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81. 发明申请

WO2006086201A2 PLATELET RICH PLASMA CONCENTRATE APPARATUS AND METHOD 审中-公开
标题翻译： PLATELET RICH等离子体浓缩装置和方法
公开(公告)号：WO2006086201A2
公开(公告)日：2006-08-17
申请号：PCT/US2006003599
申请日：2006-01-30
申请人： HANUMAN LLC , CELL FACTOR TECHNOLOGIES INC , LEACH MICHAEL D
发明人： LEACH MICHAEL D , DORIAN RANDEL
IPC分类号： A61M1/36 , B04B5/00
CPC分类号： B01D63/02 , A61M1/0281 , A61M1/3482 , A61M1/3496 , A61M1/3633 , A61M1/3679 , A61M1/3693 , A61M1/3696 , A61M2202/0415 , A61M2202/0427 , B01D2313/44 , B01D2313/58 , B01F11/0005 , B01F13/0052 , B04B5/0442 , B04B2005/0478
摘要： The PRP separator-concentrator of this invention is suitable for office use or emergency use for trauma victims. The PRP separator comprises a motorized centrifugal separation assembly, and a concentrator assembly. The centrifugal separator assembly comprises a centrifugal drum separator that includes an erythrocyte capture module and a motor having a drive axis connected to the centrifugal drum separator. The concentrator assembly comprises a water-removal module for preparing PRP concentrate. The centrifugal drum separator has an erythrocyte trap. The water removal module can be a syringe device with water absorbing beads or it can be a pump-hollow fiber cartridge assembly. The hollow fibers are membranes with pores that allow the flow of water through the fiber membrane while excluding flow of clotting factors useful for sealing and adhering tissue and growth factors helpful for healing while avoiding activation of platelets and disruption of any trace erythrocytes present in the PRP.
摘要翻译：本发明的PRP分离器集中器适用于创伤受害者的办公用途或紧急用途。 PRP分离器包括电动离心分离组件和集中器组件。离心分离器组件包括离心鼓分离器，其包括红细胞捕获模块和具有连接到离心鼓分离器的驱动轴的马达。浓缩器组件包括用于制备PRP浓缩物的去水模块。离心鼓分离器具有红细胞捕集器。除水模块可以是具有吸水珠的注射器装置，或者其可以是泵中空纤维筒组件。中空纤维是具有孔的膜，其允许水流过纤维膜，同时排除可用于密封和粘附组织的凝血因子的流动和有助于愈合的生长因子，同时避免血小板活化和破坏PRP中存在的任何痕量红细胞。

82. 发明公开

US20240361348A1 Systems, Methods, And Devices For Automated Nucleic Acid And Protein Isolation 审中-公开
公开(公告)号：US20240361348A1
公开(公告)日：2024-10-31
申请号：US18640345
申请日：2024-04-19
申请人： Life Technologies Corporation
发明人： Alexandre VLASSOV , Timothy BARTA , Justin INSLEE , Ethan GENTERT , Robert SMITH , Sara THIELE , Carolyn ADAMS , Kraig KRUGER , Robert Schneider , Wade LUKIANOW , Jay GRECO , Jason JONES , David CERRONE , Sumonto GHOSH , Brian VAJDA , Andrew BASTA , Allan EVANS , Christopher CROWLEY , Robert SETTERQUIST , Anne COX , Mark MAYERNICK
IPC分类号： G01N35/10 , B01D61/58 , B01D69/02 , G01N1/40 , G01N21/59 , G01N35/00
CPC分类号： G01N35/1016 , B01D61/58 , B01D69/02 , G01N1/405 , G01N1/4077 , G01N21/59 , G01N35/00584 , G01N35/1081 , B01D2311/2642 , B01D2313/44 , B01D2313/50 , B01D2313/58 , B01D2319/025 , B01D2325/42 , G01N2001/4088 , G01N2035/1025 , G01N2035/1053
摘要： Purifying target biomolecules, such as nucleic acids or proteins, from a biological source is a time intensive process and is typically performed by a skilled technician or scientist owing to the highly technical nature of the work. Systems, devices, and methods disclosed herein enable the automated bioprocessing and purification of target biomolecules from a biological source. For example, an instrument and disposable cartridge are provided for automatedly isolating and purifying nucleic acids (such as plasmid DNA from a bacterial culture) or for isolating protein from any biological sample. Such an exemplary instrument and cartridge can work in concert to timely release, mix, and move the target biomolecule and various reagents and buffers through a target biomolecule purification process, resulting in a purified target biomolecule with less manual oversight than traditional approaches.

