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81. 发明申请

US20150223718A1 APPARATUS FOR ACQUIRING ELECTRIC ACTIVITY IN THE BRAIN AND UTILIZATION OF THE SAME 审中-公开
标题翻译：用于获取脑中电活动的装置和其利用
公开(公告)号：US20150223718A1
公开(公告)日：2015-08-13
申请号：US14433431
申请日：2013-10-04
申请人： INTER-UNIVERSITY RESEARCH INSTITUTE CORPORATION NATIONAL INSTITUTES OF NATURAL SCIENCES
发明人： Atsushi Nambu , Satomi Chiken , Yukio Nishimura , Sayuki Takara
IPC分类号： A61B5/0478 , A61N1/05 , A61B18/14 , A61N1/36
CPC分类号： A61B5/0478 , A61B5/0484 , A61B18/1477 , A61B2018/00446 , A61B2018/00595 , A61B2018/00642 , A61B2018/00839 , A61N1/0529 , A61N1/0534 , A61N1/36082 , A61N1/36135
摘要： The present disclosure provides an apparatus including: one or more needle-like bases enabled to be inserted into the brain; a first electrode having a first impedance and enabling an input of an electric activity of a nucleus with which the first electrode comes into contact; and a second electrode having a second impedance lower than the first impedance and being able to output an electric stimulation to the nucleus, wherein the first electrode is provided at a tip portion of at least one of the bases, and the second electrode is provided on a part of the at least one of the bases at a position identical to a position of at least one of the first electrode or on a proximal side with respect to the first electrode, in a direction along a long axis of the base on which the first electrode is provided.
摘要翻译：本公开提供了一种装置，包括：能够将一个或多个针状基底插入脑中; 第一电极，其具有第一阻抗并且能够输入与第一电极接触的核的电活动; 以及第二电极，其具有比所述第一阻抗低的第二阻抗，并且能够向所述核输出电刺激，其中所述第一电极设置在所述至少一个所述基底的尖端部分，并且所述第二电极设置在所述至少一个基座的一部分位于与所述第一电极的至少一个位置相对于所述第一电极的近侧的位置相同的位置处，沿着所述基座的长轴方向，提供第一电极。

82. 发明申请

US20150216595A1 OPTIMIZED METHOD OF COATING THE MICROWAVE ABLATION PROBE FOR SURGICAL APPLICATION 审中-公开
标题翻译：用于外科应用的微波消融探针的优化方法
公开(公告)号：US20150216595A1
公开(公告)日：2015-08-06
申请号：US14614741
申请日：2015-02-05
申请人： Microsurgeon, Inc.
发明人： Babak Kateb , Edward Dean Hammerslag , Hosmel Galan
IPC分类号： A61B18/18
CPC分类号： A61B18/1815 , A61B2017/00526 , A61B2018/00107 , A61B2018/00136 , A61B2018/00446 , A61B2018/00577 , A61B2018/00797 , A61B2018/00815 , A61B2018/1861 , A61B2018/1892
摘要： An ablation probe which includes a probe body with a distal and proximal end, an ablation tip at the distal end of the probe body, an anode provided proximate to the ablation tip, a coaxial cable disposed within the probe body and coupled to the ablation tip and anode so that electromagnetic energy of a predetermined frequency is communicated thereto for dielectric heating of tissue, and a Parylene C coating on at least the ablation tip and anode to electrically isolate the ablation tip and anode from tissue without interference with microwave energy transmission through the probe to the tissue. The Parylene C is a vapor deposited coating on at least the ablation tip and anode to electrically isolate the ablation tip and anode from tissue.
摘要翻译：一种消融探针，其包括具有远端和近端的探针体，探针主体远端处的消融尖端，靠近消融尖端设置的阳极，设置在探针主体内并耦合到消融尖端的同轴电缆和阳极，使得将预定频率的电磁能传递到其上用于组织的电介质加热，以及在至少消融尖端和阳极上的帕利灵C涂层，以将消融尖端和阳极与组织电隔离，而不会干扰通过探测到组织。聚对二甲苯C是至少在消融尖端和阳极上的气相沉积涂层，以将消融尖端和阳极与组织电隔离。

