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81. 发明申请

US20040121370A1 Novel composition and methods for the treatment of immune related diseases 审中-公开
标题翻译：用于治疗免疫相关疾病的新型组合物和方法
公开(公告)号：US20040121370A1
公开(公告)日：2004-06-24
申请号：US10658482
申请日：2003-09-09
申请人： Genentech, Inc.
发明人： Daryl T. Baldwin , Sarah C. Bodary , Andrew C. Chan , Hilary Clark , Janet K. Jackman , William I. Wood
IPC分类号： C12Q001/68 , C07H021/04 , C07K014/47 , C07K016/18 , C12P021/02 , C12N001/21 , C12N001/18
CPC分类号： C07K16/18 , A61K2039/505 , C07K14/47 , C12N2799/026 , C12Q1/6883 , C12Q2600/158 , G01N2500/10 , G01N2800/065 , G01N2800/205 , G01N2800/24
摘要： The present invention relates to compositions containing a novel protein and methods of using those compositions for the diagnosis and treatment of immune related diseases.
摘要翻译：本发明涉及含有新蛋白质的组合物和使用这些组合物来诊断和治疗免疫相关疾病的方法。

82. 发明申请

US20040121361A1 Nucleic acid-associated proteins 审中-公开
公开(公告)号：US20040121361A1
公开(公告)日：2004-06-24
申请号：US10473575
申请日：2003-09-29
发明人： Junming Yang , April J.A. Hafalia , Neil Burford , Danniel B. Nguyen , Shanya D. Becha , Y. Tom Tang , Thomas W. Richardson , Henry Yue , Bridget A. Warren , Brooke M. Emerling , Mariah R. Baughn , Jennifer A. Griffin , Vicki S. Elliott , Narinder K. Chawla , Preeti G. Lal , Yalda Azimzai , Patricia M. Mason , Anna M. Chinn , Huibin Yue
IPC分类号： A01N037/18 , C12Q001/68 , C07H021/04 , C12N009/22 , C07K014/47
CPC分类号： C07H21/04 , A01K2217/05 , C07K14/47 , C12N9/00
摘要： The invention provides human nucleic acid-associated proteins (NAAP) and polynucleotides which identify and encode NAAP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of NAAP.

83. 发明申请

US20040121351A1 Nucleic acid sequence for a human beta tubulin 审中-公开
标题翻译：人β微管蛋白的核酸序列
公开(公告)号：US20040121351A1
公开(公告)日：2004-06-24
申请号：US10415420
申请日：2003-11-20
发明人： Ingo Hansmann , Kietmar Scholte , Claudia Gross
IPC分类号： C12Q001/68 , C07K014/47 , C07H021/04
CPC分类号： C07H21/04 , A61K38/00 , C07K14/47
摘要： The present invention is related to a nucleic acid molecule comprising a nucleotide sequence encoding the C terminal end of a tubulin molecule, wherein the C terminal end comprises the following sequence: VLEEDEEVTEEAEMEPEDKGH (SEQ ID. No. 4)
摘要翻译：本发明涉及包含编码微管蛋白分子的C末端的核苷酸序列的核酸分子，其中C末端包含以下序列：VLEEDEEVTEEAEMEPEDKGH（SEQ ID No.4）

