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81. 发明授权

US09658242B2 Automated ultra-filtration apparatus 有权
公开(公告)号：US09658242B2
公开(公告)日：2017-05-23
申请号：US14725690
申请日：2015-05-29
申请人： ChroMedX Corp.
发明人： James Samsoondar
IPC分类号： B01D61/14 , B01L99/00 , B01D27/00 , G01N35/10 , B01D61/20 , G01N33/49 , B01D63/02 , B01D65/02 , B01D61/22 , B01L3/02 , G01N33/74 , G01N33/94 , G01N35/00
CPC分类号： G01N1/4077 , B01D61/145 , B01D61/20 , B01D61/22 , B01D63/02 , B01D65/02 , B01D2313/16 , B01D2313/44 , B01D2313/58 , B01D2321/04 , B01L3/0237 , B01L3/0279 , B01L2300/0663 , B01L2300/0681 , B01L2400/0478 , G01N33/491 , G01N33/74 , G01N33/94 , G01N35/00732 , G01N35/00871 , G01N35/026 , G01N35/1011 , G01N35/1083 , G01N2001/4088 , G01N2035/00475 , G01N2035/00752 , G01N2035/00801 , G01N2035/00811 , G01N2035/1013 , G01N2035/103 , G01N2035/1053
摘要： The present invention provides a disposable ultra-filtration system comprising a disposable pipetting tip and a disposable ultra-filtration cartridge, wherein the cartridge includes a membrane filtration chamber and a dead-end channel. In use, a piston in the pipette pressurizes air within the channel; the pressurized air can subsequently move the piston and cause a reverse flow back through the membrane of the cartridge, unplugging the pores thereof. Also disclosed is an automated workstation incorporating the disposable ultra-filtration system, and a system comprising the automated workstation, useful for measuring the free therapeutic drug concentration and free hormone concentration in a sample.

82. 发明申请

US20170001146A1 Disposable Membrane Stacks 审中-公开
标题翻译：一次性膜堆
公开(公告)号：US20170001146A1
公开(公告)日：2017-01-05
申请号：US15113523
申请日：2015-01-23
申请人： FUJIFILM MANUFACTURING EUROPE BV
发明人： Willem Van Baak , Vinodnarain Bhikhi , Bastiaan Van Berchum , Johannes Van Engelen
IPC分类号： B01D61/50 , B01D65/00 , B01D63/08
CPC分类号： B01D61/50 , B01D63/082 , B01D65/003 , B01D2313/58 , B01D2315/16 , B01D2325/08 , B01D2325/40
摘要： A disposable, crossflow membrane stack suitable for use in an ion exchange unit, the stack comprising alternate dilution compartments and concentration compartments, each compartment being defined by a flat cation-permeable membrane (2) and a flat anion-permeable membrane (1) and at least two edges along which the cation-permeable and an anion-permeable membranes are permanently secured together wherein the cation-permeable membranes and/or the anion-permeable membranes have a textured surface profile which keep said membranes apart and/or from touching each other and wherein the edges secured together define the direction in which liquid may flow through the compartments. Also claimed are ion exchange units comprising the stack, optionally comprising a quick-release securement means to allow facile attachment and release of modular units comprising the stacks.
摘要翻译：一种适合用于离子交换单元的一次性横流膜堆，所述堆叠包括可选的稀释室和浓缩隔室，每个室由平阳离子可渗透膜（2）和平阴离子可渗透膜（1）和阳离子可渗透膜和阴离子可渗透膜永久固定在一起的至少两个边缘，其中阳离子可渗透膜和/或阴离子可渗透膜具有纹理表面轮廓，其保持所述膜分离和/或接触每个其中并且其中固定在一起的边缘限定液体可以流过隔室的方向。还要求保护的是包括该堆叠的离子交换单元，其可选地包括快速释放固定装置，以允许容易地附接和释放包括该堆叠的模块化单元。