83. 发明授权

US09072532B2 Energy delivery systems and uses thereof 有权
公开(公告)号：US09072532B2
公开(公告)日：2015-07-07
申请号：US13016204
申请日：2011-01-28
申请人： Daniel Warren van der Weide , Fred T. Lee, Jr. , Paul F. Laeseke , Christopher Lee Brace
发明人： Daniel Warren van der Weide , Fred T. Lee, Jr. , Paul F. Laeseke , Christopher Lee Brace
IPC分类号： A61B18/18 , A61B17/00 , A61B18/00
CPC分类号： A61B18/1815 , A61B18/18 , A61B90/37 , A61B2017/00274 , A61B2018/00005 , A61B2018/00023 , A61B2018/00351 , A61B2018/00404 , A61B2018/0044 , A61B2018/00446 , A61B2018/00494 , A61B2018/00511 , A61B2018/00517 , A61B2018/00529 , A61B2018/00541 , A61B2018/00547 , A61B2018/00559 , A61B2018/00577 , A61B2018/00642 , A61B2018/00702 , A61B2018/00714 , A61B2018/00791 , A61B2018/00904 , A61B2018/00982 , A61B2018/1823 , A61B2018/1861 , A61B2090/374 , A61B2090/376 , A61B2090/3762 , A61B2090/378
摘要： The present invention relates to comprehensive systems, devices and methods for delivering energy to tissue for a wide variety of applications, including medical procedures (e.g., tissue ablation, resection, cautery, vascular thrombosis, treatment of cardiac arrhythmias and dysrhythmias, electrosurgery, tissue harvest, etc.). In certain embodiments, systems, devices, and methods are provided for treating a tissue region (e.g., a tumor) through application of energy.

84. 发明申请

US20150093337A1 MEDICAL DEVICE RAPID DRUG RELEASING COATINGS COMPRISING A THERAPEUTIC AGENT AND A CONTRAST AGENT 审中-公开
标题翻译：包含治疗药物和对照药物的医疗装置快速释放涂层
公开(公告)号：US20150093337A1
公开(公告)日：2015-04-02
申请号：US14560640
申请日：2014-12-04
申请人： Lutonix, Inc.
发明人： Lixiao Wang
IPC分类号： A61L31/18 , A61L31/10 , A61L29/18 , A61L29/16 , A61L29/08 , A61M25/10 , A61M5/00 , A61M31/00 , A61B18/24 , A61F2/82 , A61F2/07 , A61M25/09 , A61F2/24 , A61M37/00 , A61L31/16
CPC分类号： A61L29/08 , A61B17/320725 , A61B18/24 , A61B18/245 , A61B2018/00327 , A61B2018/00345 , A61B2018/00446 , A61B2018/00488 , A61B2018/00505 , A61F2/07 , A61F2/24 , A61F2/82 , A61K31/337 , A61K31/436 , A61L29/085 , A61L29/16 , A61L29/18 , A61L31/08 , A61L31/10 , A61L31/16 , A61L31/18 , A61L2300/416 , A61L2300/606 , A61L2300/608 , A61L2420/06 , A61L2420/08 , A61L2430/20 , A61M5/007 , A61M25/09 , A61M25/10 , A61M25/1002 , A61M31/005 , A61M37/00 , A61M2025/105 , A61K2300/00
摘要： The invention relates to a coated medical device for rapid delivery of a therapeutic agent to a tissue in seconds to minutes. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent, a contrast agent, and an additive.
摘要翻译：本发明涉及一种用于将治疗剂快速递送至组织的涂覆的医疗装置，其数秒至数分钟。医疗装置具有覆盖医疗装置的外表面的层。该层含有治疗剂，造影剂和添加剂。

