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81. 发明授权

US5951458A Local application of oxidizing agents to prevent restenosis 失效
标题翻译：局部应用氧化剂预防再狭窄
公开(公告)号：US5951458A
公开(公告)日：1999-09-14
申请号：US905296
申请日：1997-08-01
申请人： Roger N. Hastings , Lixiao Wang , Dachuan Yang , Mark T. Ungs , Michael J. Urick
发明人： Roger N. Hastings , Lixiao Wang , Dachuan Yang , Mark T. Ungs , Michael J. Urick
IPC分类号： A61F2/958 , A61M25/01 , A61M29/02 , A61M36/04 , A61N5/10 , A61M5/00
CPC分类号： A61M25/1002 , A61M25/0127 , A61N5/1002 , A61M2025/0177 , A61M2025/1047 , A61M2025/105 , A61M2025/1095 , A61N2005/1003
摘要： A method for inhibiting restenosis including local application of an oxidizing agent to blood vessel walls. Preferred oxidizing agents include peroxides, most preferably hydrogen peroxide. Oxidizing agents can be delivered utilizing drug delivery balloon catheters. Preferred delivery catheters include an inflatable balloon having a perfusion lumen therethrough to allow for longer application periods. Oxidizing agents can be delivered either alone or in conjunction with radiation or stent delivery. One method includes local delivery of 0.1% hydrogen peroxide to a dilated stenosis wall for a period of 10 minutes at a rate of 0.5 cc per minute.
摘要翻译：一种抑制再狭窄的方法，包括将氧化剂局部施用于血管壁。优选的氧化剂包括过氧化物，最优选过氧化氢。可以使用药物递送球囊导管递送氧化剂。优选的输送导管包括具有穿过其中的灌注腔的可充气气囊，以允许更长的施用周期。氧化剂可单独或与辐射或支架递送联合递送。一种方法包括以0.5cc /分钟的速率将0.1％过氧化氢局部递送至扩张狭窄壁10分钟。

82. 发明授权

US5782740A Radiation dose delivery catheter with reinforcing mandrel 失效
公开(公告)号：US5782740A
公开(公告)日：1998-07-21
申请号：US705945
申请日：1996-08-29
申请人： Gary Schneiderman
发明人： Gary Schneiderman
IPC分类号： A61M25/00 , A61F2/958 , A61M29/02 , A61M36/04 , A61N5/10 , A61N5/00
CPC分类号： A61M25/104 , A61N5/1002 , A61M2025/0063 , A61M2025/0183 , A61M2025/1056 , A61M2025/1072 , A61M2025/1086 , A61M25/1002 , A61N2005/1003
摘要： The invention is directed to a rapid exchange type intravascular catheter suitable for maintaining patency of a body lumen for a period of time sufficient to permit delivery of a radiation source to the body lumen. The catheter utilizes a reinforcing mandrel to improve the pushability and strength of the catheter as it tracks along a guide wire, and permits blood flow through an inflatable member while radiation therapy is being provided.

83. 发明授权

US5720717A Intracavitary catheter for use in therapeutic radiation procedures 失效
标题翻译：用于治疗放射手术的腔内导管
公开(公告)号：US5720717A
公开(公告)日：1998-02-24
申请号：US787272
申请日：1997-01-24
申请人： Mark A. D'Andrea
发明人： Mark A. D'Andrea
IPC分类号： A61B17/22 , A61M36/04 , A61N5/10 , A61B17/36
CPC分类号： A61N5/1014 , A61B2017/22068 , A61M2025/1047 , A61N2005/1003 , A61N2005/1012 , A61N2005/1018 , A61N5/1016
摘要： The present invention provides a significantly improved therapeutic tool for radiation therapy in or near body cavities accessible through existing orifices. At least one therapeutic balloon of a catheter and balloon assembly is inflated by fluid communication through the catheter. Several embodiments provide radiation therapy, at times in association with one or more of formation of seals, control of movement, nutrient passage and drainage. The radiation therapy is provided by means of rods or other radiotherapeutic items secured, positioned or inserted along the contour of the surface of the therapeutic balloon and which are thus deployed to treatment position by balloon inflation. Control of movement can be achieved through the use of a small balloon usually located where the body cavity changes size, such as at the body orifice; through the use of a template, which may be sutured to nearby tissue or secured with tether catheter assemblies inserted in other body cavities; through the use of a catheter lead which is inserted into narrow portions of a body cavity; or through the use of a secondary balloon located distally of the larger therapeutic balloon. Drainage, often required when performing this procedure in the bladder or rectum, is achieved by the use of a Foley-type catheter. Feeding, inhalation and exhalation are permitted through a communication channel within the catheter.
摘要翻译：本发明提供了一种显着改进的治疗工具，用于通过现有孔可接近的体腔内或附近的放射治疗。导管和球囊组件的至少一个治疗气球通过通过导管的流体连通而膨胀。有几个实施例提供放射治疗，有时与形成密封件，运动控制，营养物通过和引流有关。放射治疗通过杆或其它放射治疗物质来提供，所述杆或其它放射治疗物质沿着治疗球囊的表面的轮廓固定，定位或插入，并且因此通过球囊膨胀而部署到治疗位置。可以通过使用通常位于体腔改变尺寸的小气球（例如在身体孔口）来实现运动的控制; 通过使用模板，其可以缝合到附近的组织或用插入其他体腔的系绳导管组件固定; 通过使用插入到体腔的狭窄部分中的导管引线; 或通过使用位于较大治疗气球远端的二次气囊。通过使用Foley型导管，可以在膀胱或直肠中进行此过程时经常需要的排水。通过导管内的通讯通道允许进食，吸入和呼气。

