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81. 发明授权

US5268252A Radiation-sensitive ester and process for its preparation 失效
标题翻译：辐射敏感酯及其制备方法
公开(公告)号：US5268252A
公开(公告)日：1993-12-07
申请号：US863679
申请日：1992-04-01
申请人： Siegfried Scheler , Wolfgang Zahn , Axel Schmitt , Gerhard Buhr
发明人： Siegfried Scheler , Wolfgang Zahn , Axel Schmitt , Gerhard Buhr
IPC分类号： C09K9/02 , C07C309/26 , C07C309/71 , C07C309/76 , C07C311/16 , C07C323/66 , G02F1/065 , G03F7/022 , G03C1/52
CPC分类号： G02F1/065 , C07C309/71 , C07C309/76 , C07C311/16 , C07C323/66 , G03F7/022
摘要： The invention relates to a radiation-sensitive ester which is the condensation product of (a) a compound containing 2 to 6 aromatic hydroxyl groups, (b) a ring-substituted (o-naphthoquinone 2-diazide)-4-sulfonic acid (compound D.sub.1 and (c) an (o-naphthoquinone 2-diazide)-4- or -5-sulfonic acid which is not further substituted (compound D.sub.2) and/or a non-radiation-sensitive organic acid (compound D.sub.0), where the (b):(c) molar ratio is between 0.1:1 and 39:1.
摘要翻译：本发明涉及一种辐射敏感性酯，它是（a）含有2-6个芳族羟基的化合物的缩合产物，（b）环取代的（邻 - 萘醌-2-二叠氮化物）-4-磺酸（化合物 D1和（c）不进一步取代的（邻 - 萘醌-2-二叠氮化物）-4-或-5-磺酸（化合物D2）和/或非辐射敏感性有机酸（化合物D0），其中（b）:( c）摩尔比为0.1:1〜39:1。

82. 发明授权

US5077395A Substituted 1,2-naphthoquinone-2-diazide-4-sulfonic acids and processes for their preparation and use 失效
标题翻译：取代的1,2-萘醌-2-二氮杂-4-磺酸及其制备和使用的方法
公开(公告)号：US5077395A
公开(公告)日：1991-12-31
申请号：US564612
申请日：1990-08-09
申请人： Siegfried Scheler , Gerhard Buhr , Klaus Bergmann
发明人： Siegfried Scheler , Gerhard Buhr , Klaus Bergmann
IPC分类号： C07D303/22 , C07C303/06 , C07C303/22 , C07C303/32 , C07C309/26 , C09K9/02 , G03F7/022
CPC分类号： C07C309/26 , G03F7/022
摘要： Substituted 1,2-naphthoquinone-2-diazide-4-sulfonic acids are disclosed having the general formula A ##STR1## in which R is an alkyl, epoxyalklyl, alkylcarbonyl or alkylsulfonyl group, the carbon chains of which may be interrupted by oxygen atoms, or a substituted or unsubstituted aralkyl, arylcarbonyl or arylsulfonyl group andX is hydrogen, a metal or an ammonium group.A process for the preparation of the compounds is also disclosed. The compounds can be used as such, or preferably after condensation of their sulfonic acid chlorides with aromatic hydroxy compounds or amines to give the corresponding esters or amides, as light-sensitive compounds in radiation-sensitive mixtures or materials.
摘要翻译：公开了具有通式A A的取代的1,2-萘醌-2-二叠氮-4-磺酸，其中R是烷基，环氧烷基，烷基羰基或烷基磺酰基，其碳链可被氧中断原子或取代或未取代的芳烷基，芳基羰基或芳基磺酰基，X是氢，金属或铵基。还公开了制备化合物的方法。化合物可以原样使用，或优选在其磺酰氯与芳族羟基化合物或胺缩合后得到相应的酯或酰胺，作为辐射敏感混合物或材料中的光敏化合物。