85. 发明申请

US20150088108A1 PROBE DRIVER 审中-公开
标题翻译：探索驱动
公开(公告)号：US20150088108A1
公开(公告)日：2015-03-26
申请号：US14557164
申请日：2014-12-01
申请人： MONTERIS MEDICAL CORPORATION
发明人： Richard TYC , Salman QURESHI , Mark Andrew GRANT , Luis Filipe Silva FERNANDES , Daniel Prazeres CARREIRA , John SCHELLHORN
IPC分类号： A61B19/00 , A61B18/22 , A61B5/055 , A61B18/20
CPC分类号： A61B18/22 , A61B5/015 , A61B5/055 , A61B5/4839 , A61B5/742 , A61B5/746 , A61B18/02 , A61B18/0206 , A61B18/06 , A61B18/148 , A61B18/1492 , A61B18/1815 , A61B18/20 , A61B18/28 , A61B34/20 , A61B34/25 , A61B34/71 , A61B90/10 , A61B90/11 , A61B90/14 , A61B2017/00017 , A61B2017/00911 , A61B2017/3407 , A61B2018/00017 , A61B2018/00023 , A61B2018/00446 , A61B2018/00577 , A61B2018/00642 , A61B2018/00702 , A61B2018/00791 , A61B2018/00994 , A61B2018/0212 , A61B2018/0293 , A61B2018/1807 , A61B2018/1861 , A61B2018/20351 , A61B2018/2211 , A61B2018/2261 , A61B2034/107 , A61B2034/2068 , A61B2034/301 , A61B2090/061 , A61B2090/374 , A61N5/0601 , A61N5/062 , A61N7/022 , G01R33/285 , G01R33/4804
摘要： Image-guided therapy of a tissue can utilize magnetic resonance imaging (MRI) or another medical imaging device to guide an instrument within the tissue. A workstation can actuate movement of the instrument via a probe driver, and can actuate energy emission and/or cooling of the instrument to effect treatment to the tissue. The workstation and/or an operator of the workstation can be located outside a vicinity of an MRI device or other medical imaging device, and drive means for positioning the instrument can be located within the vicinity of the MRI device or the other medical imaging device. The instrument can be an MRI compatible laser probe that provides thermal therapy to, e.g., a tissue in a brain of a patient. The probe driver allows for precise positioning, stabilization and manipulation of a probe.
摘要翻译：组织的图像引导治疗可以利用磁共振成像（MRI）或其他医学成像装置来引导组织内的器械。工作站可以通过探头驱动器启动仪器的运动，并且可以致动仪器的能量发射和/或冷却以对组织进行处理。工作站的工作站和/或操作者可以位于MRI装置或其他医疗成像装置附近的外部，并且用于定位仪器的驱动装置可以位于MRI装置或其它医疗成像装置的附近。该仪器可以是MRI兼容的激光探针，其向例如患者的脑中的组织提供热治疗。探头驱动器允许精确定位，稳定和操纵探头。

86. 发明申请

US20140276716A1 CATALYZED EXOTHERMIC ABLATION DEVICE 有权
标题翻译：催化灭菌装置
公开(公告)号：US20140276716A1
公开(公告)日：2014-09-18
申请号：US14202956
申请日：2014-03-10
申请人： Jeffry S. Melsheimer
发明人： Jeffry S. Melsheimer
IPC分类号： A61B18/06
CPC分类号： A61B18/06 , A61B2018/00333 , A61B2018/00446 , A61B2018/00494 , A61B2018/005 , A61B2018/00529 , A61B2018/00535 , A61B2018/00541 , A61B2018/00565 , A61B2018/00577 , A61B2018/066
摘要： The invention relates to devices, systems, and methods for heating tissue, including ablating a tumor, using the catalyzed heat of decomposition of hydrogen peroxide solutions. A hydrogen peroxide solution is contacted with a catalyst to decompose the hydrogen peroxide and heat the distal tip of a catheter to a temperature effective to ablate a target tissue.
摘要翻译：本发明涉及使用催化的过氧化氢溶液分解热来加热组织的装置，系统和方法，包括烧蚀肿瘤。过氧化氢溶液与催化剂接触以分解过氧化氢并将导管的远端加热到有效消融靶组织的温度。

87. 发明申请

US20130281968A1 Irreversible Electroporation using Nanoparticles 有权
标题翻译：使用纳米颗粒的不可逆电穿孔
公开(公告)号：US20130281968A1
公开(公告)日：2013-10-24
申请号：US13919640
申请日：2013-06-17
申请人： Virginia Tech Intellectual Properties, Inc.
发明人： Rafael V. DAVALOS , Marissa N. RYLANDER , Christopher B. ARENA
IPC分类号： A61N1/32
CPC分类号： A61B18/1477 , A61B18/1206 , A61B2018/00446 , A61B2018/00613 , A61N1/05 , A61N1/327 , C12N13/00
摘要： The present invention provides methods, devices, and systems for in vivo treatment of cell proliferative disorders. The invention can be used to treat solid tumors, such as brain tumors. The methods rely on non-thermal irreversible electroporation (IRE) to cause cell death in treated tumors. In embodiments, the methods comprise the use of high aspect ratio nanoparticles with or without modified surface chemistry.
摘要翻译：本发明提供用于体内治疗细胞增殖性疾病的方法，装置和系统。本发明可用于治疗诸如脑肿瘤的实体瘤。该方法依赖于非热不可逆电穿孔（IRE）在治疗的肿瘤中引起细胞死亡。在实施方案中，所述方法包括使用具有或不具有改性表面化学性质的高纵横比纳米颗粒。