84. 发明授权

US5618266A Catheter for maneuvering radioactive source wire to site of treatment 失效
标题翻译：用于将放射源线操纵到导管部位的导管
公开(公告)号：US5618266A
公开(公告)日：1997-04-08
申请号：US316500
申请日：1994-09-30
申请人： Samuel F. Liprie
发明人： Samuel F. Liprie
IPC分类号： A61M25/00 , A61B17/22 , A61F2/958 , A61M25/09 , A61M29/02 , A61M36/04 , A61M36/06 , A61N5/10 , A61N1/30
CPC分类号： A61M25/104 , A61M25/1002 , A61N5/1002 , A61B2017/22002 , A61M2025/1047 , A61M2025/1079 , A61M2025/1086 , A61M2025/1093 , A61N2005/1003
摘要： An apparatus for treating an occlusion or constriction, such as a stenosis in a blood vessel or other conduit in the body, as well as an apparatus for treating bodily diseases (e.g. a tumor or cancerous area) occurring around a conduit or duct in the body. The apparatus includes a catheter which is correctly positioned within a conduit of the body utilizing a guide wire. The guide wire would pass through the entire length of the catheter, or a portion of the length of the catheter, and would exit the catheter through a constriction plug affixed to the end of the catheter. A radioactive treatment source wire is then introduced into the catheter and is maneuvered to the site of treatment. The constriction plug is provided with an internal diameter which is less than the diameter of the radioactive source wire, but greater than the diameter of the guide wire. This construction would prevent the radioactive source wire from remaining in the body after the catheter has been removed.
摘要翻译：用于治疗闭塞或收缩的装置，例如体内血管或其他导管中的狭窄，以及用于治疗身体中导管或导管周围发生的身体疾病（例如肿瘤或癌性区域）的装置。该装置包括使用导丝线正确定位在主体的导管内的导管。导丝将穿过导管的整个长度或导管长度的一部分，并且将通过固定到导管末端的收缩塞离开导管。然后将放射性治疗源线引入导管，并被操纵到治疗部位。收缩塞的内径设定为小于放射源线的直径，但大于导丝的直径。这种结构将在导管被移除之后防止放射源线残留在体内。

85. 发明授权

US5472425A Rapid exchange catheter 失效
标题翻译：快速交换导管
公开(公告)号：US5472425A
公开(公告)日：1995-12-05
申请号：US231423
申请日：1994-04-22
申请人： Paul S. Teirstein
发明人： Paul S. Teirstein
IPC分类号： A61F2/958 , A61M25/00 , A61M29/02 , A61M36/04 , A61N5/10 , A61M29/00
CPC分类号： A61M25/0029 , A61M25/1002 , A61M25/104 , A61M29/02 , A61N5/1002 , A61M2025/0177 , A61M2025/0183 , A61M2025/1047 , A61M2025/1056 , A61M25/0023 , A61M25/0032 , A61N2005/1003
摘要： An over-the-wire rapid-exchange catheter having a guidewire channel and a rupturable membrane along one side of the guidewire channel. The catheter is exchanged by withdrawing the catheter from a guiding catheter, while stripping the operative catheter from the guidewire by tearing the guidewire through the rupturable membrane. The guidewire channel provides a sealing surface for a releasable seal on the guiding catheter, avoiding the gripping of the guidewire. A replacement catheter can be threaded onto the guidewire, and the end of the guidewire can puncture the rupturable membrane at a selected location to establish a guidewire channel at the distal end of the catheter.
摘要翻译：一种线上快速交换导管，其具有沿着导丝通道的一侧的导丝通道和可破裂膜。通过从引导导管中抽出导管来交换导管，同时通过将引导线撕裂穿过可破裂的膜而从导丝线上剥离手术导管。导丝通道为引导导管上的可释放密封提供密封表面，避免了导丝的夹持。替代导管可以被螺纹连接到导丝上，并且导丝的端部可以在选定位置刺穿可破裂的膜，以在导管的远端处建立导丝通道。

