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81. 发明申请

WO1995031945A1 IMPROVED TISSUE SUPPORTING DEVICES 审中-公开
标题翻译：改进的组织支持设备
公开(公告)号：WO1995031945A1
公开(公告)日：1995-11-30
申请号：PCT/US1995006228
申请日：1995-05-18
申请人： SCIMED LIFE SYSTEMS, INC. , BURMEISTER, Paul, H. , EUTENEUER, Charles, L. , BROWN, Brian, J. , FORDENBAUCHER, Paul, J. , VRBA, Anthony, C.
发明人： SCIMED LIFE SYSTEMS, INC.
IPC分类号： A61F02/06
CPC分类号： A61F2/88 , A61F2/844 , A61F2/90 , A61F2/91 , A61F2/915 , A61F2002/91533 , A61F2002/9155 , A61F2002/91558 , A61F2002/91575 , A61F2210/0019 , A61F2210/0076 , A61F2220/0075 , A61F2250/0029 , A61F2250/0042 , A61L31/022
摘要： A new multiple component stent (10) which allows for initial self-expansion and subsequent deformation to a final enlarged size. In one embodiment, stent (10) comprises a first resilient element (12) and a second deformable element (14). In another embodiment, stent (30) is made of a first austenite component (32) and a second martensite component (34).
摘要翻译：一种新的多组分支架（10），允许初始自膨胀和随后的变形到最终的放大尺寸。在一个实施例中，支架（10）包括第一弹性元件（12）和第二可变形元件（14）。在另一个实施例中，支架（30）由第一奥氏体组分（32）和第二马氏体组分（34）制成。

82. 发明申请

WO1995030384A3 CLAD COMPOSITE STENT 审中-公开
公开(公告)号：WO1995030384A3
公开(公告)日：1995-11-16
申请号：PCT/IB1995000253
申请日：1995-04-10
申请人： SCHNEIDER (USA) INC.
发明人： SCHNEIDER (USA) INC. , MAYER, David, W.
IPC分类号： A61F02/06

83. 发明申请

WO1995009586A1 SELF-EXPANDING INTRALUMINAL COMPOSITE PROSTHESIS 审中-公开
标题翻译：自我扩张的内在复合材料
公开(公告)号：WO1995009586A1
公开(公告)日：1995-04-13
申请号：PCT/US1994011098
申请日：1994-09-29
申请人： EMORY UNIVERSITY , GEORGIA TECH RESEARCH CORPORATION
发明人： EMORY UNIVERSITY , GEORGIA TECH RESEARCH CORPORATION , CHAIKOF, Elliot, L. , LUDOVICE, Peter, J.
IPC分类号： A61F02/06
CPC分类号： A61F2/90 , A61F2/07 , A61F2002/072 , A61F2210/0076 , A61F2220/0008
摘要： This invention relates to a self-expanding intraluminal composite prothesis (10) comprised of a rigid reinforcing component (8) and sealing component (12). The prosthesis may be fabricated as either a straight or bifurcated tubular structure and is applicable to the treatment of any bodily passage including, but not limited to, vascular applications, e.g., aneurysms, arteriovenous fistulas, as well as stenotic regions of the peripheral circulation which have been percutaneously dilated but are at high risk for restenosis. The major attributes of this prosthesis can include the use of a unique multilayered biaxial braid which thereby creates a homogeneously blended composite with isotropic deformation and expansion characteristics and an associated high contraction ratio. The use of multiple layers allows for the fabrication of a device of varied porosity while retaining adequate tensile or mechanical wall strength.
摘要翻译：本发明涉及由刚性增强部件（8）和密封部件（12）组成的自膨胀管腔内复合材料（10）。假体可以被制造成直的或分叉的管状结构，并且适用于任何身体通路的治疗，包括但不限于血管应用，例如动脉瘤，动静脉瘘以及周边循环的狭窄区域已经经皮扩张，但是具有再狭窄的高风险。该假体的主要特征可以包括使用独特的多层双轴编织物，从而产生具有各向同性变形和膨胀特性和相关联的高收缩率的均匀混合的复合材料。使用多层允许制造具有不同孔隙率的装置，同时保持足够的拉伸或机械壁强度。

