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81. 发明申请

WO2011031739A1 METHOD AND APPARATUS FOR POST-SHOCK EVALUATION USING TISSUE OXYGENATION MEASUREMENTS 审中-公开
标题翻译：使用组织氧化测量法进行后期评估的方法和装置
公开(公告)号：WO2011031739A1
公开(公告)日：2011-03-17
申请号：PCT/US2010/048103
申请日：2010-09-08
申请人： MEDTRONIC, INC. , KUHN, Jonathan L. , CINBIS, Can , ANDERSON, David A. , HAVEL, William J.
发明人： KUHN, Jonathan L. , CINBIS, Can , ANDERSON, David A. , HAVEL, William J.
IPC分类号： A61N1/39 , A61B5/00
CPC分类号： A61B5/14551 , A61B5/1459 , A61B5/6846 , A61B5/7285 , A61N1/36557 , A61N1/3925 , A61N1/3956
摘要： A method and device for delivering therapy that includes an electrode to sense cardiac signals and to deliver a therapy, a therapy delivery module coupled to the electrode to deliver a therapy via the electrode in response to the sensed cardiac signals, a sensor emitting light and detecting emitted light scattered by a tissue volume adjacent the optical sensor to generate a corresponding detected light intensity output signal, a control module coupled to the sensor to control light emission of the sensor in response to delivering the therapy, and a controller coupled to the therapy delivery module and the sensor, the controller configured to determine tissue oxygenation measurements in response to the output signal, determine a tissue oxygenation trend in response to the tissue oxygenation measurements, and determine whether the delivered therapy restored cardiac hemodynamic function in response to the determined tissue oxygenation trend.
摘要翻译：一种用于递送疗法的方法和装置，其包括用于感测心脏信号并递送治疗的电极;治疗递送模块，其耦合到所述电极，以响应于所感测的心脏信号经由所述电极递送治疗;发射光和检测的传感器发射由邻近光学传感器的组织体积散射的光以产生相应的检测到的光强度输出信号;耦合到传感器的控制模块，用于响应于递送治疗来控制传感器的光发射;以及控制器，耦合到治疗递送模块和传感器，所述控制器被配置为响应于输出信号确定组织氧合测量，响应于组织氧合测量确定组织氧合趋势，并且确定所递送的治疗是否响应于所确定的组织氧合来恢复心脏血液动力学功能趋势。

82. 发明申请

WO2011031721A1 METHOD AND APPARATUS FOR POST-SHOCK EVALUATION USING TISSUE OXYGENATION MEASUREMENTS 审中-公开
标题翻译：使用组织氧化测量法进行后期评估的方法和装置
公开(公告)号：WO2011031721A1
公开(公告)日：2011-03-17
申请号：PCT/US2010/048081
申请日：2010-09-08
申请人： MEDTRONIC, INC. , KUHN, Jonathan, L.
发明人： KUHN, Jonathan, L.
IPC分类号： A61N1/39 , A61B5/00
CPC分类号： A61B5/14551 , A61B5/1459 , A61B5/6846 , A61B5/7285 , A61N1/36557 , A61N1/3925 , A61N1/3956
摘要： A method and apparatus for controlling delivery of therapy that includes an emitting portion emitting light at a predetermined emitted light intensity to a volume of tissue at a plurality of wavelengths, and a detecting portion detecting the emitted light scattered by the volume of tissue to generate corresponding detected light intensity output signals. A control module controls the light emission so that an emitted light intensity at each of the plurality of wavelengths is within a predetermined intensity range, and determines a tissue oxygenation index in response to only the detected light intensity output signals, and a therapy delivery module delivers therapy in response to the determined tissue oxygenation index.
摘要翻译：一种用于控制治疗递送的方法和装置，其包括以预定的发射光强度发射多个波长的组织体积的发射部分，以及检测部分，其检测由组织体积散射的发射光，以产生相应的检测到光强输出信号。控制模块控制发光，使得在多个波长中的每个波长处的发射光强度在预定强度范围内，并且响应于检测到的光强度输出信号确定组织氧合指数，并且治疗递送模块递送响应于确定的组织氧合指数的治疗。