83. 发明授权

US4931549A Process for aryl-quinone and aryl-naphthoquinone diazide sulfonic acids 失效
标题翻译：芳基 - 醌和芳基 - 萘醌二叠氮磺酸的方法
公开(公告)号：US4931549A
公开(公告)日：1990-06-05
申请号：US29843
申请日：1987-03-24
申请人： Paul Berner
发明人： Paul Berner
IPC分类号： C07C309/23 , C07C67/00 , C07C301/00 , C07C303/22 , C07C309/26 , C07C309/53 , G03F7/008 , G03F7/022
CPC分类号： C07C303/22
摘要： A process for the preparation of aryl-diazide-sulfonic acids by a series of sequential in-situ process steps. The process comprises the nitrosation of a hydroxyarylsulfonic acid; conversion of the nitroso-derivative to a sulfamate which is then diazotized to the diazide. Temperature and pH are maintained in predetermined ranges to maintain the reaction products in solution without the formation side-products or the need to isolate intermediates.The process of the invention is particularly useful in the preparation of light-sensitive materials such as naphthoquinonediazide sulfonic acids which are used in the preparation of photoresist compositions. The invention provides a high purity product at a high material efficiency, high equipment utilization, low effluent discharge, and reduced cost.
摘要翻译：通过一系列顺序原位工艺步骤制备芳基二叠氮磺酸的方法。该方法包括羟基芳基磺酸的亚硝化; 将亚硝基衍生物转化成氨基磺酸盐，然后将其重氮化成二叠氮化物。将温度和pH保持在预定范围内，以将反应产物保持在溶液中而不会形成副产物或需要分离中间体。本发明的方法特别可用于制备用于制备光致抗蚀剂组合物的光敏材料如萘醌二叠氮化物磺酸。本发明提供高纯度的产品，材料效率高，设备利用率高，污水排出量低，成本降低。

84. 发明授权

US3344189A Amino-fluorene-compounds and process for the preparation thereof 失效
标题翻译：氨基芴化合物及其制备方法
公开(公告)号：US3344189A
公开(公告)日：1967-09-26
申请号：US29025663
申请日：1963-06-24
申请人： CHESTER DAVIS
发明人： CHESTER DAVIS
IPC分类号： C07C309/26
CPC分类号： C07C309/26 , C07C2603/18

85. 发明公开

EP0888290A4 AZULENYL NITRONE SPIN TRAPPING AGENTS, METHODS OF MAKING AND USING SAME 失效
标题翻译： AZULENYLNITRONE激进范格（SPIN捕获剂）方法用于生产及其应用
公开(公告)号：EP0888290A4
公开(公告)日：2004-08-18
申请号：EP96940538
申请日：1996-11-15
申请人： FLORIDA INTERNAT UNIVERSITY
发明人： BECKER DAVID A
IPC分类号： C07D219/10 , A61K31/00 , A61K31/15 , A61K31/16 , A61K31/47 , A61K31/473 , A61P39/00 , A61P39/06 , C07C49/21 , C07C291/02 , C07C291/04 , C07C309/26 , C07C317/30 , C07F9/38 , C07F9/40 , C07C251/14 , A61K31/095 , A61K31/12 , A61K31/13 , C07C49/213 , C07C251/32 , C07C325/02
CPC分类号： C07C291/02 , C07C291/04 , C07C2602/30
摘要： The present invention relates to chromotropic nitrone spin trapping agents, methods of making these agents, compositions comprising same, and methods of their use. In particular, azulenyl nitrones of the present invention are effective agents for trapping free radical species and find use as efficient antioxidants in physicochemical and biological systems. Accordingly, the invention also relates to spin adducts formed from the combination of azulenyl nitrones with free radicals. The compounds of the present invention are readily prepared from available starting materials and find further use in assays and in a number of diagnostic, prophylactic and therapeutic applications, including but not limited to the alleviation, modulation and inhibition of the negative effects of carbon-centered or oxygen-centered radical species and other products of oxidation. Moreover, the combination adducts may be calorimetrically detected and, optionally, isolated and characterized to obtain valuable information (e.g., structural and the like) about the original reactive free radical species.

