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81. 发明申请

US20110226622A1 NOVEL CLEAR NATIVE ELECTROPHORESIS METHOD UTILIZING AROMATIC SULFONIC ACID COMPOUND 审中-公开
标题翻译：使用芳香磺酸化合物的新颖清晰的电泳方法
公开(公告)号：US20110226622A1
公开(公告)日：2011-09-22
申请号：US13130995
申请日：2009-12-01
申请人： Tomoya Hino , Takeshi Murata , So Iwata , Toshiyuki Kan
发明人： Tomoya Hino , Takeshi Murata , So Iwata , Toshiyuki Kan
IPC分类号： C07K1/26 , C07C309/49
CPC分类号： C07C309/46 , G01N27/44747
摘要： This invention provides a reagent for protein electrophoresis, an electrophoresis gel or buffer composition containing the reagent, and a protein separation method and an electrophoresis kit using the reagent and the composition.
摘要翻译：本发明提供了一种蛋白质电泳用试剂，含有试剂的电泳凝胶或缓冲组合物，以及蛋白质分离方法以及使用该试剂和组合物的电泳试剂盒。

82. 发明授权

US06927303B2 Tetrafluorobenzyl derivatives and pharmaceutical composition for preventing and treating acute and chronic neurodegenerative diseases in central nervous system containing the same 有权
公开(公告)号：US06927303B2
公开(公告)日：2005-08-09
申请号：US10481648
申请日：2003-06-19
申请人： Byoung-Joo Gwag , Sung-Hwa Yoon , Ho-Sang Moon , Eun-Chan Park , Seok-Joon Won , Young-Ae Lee , Hae-Un Lee
发明人： Byoung-Joo Gwag , Sung-Hwa Yoon , Ho-Sang Moon , Eun-Chan Park , Seok-Joon Won , Young-Ae Lee , Hae-Un Lee
IPC分类号： A61P9/10 , A61K31/135 , A61K31/137 , A61K31/166 , A61K31/196 , A61K31/255 , A61P21/02 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/24 , A61P25/28 , A61P25/30 , A61P27/02 , A61P27/06 , A61P39/02 , A61P39/06 , A61P43/00 , C07C215/76 , C07C229/60 , C07C229/64 , C07C235/60 , C07C237/44 , C07C309/49 , C07C261/00
CPC分类号： C07C215/76 , A61K31/136 , C07C229/60 , C07C229/64 , C07C235/60 , C07C309/49 , C07C2601/14
摘要： The present invention relates to a tetrafluorobenzyl derivative and a pharmaceutical composition for prevention and treatment of acute and chronic neurodegenerative disease in central nervous system and ophthalmic diseases containing the same. The tetrafluorobenzyl derivative of the present invention can effectively be used to prevent and treat chronic neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease and Huntington's disease, degenerative brain disease such as epilepsy and ischemic brain disease such as stroke.

83. 发明授权

US5009985A Iron complexes and bleaching baths containing same 失效
标题翻译：铁络合物和含有相同的漂白浴
公开(公告)号：US5009985A
公开(公告)日：1991-04-23
申请号：US571504
申请日：1990-08-22
申请人： Friedrich-Wilhelm Kunitz , Ralf Wichmann
发明人： Friedrich-Wilhelm Kunitz , Ralf Wichmann
IPC分类号： C07C229/18 , C07C309/49 , C07C311/42 , G03C7/42
CPC分类号： C07C311/42 , C07C229/18 , C07C309/49 , G03C7/42
摘要： Iron(III)-complexes of compounds of the formula ##STR1## wherein R.sub.1 denotes a substituent,m denotes 1 or 2 andn denotes 0, 1 or 2are valuable and biodegradable bleaching agents for photographic elements.
摘要翻译：式（III）化合物的铁（III） - 复合物，其中R 1表示取代基，m表示1或2，n表示0,1或2是用于照相元件的有价值且可生物降解的漂白剂。