83. 发明申请

WO2011014311A1 ALGORITHM TO MODULATE ATRIAL-VENTRICULAR DELAY AND RATE RESPONSE BASED ON AUTONOMIC FUNCTION 审中-公开
标题翻译：基于自动功能调节心律延迟和速率响应的算法
公开(公告)号：WO2011014311A1
公开(公告)日：2011-02-03
申请号：PCT/US2010/039202
申请日：2010-06-18
申请人： MEDTRONIC, INC. , FISCHER, Trent, M. , HETTRICK, Douglas, A. , SHELDON, Todd, J. , BELK, Paul, A. , MULLEN, Thomas, J. , RUETER, John, C. , KAISER, Daniel, R.
发明人： FISCHER, Trent, M. , HETTRICK, Douglas, A. , SHELDON, Todd, J. , MULLEN, Thomas, J. , RUETER, John, C. , KAISER, Daniel, R.
IPC分类号： A61N1/362 , A61N1/368 , A61N1/365 , A61B5/0205
CPC分类号： A61N1/3627 , A61B5/0456 , A61N1/36514 , A61N1/36542 , A61N1/36557 , A61N1/36564 , A61N1/36571 , A61N1/36578 , A61N1/36585 , A61N1/368 , A61N1/3682 , A61N1/3688
摘要： An implantable medical device and associated method provide atrial pacing and measure an atrial ventricular (AV) delay. An autonomic function index is computed using the AV delay. The autonomic function index may be compiled in a medical report. In some embodiments, the autonomic function index is used to adjust atrial pacing control parameters.
摘要翻译：可植入医疗器械和相关方法提供心房起搏并测量心房（AV）延迟。使用AV延迟计算自主功能指数。自主功能指数可以在医疗报告中编制。在一些实施例中，自主功能指数用于调节心房起搏控制参数。

84. 发明申请

WO2010144665A1 DEVICE AND METHOD FOR MONITORING OF ABSOLUTE OXYGEN SATURATION AND TOTAL HEMOGLOBIN CONCENTRATION 审中-公开
标题翻译：用于监测绝对氧化饱和度和总HEMOGLOBIN浓度的装置和方法
公开(公告)号：WO2010144665A1
公开(公告)日：2010-12-16
申请号：PCT/US2010/038114
申请日：2010-06-10
申请人： MEDTRONIC, INC. , KUHN, Jonathan L. , CINBIS, Can , CARNEY, James K. , ANDERSON, David A.
发明人： KUHN, Jonathan L. , CINBIS, Can , CARNEY, James K. , ANDERSON, David A.
IPC分类号： A61B5/00
CPC分类号： A61B5/14552 , A61B5/0084 , A61B5/14546 , A61B5/1459 , A61B5/7239 , A61N1/36557
摘要： A medical device for monitoring of oxygen saturation includes an optical sensor adapted for positioning adjacent to a tissue volume. The optical sensor has a light emitting portion capable of emitting light at a plurality of wavelengths and a light detecting portion capable of generating an electrical output signal corresponding to light incident on the detecting portion. A control module coupled to the optical sensor controls the light emitted by the light emitting portion. A monitoring module receives the output signal from the light detecting portion and computes a volume-independent measure of oxygen saturation in the volume of tissue using the output signal.
摘要翻译：用于监测氧饱和度的医疗装置包括适于邻近组织体积定位的光学传感器。光学传感器具有能够发射多个波长的光的发光部和能够产生与入射到检测部上的光对应的电输出信号的光检测部。耦合到光学传感器的控制模块控制由发光部分发射的光。监测模块接收来自光检测部分的输出信号，并使用输出信号计算组织体积中的氧饱和度的体积无关测量。