86. 发明公开

EP1044964A2 Method for producing 1,2-naphthoquinone-2-diazide-4-sulphonyl chloride 审中-公开
标题翻译： Verfahren zur Herstellung von 1,2-萘醌-2-二叠氮-4-磺基氯化物
公开(公告)号：EP1044964A2
公开(公告)日：2000-10-18
申请号：EP00107396.4
申请日：2000-04-05
申请人： Toyo Gosei Kogyo Co., Ltd.
发明人： Iida, Hirotada, c/o Toyo Gosei Kogyo Co., Ltd. , Tobishima, Seiju, c/o Toyo Gosei Kogyo Co., Ltd. , Sato, Naoki, c/o Toyo Gosei Kogyo Co., Ltd. , Yoneyama, Nobuhiro, c/o Toyo Gosei Kogyo Co., Ltd. , Hotta, Yuki, c/o Toyo Gosei Kogyo Co., Ltd. , Itahana, Toshio, c/o Toyo Gosei Kogyo Co., Ltd. , Hagiwara, Yuichi, c/o Toyo Gosei Kogyo Co., Ltd.
IPC分类号： C07C303/08 , C07C303/22 , C07C309/26
CPC分类号： C07C303/22 , C07C303/08 , C07C309/26
摘要： An effective method for producing 1,2-naphthoquinone-2-diazide-4-sulfonyl chloride at high yield, wherein formation of impurities is prevented. The method includes the following steps: 1,2-naphthoquinone-2-diazide is reacted with chlorosulfuric acid, to thereby produce a mixture of a sulfonated compound and a chlorosulfonated compound of the diazide; and to the mixture, at least one substance selected from among thionyl chloride and phosphorus pentachloride is added for further reaction, to thereby obtain 1,2-naphthoquinone-2-diazide-4-sulfonyl chloride.
摘要翻译：以高产率生产1,2-萘醌-2-二叠氮-4-磺酰氯的有效方法，其中防止了杂质的形成。该方法包括以下步骤：将1,2-萘醌-2-二叠氮化物与氯磺酸反应，由此制得磺化化合物与二磺酰氯的氯磺化合物的混合物; 向混合物中加入至少一种选自亚硫酰氯和五氯化磷的物质进一步反应，从而得到1,2-萘醌-2-二叠氮-4-磺酰氯。

87. 发明授权

EP0413201B1 Verfahren zur Herstellung von 7-Hydroxy-1,2-naphthochinon-(2)-diazid-4-sulfonsäure oder ihrer Salze und deren Verwendung 失效
标题翻译：一种用于7-羟基-1,2-萘醌（2）重氮基-4-磺酸或它的盐和其用途的制备方法。
公开(公告)号：EP0413201B1
公开(公告)日：1994-10-26
申请号：EP90114802.3
申请日：1990-08-02
申请人： HOECHST AKTIENGESELLSCHAFT
发明人： Scheler, Siegfried, Dr., Dipl.-chem. , Buhr, Gerhard, Dr., Dipl.-Chem. , Bergmann, Klaus
IPC分类号： C07C309/26 , C07C303/20 , C07C303/22 , G03F7/022
CPC分类号： G03F7/022 , C07C309/26

88. 发明申请

WO2010030781A2 AROMATIC CARBOXYLIC ACID DERIVATIVES FOR TREATMENT AND PROPHYLAXIS OF GASTROINTESTINAL DISEASES INCLUDING COLON CANCER 审中-公开
标题翻译：用于治疗和预防胃肠疾病的芳香羧酸衍生物，包括结肠癌
公开(公告)号：WO2010030781A2
公开(公告)日：2010-03-18
申请号：PCT/US2009/056515
申请日：2009-09-10
申请人： NUMED INTERNATIONAL, INC. , EKWURIBE, Nnochiri
发明人： EKWURIBE, Nnochiri
IPC分类号： C07C311/45 , C07C309/26 , C07C245/08 , C07D311/58 , C07D311/36 , A61K31/18 , A61K31/185 , A61P1/04 , A61P35/00
CPC分类号： A61K31/655 , A01N41/04 , A01N41/06 , A01N41/08 , A61K45/06 , C07C245/06 , C07C245/08 , C07C309/15 , C07C309/24 , C07C311/46 , C07C311/49 , C07C311/54 , C07D311/54 , C07D311/68
摘要： Prodrug compounds which metabolize into 5-ASA or analogs thereof, and taurine or analogs thereof, in the colon site are disclosed. Pharmaceutical compositions including the compounds, and methods of treatment using the compounds, are also disclosed. Such compounds have utility for treating or preventing gastrointestinal disorders, including colon cancer, ulcerative colitis and Crohn's disease.
摘要翻译：公开了在结肠部位代谢为5-ASA或其类似物的前体化合物及其牛磺酸或其类似物。还公开了包括该化合物的药物组合物和使用该化合物的治疗方法。这些化合物可用于治疗或预防胃肠道疾病，包括结肠癌，溃疡性结肠炎和克罗恩氏病。

