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    • 5. 发明申请
    • ORGANOGENESIS FROM DISSOCIATED CELLS
    • 离散细胞中的有机体
    • WO2006020958A2
    • 2006-02-23
    • PCT/US2005/028933
    • 2005-08-15
    • ADERANS RESEARCH INSTITUTE, INC.ZHENG, YingDU, XiaobingWANG, WeiBOUCHER, MarylenePARIMOO, SatishSTENN, Kurt, Stricker
    • ZHENG, YingDU, XiaobingWANG, WeiBOUCHER, MarylenePARIMOO, SatishSTENN, Kurt, Stricker
    • A61K35/12A61K35/36C12N5/071
    • A61K35/36A61K8/02A61K8/985A61K35/12A61Q7/00C12N5/0627
    • A method assay for rapidly and reproducibly generating hair follicles from dissociated epithelial and mesenchymal cells is disclosed. The method serves both as a tool for measuring the trichogenic (i.e., hair growth-inducing) property of cells and for studying the mechanisms dissociated cells employ to assemble an organ. In a method of this application dissociated cells, isolated from newborn mouse skin, are injected into adult mouse truncal skin, hair follicles develop. This process involves the aggregation of epithelial cells to form clusters which are sculpted by apoptosis to generate "infundibular cysts". From the "infundibular cysts" hair germs form followed by follicular buds and then pegs which grow asymmetrically to differentiate into cycling mature pilosebaceous structures. Using various techniques, exposure of the "infundibular cysts" by puncturing, piercing, or scratching the skin and, in an approach, covering the exposed cysts with a wound dressing material produced egressing hair follicles.
    • 公开了用于从分离的上皮细胞和间充质细胞快速并可重复产生毛囊的方法测定。 该方法既可用作测量细胞毛发生成(即毛发生长诱导)特性的工具,也可用于研究分离细胞用于组装器官的机制。 在本申请的方法中,将从新生小鼠皮肤分离的分离的细胞注射到成年小鼠躯干皮肤中,形成毛囊。 该过程涉及上皮细胞的聚集以形成通过细胞凋亡而雕刻以产生“漏斗状囊肿”的簇。 从“漏斗囊肿” 头发细菌形成,然后是毛囊芽,然后是不对称生长的毛球,以分化成为循环成熟的毛皮脂肪结构。 使用各种技术,暴露“漏斗囊肿” 通过穿刺,刺穿或刮擦皮肤,并且在一种方法中,使用流出毛囊的伤口敷料材料覆盖暴露的囊肿。