84. 发明申请

US20040121349A1 Novel 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 and 65577 molecules and uses therefor 失效
标题翻译：小分子27877,18080,14081,32140,50352,16658,14223,16002,50566,65552和65577分子及其用途
公开(公告)号：US20040121349A1
公开(公告)日：2004-06-24
申请号：US10391364
申请日：2003-03-18
申请人： Millennium Pharmaceuticals, Inc.
发明人： Rachel E. Meyers , Joseph M. Carroll , William James Cook , Rosana Kapeller-Libermann , Nadine S. Weich , Rajasekhar Bandaru
IPC分类号： C12Q001/68 , A01K067/00 , C07H021/04 , C12N009/00 , C07K014/47 , C12P021/02 , C12N005/06
CPC分类号： A61K38/16 , A01K2217/05 , A61K38/4813 , A61K39/00 , A61K2039/53 , C07K14/47 , C07K2319/00 , C12N9/0008 , C12N9/12 , C12N9/16 , C12N9/20 , C12N9/6416 , C12N9/6424 , C12N9/6491 , C12N9/93 , C12Q1/25 , C12Q1/37 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Y603/02019 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/573 , G01N33/68 , G01N2500/10 , Y10T436/143333 , A61K2300/00
摘要： The invention provides isolated nucleic acids molecules, designated 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 and 65577 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 and 65577 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 or 65577 gene has been introduced or disrupted. The invention still further provides isolated 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 or 65577 proteins, fusion proteins, antigenic peptides and anti-27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 or 65577 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子，命名为27877,18080,14081,32140,50352,16658,14223,16002,50566,65552和65577核酸分子。本发明还提供反义核酸分子，含有27877,18080,14081,32140,50502,16658,14223,16002,50566,65552和65577核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及已经引入或破坏了27877,18080,14081,32140,50352,16658,14223,16002,50566,65552或65577基因的非人类转基因动物。本发明还进一步提供分离的27877,18080,14081,32140,50352,16658,14223,16002,50566,65552或65577蛋白，融合蛋白，抗原肽和抗27877,18080,14081,32140,50352,16658,14223 ，16002,50566,65552或65577抗体。还提供了利用本发明组合物的诊断和治疗方法。

85. 发明申请

US20040116677A1 Glycopolymers and free radical polymerization methods 失效
标题翻译：甘油聚合物和自由基聚合方法
公开(公告)号：US20040116677A1
公开(公告)日：2004-06-17
申请号：US10451011
申请日：2003-11-24
发明人： Elliot L. Chaikof , Daniel Grande , Subramanian Baskaran
IPC分类号： C07K014/47 , C08B037/00
CPC分类号： C08B37/00 , C08B37/0063
摘要： A glycopolymer composition is provided comprising glycopolymer molecules having a polymer backbone; a first pendent unit comprising a linking group connected to said polymer backbone and a saccharide moiety connected to said linking group, optionally a second pendent unit; a phenyl ring at a first end of the polymer backbone; and a cyanoxyl group at the second end of the polymer backbone, useful as intermediates for making bioactive glycopolymers which bind to bioactive molecules, viruses, cells and substrates for protein separation, cell culture, ad drug delivery systems, as well as in targeting for treatment of wound healing and other pathological conditions.
摘要翻译：提供了包含具有聚合物主链的聚合物聚合物分子的糖聚合物组合物; 第一悬挂单元，其包含连接到所述聚合物主链的连接基团和连接到所述连接基团的糖部分，任选地是第二侧挂单元; 在聚合物骨架的第一端的苯环; 和在聚合物主链的第二端的氰氧基，其可用作生物活性糖聚合物的中间体，其结合用于蛋白质分离，细胞培养，药物递送系统的生物活性分子，病毒，细胞和底物，以及靶向治疗的伤口愈合等病理状况。

86. 发明申请

US20040116337A1 Soluble cyclic analogues of beta amyloid peptide 失效
标题翻译： β淀粉样肽的可溶性环状类似物
公开(公告)号：US20040116337A1
公开(公告)日：2004-06-17
申请号：US10250581
申请日：2004-01-14
发明人： Afroditi Kapurniotu , Jurgen Bernhagen , Herwig Brunner
IPC分类号： A61K038/17 , C07K014/47
CPC分类号： C07K14/4711 , A61K38/00
摘要： The invention concerns a peptide having the biological activity of an inhibitor of amyloid formation and its diagnostic and medical use.
摘要翻译：本发明涉及具有淀粉样蛋白形成抑制剂的生物活性及其诊断和医学用途的肽。