85. 发明申请

WO2010014483A3 IMPLANTABLE OPTICAL HEMODYNAMIC SENSOR INCLUDING AN EXTENSION MEMBER 审中-公开
标题翻译：可伸缩的光学血液动力学传感器，包括延伸部件
公开(公告)号：WO2010014483A3
公开(公告)日：2010-03-25
申请号：PCT/US2009051477
申请日：2009-07-23
申请人： MEDTRONIC INC , CINBIS CAN , O'BRIEN RICHARD JAMES , CARNEY JAMES KEVIN
发明人： CINBIS CAN , O'BRIEN RICHARD JAMES , CARNEY JAMES KEVIN
IPC分类号： A61B5/00 , A61N1/365
CPC分类号： A61N1/3704 , A61B5/0031 , A61B5/0084 , A61B5/0086 , A61B5/02154 , A61B5/0261 , A61B5/14542 , A61B5/1459 , A61N1/36557 , A61N1/36571 , A61N1/375 , A61N1/3962
摘要： An implantable medical device includes an optical hemodynamic sensor comprising at least one optical emitter and at least one detector. In some examples, the at least one optical emitter may be optically coupled to at least one light transmission member that extends from a housing of the medical device. In addition, in some examples, the at least one detector may be optically coupled to at least one light transmission member that extends from the housing of the medical device. In other examples, an optical emitter and/or detector of a hemodynamic sensor may be carried by an elongated member that extends from a housing of the IMD. The elongated member may electrically couple the optical emitter and/or detector to a controller or other components within the IMD housing.
摘要翻译：可植入医疗装置包括光学血液动力学传感器，其包括至少一个光发射器和至少一个检测器。在一些示例中，至少一个光发射器可以光耦合到从医疗装置的壳体延伸的至少一个光透射构件。此外，在一些示例中，至少一个检测器可以光耦合到从医疗装置的壳体延伸的至少一个光传输构件。在其他示例中，血液动力学传感器的光学发射器和/或检测器可以由从IMD的壳体延伸的细长构件承载。细长构件可以将光学发射器和/或检测器电耦合到IMD壳体内的控制器或其它部件。

86. 发明申请

WO2010008597A2 INTERMITTENT PACING THERAPY FOR ANGINA AND DISEASE PREVENTION 审中-公开
标题翻译：间歇性起搏治疗安慰剂和预防疾病
公开(公告)号：WO2010008597A2
公开(公告)日：2010-01-21
申请号：PCT/US2009/004169
申请日：2009-07-16
申请人： CARDIAC PACEMAKERS, INC. , ARCOT-KRISHNAMURTHY, Shantha , SHUROS, Allan, C. , SHIPLEY, Robert , HAMANN, Jason, J.
发明人： ARCOT-KRISHNAMURTHY, Shantha , SHUROS, Allan, C. , SHIPLEY, Robert , HAMANN, Jason, J.
IPC分类号： A61N1/362 , A61N1/365
CPC分类号： A61N1/3627 , A61N1/3601 , A61N1/36528 , A61N1/36557 , A61N1/36564 , A61N1/36571 , A61N1/3684
摘要： A pacing system delivers cardiac protective pacing therapy (CPPT) to protect the heart from injuries and/or to treat existing injuries. The pacing system receives a set of inputs and delivers optimized cardiac protection pacing tailored for each of different purposes. The system delivers electrical stimulation to provide therapy for angina and/or to provide therapy for comorbidities related to neural imbalance. In one embodiment, a method for treating angina is provided. A signal is sensed indicative of an incidence of angina and an angina region being a myocardial region affected by the angina. The incidence of angina is detected and the angina region is located. A pacing location is selected remote from the angina region, and CPPT is initiated at the pacing location. The CPPT is adapted to create increased stress at the angina region, to promote mass-redistribution and angiogenesis at the angina region to treat the angina.
摘要翻译：起搏系统提供心脏保护性起搏治疗（CPPT）以保护心脏免受伤害和/或治疗现有伤害。起搏系统接收一组输入，并为每个不同目的提供量身定制的优化心脏保护起搏。该系统提供电刺激以提供心绞痛治疗和/或为与神经失衡有关的合并症提供治疗。在一个实施方案中，提供了治疗心绞痛的方法。检测到指示心绞痛和心绞痛区域发病的信号，所述心绞痛区域是受心绞痛影响的心肌区域。检测出心绞痛的发病率和心绞痛部位。远离心绞痛区域选择起搏位置，并在起搏位置开始CPPT。 CPPT适用于在心绞痛部位产生更大的压力，促进心绞痛部位的肿块再分布和血管生成，从而治疗心绞痛。