83. 发明授权

US09254464B2 Filter module 有权
标题翻译：过滤模块
公开(公告)号：US09254464B2
公开(公告)日：2016-02-09
申请号：US13551222
申请日：2012-07-17
申请人： Torsten Keller , Franz Kugelmann , Wolfgang Wehmeyer
发明人： Torsten Keller , Franz Kugelmann , Wolfgang Wehmeyer
IPC分类号： B01D63/04 , B01D27/14 , B01D69/08 , B01D61/58 , A61M1/34 , B01D61/14 , B01D61/24
CPC分类号： B01D63/04 , A61M1/3413 , B01D61/145 , B01D61/243 , B01D61/58 , B01D2313/04 , B01D2313/21 , B01D2313/58 , B01D2319/025
摘要： A filter module includes a first filter stage and a second filter stage which are substantially concentrically arranged. The first filter stage and the second filter stage each include a plurality of hollow fiber membranes having a first fiber end and a second fiber end, which are embedded in a respective casting compound. The first filter stage is a filter stage for the filtration of a first medical fluid, and the second filter stage is a filter stage for the filtration of a second medical fluid. The first filter stage has unilaterally closed fiber ends, and is surrounded by a boundary element which separates the first filter stage and the second filter stage from one another. The boundary element has at least one opening which provides fluid communication between the first filter stage and the second filter stage.
摘要翻译：滤波器模块包括基本同心布置的第一滤波器级和第二滤波级。第一过滤段和第二过滤段各自包括多个具有第一纤维端和第二纤维端的中空纤维膜，它们嵌入各自的铸造化合物中。第一过滤段是用于过滤第一医用流体的过滤段，第二过滤段是用于过滤第二医用流体的过滤器级。第一滤波器级具有单向封闭的光纤端，并且被分隔第一滤波器级和第二滤波级的边界元件围绕。边界元件具有至少一个开口，其提供第一过滤器级和第二过滤级之间的流体连通。

84. 发明授权

US09174171B2 Bag for a circuit of a biological liquid treatment installation 有权
标题翻译：生物液体处理装置电路袋
公开(公告)号：US09174171B2
公开(公告)日：2015-11-03
申请号：US13161975
申请日：2011-06-16
申请人： Jean-Louis Weissenbach , Sebastien Cirou
发明人： Jean-Louis Weissenbach , Sebastien Cirou
IPC分类号： B01D63/00 , B01D61/20
CPC分类号： B01D63/00 , B01D61/20 , B01D2313/105 , B01D2313/125 , B01D2313/13 , B01D2313/18 , B01D2313/58 , B01D2313/90 , B01D2315/10 , Y10T137/6851 , Y10T137/8593
摘要： The invention concerns a bag comprising a first conduit (13C) which extends longitudinally between a flow pump connector (11C) emerging on a first side (68) and a tangential filter connector (11M) emerging on a second side (69); a second conduit (13B) which extends longitudinally from a first side of said conduit (13C) between a supply container connector (11B) emerging on said first side (68), and another tangential flow connector (11N) emerging on said second side (69); a third conduit (13H) which extends from a second side of said conduit (13C), starting at a collecting container connector (11J), until it enters said first conduit (13C); and a fourth conduit (13A) which extends from the first side of said conduit (13C), starting at a transfer pump connector (11A), until it enters said second conduit (13B).
摘要翻译：本发明涉及一种袋子，其包括在出现在第一侧面（68）上的流动泵连接器（11C）和出现在第二侧面（69）上的切向过滤器连接器（11M）之间纵向延伸的第一管道（13C）。第二导管（13B），其从所述导管（13C）的第一侧沿着出现在所述第一侧（68）上的供应容器连接器（11B）和出现在所述第二侧（68）上的另一个切向流动连接器（11N） 69）; 从所述导管（13C）的第二侧延伸的第三导管（13H），从收集容器连接器（11J）开始，直至其进入所述第一导管（13C）; 以及从所述导管（13C）的第一侧从转移泵连接器（11A）开始直到其进入所述第二导管（13B）的第四导管（13A）。

85. 发明申请

US20150008184A1 Device For A Biological Liquid Treatment Installation 有权
标题翻译：生物液体处理装置
公开(公告)号：US20150008184A1
公开(公告)日：2015-01-08
申请号：US14493678
申请日：2014-09-23
申请人： EMD Millipore Corporation
发明人： Sebastien Cirou , Rene Reinbigler , Virginie Buisson , Jean-Louis Weissenbach
IPC分类号： B01D33/00 , B01D61/24 , A61M1/16 , B01D15/08
CPC分类号： B01D33/00 , A61M1/16 , B01D15/08 , B01D61/18 , B01D61/20 , B01D61/243 , B01D2313/105 , B01D2313/125 , B01D2313/18 , B01D2313/58 , C12M47/12 , F04B43/08 , Y10T16/522 , Y10T137/8593 , Y10T137/86187 , Y10T137/86196
摘要： The invention concerns a device comprising a base (2) and a door (20), said device having a closed door position in which a circuit (8) of the device comprises a bag comprising two flexible films and connectors of the conveying network, and a press (9) comprising a first she (16) disposed on a front face (5) of said base (2) and a second shed (17) disposed in said door (20); and a hinge system hinging said door (20) relative to said base (2), and disposed only on one side of said door (20) so as to form lateral clearances between said door (20) and said base (2) over the rest of a perimeter of said door (20)
摘要翻译：本发明涉及一种包括基座（2）和门（20）的装置，所述装置具有关闭的门位置，其中装置的电路（8）包括包括输送网络的两个柔性膜和连接器的袋，以及包括设置在所述基座（2）的前表面（5）上的第一she（16）和设置在所述门（20）中的第二梭口（17）的按压机（9）。以及铰链系统，其将所述门（20）相对于所述基座（2）铰接，并且仅设置在所述门（20）的一侧上，以便在所述门（20）和所述基座（2）之间形成横向间隙所述门（20）的周边的其余部分