84. 发明授权

US4912258A Fluorinated aniline derivatives and their use 失效
标题翻译：氟化苯胺衍生物及其用途
公开(公告)号：US4912258A
公开(公告)日：1990-03-27
申请号：US159422
申请日：1988-02-05
申请人： Hans-Georg Batz , Rupert Herrmann
发明人： Hans-Georg Batz , Rupert Herrmann
IPC分类号： C07C67/00 , C07C209/00 , C07C211/52 , C07C213/00 , C07C215/16 , C07C231/00 , C07C233/36 , C07C233/43 , C07C301/00 , C07C309/14 , C07C309/46 , C07C309/48 , C07C309/49 , C07C311/05 , C07D215/18 , C07D455/04 , C12Q1/28
CPC分类号： C12Q1/28 , C07D215/18 , C07D455/04 , C12Q2326/00
摘要： Fluorinated aniline derivatives of the general formula I are described ##STR1## in which R.sup.1 represents H or (CH.sub.2).sub.n -X, n is a whole number from 1 to 3, X is H, OH, NH.sub.2, CH.sub.3 CONH, CH.sub.3 SO.sub.2 NH, SO.sub.3 H or ArSO.sub.3 H, Ar is optionally substituted arylene radical, R.sup.1 is alternatively also a --(CH.sub.2).sub.3 -- group, which is bonded to the free o-position next to the N-atom, Y is H, --O--, --NH--, --S-- or a C--C single bond, R.sup.2, in the event that Y=H, is the same as or different from R.sup.1 and means one of the radicals shown for R.sup.1, and in the event that Y is a C--C single bond or --O--, --NH-- or --S--, is an alkylene group having 1 to 3 carbon atoms linked with Y, and R.sup.3 =H, alkyl having 1 to 3 carbon atoms, OCH.sub.3, CH.sub.3 CONH, CO.sub.2 H or SO.sub.3 H.The compounds of formula I form as coupling components together with the conventional color couplers a very sensitive chromogenic system which is suitable for the analytical determination of oxidizing substances, for example for the determination of H.sub.2 O.sub.2 and POD in body fluids.
摘要翻译：描述通式I的氟化苯胺衍生物描述为其中R 1表示H或（CH 2）n X，n为1至3的整数，X为H，OH，NH 2，CH 3 CONH，CH 3 SO 2 NH，SO 3 H 或ArSO 3 H，Ar为任选取代的亚芳基，R 1还可为 - （CH 2）3 - 基团，其与N-原子上的游离邻位键合，Y为H，-O-，-NH- ，-S-或CC单键，在Y = H的情况下，R 2与R 1相同或不同，并且表示R1所示的基团之一，并且在Y为CC单键或 -O-，-NH-或-S-是与Y连接的具有1至3个碳原子的亚烷基，R 3 = H，具有1至3个碳原子的烷基，OCH 3，CH 3 CONH，CO 2 H或SO 3 H。式I的化合物与常规的色成色剂一起形成耦合组分，这是非常敏感的显色系统，其适用于氧化物质的分析测定，例如用于测定体液中的H 2 O 2和POD。