83. 发明授权

US11964237B2 Molecular weight filtration system and apparatus with additional flow configurations 有权
公开(公告)号：US11964237B2
公开(公告)日：2024-04-23
申请号：US17693155
申请日：2022-03-11
申请人： Integrated Protein Technologies, Inc.
发明人： Philip D. Compton , Jared Drader
IPC分类号： B01D63/08 , B01D69/02 , G01N1/40
CPC分类号： B01D63/087 , B01D63/082 , B01D69/02 , G01N1/4005 , B01D2313/025 , B01D2313/04 , B01D2313/08 , B01D2313/10 , B01D2313/13 , B01D2313/20 , B01D2313/50 , B01D2313/54 , B01D2313/56 , B01D2313/58 , B01D2317/02 , B01D2317/08 , B01D2325/20 , B01D2325/34
摘要： A molecular filtration device and method of use capable of filtering and purifying molecules of a particular characteristic, wherein the amount of molecule to be filtered may be in the nanogram range and may be dispersed in a relatively large volume of solution. The resultant elution may include a relatively high concentration of desired molecule, due to a relatively small volume.

84. 发明授权

US11813573B2 Plunger pumping arrangement for a hollow fiber filter 有权
公开(公告)号：US11813573B2
公开(公告)日：2023-11-14
申请号：US17869077
申请日：2022-07-20
申请人： REPLIGEN CORPORATION
发明人： Rudolf Pavlik
IPC分类号： B01D63/02 , B01D69/08 , B01D37/04 , B01D35/26 , B01D29/11 , B01D29/90 , F04B43/00 , F04B43/06 , F04B53/20 , C12M1/00 , C12M1/12 , F04B43/067
CPC分类号： B01D63/02 , B01D29/11 , B01D29/908 , B01D35/26 , B01D37/04 , B01D69/08 , C12M25/02 , C12M29/10 , F04B43/0063 , F04B43/0081 , F04B43/067 , F04B53/20 , B01D2313/243 , B01D2313/58 , B01D2313/90
摘要： A fluid filtration assembly includes a filter housing having a first end for fluid connection with a fluid storage vessel. A filter cartridge is disposable within the filter housing, and a plunger pump is coupled at a second end of the filter housing. The plunger pump includes a housing having a rigid portion and a flexible portion. The flexible portion has a plunger-engaging portion for coupling to the plunger of an actuator. The flexible portion selectively movable with respect to the rigid portion via the actuator. The filter cartridge can be a hollow fiber filter. The plunger pump can be configured to induce alternating tangential flow in at least a portion of the assembly. The fluid filtration assembly can be provided as a disposable single-use arrangement.

85. 发明申请

US20180346861A1 Hollow Fiber Filter Arrangement 审中-公开
公开(公告)号：US20180346861A1
公开(公告)日：2018-12-06
申请号：US15609787
申请日：2017-05-31
申请人： GE HEALTHCARE BIO-SCIENCES CORP.
发明人： Yasser Ali
IPC分类号： C12M1/12 , B01D29/11 , B01D35/30 , C12M1/00
CPC分类号： B01D63/02 , B01D65/00 , B01D2313/20 , B01D2313/23 , B01D2313/58 , C12M23/14 , C12M29/16
摘要： Disclosed is a hollow fiber filter arrangement and a bioreactor system comprising such a hollow fiber filter arrangement. The hollow fiber filter arrangement comprising: an inlet for receiving a sample to be filtered in the hollow fiber filter arrangement; an outlet for delivering of the filtered sample out from the hollow fiber filter arrangement; a bundle of elongate hollow fibers connected at a first end to the inlet and connected at an opposite second end to the outlet; and an outer housing enclosing the bundle, wherein a filtrate/waste collection space is provided between the outer housing and the at least one elongated hollow fiber, and wherein the outer housing is made from a flexible material.