84. 发明申请

WO1994015549A1 APPARATUS FOR DEPLOYING BODY IMPLANTABLE STENTS 审中-公开
标题翻译：装备身体可植入的装置
公开(公告)号：WO1994015549A1
公开(公告)日：1994-07-21
申请号：PCT/US1993010978
申请日：1993-11-17
申请人： SCHNEIDER (USA) INC.
发明人： SCHNEIDER (USA) INC. , HEALY, Steven, J. , YUREK, Matthew, T.
IPC分类号： A61F02/06
CPC分类号： A61F2/958 , A61F2/95 , A61F2/966 , A61F2002/9528 , A61F2002/9583 , A61F2002/9665
摘要： A stent deployment device includes a flexible, elongate interior catheter (38) and a retaining structure (20) cooperating with the catheter (38) to support a stent along a distal end support region of the catheter (38). The stent is supported in a reduced radius delivery state to facilitate delivery to a treatment site in a body lumen, by advancing the device over a previously positioned guidewire. An opening at the distal end of the device receives the guidewire into a guidewire lumen (46) of the interior catheter (38). A second opening (52) through the catheter wall just proximally of the support region allows passage of the guidewire to the exterior of the catheter, whereby the guidewire is contained within the device only along the distal end region. The retaining means (20) can include an exterior catheter (20) surrounding the interior catheter (38) and stent, and moveable axially relative to the interior catheter (38). A portion of the guidewire proximally of the second opening (52) is contained between the catheters, and can be removed from the exterior catheter (20) through a slit (53) running axially along the exterior catheter (20). Alternatively, the retaining means can include a pair of spaced apart sleeves (124, 126) integral with the interior catheter (112) and frictionally retaining opposite ends of the stent, to maintain the stent in the delivery state. In this case the catheter further supports a dilatation balloon (122) surrounded by the stent. The balloon (122) is expanded to free the stent from the sleeves (124, 126).
摘要翻译：支架展开装置包括柔性细长内部导管（38）和与导管（38）配合以沿导管（38）的远端支撑区域支撑支架的保持结构（20）。通过将装置推进在先前定位的导丝上，支架以减小的半径递送状态被支撑以便于输送到体腔内的治疗部位。设备远端处的开口将导丝接纳到内导管（38）的导丝管腔（46）内。穿过导管壁的第二个开口（52）可靠近支撑区域的近侧，允许导丝通过导管的外部，由此导丝仅沿着远端区域容纳在装置内。保持装置（20）可以包括围绕内部导管（38）和支架的外部导管（20），并且可相对于内部导管（38）沿轴向移动。在第二开口（52）的近侧的导丝线的一部分被容纳在导管之间，并且可以通过沿着外部导管（20）轴向运动的狭缝（53）从外部导管（20）移除。或者，保持装置可以包括与内部导管（112）成一体并且摩擦地保持支架的相对端的一对间隔开的套筒（124,126），以将支架保持在输送状态。在这种情况下，导管还支撑由支架包围的扩张球囊（122）。将球囊（122）膨胀以从套筒（124,126）释放支架。

85. 发明申请

WO1994006373A1 THREE-DIMENSIONAL BRAIDED SOFT TISSUE PROSTHESIS 审中-公开
标题翻译：三维BRAIDED软组织展现
公开(公告)号：WO1994006373A1
公开(公告)日：1994-03-31
申请号：PCT/US1993008658
申请日：1993-09-14
申请人： MEADOX MEDICALS, INC.
发明人： MEADOX MEDICALS, INC. , SCHMITT, Peter, J.
IPC分类号： A61F02/06
CPC分类号： A61F2/06 , D04C1/06 , D10B2403/023 , D10B2403/02411 , D10B2509/06
摘要： The present invention provides a soft tissue prosthesis which is formed from a three-dimensional braided structure having an inner surface (22) and an outer surface (24). The three-dimensional braided structure preferably may be made in the form of a solid three-dimensional braid, a three-dimensional braid having at least one interlocking yarn coupling contiguous layers or in the form of a plurality of two-dimensional braided layers adhesively laminated, separately sewn or otherwise connected together to form the three-dimensional braided prosthesis.
摘要翻译：本发明提供一种由具有内表面（22）和外表面（24）的三维编织结构形成的软组织假体。三维编织结构优选地可以制成固体三维编织物的形式，三维编织物具有至少一个连接连续层的互锁纱线或以多个二维编织层的形式粘合层压，分别缝合或以其他方式连接在一起以形成三维编织假体。

