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81. 发明公开

EP4370715A1 LIQUID CHROMATOGRAPHY ASSAY FOR DETERMINING AAV CAPSID RATIO 审中-实审
公开(公告)号：EP4370715A1
公开(公告)日：2024-05-22
申请号：EP22758605.4
申请日：2022-07-11
申请人： Regeneron Pharmaceuticals, Inc.
发明人： WERT, Jonathan , ZHI, Li , LIU, Dingjiang
IPC分类号： C12Q1/70 , G01N30/88 , G01N33/569 , B01D15/18 , G01N30/96 , G01N30/34
CPC分类号： G01N30/88 , G01N33/56983 , B01D15/1878 , G01N2030/883120130101 , G01N30/96 , G01N30/34 , G01N33/6848 , G01N2333/01520130101

82. 发明公开

EP3148664A1 APPARATUS AND METHOD FOR INTRODUCING A SAMPLE INTO A SEPARATION UNIT OF A CHROMATOGRAPHY SYSTEM 有权
标题翻译：装置和方法对样品在单位色谱的隔离简介
公开(公告)号：EP3148664A1
公开(公告)日：2017-04-05
申请号：EP14892885.6
申请日：2014-05-29
申请人： Agilent Technologies, Inc.
发明人： WIKFORS, Edwin, E.
IPC分类号： B01D15/40 , B01D15/14 , B01D15/30 , G01N30/02 , G01N30/16
CPC分类号： B01D15/40 , B01D15/1878 , G01N30/02 , G01N30/16 , G01N30/20 , G01N30/32 , G01N30/34 , G01N30/38 , G01N30/463 , G01N30/465 , G01N2030/324 , G01N2030/342
摘要： An apparatus introduces a sample into a separation unit of a chromatography system with a mobile phase, including first and second mobile phase components. The apparatus includes first and second pump systems, and an injection unit. The first pump system provides the first mobile phase component, first and second portions of the first mobile phase component flowing through first and second branches, respectively. The second pump system provides the second mobile phase component, a first portion of the second mobile phase component flowing through a third branch. The injection unit receives a combined stream of the first portions of the first and second mobile phase components provided via the first and third branches, respectively, and injects the sample into the combined stream to form a sample-containing stream, which is subsequently combined with the second portion of the first mobile phase component to form a diluted sample-containing stream.
摘要翻译：一种装置，介绍了一种样品到色谱系统的一个分离单元，用流动相，其包括第一和第二流动相组分。该装置包括第一和第二泵系统，以及喷射单元。第一泵系统提供的第一移动相成分时，流过第一和第二分支，分别与第一流动相分量的第一和第二部分。第二泵系统提供所述第二移动相位分量，流过第三支路中的第二流动相分量的第一部分。注射装置接收经由第一和第三分支，分别设置在第一和第二流动相分量的第一部分的组合流，并且喷射样品进入组合流，以形成一个含有样品的流，所有其随后与组合第一移动相位分量的第二部分以形成稀释的含有样品的流。

83. 发明公开

EP2891881A4 MULTIDIMENSIONAL LIQUID CHROMATOGRAPHY SEPARATION SYSTEM AND SEPARATION METHOD FOR PROTEIN SEPARATION 有权转让
标题翻译：多维FLÜSSIGKEITSCHROMATOGRAFISCHES分离系统与分离蛋白质分离
公开(公告)号：EP2891881A4
公开(公告)日：2016-08-24
申请号：EP12883934
申请日：2012-08-31
申请人： XI AN AOLAN SCIENCE AND TECHNOLOGY CO , UNIV NORTHWEST
发明人： GENG XINDU
IPC分类号： G01N30/46 , B01D15/18 , B01D15/30 , B01D15/34 , B01D15/36 , B01D15/42 , C07K1/16 , G01N30/02 , G01N30/10 , G01N30/20 , G01N30/88
CPC分类号： B01D15/1878 , B01D15/30 , B01D15/34 , B01D15/362 , B01D15/424 , C07K1/16 , G01N30/10 , G01N30/20 , G01N30/462 , G01N30/463 , G01N30/465 , G01N2030/8831
摘要： A multidimensional liquid chromatography separation system and separation method for protein separation. The multidimensional liquid chromatography separation system for protein separation comprises a mobile-phase storage tank (2), a first liquid transfer device (3, 1-2), a second liquid transfer device (9, 1-1), a first sample introduction device (4-1, 4-2), a second sample introduction device (12), a separation device (7), a collection and storage device (10), at least two drainage devices (7-1, 7-2, 7-3) and a flow path switching device (11). When the liquid chromatography separation of each dimension is conducted, the collection and storage device collects target middle distillates needing to conduct the next step of liquid chromatography separation and stores same in a collection and storage device. During the liquid chromatography separation of the second dimension or more dimensions, all the target middle distillates from the collection and storage device are mixed with mobile phases through a sample introduction mixer of the second sample introduction device, and the amount of the mobile phases conveyed by same is adjusted and measured using the first liquid transfer device and the second liquid transfer device, so as to enable the eluent concentration in the sample introduction mixture to be lower than the critical migration eluent concentration of all the target proteins in the target middle distillates which need to be preserved in the separation of this dimension.

