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1. 发明专利

JPH10502631A 失效
公开(公告)号：JPH10502631A
公开(公告)日：1998-03-10
申请号：JP50425396
申请日：1995-06-21
申请人： ASTRA AB
发明人： BRODIN ARNE FOLKE , CARLSSON ANDERS , HERSLOEF BENGT GOERAN , NICKLASSON ALF GUNNAR MARTIN , RYDHAG LISBETH ELEONOR MARG
IPC分类号： A61K9/06 , A61K9/127 , A61K9/70 , A61K31/245 , A61K45/00 , A61K47/44 , A61P25/04

2. 发明专利

JPH06501262A 失效
公开(公告)号：JPH06501262A
公开(公告)日：1994-02-10
申请号：JP51624291
申请日：1991-09-25
申请人： ASTRA AB
IPC分类号： A61K31/165 , A61P11/00 , A61P11/08 , C07C231/10 , C07C231/14 , C07C231/20 , C07C233/42 , C07C233/43

3. 发明专利

JPH11504844A 失效
公开(公告)号：JPH11504844A
公开(公告)日：1999-05-11
申请号：JP52591897
申请日：1997-01-16
申请人： ASTRA AB
IPC分类号： A61B17/56 , A61B17/58 , A61B17/74 , A61B17/86 , A61C8/00 , A61F2/00 , A61F2/28 , A61F2/30 , A61F2/32 , A61F2/36

4. 发明专利

JPH09501930A 失效
公开(公告)号：JPH09501930A
公开(公告)日：1997-02-25
申请号：JP50751695
申请日：1994-08-25
申请人： ASTRA AB
发明人： TROFAST EVA ANN-CHRISTIN , BRIGGNER LARS-ERIK
IPC分类号： A61K9/00 , A61K9/14 , A61K9/72 , A61K31/137 , A61K31/41 , A61K31/4245 , A61K31/425 , A61K31/426 , A61K31/433 , A61K31/44 , A61K31/496 , A61K31/505 , A61K47/12 , A61P29/00 , A61P43/00 , B01J2/28 , C07C45/68 , C07C49/753 , C07C65/40 , C07C69/94 , C07C205/45 , C07C225/22 , C07C233/33 , C07C255/56 , C07C311/08 , C07D213/28 , C07D213/30 , C07D213/38 , C07D213/40 , C07D239/42 , C07D271/06 , C07D271/10 , C07D277/24 , C07D285/12 , C07D333/38 , C07D413/04
摘要： PCT No. PCT/SE94/00780 Sec. 371 Date Jan. 30, 1995 Sec. 102(e) Date Jan. 30, 1995 PCT Filed Aug. 25, 1994 PCT Pub. No. WO95/05805 PCT Pub. Date Mar. 2, 1995The present invention relates to a process for providing a stable crystallinic form to a fine-grained substance or a substance mixture, which can be produced, stored and used while maintaining the aerodynamic properties required for inhalation of such a substance or a substance mixture, by a) in case of a substance mixture, preparing a homogenous mixture of the substances; b) micronizing, direct precipitating or diminishing by any conventional method the substance or substance mixture into a particle size required for inhalation, the particle size being less than 10 mu m; c) optionally preparing a homogenous mixture of the desired substances when each substance has been introduced from stage b) as separate fine-grained particles; d) conditioning said substance or substance mixture by treatment with a water containing vapor phase in a controlled fashion; and e) drying.

5. 发明专利

JPH08503870A 失效
公开(公告)号：JPH08503870A
公开(公告)日：1996-04-30
申请号：JP51404394
申请日：1993-12-01
申请人： ASTRA AB
发明人： ELLINGSEN JAN EIRIK , ROLLA GUNNAR
IPC分类号： A61L26/00 , A61F2/00 , A61L20060101 , A61L27/00 , A61L27/06 , A61L25/00

6. 发明专利

JPH06506454A 失效
公开(公告)号：JPH06506454A
公开(公告)日：1994-07-21
申请号：JP50719592
申请日：1992-03-24
申请人： ASTRA AB
发明人： TROFAST JAN , TROFAST EVA , BYSTROEM KATARINA , JAKUPOVIC EDIB
IPC分类号： A61K9/72 , A61K20060101 , A61K9/00 , A61K9/14 , A61K31/13 , A61K31/137 , A61K31/198 , A61K31/715 , A61K47/26 , A61P11/08 , A61P43/00

7. 发明专利

JP2801401B2 失效
公开(公告)号：JP2801401B2
公开(公告)日：1998-09-21
申请号：JP51624291
申请日：1991-09-25
申请人： ASTRA AB
IPC分类号： A61K31/165 , A61P11/00 , A61P11/08 , C07C231/10 , C07C231/14 , C07C231/20 , C07C233/42 , C07C233/43

8. 发明专利

JPH10509062A 失效
公开(公告)号：JPH10509062A
公开(公告)日：1998-09-08
申请号：JP51432196
申请日：1995-10-27
申请人： AID MEDIC LTD , ASTRA AB
发明人： DENYER JONATHAN STANLEY HAROLD , NIKANDER KURT VERNER HOLGER
IPC分类号： A61M11/00 , A61M11/04 , A61M15/00 , A61M15/08 , A61M16/00
摘要： PCT No. PCT/EP95/04254 Sec. 371 Date Jul. 14, 1997 Sec. 102(e) Date Jul. 14, 1997 PCT Filed Oct. 27, 1995 PCT Pub. No. WO96/13294 PCT Pub. Date May 9, 1996An apparatus for administering a fluid medicament to a patient in a gas for inhalation and for calculating the dosage administered to the patient comprising a holding member (1) for temporarily holding the medicament and gas prior to inhalation, means for introducing a quantity of the medicament into the holding chamber (1), a sensor (4) for detecting the introduction of the medicament into the holding chamber (1), detector means for detecting the rate of flow of gas inhaled by a patient from the holding chamber (1) and calculation means (25, 27, 29, 30, 31) operably connected to the sensor (4) and to the detector means for calculating the amount of medicament received by a patient. The calculating means (25, 27, 29, 30, 31) makes its calculation on the basis of the quantity of medicament released into the holding chamber (1), the volume of the holding chamber (1), the time elapsed from the detection of the introduction of the medicament, and the detected rate of flow of gas inhaled from the holding chamber (1). The calculation being made by assessing the concentration of the medicament in the holding chamber (1) on a time basis during reduction of the said concentration within the holding chamber (1), and be determining the volume of the gas received by the patient during inhalation, and the time elapsed from the detected introduction of medicament to the inhalation by the patient.

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