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81. 发明专利

JPS61178974A PRODUCTION OF POLYHYDRIC ALCOHOL GLYCIDYL ETHER 失效
公开(公告)号：JPS61178974A
公开(公告)日：1986-08-11
申请号：JP1966585
申请日：1985-02-04
申请人： DAICEL CHEM
发明人： MIZUMOTO SEIJI , HORIKAWA TAKESHI
IPC分类号： C08G59/00 , C07D301/24 , C07D301/28 , C07D303/26 , C08G59/04 , C08G59/06
摘要： PURPOSE:To obtain the titled compound useful as a raw material for synthetic resins, etc., selectively in good yield in a short time, by reacting a polyhydric alcohol with an epihalohydrin in the presence of a catalyst at a low temperature, and adding a dehydrohalogenating agent thereto to epoxidize the reaction prod uct. CONSTITUTION:A polyhydric alcohol is reacted with 1-1.5 equivalents, preferably 1.05-1.2 equivalents, based on the above-mentioned compound, epihalohydrin in the presence of a catalyst, e.g. boron trifluoride ethyl etherate, at -20-5 deg.C, preferably -10-0 deg.C particularly in the presence of the boron troifluoride ethyl etherate, at

82. 发明专利

JPS5726677A Preparation of oxirane compound 失效
标题翻译：氧化物的制备
公开(公告)号：JPS5726677A
公开(公告)日：1982-02-12
申请号：JP10121080
申请日：1980-07-25
申请人： Sagami Chem Res Center
发明人： IRIUCHIJIMA SHINOBU , KOJIMA NATSUKO
IPC分类号： C07D301/24
摘要： PURPOSE: To obtain the titled substance, an intermediate for synthesizing a compound useful as a remedy for arrhythmia by a few processes easily, by treating a readily obtainable bromohydrin compound as a raw material with a base without using epichlorohydrin, a carcinogenic substance.
CONSTITUTION: A bromohydrin compound [e.g., 1-bromo-2-acetoxy-3-(1-naphtoxy)propane, etc.] shown by the formula I (Ar is aromatic group; R is lower alkyl) is treated with a base, e.g., sodium methoxide, potassium hydroxide, etc. at about room temperature, to give a compound shown by the formula II. The amount of the base used is preferably equimolar to about 2mol based on bromohydrin compound shown by the formula I. The compound shown by the formula I can be easily synthesized by reacting a diol compound shown by the formula III with hydrobromic acid and a lower fatty acid shown by the formula IV.
COPYRIGHT: (C)1982,JPO&Japio
摘要翻译：目的：为了获得标题物质，可以容易地通过用碱处理容易获得的作为原料的溴代醇化合物，而不使用表氯醇（致癌物质）合成可用作心律失常药物的化合物的中间体。构成：用式I（Ar为芳基; R为低级烷基）表示的溴代醇化合物[例如1-溴-2-乙酰氧基-3-（1-萘氧基）丙烷等]用碱处理，例如在约室温下的甲醇钠，氢氧化钾等，得到式II所示的化合物。所用碱的量优选基于式I所示的溴代醇化合物等摩尔至约2摩尔。式I所示的化合物可以通过使由式III表示的二醇化合物与氢溴酸和低级脂肪酸酸由式IV表示。

83. 发明专利

JPS52116405A METHOD OF PRODUCING EPOXY COMPOUND 失效
公开(公告)号：JPS52116405A
公开(公告)日：1977-09-29
申请号：JP4938676
申请日：1976-04-28
申请人： LUMMUS CO
发明人： JIYOON TAEKU KUUON , ABURAHAMU PII GERUBEIN
IPC分类号： C07D301/26 , C07D301/24 , C07D301/28 , C07D303/02 , C07D303/04 , C25B1/24 , C25B3/00