84. 发明授权

EP2777793B1 Multi-dimensional chromatography of polyolefins using a graphitic carbon stationary phase in the second dimension 有权
标题翻译：在第二维度中的石墨固定相多维色谱聚烯烃聚合物
公开(公告)号：EP2777793B1
公开(公告)日：2016-06-29
申请号：EP14171112.7
申请日：2010-12-21
申请人： Dow Global Technologies LLC
发明人： Winniford, William , Cong, Rongjuan , Stokich, Theodore , Pell, Randy , Miller, Matthew , Roy, Abhishek , Van Damme, Freddy , Degroot, Alexander , Lyons, John , Meunier, David
IPC分类号： B01D15/16 , G01N30/30 , G01N30/34 , B01D15/18
CPC分类号： B01D15/161 , B01D15/166 , B01D15/1878 , B01J20/24 , B01J2220/4825 , G01N30/34 , G01N2030/3076 , G01N2030/885

85. 发明公开

EP2891881A1 MULTIDIMENSIONAL LIQUID CHROMATOGRAPHY SEPARATION SYSTEM AND SEPARATION METHOD FOR PROTEIN SEPARATION 有权转让
标题翻译： MEHRDIMENSIONALESFLÜSSIGKEITSCHROMATOGRAFISCHESTRENNSYSTEM UND TRENNVERFAHREN ZUR PROTEINTRENNUNG
公开(公告)号：EP2891881A1
公开(公告)日：2015-07-08
申请号：EP12883934.7
申请日：2012-08-31
申请人： Xi'an Aolan Science and Technology Co. , Northwest University
发明人： GENG, Xindu
IPC分类号： G01N30/02 , G01N30/10 , G01N30/20
CPC分类号： B01D15/1878 , B01D15/30 , B01D15/34 , B01D15/362 , B01D15/424 , C07K1/16 , G01N30/10 , G01N30/20 , G01N30/462 , G01N30/463 , G01N30/465 , G01N2030/8831
摘要： A multidimensional liquid chromatography separation system and separation method for protein separation. The multidimensional liquid chromatography separation system for protein separation comprises a mobile-phase storage tank (2), a first liquid transfer device (3, 1-2), a second liquid transfer device (9, 1-1), a first sample introduction device (4-1, 4-2), a second sample introduction device (12), a separation device (7), a collection and storage device (10), at least two drainage devices (7-1, 7-2, 7-3) and a flow path switching device (11). When the liquid chromatography separation of each dimension is conducted, the collection and storage device collects target middle distillates needing to conduct the next step of liquid chromatography separation and stores same in a collection and storage device. During the liquid chromatography separation of the second dimension or more dimensions, all the target middle distillates from the collection and storage device are mixed with mobile phases through a sample introduction mixer of the second sample introduction device, and the amount of the mobile phases conveyed by same is adjusted and measured using the first liquid transfer device and the second liquid transfer device, so as to enable the eluent concentration in the sample introduction mixture to be lower than the critical migration eluent concentration of all the target proteins in the target middle distillates which need to be preserved in the separation of this dimension.
摘要翻译：一种多维液相色谱分离系统和分离蛋白质分离方法。用于蛋白质分离的多维液相色谱分离系统包括流动相储存罐（2），第一液体输送装置（3,2-1），第二液体转移装置（9-1-1），第一样品引入装置（4-1,4-2），第二样品引入装置（12），分离装置（7），收集和存储装置（10），至少两个排水装置（7-1,7-2， 7-3）和流路切换装置（11）。当进行每个维度的液相色谱分离时，收集和收集装置收集需要进行下一步液相色谱分离的目标中间馏分，并将其存储在收集和储存装置中。在第二维或更多维的液相色谱分离期间，来自收集和储存装置的所有目标中间馏分通过第二样品引入装置的样品引入混合器和流动相的量与流动相混合，并且通过使用第一液体转移装置和第二液体转移装置进行相同的调整和测量，以使样品导入混合物中的洗脱液浓度低于目标中间馏分中所有目标蛋白质的临界迁移洗脱液浓度，需要保留在这个维度的分离。