86. 发明授权

US09658242B2 Automated ultra-filtration apparatus 有权
公开(公告)号：US09658242B2
公开(公告)日：2017-05-23
申请号：US14725690
申请日：2015-05-29
申请人： ChroMedX Corp.
发明人： James Samsoondar
IPC分类号： B01D61/14 , B01L99/00 , B01D27/00 , G01N35/10 , B01D61/20 , G01N33/49 , B01D63/02 , B01D65/02 , B01D61/22 , B01L3/02 , G01N33/74 , G01N33/94 , G01N35/00
CPC分类号： G01N1/4077 , B01D61/145 , B01D61/20 , B01D61/22 , B01D63/02 , B01D65/02 , B01D2313/16 , B01D2313/44 , B01D2313/58 , B01D2321/04 , B01L3/0237 , B01L3/0279 , B01L2300/0663 , B01L2300/0681 , B01L2400/0478 , G01N33/491 , G01N33/74 , G01N33/94 , G01N35/00732 , G01N35/00871 , G01N35/026 , G01N35/1011 , G01N35/1083 , G01N2001/4088 , G01N2035/00475 , G01N2035/00752 , G01N2035/00801 , G01N2035/00811 , G01N2035/1013 , G01N2035/103 , G01N2035/1053
摘要： The present invention provides a disposable ultra-filtration system comprising a disposable pipetting tip and a disposable ultra-filtration cartridge, wherein the cartridge includes a membrane filtration chamber and a dead-end channel. In use, a piston in the pipette pressurizes air within the channel; the pressurized air can subsequently move the piston and cause a reverse flow back through the membrane of the cartridge, unplugging the pores thereof. Also disclosed is an automated workstation incorporating the disposable ultra-filtration system, and a system comprising the automated workstation, useful for measuring the free therapeutic drug concentration and free hormone concentration in a sample.

87. 发明申请

US20170001146A1 Disposable Membrane Stacks 审中-公开
标题翻译：一次性膜堆
公开(公告)号：US20170001146A1
公开(公告)日：2017-01-05
申请号：US15113523
申请日：2015-01-23
申请人： FUJIFILM MANUFACTURING EUROPE BV
发明人： Willem Van Baak , Vinodnarain Bhikhi , Bastiaan Van Berchum , Johannes Van Engelen
IPC分类号： B01D61/50 , B01D65/00 , B01D63/08
CPC分类号： B01D61/50 , B01D63/082 , B01D65/003 , B01D2313/58 , B01D2315/16 , B01D2325/08 , B01D2325/40
摘要： A disposable, crossflow membrane stack suitable for use in an ion exchange unit, the stack comprising alternate dilution compartments and concentration compartments, each compartment being defined by a flat cation-permeable membrane (2) and a flat anion-permeable membrane (1) and at least two edges along which the cation-permeable and an anion-permeable membranes are permanently secured together wherein the cation-permeable membranes and/or the anion-permeable membranes have a textured surface profile which keep said membranes apart and/or from touching each other and wherein the edges secured together define the direction in which liquid may flow through the compartments. Also claimed are ion exchange units comprising the stack, optionally comprising a quick-release securement means to allow facile attachment and release of modular units comprising the stacks.
摘要翻译：一种适合用于离子交换单元的一次性横流膜堆，所述堆叠包括可选的稀释室和浓缩隔室，每个室由平阳离子可渗透膜（2）和平阴离子可渗透膜（1）和阳离子可渗透膜和阴离子可渗透膜永久固定在一起的至少两个边缘，其中阳离子可渗透膜和/或阴离子可渗透膜具有纹理表面轮廓，其保持所述膜分离和/或接触每个其中并且其中固定在一起的边缘限定液体可以流过隔室的方向。还要求保护的是包括该堆叠的离子交换单元，其可选地包括快速释放固定装置，以允许容易地附接和释放包括该堆叠的模块化单元。

88. 发明授权

US09254464B2 Filter module 有权
标题翻译：过滤模块
公开(公告)号：US09254464B2
公开(公告)日：2016-02-09
申请号：US13551222
申请日：2012-07-17
申请人： Torsten Keller , Franz Kugelmann , Wolfgang Wehmeyer
发明人： Torsten Keller , Franz Kugelmann , Wolfgang Wehmeyer
IPC分类号： B01D63/04 , B01D27/14 , B01D69/08 , B01D61/58 , A61M1/34 , B01D61/14 , B01D61/24
CPC分类号： B01D63/04 , A61M1/3413 , B01D61/145 , B01D61/243 , B01D61/58 , B01D2313/04 , B01D2313/21 , B01D2313/58 , B01D2319/025
摘要： A filter module includes a first filter stage and a second filter stage which are substantially concentrically arranged. The first filter stage and the second filter stage each include a plurality of hollow fiber membranes having a first fiber end and a second fiber end, which are embedded in a respective casting compound. The first filter stage is a filter stage for the filtration of a first medical fluid, and the second filter stage is a filter stage for the filtration of a second medical fluid. The first filter stage has unilaterally closed fiber ends, and is surrounded by a boundary element which separates the first filter stage and the second filter stage from one another. The boundary element has at least one opening which provides fluid communication between the first filter stage and the second filter stage.
摘要翻译：滤波器模块包括基本同心布置的第一滤波器级和第二滤波级。第一过滤段和第二过滤段各自包括多个具有第一纤维端和第二纤维端的中空纤维膜，它们嵌入各自的铸造化合物中。第一过滤段是用于过滤第一医用流体的过滤段，第二过滤段是用于过滤第二医用流体的过滤器级。第一滤波器级具有单向封闭的光纤端，并且被分隔第一滤波器级和第二滤波级的边界元件围绕。边界元件具有至少一个开口，其提供第一过滤器级和第二过滤级之间的流体连通。