84. 发明专利

JPWO2011118349A1 高純度エポキシ化合物およびその製造方法审中-公开
公开(公告)号：JPWO2011118349A1
公开(公告)日：2013-07-04
申请号：JP2011521393
申请日：2011-03-02
申请人：東レ・ファインケミカル株式会社
发明人：学哉石川 , 学哉石川 , 秀利加藤 , 秀利加藤 , 仁郎中谷 , 仁郎中谷 , 厚仁新井 , 厚仁新井 , 宏明坂田 , 宏明坂田 , 寛大皷 , 大皷　　寛
IPC分类号： C07D303/36 , C07D301/24
CPC分类号： C07D301/27 , B01J31/0239 , B01J31/0268 , B01J2231/40 , C07D303/36
摘要：高純度のN,N,N′,N′−テトラグリシジル−3,4′−ジアミノジフェニルエーテルからなるエポキシ化合物およびその製造方法を提供する。プロトン性極性溶媒中で3,4′−ジアミノジフェニルエーテルにエピクロロヒドリンを65〜100℃で12時間以上反応させ、N,N,N′,N′−テトラキス(3−クロロ−2−ヒドロキシプロピル)−3,4′−ジアミノジフェニルエーテルを生成する付加反応工程と、前記N,N,N′,N′−テトラキス(3−クロロ−2−ヒドロキシプロピル)−3,4′−ジアミノジフェニルエーテルをアルカリ化合物と反応させ、脱塩化水素する環化反応工程、により高純度のN,N,N′,N′−テトラグリシジル−3,4′−ジアミノジフェニルエーテルを製造する。

85. 发明专利

JP5163659B2 Method for producing a fluorine-containing epoxide 有权
公开(公告)号：JP5163659B2
公开(公告)日：2013-03-13
申请号：JP2009551469
申请日：2009-01-20
申请人：ダイキン工業株式会社
发明人：明平杉山
IPC分类号： C07C303/08 , C07B61/00 , C07C305/26 , C07D301/24 , C07D303/08
CPC分类号： C07C305/26 , C07D301/24 , C07D303/08

87. 发明专利

JP2010168289A Method for producing epoxy compound 审中-公开
标题翻译：生产环氧化合物的方法
公开(公告)号：JP2010168289A
公开(公告)日：2010-08-05
申请号：JP2009010180
申请日：2009-01-20
申请人： Daiso Co Ltd , ダイソー株式会社
发明人： INOKI KIMITAKA , ISHIBASHI KAZUAKI
IPC分类号： C07D301/24 , C07D303/04 , C07D303/08
摘要： PROBLEM TO BE SOLVED: To provide: a method for producing an epoxy compound, which can solve the problems of a method using a heteropolyacid, wherein an expensive heavy metal is used as a catalyst and the catalyst cannot be recovered; a method using a titanosilicate catalyst, wherein it has been reported that the reaction conversion rate of methacryl chloride or the like is low; a method passing through a chlorohydrylation process, wherein an olefin compound is produced as a by-product and the objective compound can not been obtained efficiently, in a process for obtaining a dichlorohydrin intermediate from methacryl chloride, and the like.
SOLUTION: This method for producing the epoxy compound comprises halohydrylating an olefin with an N-bromo compound or an N-iodo compound in the presence of water, and then reacting the product with a base to close the ring. Thereby, the epoxy compound can efficiently and simply be obtained by the two step processes.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供一种环氧化合物的制造方法，其可以解决使用杂多酸的方法的问题，其中昂贵的重金属用作催化剂并且催化剂不能回收; 使用钛硅酸盐催化剂的方法，其中已经报道甲基丙烯酰氯等的反应转化率低; 通过氯代氢化方法的方法，其中在由甲基丙烯酰氯获得二氯丙醇中间体的方法等中，作为副产物生产烯烃化合物，并且不能有效地获得目标化合物。解决方案：该制备环氧化合物的方法包括在水存在下将烯烃与N-溴化合物或N-碘化合物卤代醇化，然后使产物与碱反应以封闭环。因此，可以通过两步法有效且简单地获得环氧化合物。版权所有（C）2010，JPO＆INPIT

