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81. 发明授权

US2234680A Process of preparing pantothenic acid 失效
标题翻译：制备泛酸的方法
公开(公告)号：US2234680A
公开(公告)日：1941-03-11
申请号：US34680740
申请日：1940-07-22
申请人： ABBOTT LAB
发明人： MOORE MARJORIE B
CPC分类号： C07C233/46

82. 发明申请

US20150336916A1 EPOXYEICOSATRIENOIC ACID ANALOGS AND METHODS OF MAKING AND USING THE SAME 有权
标题翻译：环氧亚油酸类似物及其制备和使用方法
公开(公告)号：US20150336916A1
公开(公告)日：2015-11-26
申请号：US14813615
申请日：2015-07-30
申请人： THE MEDICAL COLLEGE OF WISCONSIN, INC. , THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
发明人： John David Imig , William B. Campbell , John Russell Falck
IPC分类号： C07D291/04 , C07D285/08 , C07D271/07 , C07D277/34 , C07D257/04 , C07D249/12
CPC分类号： C07F9/40 , C07C233/46 , C07C233/47 , C07C233/56 , C07C237/22 , C07C275/20 , C07C309/15 , C07C311/18 , C07C311/19 , C07C311/51 , C07C317/28 , C07C323/44 , C07D249/12 , C07D257/04 , C07D271/06 , C07D271/07 , C07D277/34 , C07D277/593 , C07D277/82 , C07D285/08 , C07D291/04
摘要： Compounds and compositions comprising epoxyeicosatrienoic acid (EET) analogs that act as EET agonists and are useful as medications in the treatment of drug-induced nephrotoxicity, hypertension and other related conditions. Methods of making and using the compounds and compositions are further described.
摘要翻译：作为EET激动剂的环氧二十碳三烯酸（EET）类似物的化合物和组合物，可用作治疗药物诱导的肾毒性，高血压和其它相关病症的药物。进一步描述制备和使用化合物和组合物的方法。

83. 发明授权

US09127027B2 Epoxyeicosatrienoic acid analogs and methods of making and using the same 有权
标题翻译：环氧二十碳三烯酸类似物及其制备和使用方法
公开(公告)号：US09127027B2
公开(公告)日：2015-09-08
申请号：US14009658
申请日：2012-04-04
申请人： John David Imig , William B. Campbell , John Russell Falck
发明人： John David Imig , William B. Campbell , John Russell Falck
IPC分类号： A61K31/66 , C07F9/40 , C07C233/46 , C07C233/56 , C07C275/20 , C07C309/15 , C07C311/18 , C07C311/51 , C07C317/28 , C07C323/44 , C07D249/12 , C07D257/04 , C07D271/06 , C07D277/34 , C07D277/82 , C07D291/04 , C07C233/47 , C07C237/22 , C07C311/19 , C07D271/07 , C07D277/593 , C07D285/08
CPC分类号： C07F9/40 , C07C233/46 , C07C233/47 , C07C233/56 , C07C237/22 , C07C275/20 , C07C309/15 , C07C311/18 , C07C311/19 , C07C311/51 , C07C317/28 , C07C323/44 , C07D249/12 , C07D257/04 , C07D271/06 , C07D271/07 , C07D277/34 , C07D277/593 , C07D277/82 , C07D285/08 , C07D291/04
摘要： Compounds and compositions comprising epoxyeicosatrienoic acid (EET) analogs that act as EET agonists and are useful as medications in the treatment of drug-induced nephrotoxicity, hypertension and other related conditions. Methods of making and using the compounds and compositions are further described.
摘要翻译：作为EET激动剂的环氧二十碳三烯酸（EET）类似物的化合物和组合物，可用作治疗药物诱导的肾毒性，高血压和其它相关病症的药物。进一步描述制备和使用化合物和组合物的方法。

84. 发明申请

US20060217533A1 Production of N-acyl compounds 审中-公开
标题翻译： N-酰基化合物的制备
公开(公告)号：US20060217533A1
公开(公告)日：2006-09-28
申请号：US11372167
申请日：2006-03-10
申请人： Max Braun , Johannes Eicher , Saskia Braukmueller
发明人： Max Braun , Johannes Eicher , Saskia Braukmueller
IPC分类号： C07K1/02 , C07C231/02
CPC分类号： C07C231/02 , C07C233/46 , C07C233/47
摘要： A process for producing a compound containing an acylated nitrogen atom in which the adduct compound formed from an N-protonated cation and a chloride, bromide or iodide anion or the free nitrogen base is reacted with an acyl halide, preferably an acyl chloride, in the presence of an acid that drives off the released hydrogen chloride (HCl), hydrogen bromide (HBr) or hydrogen iodide (HI).
摘要翻译：一种制备含有酰化氮原子的化合物的方法，其中将由N-质子化阳离子和氯化物，溴化物或碘化物阴离子形成的加合物化合物或游离氮碱与酰卤，优选酰氯反应，存在释放氯化氢（HCl），溴化氢（HBr）或碘化氢（HI）的酸。