87. 发明申请

US20040110928A1 Peptide conjugates for drug delivery 审中-公开
标题翻译：用于药物递送的肽缀合物
公开(公告)号：US20040110928A1
公开(公告)日：2004-06-10
申请号：US10240430
申请日：2003-04-15
发明人： Andrea Crisanti , Selma Esseghir
IPC分类号： A61K038/16 , C07K014/47
CPC分类号： A61K49/0013 , A61K47/62 , A61K47/645 , A61K47/665 , A61K47/6898 , A61K48/00 , B82Y5/00 , C12N15/87
摘要： A conjugate of a peptide capable of translocation across a cell membrane, and a therapeutic agent. The peptide comprises a defined amino acid sequence that provides the signal necessary for translocation.
摘要翻译：能够穿过细胞膜的肽的结合物和治疗剂。肽包含提供易位必需信号的限定的氨基酸序列。

88. 发明申请

US20040110234A1 Method of detecting colon cancer 失效
标题翻译：检测结肠癌的方法
公开(公告)号：US20040110234A1
公开(公告)日：2004-06-10
申请号：US10721434
申请日：2003-11-25
发明人： Keshab D. Pant , John D. McCracken , Omar Fagoaga , Wayne Kelln , Sandra Nehlsen-Cannarella
IPC分类号： G01N033/53 , C07K014/47
CPC分类号： G01N33/57419 , Y10S435/975
摘要： An immunological assay and kit for colon cancer screening is disclosed. Fecal glycoproteins are extracted from individual samples such that immunogenicity is maintained. The purified fecal glycoproteins are reacted with antibodies to Colon and Ovarian Tumor Antigen (COTA). The mucin antigen COTA is specifically present in colorectal cancer tissue and not in normal colons. The amount of COTA in the fecal sample is determined and used to indicate the presence of colon cancer.
摘要翻译：公开了用于结肠癌筛选的免疫学测定和试剂盒。从各个样品中提取粪便糖蛋白，从而保持免疫原性。纯化的粪便糖蛋白与结肠和卵巢肿瘤抗原（COTA）的抗体反应。粘蛋白抗原COTA特异性存在于结肠直肠癌组织中，而不是正常的冒号。确定粪便样品中COTA的量并用于指示结肠癌的存在。

89. 发明申请

US20040106776A1 Methods of crystal optimisation 失效
标题翻译：晶体优化方法
公开(公告)号：US20040106776A1
公开(公告)日：2004-06-03
申请号：US10680390
申请日：2003-10-02
申请人： Imperial College Innovations Limited
发明人： Naomi E. Chayen
IPC分类号： G01N033/53 , C07K014/47
CPC分类号： C07K14/43 , C07K14/42 , C07K2299/00 , C30B7/00 , C30B29/58
摘要： The present invention provides an automated method of optimising crystallisation conditions for macromolecules comprising forming a trial comprising a sample comprising a gel forming component and the macromelecule to be crystallised, wherein at least one component of the trial is dispensed using an automatic liquid dispensing system.
摘要翻译：本发明提供了一种优化大分子的结晶条件的自动化方法，其包括形成包含凝胶形成组分和待结晶的大分子的样品的试验，其中使用自动液体分配系统分配试验的至少一种组分。

90. 发明申请

US20040106773A1 Human tuberoinfundibular peptide of 39 residues 审中-公开
标题翻译：人结核分枝杆菌肽39个残基
公开(公告)号：US20040106773A1
公开(公告)日：2004-06-03
申请号：US10399602
申请日：2003-11-06
发明人： Hao Wang , Kenneth S Koblan , Hong Sun , Kimberly Della Penna
IPC分类号： C07K014/47 , C07H021/04
CPC分类号： C07K14/635 , C07K14/47
摘要： Disclosed herein are newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide is a human protein, which has been putatively identified as a ligand of a parathyroid hormone receptor homolog, hereinafter referred to as PTH2 Receptor. In particular, the invention relates to isolated nucleic acid molecules, such as DNA and RNA encoding a novel human tuberoinfundibular peptide of 39 residues.
摘要翻译：本文公开了新鉴定的多核苷酸，由这种多核苷酸编码的多肽，使用这种多核苷酸和多肽，以及产生这种多核苷酸和多肽。更具体地，多肽是人类蛋白质，其已被推定为甲状旁腺激素受体同系物的配体，以下称为PTH2受体。特别地，本发明涉及分离的核酸分子，例如编码39个残基的新型人结核分枝杆菌肽的DNA和RNA。

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