85. 发明授权

US4260558A Process for the preparation of aromatic aminohydroxy compounds 失效
标题翻译：芳香族氨基羟基化合物的制备方法
公开(公告)号：US4260558A
公开(公告)日：1981-04-07
申请号：US953805
申请日：1978-10-23
申请人： Theodor Pfister
发明人： Theodor Pfister
IPC分类号： C07C67/00 , C07C213/00 , C07C213/02 , C07C215/74 , C07C215/76 , C07C229/64 , C07C301/00 , C07C303/22 , C07C303/32 , C07C309/49 , C07C99/00 , C07C139/00 , C07C143/56 , C07C143/64
CPC分类号： C07C215/76 , C07C309/49
摘要： An improvement in the process for the preparation of an aromatic hydroxy compounds by reacting an aromatic nitroso compound of the formula ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 independently represent hydrogen, a lower alkyl radical, halogen, a carboxyl or sulfo group or the corresponding alkali metal salt thereof orR.sup.1, R.sup.2 or R.sup.3 individually represent an optionally substituted aromatic ring formed by linking two adjacent radicals,with hydrazine, the improvement residing in reacting the aromatic nitroso compound with the hydrazine in approximately equivalent amounts in an aqueous medium at temperatures from 10.degree. to 50.degree. C., in the absence of a catalyst the aromatic nitroso compound being initially introduced into a reaction chamber and the hydrazine being added thereto.
摘要翻译：通过使式（I）的芳族亚硝基化合物（其中R 1，R 2和R 3独立地表示氢，低级烷基，卤素，羧基或磺基）反应制备芳族羟基化合物的方法的改进或其相应的碱金属盐或R 1，R 2或R 3分别表示通过将两个相邻基团与肼连接而形成的任选取代的芳环，其改进位于使芳族亚硝基化合物与肼在大约相当量的水性介质中反应在10℃至50℃的温度下，在不存在催化剂的情况下，芳族亚硝基化合物最初被引入反应室，并加入肼。

86. 发明专利

JP2768505B2 失效
公开(公告)号：JP2768505B2
公开(公告)日：1998-06-25
申请号：JP21512389
申请日：1989-08-23
IPC分类号： C07C253/30 , C07C217/22 , C07C217/48 , C07C217/52 , C07C227/22 , C07C229/64 , C07C237/06 , C07C255/24 , C07C255/30 , C07C305/26 , C07C307/02 , C07C309/42 , C07C309/46 , C07C309/49 , C07D267/14 , C07D291/08 , C09B19/00 , C09B19/02 , C09B62/04 , C09B62/44 , C09B62/503 , C09B62/523

87. 发明专利

JPH09278694A ANTIFOULING COMPOUND 失效
公开(公告)号：JPH09278694A
公开(公告)日：1997-10-28
申请号：JP11534396
申请日：1996-04-11
申请人： NIPPON PAINT CO LTD , MITSUBISHI CHEM CORP
发明人： YAMAMORI NAOKI , YOKOI JUNJI , IMANISHI YUKIO , KINUGASA KAZUNARI , HIGUCHI HIROSHI , IWANE HIROSHI
IPC分类号： C07C39/11 , A01N33/10 , A01N37/44 , A01N41/08 , C07C43/205 , C07C43/23 , C07C69/54 , C07C233/20 , C07C309/46 , C07C309/49 , C09D5/14
摘要： PROBLEM TO BE SOLVED: To obtain an antifouling compound useful for preventing damage caused by adhesion and proliferation of underwater organisms in underwater offshore structures, having antifouling properties durable for a long period of time, low in toxicity and residual properties. SOLUTION: This antifouling compound is shown by formula I (at least one of X to X is a branched or straight-chain 6-10C alkyl and at least one is OH, NH2 , COOH, SO3 H, etc.; Z is acryloyl, methacryloyl or H; D is a chain compound consisting essentially of a polyoxyalkylene chain) such as hexaethylene glycol-2-hydroxy-5-nonylbenzyl ether. The compound of formula I is obtained by a reaction using a compound of formula II (X is a 6-10C alkyl; R is CH2 OH, CH2 COOH, NH2 , OCH2 CH2 OH, etc.) as a starting raw material or an intermediate.

88. 发明专利

JPH0625259A SULFO-CONTAINING BISAZOMETHINE/METAL COMPLEX SALT AND ITS PRODUCTION 失效
公开(公告)号：JPH0625259A
公开(公告)日：1994-02-01
申请号：JP2920393
申请日：1993-02-18
申请人： CIBA GEIGY AG
发明人： GERUHARUTO RAINAATO , GERUHARUTO BATSUKU , HERUMUUTO HIYUUBAA EMUDEN
IPC分类号： C07F1/08 , C07C243/38 , C07C309/49 , C07F13/00 , C07F15/04 , C09B55/00 , D06M13/02 , D06M13/322 , D06M13/50 , D06M13/503 , D06M101/00 , D06M101/16 , D06M101/30 , D06M101/34 , D06M101/36 , D06P1/62 , D06P1/642 , D06P3/24 , D06P3/26 , D06P5/00 , D06P5/06 , D06P5/10 , D06M13/425