85. 发明授权

US06908935B2 Calcium receptor modulating agents 有权
标题翻译：钙受体调节剂
公开(公告)号：US06908935B2
公开(公告)日：2005-06-21
申请号：US10444946
申请日：2003-05-22
申请人： Michael G. Kelly , Shimin Xu , Ning Xi , Philip Miller , John F. Kincaid , Chiara Ghiron , Thomas Coulter
发明人： Michael G. Kelly , Shimin Xu , Ning Xi , Philip Miller , John F. Kincaid , Chiara Ghiron , Thomas Coulter
IPC分类号： A61K31/137 , A61K31/145 , A61K31/167 , A61K31/275 , A61K31/341 , A61K31/357 , A61K31/36 , A61K31/381 , A61K31/4045 , A61K31/417 , A61K31/4184 , A61K31/42 , A61K31/423 , A61K31/426 , A61K31/4418 , A61K31/443 , A61K31/4439 , A61K31/4465 , A61K31/47 , A61K31/4965 , A61K31/50 , A61K31/505 , A61K31/52 , A61K31/5377 , A61P3/14 , A61P5/18 , A61P5/20 , A61P19/10 , C07B53/00 , C07C209/28 , C07C211/27 , C07C211/29 , C07C211/30 , C07C211/55 , C07C215/46 , C07C217/54 , C07C217/58 , C07C229/38 , C07C233/43 , C07C235/20 , C07C237/30 , C07C255/58 , C07C255/59 , C07C275/40 , C07C311/08 , C07C317/32 , C07D207/26 , C07D207/32 , C07D207/325 , C07D209/08 , C07D209/10 , C07D209/44 , C07D211/22 , C07D211/26 , C07D211/70 , C07D213/26 , C07D213/30 , C07D213/38 , C07D213/61 , C07D213/62 , C07D213/64 , C07D213/65 , C07D213/68 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/82 , C07D215/12 , C07D231/56 , C07D233/22 , C07D235/06 , C07D235/08 , C07D235/10 , C07D235/12 , C07D235/14 , C07D237/14 , C07D239/26 , C07D239/34 , C07D239/42 , C07D239/47 , C07D241/12 , C07D241/42 , C07D249/18 , C07D261/08 , C07D263/32 , C07D263/56 , C07D271/06 , C07D271/10 , C07D271/12 , C07D277/24 , C07D277/28 , C07D277/40 , C07D277/42 , C07D277/66 , C07D277/78 , C07D285/00 , C07D285/01 , C07D295/096 , C07D295/135 , C07D295/185 , C07D295/26 , C07D307/42 , C07D307/52 , C07D307/68 , C07D317/46 , C07D317/54 , C07D317/58 , C07D319/18 , C07D321/10 , C07D333/16 , C07D333/20 , C07D333/56 , C07D401/12 , C07D405/12 , C07D471/04 , C07D473/00 , C07D487/04
CPC分类号： C07C233/36 , C07C211/27 , C07C211/29 , C07C211/30 , C07C211/55 , C07C215/46 , C07C217/54 , C07C217/58 , C07C229/38 , C07C233/43 , C07C233/46 , C07C235/20 , C07C237/30 , C07C255/58 , C07C255/59 , C07C275/40 , C07C311/08 , C07C317/32 , C07C2601/02 , C07D207/26 , C07D207/27 , C07D207/325 , C07D209/08 , C07D209/10 , C07D209/44 , C07D211/22 , C07D211/70 , C07D213/26 , C07D213/30 , C07D213/38 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/68 , C07D213/73 , C07D213/75 , C07D213/82 , C07D215/12 , C07D215/14 , C07D231/56 , C07D233/22 , C07D235/06 , C07D235/10 , C07D235/12 , C07D237/08 , C07D237/14 , C07D239/26 , C07D239/34 , C07D239/42 , C07D241/12 , C07D241/42 , C07D249/18 , C07D261/08 , C07D263/32 , C07D263/56 , C07D271/06 , C07D271/08 , C07D271/10 , C07D271/12 , C07D277/24 , C07D277/28 , C07D277/40 , C07D277/42 , C07D277/66 , C07D285/01 , C07D295/096 , C07D295/135 , C07D295/185 , C07D295/26 , C07D307/42 , C07D307/52 , C07D307/68 , C07D317/46 , C07D317/54 , C07D319/18 , C07D321/10 , C07D333/16 , C07D333/20 , C07D333/56 , C07D401/12 , C07D405/12 , C07D471/04 , C07D487/04
摘要： The compounds of the invention are represented by the following general structure or a pharmaceutically acceptable salt thereof, and compositions containing them, wherein the variables are defined herein, and their use to reduce or inhibit PTH secretion, including methods for reducing or inhibiting PTH secretion and methods for treatment or prophylaxis of diseases associated with bone disorders, such as osteoporosis, or associated with excessive secretion of PTH, such as hyperparathyroidism. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译：本发明的化合物由以下一般结构或其药学上可接受的盐以及含有它们的组合物表示，其中变量在本文中定义，及其用于减少或抑制PTH分泌的用途，包括减少或抑制PTH分泌的方法，以及用于治疗或预防与骨疾病相关的疾病如骨质疏松症或与过度分泌的PTH相关的疾病如甲状旁腺功能亢进的方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

