/NL2019/050589
申请日：2019-09-11
申请人： ACADEMISCH ZIEKENHUIS LEIDEN H.O.D.N. LEIDS UNIVERSITAIR MEDISCH CENTRUM
发明人： GEELHOED, Wouter Jan , VAN DER BOGT, Koen Elzert Adriaan , ROTMANS, Joris Ivo
IPC分类号： A61F2/06 , A61F2/24 , A61M1/36 , A61M39/02 , A61M39/22
摘要： The invention provides a subcutaneous arteriovenous graft system, comprising an arteriovenous graft having an arterial end, a venous end opposite to the arterial end and an internal volume between the arterial end and the venous end, and a valve device that can be arranged in an open state, in which fluid flow through the graft is possible and a closed state in which the fluid flow through the arteriovenous graft is blocked.The valve device is constructed to decrease, in the closed state of the valve device, the internal volume of the complete graft to substantially zero.

5. 发明申请

WO2017135815A1 ANALOGUE TO DIGITAL DATA CONVERTER 审中-公开
标题翻译：模拟数字数据转换器
公开(公告)号：WO2017135815A1
公开(公告)日：2017-08-10
申请号：PCT/NL2017/050061
申请日：2017-02-01
申请人： TECHNISCHE UNIVERSITEIT DELFT , TECHNOLOGIESTICHTING STW , PUBLIEKRECHTELIJK RECHTSPERSOON ACADEMISCH ZIEKENHUIS LEIDEN H.O.D.N. LEIDS UNIVERSITAIR MEDISCH CENTRUM
发明人： BES, Cees Jeroen , SERDIJN, Wouter Anton , LOTFI, Reza
IPC分类号： H03M1/12 , H03M1/18 , H03M1/14 , H03M1/48 , H03M1/36
CPC分类号： H03M1/1295 , H03M1/145 , H03M1/181 , H03M1/361 , H03M1/48
摘要： Analogue to digital data converter (ADC) (1) comprising an analogue signal input (2) and a digital signal output (3), wherein an analogue amplifier (4) is provided in a signal path (6) from the analogue signal input (2) to the digital signal output (3), and comprising a processor (5) that receivingly connects to the analogue amplifier (4) and forms a feedback loop with said analogue amplifier (4), wherein the processor (5) provides an analogue offset signal that modifies an analogue signal in the signal path (6) from the analogue signal input to the digital signal output (3), wherein both the input signal and the analogue offset signal are provided to the analogue amplifier (4) through separate circuit elements (C1, C3), and the processor (5) comprises control logic (11) for switches (phi1 - phi5) that are arranged to connect a charge-injecting organ, preferably a charged capacitor (C3), to the input (7) of the analogue amplifier (4) so as to provide the analogue off-set signal to the analogue amplifier (4).
摘要翻译：包括模拟信号输入端（2）和数字信号输出端（3）的模数数据转换器（ADC）（1），其中模拟放大器（4）设置在信号路径 6）从模拟信号输入（2）到数字信号输出（3），并且包括接收连接到模拟放大器（4）并与所述模拟放大器（4）形成反馈回路的处理器（5），其中处理器（5）提供模拟偏移信号，该模拟偏移信号从输入到数字信号输出（3）的模拟信号修改信号路径（6）中的模拟信号，其中输入信号和模拟偏移信号都被提供给模拟放大器（4）通过分离的电路元件（C1，C3），并且处理器（5）包括用于开关（ph1-ph5）的控制逻辑（11），其被布置为连接电荷注入器件，优选地为充电电容器 C3）连接到模拟放大器（4）的输入端（7），以提供模拟偏置信号到模拟放大器（4）。

6. 发明申请

US20220193258A1 RECOMBINANT AAV-CRUMBS HOMOLOGUE COMPOSITION AND METHODS FOR TREATING LCA-8 AND PROGRESSIVE RP 有权
公开(公告)号：US20220193258A1
公开(公告)日：2022-06-23
申请号：US17558052
申请日：2021-12-21
申请人： Academisch Ziekenhuis Leiden H.O.D.N. Leids Universitair Medisch Centrum
发明人： Jan Wijnholds , Lucie Pierrette Francoise Pellissier
IPC分类号： A61K48/00 , C07K14/47 , C12N15/86 , C12N15/864 , C07K14/705
摘要： The present invention relates to a Crumbs homologue (CRB) therapeutic for use as a medicament or in a method of treatment or prophylaxis, for example in the treatment or prophylaxis of a retinal disorder due to mutations in the Crumbs homologue-1 (CRB1) gene, such as Leber's congenital amaurosis 8 (LCA8) or retinitis pigmentosa 12 (RP12). In particular, the present invention relates to a recombinant viral vector comprising CRB2 or modified non-toxic forms of either CRB1 or CRB3 that resemble CRB2.