86. 发明申请

WO1993020779A1 URETHRAL PROSTHESIS 审中-公开
公开(公告)号：WO1993020779A1
公开(公告)日：1993-10-28
申请号：PCT/FR1992000321
申请日：1992-04-10
申请人： BERBERIAN, Jean-Pierre, Martial
IPC分类号： A61F02/06
CPC分类号： A61F2/92 , A61F2/94
摘要： A urethral prosthesis consisting of a generally cylindrical flexible tubular member (1) made of a biologically acceptable elastomer. The flexible tube (1), from which a longitudinal strip has been cut out, may be placed in a urethra with its two longitudinal edges (4a, 4b) together. Said tube is held within the urethra by the tube (1) itself, as it tends to open out on either side of the median line of its longitudinal opening, and thereby provides at the same time a communicating passageway between the inside of the tube (1) and the urethra.
摘要翻译：一种尿道假体，其由通常为圆柱形的柔性管状构件（1）组成，其由生物可接受的弹性体制成。可以从其中切出纵向条带的柔性管（1）可以放置在其两个纵向边缘（4a，4b）在一起的尿道中。所述管由管（1）自身保持在尿道内，因为它倾向于在其纵向开口的中线的任一侧开口，从而同时提供管内部之间的连通通道（ 1）和尿道。

87. 发明申请

WO1993000051A1 TREATMENT OF DISEASES BY SITE-SPECIFIC INSTILLATION OF CELLS OR SITE-SPECIFIC TRANSFORMATION OF CELLS AND KITS THEREFOR 审中-公开
标题翻译：通过细胞的立即特异性灌注或细胞及其成套工具的特异性转化处理疾病
公开(公告)号：WO1993000051A1
公开(公告)日：1993-01-07
申请号：PCT/US1992005242
申请日：1992-06-26
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , NABEL, Elizabeth, G. , NABEL, Gary, J.
IPC分类号： A61F02/06
CPC分类号： A61K48/0075 , A61B17/22 , A61B2017/22082 , A61B2017/22084 , A61K9/0024 , A61K39/00 , A61K47/6957 , A61K48/00 , A61K48/0083 , A61L29/16 , A61L2300/254 , A61L2300/256 , A61L2300/258 , A61L2300/414 , A61L2300/426 , A61L2300/64 , A61L2300/802 , Y02A50/472
摘要： A method for the direct treatment towards the specific sites of a disease is disclosed. This method is based on the delivery of proteins by catheterization to discrete blood vessel segments using genetically modified or normal cells or other vector systems. Endothelial cells expressing recombinant therapeutic agent or diagnostic proteins are situated on the walls of the blood vessel or in the tissue perfused by the vessel in a patient. This technique provides for the transfer of cells or vectors and expression of recombinant genes in vivo and allows the introduction of proteins of therapeutic or diagnostic value for the treatment of diseases.
摘要翻译：针对特定病理部位的直接治疗方法。该方法基于通过使用遗传修饰的细胞或正常细胞或其他载体系统将导管形成的蛋白质递送至不连续的血管节段。表达治疗剂或重组诊断蛋白的内皮细胞位于血管壁上或由患者血管灌注的组织中。该技术允许体内细胞或载体的转移和重组基因的表达，以及引入治疗或诊断感兴趣的蛋白质以治疗病症。