86. 发明授权

US4943679A Process for the N-.omega.-trifluoroacetylation of saturated aliphatic monocarboxylic .alpha.,.omega.-diamino acids 失效
标题翻译：饱和脂肪族单羧基α，ω-二氨基酸的N-ω-三氟乙酰化方法
公开(公告)号：US4943679A
公开(公告)日：1990-07-24
申请号：US147531
申请日：1988-01-25
申请人： Paul Aviron-Violet , Christian Gervals
发明人： Paul Aviron-Violet , Christian Gervals
IPC分类号： C07C231/02 , C07C67/00 , C07C231/00 , C07C233/46 , C07C233/47
CPC分类号： C07C233/46
摘要： A process for the N-.omega.-trifluoroacetylation of a saturated aliphatic monocarboxylic .alpha.,.omega.-diamino acid. A saturated aliphatic monocarboxylic .alpha.,.omega.-diamino acid of the formula: ##STR1## wherein R represents a straight-chain or branched-chain C.sub.1 -C.sub.6 alkylene radical, is contacted with a C.sub.1 -C.sub.6 straight-chain or branched-chain alkyl trifluoroacetate.
摘要翻译：饱和脂肪族单羧酸α，ω-二氨基酸的N-ω-三氟乙酰化的方法。具有下式的饱和脂族单羧酸α，ω-二氨基酸：其中R表示直链或支链C1-C6亚烷基，与C1-C6直链或支链烷基三氟乙酸酯。

87. 发明授权

US4918222A Process for synthesis of N-acetylglycine 失效
标题翻译： N-乙酰甘氨酸合成方法
公开(公告)号：US4918222A
公开(公告)日：1990-04-17
申请号：US83397
申请日：1987-08-10
申请人： Jiang-Jen Lin , John F. Knifton , Ernest L. Yeakey
发明人： Jiang-Jen Lin , John F. Knifton , Ernest L. Yeakey
IPC分类号： C07C231/00 , C07C233/46
CPC分类号： C07C231/00 , C07C233/46
摘要： An N-acetylglycine is manufactured by reacting paraformaldehyde with an acetamide and carbon monoxide in the present of a cobalt-containing catalyst promoted by a sulfoxide or dinitride compounds. The presence of sulfoxide or dinitrile ligands are essential for the high yield synthesis of N-acetylglycine and good cobalt recovery.
摘要翻译：通过使多聚甲醛与乙酰胺和一氧化碳反应，在由亚砜或二氮化硼化合物促进的含钴催化剂存在下制备N-乙酰甘氨酸。亚砜或二腈配体的存在对于N-乙酰甘氨酸的高产率合成和良好的钴回收是必需的。