7. 发明授权

US09656067B2 Medical probe for electro-stimulation and training of pelvic floor musculature 有权
公开(公告)号：US09656067B2
公开(公告)日：2017-05-23
申请号：US14620277
申请日：2015-02-12
申请人： Publiekrechtelijke Rechtspersoon Academisch Ziekenhuis Leiden h.o.d.n. Leids Universitair Medisch Centrum
发明人： Robertus Coenraad Maria Pelger , Theodorus Johannes Ouwerkerk , Pieternella Johanna Voorham-Van Der Zalm
IPC分类号： A61N1/04 , A61N1/36 , A61B5/0488 , A61N1/05 , A63B23/20 , A61B5/00 , A61H19/00 , A61H21/00 , A61N1/08
CPC分类号： A61N1/36007 , A61B5/0488 , A61B5/04882 , A61B5/486 , A61H19/00 , A61H19/44 , A61H21/00 , A61H2205/085 , A61H2205/086 , A61H2230/605 , A61N1/0509 , A61N1/0512 , A61N1/0524 , A61N1/08 , A63B23/20
摘要： A probe system for electro-stimulation and bio-feedback training of muscles in the pelvic floor region, in particular for pelvic floor physiotherapy and diagnosis, includes a probe having a probe body which is insertable into a vagina or a rectum, and a plurality of electrodes which are positioned at several locations along the length and around the circumference on the outer surface of the probe, the probe system further includes a control unit, operationally coupled to the probe, adapted for receiving EMG signals from each of the electrodes and for processing each of the signals for mapping the response of the muscles in the pelvic floor region.

8. 发明授权

US12059339B2 Arteriovenous graft system, arteriovenous valve device and method to implant an arteriovenous graft system 有权
公开(公告)号：US12059339B2
公开(公告)日：2024-08-13
申请号：US17275326
申请日：2019-09-11
申请人： Academisch Ziekenhuis Leiden h.o.d.n. Leids Universitair Medisch Centrum
发明人： Wouter Jan Geelhoed , Koen Elzert Adriaan van der Bogt , Joris Ivo Rotmans
IPC分类号： A61F2/07 , A61F2/24 , A61M1/36 , A61M39/22
CPC分类号： A61F2/07 , A61F2/2475 , A61M1/3655 , A61M39/228
摘要： A subcutaneous arteriovenous graft system includes an arteriovenous graft having an arterial end, a venous end opposite to the arterial end and an internal volume between the arterial end and the venous end, and a valve device that can be arranged in an open state, in which fluid flow through the graft is possible and a closed state in which the fluid flow through the arteriovenous graft is blocked. The valve device is constructed to decrease, in the closed state of the valve device, the internal volume of the complete graft to substantially zero.

9. 发明授权

US11246947B2 Recombinant AAV-crumbs homologue composition and methods for treating LCA-8 and progressive RP 有权
公开(公告)号：US11246947B2
公开(公告)日：2022-02-15
申请号：US14910302
申请日：2014-08-05
申请人： Academisch Ziekenhuis Leiden H.O.D.N. Leids Universitair Medisch Centrum
发明人： Jan Wijnholds , Lucie Pierrette Francoise Pellissier
IPC分类号： A61K48/00 , C07K14/47 , C12N15/86 , C12N15/864 , C07K14/705 , A61K35/76
摘要： The present invention relates to a Crumbs homologue (CRB) therapeutic for use as a medicament or in a method of treatment or prophylaxis, for example in the treatment or prophylaxis of a retinal disorder due to mutations in the Crumbs homologue-1 (CRB1) gene, such as Leber's congenital amaurosis 8 (LCA8) or retinitis pigmentosa 12 (RP12). In particular, the present invention relates to a recombinant viral vector comprising CRB2 or modified non-toxic forms of either CRB1 or CRB3 that resemble CRB2.

10. 发明授权

US08983627B2 Medical probe for electro-stimulation and bio-feedback training of pelvic floor musculature 有权
标题翻译：盆底肌肉电刺激和生物反馈训练的医学探针
公开(公告)号：US08983627B2
公开(公告)日：2015-03-17
申请号：US12302145
申请日：2007-05-23
申请人： Robertus Coenraad Maria Pelger , Theodorus Johannes Ouwerkerk , Pieternella Johanna Voorham-van der Zalm
发明人： Robertus Coenraad Maria Pelger , Theodorus Johannes Ouwerkerk , Pieternella Johanna Voorham-van der Zalm
IPC分类号： A61N1/04 , A61N1/05 , A61B5/0488 , A61N1/36 , A63B23/20 , A61B5/00 , A61H19/00 , A61H21/00 , A61N1/08
CPC分类号： A61N1/36007 , A61B5/0488 , A61B5/04882 , A61B5/486 , A61H19/00 , A61H19/44 , A61H21/00 , A61H2205/085 , A61H2205/086 , A61H2230/605 , A61N1/0509 , A61N1/0512 , A61N1/0524 , A61N1/08 , A63B23/20
摘要： A probe system for electro-stimulation and bio-feedback training of muscles in the pelvic floor region, in particular for pelvic floor physiotherapy and diagnosis, includes a probe having a probe body which is insertable into a vagina or a rectum, and a plurality of electrodes which are positioned at several locations along the length and around the circumference on the outer surface of the probe, the probe system further includes a control unit, operationally coupled to the probe, adapted for receiving EMG signals from each of the electrodes and for processing each of the signals for mapping the response of the muscles in the pelvic floor region.
摘要翻译：用于骨盆底部区域的肌肉的电刺激和生物反馈训练的探针系统，特别是用于盆底物理治疗和诊断的探针系统包括具有可插入阴道或直肠的探针体的探针，以及多个电极位于探头外表面上的长度和周围的多个位置处，探针系统还包括操作上耦合到探头的控制单元，适于从每个电极接收EMG信号并用于处理每个信号用于映射骨盆底部区域肌肉的反应。

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