88. 发明申请

WO1992011824A1 RESECTABLE SELF-EXPANDING STENT 审中-公开
标题翻译：可持续的自我扩张
公开(公告)号：WO1992011824A1
公开(公告)日：1992-07-23
申请号：PCT/US1991008587
申请日：1991-11-22
申请人： AMERICAN MEDICAL SYSTEMS, INC.
发明人： AMERICAN MEDICAL SYSTEMS, INC. , BURTON, John, H. , STAEHLE, Bradford, G. , TIHON, Claude , MIKULICH, Michael, A.
IPC分类号： A61F02/06
CPC分类号： A61F2/90 , A61F2220/0016
摘要： A stent (10) for transluminal implantation comprising a single-piece tubular member (12) having a fenestrated sidewall (18) exhibiting a pattern of uniformly spaced openings defined by intersecting strands (20, 22) where the strands (20, 22) are integrally joined together at their points of intersection whereby the tubular member (12) can be radially compressed from a larger diameter to a smaller diameter by the application of a uniform inwardly directed radial force and which self-expands to a larger diameter when the radial compressive force is removed. The compression and subsequent self-expansion occurs without an appreciable change in the stent's length. By forming the stent (10) from a thermoplastic material, it may later be resected by carving it up into small pieces preferably using an electrosurgical instrument.
摘要翻译：一种用于腔内植入的支架（10），其包括具有开窗侧壁（18）的单件式管状构件（12），所述开窗侧壁（18）呈现由相互绞合线（20,22）限定的均匀间隔开口的图案，其中股线（20,22）在其交叉点处一体地接合在一起，由此通过施加均匀的向内径向的力，管状构件（12）可以从较大直径径向压缩至较小直径，并且当径向压缩力被去除压缩和随后的自膨胀在支架长度没有明显变化的情况下发生。通过从热塑性材料形成支架（10），可以稍后通过将其雕刻成小片而优选使用电外科器械切除。

89. 发明申请

WO1992009246A1 INTRAVASCULAR RADIALLY EXPANDABLE STENT AND METHOD 审中-公开
标题翻译：血管内放射性可扩张性和方法
公开(公告)号：WO1992009246A1
公开(公告)日：1992-06-11
申请号：PCT/US1991008916
申请日：1991-11-26
申请人： NUMED, INC.
发明人： NUMED, INC. , TOWER, Allen, J.
IPC分类号： A61F02/06
CPC分类号： A61F2/88
摘要： An improved radially expandable stent formed from a fine wire bent into a serpentine flat ribbon which is wound around a mandrel (14) into a cylindrical sleeve for mounting on a balloon catheter for transluminal insertion in a vessel such as a blood vessel is provided. A very small diameter fine platinum wire is used to form the basic cylindrical sleeve and it is welded (22), (24), (26) to a pigtail (20) of the wire forming the sleeve to provide longitudinal stability.

90. 发明申请

WO1990014054A1 NON-POROUS COATED PTFE GRAFT 审中-公开
标题翻译：非多孔涂层PTFE砂轮
公开(公告)号：WO1990014054A1
公开(公告)日：1990-11-29
申请号：PCT/US1990002957
申请日：1990-05-25
申请人： IMPRA, INC.
发明人： IMPRA, INC. , KOWLIGI, Rajagopal, R. , FARNAN, Robert, Charles , COLONE, William, Michael , DELLA CORNA, Linda, V. , SINNOTT, Joseph, Brian
IPC分类号： A61F02/06
CPC分类号： A61L27/507 , A61F2/06 , A61L27/16 , A61L27/34 , C08L83/04 , C08L75/04 , C08L27/18
摘要： A non-porous coated PTFE graft (20) includes a PTFE tube (32) having a conventional porous inner cylindrical wall (34) and a non-porous elastomeric coating (38) applied over at least a portion of the outer cylindrical wall (36) of the PTFE tube to render such portion of the outer cylindrical wall non-porous. The elastomeric coating is made of polyurethane or another biocompatible non-porous elastomer and precludes tissue ingrowth into the outer cylindrical wall, minimizes suture hole bleeding, and increases suture retention strength, while reducing the incidence of serious weepage. The elastomeric coating is preferably applied by mounting the PTFE tube upon a mandrel (68) of like diameter and either dip coating or spray coating all, or selected portions, of the PTFE tube with liquified polyurethane. After the polyurethane coating is completely dried, the non-porous vascular graft is removed from the mandrel and is ready for use.

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