86. 发明授权

US5468225A Rapid exchange catheter 失效
标题翻译：快速交换导管
公开(公告)号：US5468225A
公开(公告)日：1995-11-21
申请号：US197970
申请日：1994-02-17
申请人： Paul S. Teirstein
发明人： Paul S. Teirstein
IPC分类号： A61M25/00 , A61M29/02 , A61N5/10 , A61M29/00 , A61M31/00
CPC分类号： A61M25/104 , A61M2025/0177 , A61M2025/0183 , A61M2025/1047 , A61M25/0023 , A61M25/0032 , A61N2005/1003
摘要： An over-the-wire rapid-exchange catheter having a distal guidewire channel and a proximal guidewire channel. The catheter is exchanged by withdrawing the catheter from a guiding catheter until the guidewire can be removed from the proximal guidewire channel and then further withdrawn in the conventional fashion. The proximal guidewire channel provides a sealing surface for a releasable seal on the guiding catheter, avoiding the gripping of the guidewire.
摘要翻译：一种线上快速交换导管，其具有远端导丝通道和近端导丝通道。通过从引导导管撤回导管来更换导管，直到导丝可以从近端导丝通道移除，然后以常规方式进一步退出。近端导丝通道为引导导管上的可释放密封提供密封表面，避免了导丝的夹持。

87. 发明专利

NL1038961C WERKWIJZE EN INRICHTING TEN BEHOEVE VAN INWENDIGE BESTRALING VAN DE SLOKDARM. 未知
公开(公告)号：NL1038961C
公开(公告)日：2013-01-22
申请号：NL1038961
申请日：2011-07-21
申请人： H M TER AVEST BEHEER B V
发明人： BRINKE GERRIT JAN
IPC分类号： A61M25/10 , A61N5/10
CPC分类号： A61N5/1002 , A61M25/10 , A61N2005/1003

88. 发明公开

EP2456520A4 SYSTEMS AND METHODS FOR TREATING CANCER USING BRACHYTHERAPY 有权
标题翻译：系统和方法治疗癌症的由近距离放射治疗手段
公开(公告)号：EP2456520A4
公开(公告)日：2015-12-30
申请号：EP10802986
申请日：2010-07-23
申请人： VOXEL RAD LTD
发明人： RAHIMIAN JAVAD
IPC分类号： A61N5/01 , A61B17/02 , A61B18/00 , A61M3/04 , A61M36/04 , A61M36/10 , A61N5/00 , A61N5/10
CPC分类号： A61B17/42 , A61B17/0206 , A61B17/0218 , A61B2017/00557 , A61B2090/3966 , A61N5/1007 , A61N5/1016 , A61N2005/1003

89. 发明公开

EP2152366A4 DOSIMETRY IMPLANT FOR TREATING RESTENOSIS AND HYPERPLASIA 审中-公开
标题翻译： DOSIMETRIEIMPLANTAT用于治疗再狭窄和增生
公开(公告)号：EP2152366A4
公开(公告)日：2010-08-04
申请号：EP08826538
申请日：2008-05-30
申请人： CLEAR VASCULAR INC , BROOKHAVEN SCIENCE ASS LLC
发明人： SRIVASTAVA SURESH C , GONZALES GILBERT R , HOWELL ROGER W , BOLCH WESLEY E , ADZIC RADOSLAV
IPC分类号： A61N5/10
CPC分类号： A61N5/1002 , A61F2/91 , A61F2210/0095 , A61F2230/0054 , A61N5/1014 , A61N2005/1003 , A61N2005/1005 , A61N2005/1019

90. 发明公开

EP1644082A2 LIGHT GENERATING DEVICE THAT SELF CENTERS WITHIN A LUMEN TO RENDER PHOTODYNAMIC THERAPY 审中-公开
标题翻译： LIGHTS令人信服的器件; 导致管腔以自我为中心，光动力治疗
公开(公告)号：EP1644082A2
公开(公告)日：2006-04-12
申请号：EP04778803.9
申请日：2004-07-08
申请人： Light Sciences Corporation
发明人： CHEN, James , GUO, Zihong , LICHTTENEGGERE, Gary , SHINE, David , BURWELL, Phillip
IPC分类号： A61N5/067
CPC分类号： A61N5/0601 , A61M2025/1047 , A61N5/062 , A61N2005/0652 , A61N2005/1003
摘要： A light generating device (1) for illuminating tissue adjacent to a body lumen while a distal end (5) of the device is centered in the lumen, to render photodynamic therapy. The device can either occlude or displace bodily fluid, both without the use of a balloon. In one embodiment, a flushing lumen (4B) has a port adjacent to an array of light sources(10) , to displace bodily fluid that might otherwise absorb light. Another embodiment employs a centering (45) member that moves between a first position and a second position. The centering member centers the device in the lumen and preferably is formed of a shape memory material. In yet another embodiment, the device includes an outer sheath and an inner member that are independently positionable, enabling the centering member to be selectively positionable. The centering member can be non porous, such that the centering member also occludes fluid flow.

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