86. 发明申请

US20140342446A1 PNEUMATIC ALTERNATING PRESSURE MEMBRANE CELL SEPARATION SYSTEM 审中-公开
标题翻译：气动替代压力膜细胞分离系统
公开(公告)号：US20140342446A1
公开(公告)日：2014-11-20
申请号：US14285480
申请日：2014-05-22
申请人： Crucell Holland B.V.
发明人： Alain PRALONG , Hans Ulrich Dellenbach
IPC分类号： B01D63/02
CPC分类号： B01D63/02 , B01D61/20 , B01D61/22 , B01D65/02 , B01D2313/243 , B01D2313/50 , B01D2313/58 , B01D2315/00 , B01D2321/04 , C12M29/16 , C12M47/10 , Y10T29/49826
摘要： Described are filtration systems that can be referred to as Pneumatic Alternating Cell Separators (PACS), useful components thereof in the form of assemblies or kits of parts that can be used to build the system, and use of the system for filtering fluids, for instance, in cell culture perfusion systems comprising a filter-containing chamber, an expansion chamber and a gas flow controller.
摘要翻译：描述了可被称为气动交替细胞分离器（PACS）的过滤系统，其可用于构建系统的部件或组件形式的有用部件，以及用于过滤流体的系统的使用，例如，包括含有过滤器的室，膨胀室和气体流量控制器的细胞培养物灌注系统中。

87. 发明授权

US08845902B2 Pneumatic alternating pressure membrane cell separation system 有权
标题翻译：气动交替膜细胞分离系统
公开(公告)号：US08845902B2
公开(公告)日：2014-09-30
申请号：US13983982
申请日：2012-02-07
申请人： Alain Pralong , Hans Ulrich Dellenbach
发明人： Alain Pralong , Hans Ulrich Dellenbach
IPC分类号： B01D61/00 , B01D63/00 , B01D35/00 , B01D21/24 , B01D63/02 , B01D65/02 , B01D61/22 , B01D61/20
CPC分类号： B01D63/02 , B01D61/20 , B01D61/22 , B01D65/02 , B01D2313/243 , B01D2313/50 , B01D2313/58 , B01D2315/00 , B01D2321/04 , C12M29/16 , C12M47/10 , Y10T29/49826
摘要： Provided are filtration systems that can be referred to as Pneumatic Alternating Cell Separator (PACS), useful components thereof in the form of assemblies or kits of parts that can be used to build the system, and use of the system for filtering fluids, for instance, in cell culture perfusion systems comprising a filter-containing chamber, an expansion chamber and a gas flow controller.
摘要翻译：提供了可以称为气动交替细胞分离器（PACS）的过滤系统，其可用于组件或其可用于构建系统的部件套件的有用组件，以及用于过滤流体的系统的使用，包括含有过滤器的室，膨胀室和气体流量控制器的细胞培养物灌注系统中。