86. 发明授权

EP2136896B1 MULTI-DIMENSIONAL CHROMATOGRAPHIC METHODS FOR SEPARATING N-GLYCANS 有权
标题翻译：多维色谱法分离FOR N-聚糖的
公开(公告)号：EP2136896B1
公开(公告)日：2015-01-21
申请号：EP08745868.3
申请日：2008-04-15
申请人： Momenta Pharmaceuticals, Inc.
发明人： PARSONS, Ian, Christopher , ZHENG, Ting , GUNAY, Nur, Sibel , BOSQUES, Carlos, J.
IPC分类号： B01D15/18 , G01N30/46 , C07K1/36 , G01N1/34
CPC分类号： G01N33/6803 , B01D15/166 , B01D15/1864 , B01D15/1878 , B01D15/325 , B01D15/363 , B01D15/426 , C07K1/36 , G01N1/34 , G01N30/463 , G01N33/6854 , G01N2400/00 , G01N2440/38 , Y10T436/14 , Y10T436/142222 , Y10T436/143333 , Y10T436/145555
摘要： A multi-dimensional chromatographic method for the separation of N-glycans. The method comprises providing a glycan preparation that includes at least one negatively charged N-glycan. The glycan preparation is then separated by anion-exchange chromatography and at least one secondary chromatographic technique.

87. 发明授权

EP2767828B1 Einspannvorrichtung zum Einspannen von mehreren Säulen für eine Vorrichtung zur Probenvorbereitung 有权转让
标题翻译：卡盘夹持的多个装置的列的样品制备
公开(公告)号：EP2767828B1
公开(公告)日：2014-12-17
申请号：EP14154705.9
申请日：2014-02-11
申请人： LCTech GmbH
发明人： Baumann, Maximilian , Brandlhuber, Martin , Aulwurm, Uwe
IPC分类号： G01N30/46 , B01D15/18
CPC分类号： B01D15/22 , B01D15/1864 , B01D15/1871 , B01D15/1878 , G01N30/461 , G01N30/465 , G01N30/6004 , G01N30/6039 , G01N30/6047 , G01N30/6065

88. 发明公开

EP2697265A1 POLYSACCHARIDES COMPRISING TWO ANTITHROMBIN III-BINDING SITES, PREPARATION THEREOF AND USE THEREOF AS ANTITHROMBOTIC MEDICAMENTS 审中-公开
标题翻译：带双抗凝血酶III结合位点，它们的生产和它们作为抗血栓多糖
公开(公告)号：EP2697265A1
公开(公告)日：2014-02-19
申请号：EP12718395.2
申请日：2012-04-11
申请人： SANOFI
发明人： MOURIER, Pierre , VISKOV, Christian
IPC分类号： C08B37/00 , A61K31/727
CPC分类号： A61K31/727 , A61K45/06 , B01D15/1878 , B01D15/34 , B01D15/363 , B01D15/3823 , C08B37/0075 , Y10T436/143333
摘要： The invention relates to sulphated polysaccharides which have the general structure of the constituent polysaccharides of heparin and which have a molecular weight of less than 8000 Daltons, comprising two antithrombin III-binding hexasaccharide sequences corresponding to formula (I) in which: R1 represents an OH group when the hexasaccharide of formula (I) is located at the reducing end of the polysaccharide, or else R1 represents a bond with another saccharide unit of said polysaccharide; R2 represents a hydrogen atom when the hexasaccharide of formula (I) is located at the non-reducing end of the polysaccharide, in which case the bond between carbon atoms 4 and 5 of the first saccharide unit of said hexasaccharide is a double bond, or else R2 represents a bond with another saccharide unit of said polysaccharide, in which case the bond between carbon atoms 4 and 5 of the first saccharide unit is a single bond. Preparation thereof, use thereof as antithrombotic medicaments, and also use thereof in a method for analyzing a sample of a heparin derivative.