88. 发明专利

JP2010111692A Highly unsaturated fatty acid derivative and pharmaceutical composition containing the same 审中-公开
标题翻译：高度不饱和脂肪酸衍生物和含有其的药物组合物
公开(公告)号：JP2010111692A
公开(公告)日：2010-05-20
申请号：JP2010000221
申请日：2010-01-04
申请人： Pronova Biopharma Norge As , プロノヴァ・バイオファーマ・ノルゲ・アーエス
发明人： YAMADA SACHIKO , YAMAMOTO KEIKO , ITO TOSHIMASA , KICHIKAI KAZUTAKA , TAMAI TADAKAZU , SATO NOBUYUKI , MUROTA KAZUTAKA , NISHIKAWA MASAZUMI
IPC分类号： C07C33/02 , C07D295/18 , A61K31/16 , A61K31/202 , A61K31/336 , A61K31/341 , A61K31/366 , A61K31/4453 , A61K31/557 , A61K31/558 , A61K31/5585 , A61K31/559 , A61P1/04 , A61P3/06 , A61P3/10 , A61P9/00 , A61P9/10 , A61P29/00 , A61P35/00 , A61P43/00 , C07C59/42 , C07C59/58 , C07C59/76 , C07C69/12 , C07C69/22 , C07C69/65 , C07C69/732 , C07C69/734 , C07C69/738 , C07C233/09 , C07C233/20 , C07C235/28 , C07C271/22 , C07C329/04 , C07C329/16 , C07D207/09 , C07D211/16 , C07D301/24 , C07D303/38 , C07D307/33 , C07D307/52 , C07D309/30
摘要： PROBLEM TO BE SOLVED: To provide a useful compound exhibiting PPAR (peroxisome proliferator-activated receptor) γ operating activity and/or PPAR α operating activity. SOLUTION: A highly unsaturated fatty acid derivative or analogue represented by formula (I) is provided. In formula (I), R1 is hydrogen, a hydroxyl group, an alkoxyl group, an acyloxy group, or a halogen; R2 is a hydrogen, or R1 and R2 are each a halogen or an alkoxyl group, or R1 and R2 may be combined together to form a carbonyl group; R3 is hydrogen, a hydroxyl group, an alkoxyl group, or an acyloxy group; R4 is hydrogen or R3 and R4 may be combined to together form a carbonyl group; R5 is hydrogen, a hydroxyl, an alkyl, an alkenyl, an alkynyl, a halogen, an aryl, an acyloxy, or an alkoxyl group; and R6 is hydrogen, an alkyl, an alkenyl, an alkynyl, an aryl, or an alkoxyl group. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供显示PPAR（过氧化物酶体增殖物激活受体）γ操作活性和/或PPARα操作活性的有用化合物。解决方案：提供由式（I）表示的高度不饱和脂肪酸衍生物或类似物。在式（I）中，R 1是氢，羟基，烷氧基，酰氧基或卤素; R2是氢，或R1和R2各自是卤素或烷氧基，或者R1和R2可以组合在一起形成羰基; R3是氢，羟基，烷氧基或酰氧基; R4是氢或R3和R4可以组合在一起形成羰基; R5是氢，羟基，烷基，烯基，炔基，卤素，芳基，酰氧基或烷氧基; R6是氢，烷基，烯基，炔基，芳基或烷氧基。版权所有（C）2010，JPO＆INPIT

89. 发明专利

JP2008273841A Ethylenediamine derivative and method for producing the same 审中-公开
标题翻译：乙烯二胺衍生物及其生产方法
公开(公告)号：JP2008273841A
公开(公告)日：2008-11-13
申请号：JP2005205324
申请日：2005-07-14
申请人： Zeria Pharmaceut Co Ltd , ゼリア新薬工業株式会社
发明人： NAGASAWA MASAAKI , KAWASE NOBUO , WATANABE TSUYOSHI , KOBAYASHI MINORU
IPC分类号： C07C211/29 , C07B57/00 , C07C45/63 , C07C49/80 , C07C209/62 , C07C213/04 , C07C215/30 , C07D203/08 , C07D301/24 , C07D303/08 , C07F3/02
CPC分类号： C07C45/63 , C07B57/00 , C07C211/29 , C07D203/08 , C07D301/24 , C07D303/08 , C07C49/80
摘要： PROBLEM TO BE SOLVED: To provide an intermediate useful for producing a benzylamine derivative, and a method for producing the intermediate.
SOLUTION: The method for producing an ethylenediamine derivative represented by formula (6) is characterized by reacting an aziridine compound represented by formula (5) with a primary amine. [In the formulae, R
1 represents an alkyl group or an aralkyl group, R
2 represents an alkyl group or an alkenyl group, R
3 represents an alkyl group, an aralkyl group or an aryl group that may contain a substituent, and Ar represents an aryl group that may contain a substituent].
COPYRIGHT: (C)2009,JPO&INPIT

90. 发明专利

JP2002532450A 失效
公开(公告)号：JP2002532450A
公开(公告)日：2002-10-02
申请号：JP2000588109
申请日：1999-12-13
IPC分类号： C07D301/24 , C07C29/66 , C07C31/36 , C07D303/04

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