89. 发明授权

US09174171B2 Bag for a circuit of a biological liquid treatment installation 有权
标题翻译：生物液体处理装置电路袋
公开(公告)号：US09174171B2
公开(公告)日：2015-11-03
申请号：US13161975
申请日：2011-06-16
申请人： Jean-Louis Weissenbach , Sebastien Cirou
发明人： Jean-Louis Weissenbach , Sebastien Cirou
IPC分类号： B01D63/00 , B01D61/20
CPC分类号： B01D63/00 , B01D61/20 , B01D2313/105 , B01D2313/125 , B01D2313/13 , B01D2313/18 , B01D2313/58 , B01D2313/90 , B01D2315/10 , Y10T137/6851 , Y10T137/8593
摘要： The invention concerns a bag comprising a first conduit (13C) which extends longitudinally between a flow pump connector (11C) emerging on a first side (68) and a tangential filter connector (11M) emerging on a second side (69); a second conduit (13B) which extends longitudinally from a first side of said conduit (13C) between a supply container connector (11B) emerging on said first side (68), and another tangential flow connector (11N) emerging on said second side (69); a third conduit (13H) which extends from a second side of said conduit (13C), starting at a collecting container connector (11J), until it enters said first conduit (13C); and a fourth conduit (13A) which extends from the first side of said conduit (13C), starting at a transfer pump connector (11A), until it enters said second conduit (13B).
摘要翻译：本发明涉及一种袋子，其包括在出现在第一侧面（68）上的流动泵连接器（11C）和出现在第二侧面（69）上的切向过滤器连接器（11M）之间纵向延伸的第一管道（13C）。第二导管（13B），其从所述导管（13C）的第一侧沿着出现在所述第一侧（68）上的供应容器连接器（11B）和出现在所述第二侧（68）上的另一个切向流动连接器（11N） 69）; 从所述导管（13C）的第二侧延伸的第三导管（13H），从收集容器连接器（11J）开始，直至其进入所述第一导管（13C）; 以及从所述导管（13C）的第一侧从转移泵连接器（11A）开始直到其进入所述第二导管（13B）的第四导管（13A）。

90. 发明申请

US20150008184A1 Device For A Biological Liquid Treatment Installation 有权
标题翻译：生物液体处理装置
公开(公告)号：US20150008184A1
公开(公告)日：2015-01-08
申请号：US14493678
申请日：2014-09-23
申请人： EMD Millipore Corporation
发明人： Sebastien Cirou , Rene Reinbigler , Virginie Buisson , Jean-Louis Weissenbach
IPC分类号： B01D33/00 , B01D61/24 , A61M1/16 , B01D15/08
CPC分类号： B01D33/00 , A61M1/16 , B01D15/08 , B01D61/18 , B01D61/20 , B01D61/243 , B01D2313/105 , B01D2313/125 , B01D2313/18 , B01D2313/58 , C12M47/12 , F04B43/08 , Y10T16/522 , Y10T137/8593 , Y10T137/86187 , Y10T137/86196
摘要： The invention concerns a device comprising a base (2) and a door (20), said device having a closed door position in which a circuit (8) of the device comprises a bag comprising two flexible films and connectors of the conveying network, and a press (9) comprising a first she (16) disposed on a front face (5) of said base (2) and a second shed (17) disposed in said door (20); and a hinge system hinging said door (20) relative to said base (2), and disposed only on one side of said door (20) so as to form lateral clearances between said door (20) and said base (2) over the rest of a perimeter of said door (20)
摘要翻译：本发明涉及一种包括基座（2）和门（20）的装置，所述装置具有关闭的门位置，其中装置的电路（8）包括包括输送网络的两个柔性膜和连接器的袋，以及包括设置在所述基座（2）的前表面（5）上的第一she（16）和设置在所述门（20）中的第二梭口（17）的按压机（9）。以及铰链系统，其将所述门（20）相对于所述基座（2）铰接，并且仅设置在所述门（20）的一侧上，以便在所述门（20）和所述基座（2）之间形成横向间隙所述门（20）的周边的其余部分

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