89. 发明公开

EP0990256A1 RETENTATE CHROMATOGRAPHY AND PROTEIN CHIP ARRAYS WITH APPLICATIONS IN BIOLOGY AND MEDICINE 失效
标题翻译：回归色谱和蛋白芯片阵列在生物和医学中的应用
公开(公告)号：EP0990256A1
公开(公告)日：2000-04-05
申请号：EP98930421.7
申请日：1998-06-19
申请人： Ciphergen Biosystems, Inc.
发明人： HUTCHENS, T., William , YIP, Tai-Tung
IPC分类号： H01J49/04
CPC分类号： C40B30/04 , B01D15/1878 , B01D15/305 , B01D15/3809 , B01J20/281 , B01J20/286 , B01J20/3204 , B01J20/3212 , B01J20/3219 , B01J20/3248 , B01J20/3253 , B01J20/3265 , B01J20/3274 , B01J20/3289 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00644 , B01J2219/00659 , B01J2219/00702 , B01J2219/00725 , B01J2220/54 , C12Q1/00 , C40B40/10 , G01N30/00 , G01N30/02 , G01N30/461 , G01N30/463 , G01N30/466 , G01N30/48 , G01N30/482 , G01N30/90 , G01N30/95 , G01N33/531 , G01N33/538 , G01N33/543 , G01N33/54306 , G01N33/54353 , G01N33/54373 , G01N33/54393 , G01N33/566 , G01N33/6803 , G01N33/6845 , G01N33/6851 , G01N2030/008 , G01N2030/009 , Y02A90/26 , Y10S422/906 , Y10S435/803 , Y10S435/81 , Y10S435/814 , Y10S435/815 , Y10S435/97 , Y10S435/973 , Y10S435/975 , Y10S436/808 , Y10S436/809 , Y10S436/811 , Y10S436/813 , Y10S436/824 , Y10S436/825 , Y10T436/24 , Y10T436/25 , Y10T436/25125 , Y10T436/2525 , Y10T436/25375 , Y10T436/255 , B01D15/363 , B01D15/322 , B01D15/327 , B01D15/3804 , B01D15/362 , B01D15/38 , B01D15/26
摘要： This is invention is directed to methods of identifying analytes that are differentially present between two samples. The methods involve determining retention data by desorption spectrometry for analytes in different samples using the same selectivity conditions, comparing the data, and identifying analytes that are differentially retained.
摘要翻译：本发明提供了用于分离样品中分析物的滞留层析方法。该方法包括在多种不同的选择性条件下将分析物吸附到基质上，并通过解吸光谱法检测保留在基质上的分析物。这些方法在生物学和医学中很有用，包括临床诊断和药物发现。

90. 发明授权

KR100629699B1 생물학과 의학에 사용할 수 있는 보유물 크로마토그래피및 단백질 칩 어레이 失效
标题翻译：保留色谱和蛋白质芯片阵列可用于生物学和医学
公开(公告)号：KR100629699B1
公开(公告)日：2006-09-29
申请号：KR1019997012077
申请日：1998-06-19
申请人： 사이퍼젠 바이오시스템스, 인코오포레이티드
发明人： 헛첸스티윌리엄 , 입타이-텅
IPC分类号： H01J49/04 , G01N33/53
CPC分类号： C40B30/04 , B01D15/1878 , B01D15/305 , B01D15/3809 , B01J20/281 , B01J20/286 , B01J20/3204 , B01J20/3212 , B01J20/3219 , B01J20/3248 , B01J20/3253 , B01J20/3265 , B01J20/3274 , B01J20/3289 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00644 , B01J2219/00659 , B01J2219/00702 , B01J2219/00725 , B01J2220/54 , C12Q1/00 , C40B40/10 , G01N30/00 , G01N30/02 , G01N30/461 , G01N30/463 , G01N30/466 , G01N30/48 , G01N30/482 , G01N30/90 , G01N30/95 , G01N33/531 , G01N33/538 , G01N33/543 , G01N33/54306 , G01N33/54353 , G01N33/54373 , G01N33/54393 , G01N33/566 , G01N33/6803 , G01N33/6845 , G01N33/6851 , G01N2030/008 , G01N2030/009 , Y02A90/26 , Y10S422/906 , Y10S435/803 , Y10S435/81 , Y10S435/814 , Y10S435/815 , Y10S435/97 , Y10S435/973 , Y10S435/975 , Y10S436/808 , Y10S436/809 , Y10S436/811 , Y10S436/813 , Y10S436/824 , Y10S436/825 , Y10T436/24 , Y10T436/25 , Y10T436/25125 , Y10T436/2525 , Y10T436/25375 , Y10T436/255 , B01D15/363 , B01D15/322 , B01D15/327 , B01D15/3804 , B01D15/362 , B01D15/38 , B01D15/26
摘要： 본 발명은 샘플내 피분석물을 분할하는 용도의 보유물 크로마토그래피 방법을 제공한다. 상기 방법은 다수의 상이한 선택 조건하에 피분석물을 기재에 흡착시키는 단계 및 기재상에 보유된 피분석물을 탈착 분광 분석에 의해 검출하는 단계를포함한다. 이 방법은 임상적 진단 및 약물 발견을 포함하는 생물학 및 의학에 유용하다.
도 2
摘要翻译：本发明提供了用于分配样品中的分析物的滞留层析方法。该方法包括在多种不同选择条件下将分析物吸附到基底上，并通过解吸光谱检测保留在基底上的分析物。这种方法在生物学和医学中很有用，包括临床诊断和药物发现。

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