89. 发明申请

WO2005000406A3 TREATMENT OF AMYLOID- AND EPILEPTOGENESIS-ASSOCIATED DISEASES 审中-公开
标题翻译：治疗淀粉样变性和纤维蛋白原相关性疾病
公开(公告)号：WO2005000406A3
公开(公告)日：2005-06-23
申请号：PCT/US2004019839
申请日：2004-06-21
申请人： NEUROCHEM INT LTD , KONG XIANQI , LU WENSHUO , WU XINFU
发明人： KONG XIANQI , LU WENSHUO , WU XINFU
IPC分类号： A61K31/185 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/28 , A61P27/00 , A61P29/00 , C07C309/14 , C07C309/26 , C07D209/14 , C07D213/38 , C07D233/24 , C07D233/28 , C07D239/06 , C07D263/10 , C07D263/16 , C07D265/08 , C07D277/10 , C07D277/12 , C07D279/06 , C07D317/58 , C07D333/20 , C07D333/58
CPC分类号： C07D239/06 , A61K31/185 , C07C309/14 , C07C309/26 , C07C2601/14 , C07C2602/10 , C07D209/14 , C07D213/38 , C07D233/24 , C07D233/28 , C07D263/10 , C07D263/16 , C07D265/08 , C07D277/10 , C07D277/12 , C07D279/06 , C07D317/58 , C07D333/20 , C07D333/58
摘要： Methods of treating or preventing an amyloid-related disease in a subject by administering to a subject a therapeutic amount of a compound of the invention are described. Also included are methods for inhibiting epileptogenesis in a subject, by administering to a subject an effective amount of an anti-epileptogenic agent. Methods for treating a subject suffering from an epileptogenesis-associated condition, by administering to the subject an effective amount of an anti-epileptogenic agent are also included. Methods for treating convulsions in a subject by administering to the subject an effective amount of a therapeutic amount of a compound of the invention are also described.
摘要翻译：描述了通过向受试者施用治疗量的本发明化合物来治疗或预防受试者中淀粉样蛋白相关疾病的方法。还包括通过向受试者施用有效量的抗癫痫发生剂来抑制受试者中癫痫发生的方法。还包括通过向受试者施用有效量的抗癫痫发生剂来治疗患有癫痫发生相关病症的受试者的方法。还描述了通过向受试者施用有效量的治疗量的本发明化合物来治疗受试者的抽搐的方法。

90. 发明专利

BRPI0519243A2 未知
公开(公告)号：BRPI0519243A2
公开(公告)日：2009-01-06
申请号：BRPI0519243
申请日：2005-12-21
申请人： NEUROCHEM INT LTD
发明人： KONG XIANQI , WU XINFU , BOUZIDE ABDERRAHIM , VALADE ISABELLE , MIGNEAULT DAVID , GERVAIS FRANCINE , DELORME DANIEL , BACHAND BENOIT , ATFANI MOHAMED , LEVESQUE SOPHIE , SAMIM BITA
IPC分类号： C07C309/14 , C07C309/19 , C07C309/21 , C07C309/24 , C07C309/26 , C07D211/22 , C07D211/24 , C07D211/54 , C07D235/28 , C07D307/14 , C07D307/52 , C07D317/58 , C07D333/18 , C07D333/38 , C07D333/58
摘要： Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-related disease.

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