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81. 发明专利

GB1462854A ORGANIC PEROXIDIC COMPOUNDS USEFUL FOR THE POLYMERISATION OR DOPOLYMERISATION OF UNSATURATED ESTERS 未知
公开(公告)号：GB1462854A
公开(公告)日：1977-01-26
申请号：GB3468676
申请日：1973-12-21
申请人： AKZO NV
IPC分类号： C07C409/22 , C07C179/06 , C07D317/02
摘要： 1462854 Aldehyde- or ketone-peroxide derivatives AKZO NV 21 Dec 1973 [22 Dec 1972] 34686/76 Divided out of 1462853 Heading C2C An organic peroxidic compound having the formula wherein R 1 , R 2 , R 3 and R 4 may be the same or different and each represents a branched or unbranched alkyl group, if desired substituted by hydroxy, alkoxy, alkoxycarbonyl or halogen; an aryl group which may be substituted by alkyl, hydroxyl alkoxy or halogen or an arakyl group wherein the aryl part may be substituted by alkyl, hydroxy, alkoxy or halogen or wherein one or more of R 1 plus R 2 ; R 3 plus R 4 or R 1 plus R 4 may form a branched or unbranched alkylene group or wherein R 1 together with R 2 and R 3 may form a branched or unbranched alkylidene group is prepared by reacting carbonyl compounds of the formula with an aqueous solution of hydrogen peroxide in an organic solvent in which both the carbonyl compounds and the product peroxidic compound are soluble in the presence of an acid catalyst in an amount of 0À2 to 200 mg. equivalent per mole of carbonyl groups, removing water by distillation and, if desired, subsequently removing the acid catalyst. Many compounds which may be prepared by said method are listed. In the examples 3,6-diethyl-3,6-dihydroperoxy - 4,5 - dioxoctane; bis - (5 - methyl- 3 - hydroperoxyheptyl - 3,3 1 - peroxide); 7,10 - dihydroperoxy - 8,9 - dioxadecane, 12,15 - dihydroperoxy - 13,14 - dioxahexacosane or 2,7 - dimethyl - 3,6 - dihydroperoxy - 4,5- dioxaoctane is prepared by reacting diethyl ketone, ethyl isoamylketone, heptanal, dodecanal or isobutyraldehyde in benzene, diisobutylphthalate toluene or n-butyl acetate in the presence of an aqueous solution of hydrogen peroxide and p-toluene sulphonic acid, sulphuric acid or a strong acid ion exchanger and in some cases, after the distillation of water, the acid is removed by the addition of base or by filtration and the product further purified.

82. 发明专利

SE376239B 未知
公开(公告)号：SE376239B
公开(公告)日：1975-05-12
申请号：SE764872
申请日：1972-06-09
申请人： SPOFA VEREINIGTE PHARMA WERKE
发明人： PROTIVA M , JILEK J , METYSOVA J
IPC分类号： A61K31/495 , C07D295/08 , C07D317/02 , C07D337/14 , C07D409/04 , C07D409/14 , C07D295/00

83. 发明专利

FR2140684A1 未知
公开(公告)号：FR2140684A1
公开(公告)日：1973-01-19
申请号：FR7221112
申请日：1972-06-12
申请人： SPOFA VEREINIGTE PHARMA WERKE
发明人： PROTIVA M , JILEK J , METYSOVA J
IPC分类号： A61K31/495 , C07D295/08 , C07D317/02 , C07D337/14 , C07D409/04 , C07D409/14 , A61K27/00 , C07D67/00

84. 发明专利

HRP20211542T1 TETRASUPSTITUIRANI SPOJEVI ALKENA I NJIHOVA UPORABA 未知
公开(公告)号：HRP20211542T1
公开(公告)日：2022-01-07
申请号：HRP20211542
申请日：2016-05-27
申请人： EISAI R&D MAN CO LTD
发明人： BOCK MARKUS , HAO MING-HONG , KORPAL MANAV , NYAVANANDI VIJAY KUMAR , PUYANG XIAOLING , SAMAJDAR SUSANTA , SMITH PETER GERARD , WANG JOHN , ZHENG GUO ZHU , ZHU PING
IPC分类号： A61K31/4439 , C07D231/56 , C07D317/02 , C07D317/06 , C07D401/06 , C07D401/14 , C07D403/06 , C07D403/12 , C07D471/14 , C07D487/04