87. 发明申请

WO2009132060A1 OPTICAL DEVICE 审中-公开
标题翻译：光学装置
公开(公告)号：WO2009132060A1
公开(公告)日：2009-10-29
申请号：PCT/US2009/041345
申请日：2009-04-22
申请人： MEDTRONIC, INC. , ECKER, Robert, M. , KUHN, Jonathan, L. , REINKE, James, D. , CINBIS, Can , DAVIS, Timothy, J. , ROBERTS, Jonathan, P. , GERRRISH, Paul, F.
发明人： ECKER, Robert, M. , KUHN, Jonathan, L. , REINKE, James, D. , CINBIS, Can , DAVIS, Timothy, J. , ROBERTS, Jonathan, P. , GERRRISH, Paul, F.
IPC分类号： A61B5/00
CPC分类号： A61B5/0086 , A61B2562/028 , A61N1/3621 , A61N1/36557 , A61N1/375 , A61N1/3956
摘要： A reflectance-type optical sensor includes one or more photodiodes formed in a semiconductor substrate. A well having sidewalls and a bottom is formed in the top surface of the substrate, and a reflective layer is formed on the sidewalls and bottom. A light-emitting diode (LED) is mounted in the well, so that light emitted laterally and rearwardly from the LED strikes the sidewalls or bottom and is redirected in a direction generally perpendicular to the top surface of the substrate. The optical sensor can be fabricated using microelectromechanical systems (MEMS) fabrication techniques.
摘要翻译：反射型光学传感器包括在半导体衬底中形成的一个或多个光电二极管。在衬底的顶表面中形成具有侧壁和底部的阱，并且在侧壁和底部上形成反射层。发光二极管（LED）安装在井中，使得从LED侧向和向后发射的光撞击侧壁或底部，并且在大致垂直于衬底的顶表面的方向上重定向。光学传感器可以使用微机电系统（MEMS）制造技术来制造。

88. 发明申请

WO2009012094A1 OSMOMETRIC HEART MONITORING DEVICE AND METHODS 审中-公开
标题翻译： OSMOMETRIC心脏监测装置及方法
公开(公告)号：WO2009012094A1
公开(公告)日：2009-01-22
申请号：PCT/US2008/069499
申请日：2008-07-09
申请人： CARDIAC PACEMAKERS, INC. , SHUROS, Allan, Charles , MOKELKE, Eric, A. , KANE, Michael, John , QU, Jihong
发明人： SHUROS, Allan, Charles , MOKELKE, Eric, A. , KANE, Michael, John , QU, Jihong
IPC分类号： A61B5/07 , A61N1/365 , A61N1/37 , G01N13/04 , G01N33/84 , A61N1/05 , A61B5/00
CPC分类号： A61N1/3702 , A61B5/0006 , A61B5/02028 , A61B5/076 , A61B5/14539 , A61B5/14546 , A61B5/4869 , A61B2562/02 , A61N1/05 , A61N1/36521 , A61N1/36557 , G01N13/04
摘要： Embodiments of the invention are related to monitoring devices and methods with osmometric sensors, amongst other things. In an embodiment, the invention includes an implantable heart failure monitoring system including an osmometric sensor, the osmometric sensor configured to generate a signal corresponding to the osmotic strength of a bodily fluid, and a controller in communication with the osmometric sensor, the controller configured to receive and process the signal corresponding to the osmotic strength of a bodily fluid. Other aspects and embodiments are provided herein.
摘要翻译：本发明的实施例涉及到具有渗压传感器的监测装置和方法以及其它方面。在一个实施例中，本发明包括可植入心力衰竭监测系统，其包括渗透传感器，所述渗透传感器被配置为产生对应于体液的渗透强度的信号，以及与所述渗透传感器通信的控制器，所述控制器被配置为接收和处理对应于体液渗透强度的信号。本文提供了其它方面和实施例。