89. 发明专利

JPH0624972A CHELATE COMPOUND AND ITS METAL COMPLEX, AND PREPARATION OF DIAGNOSTIC AGENT CONTAINING SAID COMPOUND, PHARMACEUTICAL DRUG FOR MEDICAL TREATMENT OF TUMOR AND CHELATE COMPOUND 失效
公开(公告)号：JPH0624972A
公开(公告)日：1994-02-01
申请号：JP4872092
申请日：1992-03-05
申请人： INST DEIAGUNOSUTEITSUKUFUORUSH
发明人： RAINHARUTO NOIMAIAA , BUORUFUGANGU KURANPU , HERUMUUTO ERU METSUKE , GERUHARUTO ROORUFUSU
IPC分类号： A61K31/13 , A61K31/195 , A61K31/22 , A61K31/44 , A61K31/4418 , A61K49/00 , A61K51/04 , A61K51/10 , A61P35/00 , C07B59/00 , C07C251/24 , C07C251/40 , C07C309/49 , C07C323/32 , C07C331/28 , C07D213/64 , C07D213/70 , C07D213/73 , C07D495/04 , C07F1/08 , C07F13/00 , C07J41/00
摘要： PURPOSE: To obtain a new comps. useful for a metallic complex and a diagnostic agent and useful to treat a tumor, etc. CONSTITUTION: This new compd. is a compd. represented by formula I [where R is H or an (OH substd.) 1-6C alkyl, R is an (OH substd.) 1-6C alkylene, R is H, a 1-6C alkyl, carboxymethyl, etc., R is H, an (OH substd.) 1-6C alkyl, etc., R is H or an (OH substd.) 1-6C alkyl, B is pyrrolyl, a group represented by formula II (wherein Z is OH, amino or mercapto and Y is H, carboxyl or sulfonyl), etc., A is amino, mercapto, carboxy, a 2-6C alkynyl, a 2-6C alkenyl, etc.], e.g. 2-methyl-2-(4'-nitrobenzyl)-N,N'-propylene-bis[(5-sulfo)- salicylideneamine]. The compd. represented by formula I is obtd., e.g. by allowing 1,3-propanediamine represented by formula III (where A' is A or a group convertible into A) to react with a compd. represented by formula IV in a polar solvent.

90. 发明专利

JPH0532906A NEW TRISAZO COMPOUND 失效
公开(公告)号：JPH0532906A
公开(公告)日：1993-02-09
申请号：JP19416691
申请日：1991-08-02
申请人： RICOH KK
发明人： SHIMODA MASAKATSU
IPC分类号： C07D213/84 , C07C245/08 , C07C245/10 , C07C255/65 , C07C309/49 , C07D231/06 , C09B35/378 , G11B7/24 , G11B7/244
摘要： PURPOSE:To obtain a new trisazo compound useful as a medium for light recording, ink, filter, optical shutter, photoelectric conversion element, light modulation element and space modulation element because of excellent solubility and large absorption coefficient and reflectance. CONSTITUTION:A trisazo compound expressed by formula I (Cp is residue of coupling component). For example, the trisazo compound is obtained by dispersing a trisamino compound, preferably expressed by formula II into an inorganic acid such as hydrochloric acid or sulfuric acid and adding sodium sulfite thereto at -10-20 deg.C and subjecting the trisamino compound to diazotization to form a tris(diazonium) salt expressed by formula III (X is anion functional group) and then dissolving the tris(diazonium) salt in an organic solvent such as N,N-dimethylformamide together with a coupler expressed by the formula H-Cp and adding dropwise an aqueous alkali solution thereto to carry out coupling reaction.

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