85. 发明专利

MD3302471T2 Compuși de alchenă tetrasubstituiți și utilizarea acestora 未知
公开(公告)号：MD3302471T2
公开(公告)日：2021-12-31
申请号：MDE20180368
申请日：2016-05-27
申请人： EISAI R&D MAN CO LTD
发明人： BOCK MARK , HAO MING-HONG , KORPAL MANAV , NYAVANANDI VIJAY KUMAR , PUYANG XIAOLING , SAMAJDAR SUSANTA , SMITH PETER GERARD , WANG JOHN , ZHENG GUO ZHU , ZHU PING
IPC分类号： A61K31/4439 , C07D231/56 , C07D317/02 , C07D317/06 , C07D401/06 , C07D401/14 , C07D403/06 , C07D403/12 , C07D471/14 , C07D487/04
摘要： Sunt dezvăluiţi compuşi sau săruri acceptabile farmaceutic ale acestora şi metode de utilizare a compuşilor pentru tratarea cancerului de sân prin administrarea unui subiect care are nevoie de acesta a unei cantităţi eficiente terapeutic din compuşi sau săruri acceptabile farmaceutic ale acestora. Cancerul de sân poate fi un cancer de sân ER-pozitiv şi/sau subiectul care are nevoie de tratament poate exprima o proteină ER-a mutantă.

86. 发明专利

LT3302471T TETRAPAKEISTIEJI ALKENŲ JUNGINIAI IR JŲ PANAUDOJIMAS 未知
公开(公告)号：LT3302471T
公开(公告)日：2021-10-11
申请号：LT16034782
申请日：2016-05-27
申请人： EISAI R&D MAN CO LTD
发明人： BOCK MARK , HAO MING-HONG , KORPAL MANAV , NYAVANANDI VIJAY KUMAR , PUYANG XIAOLING , SAMAJDAR SUSANTA , SMITH PETER GERARD , WANG JOHN , ZHENG GUO ZHU , ZHU PING
IPC分类号： A61K31/4439 , C07D231/56 , C07D317/02 , C07D317/06 , C07D401/06 , C07D401/14 , C07D403/06 , C07D403/12 , C07D471/14 , C07D487/04

87. 发明专利

JO3735B1 مركبات ألكين بها استبدال رباعي واستخداماتها 未知
公开(公告)号：JO3735B1
公开(公告)日：2021-01-31
申请号：JOP20160102
申请日：2016-05-29
申请人： EISAI R&D MAN CO LTD
发明人： JOHN WANG , MING-HONG HAO , GUO ZHU ZHENG , MANAV KORPAL , PING ZHU , MARK BOCK , VIJAY KUMAR NYAVANANDI , SUSANTA SAMAJDAR , XIAOLING PUYANG , PETER GERARD SMITH
IPC分类号： C07D317/02 , A61K31/4439 , C07D317/06 , C07D487/04
摘要： يتعلقالاختراعالحاليبالكشفعنمركبات،أوأملاحمقبولةصيدلانياًمنها،وطرقاستخدامالمركباتلمعالجةسرطانالثديبواسطةإعطاءالخاضعالذيبحاجةإلىالعلاجكميةفعالةصيدلانياًمنالمركباتأوالأملاحالمقبولةصيدلانياًمنها. يمكنأنيكونسرطانالثديهوسرطانثديإيجابيلـ ER و/أويمكنأنيعبرالخاضعالذيبحاجةإلىالمعالجةعنبروتين ER-? بهطفرة.