89. 发明申请

WO2008088897A3 HEART ATTACK DETECTOR 审中-公开
标题翻译：心脏攻击检测器
公开(公告)号：WO2008088897A3
公开(公告)日：2008-12-18
申请号：PCT/US2008000720
申请日：2008-01-18
申请人： CARDIAC PACEMAKERS INC , ZHANG YI , FOGOROS RICHARD , THOMPSON JULIE , KENKNIGHT BRUCE H , PEDERSON MICHAEL J , PATANGAY ABHILASH , BAYNHAM TAMARA C , MANICKA YATHEENDHAR D , MAZAR SCOTT T
发明人： ZHANG YI , FOGOROS RICHARD , THOMPSON JULIE , KENKNIGHT BRUCE H , PEDERSON MICHAEL J , PATANGAY ABHILASH , BAYNHAM TAMARA C , MANICKA YATHEENDHAR D , MAZAR SCOTT T
IPC分类号： A61N1/365 , A61B5/0215 , A61B5/053 , A61B7/00
CPC分类号： A61N1/365 , A61B5/0031 , A61B5/0205 , A61B5/0215 , A61B5/0452 , A61B5/053 , A61B5/7203 , A61B7/023 , A61N1/36521 , A61N1/36542 , A61N1/3655 , A61N1/36557 , A61N1/36564 , A61N1/36585
摘要： A system including an implantable trigger event detector and an implantable ischemia detector. The implantable trigger event detector is adapted to detect at least one first condition and to output a responsive trigger signal including information about whether the first condition has been detected. The implantable ischemia detector is adapted to detect a second condition indicative of one or more physiologic cardiovascular events in a subject that are indicative of ischemia. The ischemia detector is coupled to the trigger event detector to receive the trigger signal, and the ischemia detector is enabled upon the trigger signal indicating that the first condition has been detected.
摘要翻译：一种包括可植入触发事件检测器和可植入缺血检测器的系统。可植入触发事件检测器适于检测至少一个第一状况并且输出包括关于是否已检测到第一状况的信息的响应触发信号。植入式局部缺血检测器适于检测指示受试者中指示局部缺血的一种或多种生理心血管事件的第二状况。缺血检测器耦合到触发事件检测器以接收触发信号，并且在触发信号指示已经检测到第一状况时启用缺血检测器。

90. 发明申请

WO2008134240A1 THERAPY ADJUSTMENT 审中-公开
标题翻译：治疗调整
公开(公告)号：WO2008134240A1
公开(公告)日：2008-11-06
申请号：PCT/US2008/060411
申请日：2008-04-16
申请人： MEDTRONIC, INC. , GERBER, Martin T. , RONDONI, John C.
发明人： GERBER, Martin T. , RONDONI, John C.
IPC分类号： A61N1/36 , G06F19/00
CPC分类号： A61N1/36514 , A61N1/36542 , A61N1/3655 , A61N1/36557 , A61N1/36564 , A61N1/36571 , G06F19/00 , G06F19/3456 , G06F19/3481 , G16H40/63
摘要： Systems and methods for adjusting a therapy delivered to a patient include detecting a value of at least one sensed patient parameter and adjusting a therapy program to accommodate different patient parameter values. A data structure including a plurality of patient parameter values and associated therapy programs may be stored within a medical device (12) or a programming device (20). Upon detecting a patient parameter value, an associated therapy program from the data structure may be selected. If no therapy program is associated with the detected patient parameter value, an intermediate program that best suits the detected patient parameter value may be generated by interpolating between the most recently implemented therapy program and a stored therapy program. In some embodiments, the rate of shifting between parameters of two stored or interpolated therapy programs may be based on the rate of change of the patient parameter value over time.
摘要翻译：用于调整递送给患者的治疗的系统和方法包括检测至少一个感测到的患者参数的值并且调整治疗程序以适应不同的患者参数值。包括多个患者参数值和相关治疗程序的数据结构可以存储在医疗装置（12）或编程装置（20）内。在检测到患者参数值时，可以选择来自数据结构的相关治疗程序。如果没有治疗程序与检测到的患者参数值相关联，则可以通过在最近实施的治疗程序和存储的治疗程序之间进行内插来产生最适合检测到的患者参数值的中间程序。在一些实施例中，两个存储或内插治疗程序的参数之间的偏移速率可以基于随时间推移的患者参数值的变化率。

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