88. 发明申请

US20130240065A1 Bag For A Circuit Of A Biological Liquid Treatment Installation 有权
标题翻译：生物液体处理装置电路袋
公开(公告)号：US20130240065A1
公开(公告)日：2013-09-19
申请号：US13889616
申请日：2013-05-08
申请人： EMD MILLIPORE CORPORATION
发明人： Jean-Louis Weissenbach , Sebastien Cirou
IPC分类号： B01D63/00
CPC分类号： B01D63/00 , B01D61/20 , B01D2313/105 , B01D2313/125 , B01D2313/13 , B01D2313/18 , B01D2313/58 , B01D2313/90 , B01D2315/10 , Y10T137/6851 , Y10T137/8593
摘要： The invention concerns a bag comprising a first conduit (13C) which extends longitudinally between a flow pump connector (11C) emerging on a first side (68) and a tangential filter connector (11M) emerging on a second side (69); a second conduit (13B) which extends longitudinally from a first side of said conduit (13C) between a supply container connector (11B) emerging on said first side (68), and another tangential flow connector (11N) emerging on said second side (69); a third conduit (13H) which extends from a second side of said conduit (13C), starting at a collecting container connector (11J), until it enters said first conduit (13C); and a fourth conduit (13A) which extends from the first side of said conduit (13C), starting at a transfer pump connector (11A), until it enters said second conduit (13B).
摘要翻译：本发明涉及一种袋子，其包括在出现在第一侧面（68）上的流动泵连接器（11C）和出现在第二侧面（69）上的切向过滤器连接器（11M）之间纵向延伸的第一管道（13C）。第二导管（13B），其从所述导管（13C）的第一侧沿着出现在所述第一侧（68）上的供应容器连接器（11B）和出现在所述第二侧（68）上的另一个切向流动连接器（11N） 69）; 从所述导管（13C）的第二侧延伸的第三导管（13H），从收集容器连接器（11J）开始，直至其进入所述第一导管（13C）; 以及从所述导管（13C）的第一侧从转移泵连接器（11A）开始直到其进入所述第二导管（13B）的第四导管（13A）。

89. 发明申请

US20130236130A1 Device For A Biological Liquid Treatment Installation 审中-公开
标题翻译：生物液体处理装置
公开(公告)号：US20130236130A1
公开(公告)日：2013-09-12
申请号：US13872248
申请日：2013-04-29
申请人： EMD MILLIPORE CORPORATION
发明人： Sebastien Cirou , Rene Reinbigler , Virginie Buisson , Jean-Louis Weissenbach
IPC分类号： B65D33/00
CPC分类号： B65D33/00 , A61M1/36 , A61M2205/125 , A61M2209/088 , B01D61/18 , B01D61/20 , B01D2313/105 , B01D2313/125 , B01D2313/58 , F04B43/08
摘要： The invention concerns a device comprising a base (2) and a door (20), said device having a closed door position in which a circuit (8) of the device comprises a bag comprising two flexible films and connectors of the conveying network, and a press (9) comprising a first shell (16) disposed on a front face (5) of said base (2) and a second shell (17) disposed in said door (20); and a hinge system hinging said door (20) relative to said base (2), and disposed only on one side of said door (20) so as to form lateral clearances between said door (20) and said base (2) over the rest of a perimeter of said door (20)
摘要翻译：本发明涉及一种包括基座（2）和门（20）的装置，所述装置具有关闭的门位置，其中装置的电路（8）包括包括输送网络的两个柔性膜和连接器的袋，以及包括设置在所述基座（2）的前表面（5）上的第一壳体（16）和设置在所述门（20）中的第二壳体（17）的压力机（9）。以及铰链系统，其将所述门（20）相对于所述基座（2）铰接，并且仅设置在所述门（20）的一侧上，以便在所述门（20）和所述基座（2）之间形成横向间隙所述门（20）的周边的其余部分

90. 发明申请

US20120138522A1 Device For A Biological Liquid Treatment Installation 有权
标题翻译：生物液体处理装置
公开(公告)号：US20120138522A1
公开(公告)日：2012-06-07
申请号：US13153804
申请日：2011-06-06
申请人： Sebastien Cirou , Rene Reinbigler , Virginie Buisson , Jean-Louis Weissenbach
发明人： Sebastien Cirou , Rene Reinbigler , Virginie Buisson , Jean-Louis Weissenbach
IPC分类号： B01D35/30
CPC分类号： B65D33/00 , A61M1/36 , A61M2205/125 , A61M2209/088 , B01D61/18 , B01D61/20 , B01D2313/105 , B01D2313/125 , B01D2313/58 , F04B43/08
摘要： The invention concerns a device comprising a base; a circuit comprising a bag comprising two flexible films and conveying network connectors, and a press (9) comprising a first shell (16) disposed upright on a front face (5) of said base (2) and a second shell (17) mounted on said first shell (16), said first shell (16) and second shell (17) clamping said bag to form conduits; said bag comprising first through apertures on one side and said first shell (16) comprising hooking studs (106) on an upper part, which studs (106) pass through said first apertures.
摘要翻译：本发明涉及一种包括基底的装置; 包括包括两个柔性膜和传送网络连接器的袋子的电路以及包括垂直设置在所述基座（2）的前面（5）上的第一壳体（16）和第二壳体（17）的压力机（9）在所述第一壳体（16）上，所述第一壳体（16）和第二壳体（17）夹紧所述袋以形成导管; 所述袋包括在一侧上的第一通孔，所述第一壳体（16）包括在上部上的钩形螺柱（106），所述螺柱（106）穿过所述第一孔。

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