88. 发明专利

AU2016271126A1 Tetrasubstituted alkene compounds and their use 未知
公开(公告)号：AU2016271126A1
公开(公告)日：2017-12-07
申请号：AU2016271126
申请日：2016-05-27
申请人： EISAI R&D MAN CO LTD
发明人： BOCK MARK , HAO MING-HONG , KORPAL MANAV , NYAVANANDI VIJAY KUMAR , PUYANG XIAOLING , SAMAJDAR SUSANTA , SMITH PETER GERARD , WANG JOHN , ZHENG GUO ZHU , ZHU PING
IPC分类号： C07D317/02 , A61K31/4439 , C07D317/06 , C07D487/04
摘要： Disclosed herein are compounds, or pharmaceutically acceptable salts thereof, and methods of using the compounds for treating breast cancer by administration to a subject in need thereof a therapeutically effective amount of the compounds or pharmaceutically acceptable salts thereof. The breast cancer may be an ER-positive breast cancer and/or the subject in need of treatment may express a mutant ER-α protein.

89. 发明专利

SK282082B6 CARBOXYLIC ACID DERIVATIVES 未知
公开(公告)号：SK282082B6
公开(公告)日：2001-10-08
申请号：SK28298
申请日：1996-08-29
申请人： BASF AG
发明人： AMBERG WILHELM , KLING ANDREAS , KLINGE DAGMAR , RIECHERS HARTMUT , UNGER LILIANE , RASCHACK MANFRED , HERGENRODER STEFAN , ELGER BERND , SCHULT SABINE
IPC分类号： A61K31/00 , A61K31/19 , A61K31/192 , A61K31/34 , A61K31/341 , A61K31/343 , C07D317/02 , A61K31/35 , A61K31/352 , A61K31/357 , A61K31/36 , A61K31/435 , A61K31/44 , A61K31/505 , A61P9/00 , A61P9/08 , C07C53/134 , C07C57/30 , C07C57/32 , C07C57/38 , C07C59/64 , C07C69/616 , C07C69/734 , C07C255/00 , C07D213/55 , C07D213/64 , C07D221/04 , C07D239/26 , C07D239/34 , C07D239/52 , C07D239/70 , C07D257/04 , C07D307/79 , C07D317/50 , C07D317/60 , C07D319/02 , C07D319/18
摘要： PCT No. PCT/EP96/03793 Sec. 371 Date Feb. 24, 1998 Sec. 102(e) Date Feb. 24, 1998 PCT Filed Aug. 29, 1996 PCT Pub. No. WO97/09294 PCT Pub. Date Mar. 13, 1997Carboxylic acid derivatives of the formula I here R1 is a tetrazole [sic], nitrile [sic], a group COOH or a radical which can be hydrolyzed to COOH, and the other substituents have the meaning explained in the description.

90. 发明专利

DE59606132D1 未知
公开(公告)号：DE59606132D1
公开(公告)日：2000-12-14
申请号：DE59606132
申请日：1996-08-29
申请人： BASF AG
发明人： AMBERG WILHELM , KLING ANDREAS , KLINGE DAGMAR , RIECHERS HARTMUT , UNGER LILIANE , RASCHACK MANFRED , HERGENROEDER STEFAN , ELGER BERND , SCHULT SABINE
IPC分类号： C07D317/02 , A61K31/00 , A61K31/19 , A61K31/192 , A61K31/34 , A61K31/341 , A61K31/343 , A61K31/35 , A61K31/352 , A61K31/357 , A61K31/36 , A61K31/435 , A61K31/44 , A61K31/505 , A61P9/00 , A61P9/08 , C07C53/134 , C07C57/30 , C07C57/32 , C07C57/38 , C07C59/64 , C07C69/616 , C07C69/734 , C07C255/00 , C07D213/55 , C07D213/64 , C07D221/04 , C07D239/26 , C07D239/34 , C07D239/52 , C07D239/70 , C07D257/04 , C07D307/79 , C07D317/50 , C07D317/60 , C07D319/02 , C07D319/18
摘要： PCT No. PCT/EP96/03793 Sec. 371 Date Feb. 24, 1998 Sec. 102(e) Date Feb. 24, 1998 PCT Filed Aug. 29, 1996 PCT Pub. No. WO97/09294 PCT Pub. Date Mar. 13, 1997Carboxylic acid derivatives of the formula I here R1 is a tetrazole [sic], nitrile [sic], a group COOH or a radical which can be hydrolyzed to COOH, and the other substituents have the meaning explained in the description.

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