88. 发明授权

US4612388A Process for producing N-acylphenylalanines 失效
标题翻译： N-酰基苯丙氨酸的制备方法
公开(公告)号：US4612388A
公开(公告)日：1986-09-16
申请号：US719300
申请日：1985-04-03
申请人： Ryuichi Mita , Toshio Katoh , Chojiro Higuchi , Akihiro Yamaguchi
发明人： Ryuichi Mita , Toshio Katoh , Chojiro Higuchi , Akihiro Yamaguchi
IPC分类号： C07C231/10 , C07C67/00 , C07C231/00 , C07C231/12 , C07C233/46 , C07C233/47 , C07C233/82 , C07C233/83 , C07C99/06
CPC分类号： C07C233/46
摘要： Disclosed herein is a process for producing an N-acyl-substituted or unsubstituted phenylalanine comprising hydrolyzing a 2-substituted-4-substituted or unsubstituted benzylidene-5-oxazolone with alkali, adjusting pH of the reaction solution containing its hydrolysis product with acid at 5-9 and reducing the resultant reaction solution catalytically in the presence of a palladium or platinum reducing catalyst.In accordance with the process of the present invention, time duration required for effecting the reduction can be shortened markedly in comparison with the reduction in an aqueous strong alkaline solution. Moreover, the catalyst recovered after completion of the reduction can be used repeatedly without any additional treatment and without any observed lowering in its activity. Accordingly, the reduction using the recovered catalyst may proceed in practically the same time as in the case of using a fresh catalyst.In the process of the present invention, the reduction is carried out continuously without isolating the alkaline hydrolysis product, i.e., a substituted or unsubstituted N-acylaminocinnamic acid from the reaction mixture, so that the process is featured advantageously by simplified process and improved overall yield.
摘要翻译：本文公开了N-酰基取代或未取代的苯丙氨酸的制备方法，其包括用碱水解2-取代-4-取代或未取代的亚苄基-5-恶唑酮，调节含有其水解产物的反应溶液的pH为5 -9并在钯或铂还原催化剂的存在下催化还原所得的反应溶液。根据本发明的方法，与强碱性水溶液的降低相比，可以显着缩短实现还原所需的时间。此外，还原后还原反应的催化剂可以重复使用，无需任何额外的处理，并且没有观察到其活性降低。因此，使用回收的催化剂的还原可以与使用新鲜催化剂的情况几乎相同的时间进行。在本发明的方法中，还原是从反应混合物中分离碱性水解产物，即取代或未取代的N-酰氨基肉桂酸，连续进行，使得该方法有利地通过简化的方法和改进的总产率。

89. 发明授权

US4032657A Haloacetanilides as microbicidal active substances 失效
标题翻译：杀菌剂作为微生物活性物质
公开(公告)号：US4032657A
公开(公告)日：1977-06-28
申请号：US562741
申请日：1977-06-28
申请人： Hans Moser
发明人： Hans Moser
IPC分类号： A01N37/46 , A01P3/00 , C07C67/00 , C07C231/00 , C07C231/02 , C07C233/46 , C07C233/47 , C07C233/88 , A01N9/20 , C07C101/447
CPC分类号： C07C233/46
摘要： Compounds of the formula ##STR1## wherein Z.sub.1 represents methyl or chlorine, Z.sub.2 represents chlorine or bromine, Z.sub.3 represents hydrogen or C.sub.1 -C.sub.3 alkyl, and X represents fluorine, chlorine, bromine or iodine, exhibit microbicidal activity, preferably against phytopathogenic fungi.

90. 发明授权

US3758525A Process for preparing n-higher aliphatic acyl acidic amino acids 失效
标题翻译：制备N-高级脂肪酸ACIDIC氨基酸的方法
公开(公告)号：US3758525A
公开(公告)日：1973-09-11
申请号：US3758525D
申请日：1970-03-20
申请人： AJINOMOTO KK
发明人： YOSHIDA R , YOSHIMURA I , TAKEHARA M
IPC分类号： A01N37/46 , C07C233/45 , C07C233/46 , C08H3/00
CPC分类号： C07C233/45 , A01N37/46 , C07C233/46 , Y10S516/06
摘要： The halides of aliphatic carboxylic acids having 8 to 22 carbon atoms can be reacted with acidic amino acids to form N-acyl amino acids in very good yields if the reaction is carried out in an alkaline solvent medium of 20 - 85 percent (vol.) water and 80 15 percent acetone, methylethylketone, dioxane, tetrahydrofuran, tert-butanol, or cyclohexanone.
摘要翻译：具有8至22个碳原子的脂族羧酸的卤化物可以与酸性氨基酸反应以非常好的产率形成N-酰基氨基酸，如果反应在20-85％（体积）的碱性溶剂介质中进行，水和80-15％丙酮，甲基乙基酮，二恶烷，四氢呋喃，叔丁醇或环己酮。

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