88. 发明申请

US20130218005A1 MINIMALLY INVASIVE NEUROSURGICAL INTRACRANIAL ROBOT SYSTEM AND METHOD 审中-公开
标题翻译：微型入侵神经外科手术机器人系统及方法
公开(公告)号：US20130218005A1
公开(公告)日：2013-08-22
申请号：US13763284
申请日：2013-02-08
申请人： UNIVERSITY OF MARYLAND, COLLEGE PARK , UNIVERSITY OF MARYLAND, BALTIMORE
发明人： JAYDEV P. DESAI , MINGYEN HO , J. MARC SIMARD , RAO GULLAPALLI
IPC分类号： A61B19/00 , A61M1/00 , A61B18/12 , A61B18/04 , A61B8/08 , A61N7/00 , A61B5/055 , A61B5/06 , A61B6/03 , A61B17/00 , A61B18/20
CPC分类号： A61B6/032 , A61B5/055 , A61B5/062 , A61B6/12 , A61B8/0841 , A61B17/00234 , A61B18/042 , A61B18/12 , A61B18/1492 , A61B18/20 , A61B34/20 , A61B34/30 , A61B2017/00477 , A61B2018/00446 , A61B2018/00577 , A61B2034/2051 , A61B2034/306 , A61B2034/715 , A61M1/0058 , A61N7/00 , A61N7/022
摘要： Minimally invasive neurosurgical intracranial robot system is introduced to the operative site by a neurosurgeon through a narrow surgical corridor. The robot is passed through a cannula and is attached to the cannula by a latching mechanism. The robot has several links interconnected via revolute joints which are tendon-driven by tendons routed through channels formed in the walls of the links. The robot is teleoperatively guided by the neurosurgeon based on real-time images of the intracranial operative site and tracking information of the robot position. The robot body is equipped with a tracking system, tissue liquefacting end-effector, at as well as irrigation and suction tubes. Actuators for the tendon-driven mechanism are positioned at a distance from the imaging system to minimize distortion to the images. The tendon-actuated navigation of the robot permits an independent control of the revolute joints in the robot body.
摘要翻译：微创神经外科颅内机器人系统由神经外科医生通过狭窄的手术走廊引入手术部位。机器人穿过套管并通过闭锁机构附接到套管。机器人具有通过旋转接头相互连接的多个连杆，其由通过形成在链节壁中的通道布置的腱驱动。机器人由神经外科医生根据颅内手术部位的实时图像和机器人位置的跟踪信息进行远程导引。机器人身体配备有跟踪系统，组织液化终端执行器，以及灌溉和抽吸管。用于腱驱动机构的致动器位于离成像系统一定距离处，以最小化图像的失真。机器人的肌腱导向导航可以独立控制机器人体内的旋转关节。

89. 发明申请

US20130189190A1 MEDICAL DEVICE RAPID DRUG RELEASING COATINGS COMPRISING A THERAPEUTIC AGENT AND A CONTRAST AGENT 审中-公开
公开(公告)号：US20130189190A1
公开(公告)日：2013-07-25
申请号：US13846078
申请日：2013-03-18
申请人： Lutonix, Inc.
发明人： Lixiao Wang
IPC分类号： A61L29/18 , A61M5/00 , A61L31/18
CPC分类号： A61L29/08 , A61B17/320725 , A61B18/24 , A61B18/245 , A61B2018/00327 , A61B2018/00345 , A61B2018/00446 , A61B2018/00488 , A61B2018/00505 , A61F2/07 , A61F2/24 , A61F2/82 , A61K31/337 , A61K31/436 , A61L29/085 , A61L29/16 , A61L29/18 , A61L31/08 , A61L31/10 , A61L31/16 , A61L31/18 , A61L2300/416 , A61L2300/606 , A61L2300/608 , A61L2420/06 , A61L2420/08 , A61L2430/20 , A61M5/007 , A61M25/09 , A61M25/10 , A61M25/1002 , A61M31/005 , A61M37/00 , A61M2025/105 , A61K2300/00
摘要： The invention relates to a coated medical device for rapid delivery of a therapeutic agent to a tissue in seconds to minutes. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent, a contrast agent, and an additive.

90. 发明申请

US20110306962A1 Method and Device for Treatment of Conditions Aggravated by Amyloid Fibrils 有权
标题翻译：用于治疗由淀粉样蛋白原纤维加重的病症的方法和装置
公开(公告)号：US20110306962A1
公开(公告)日：2011-12-15
申请号：US13161362
申请日：2011-06-15
申请人： Karl H. Schoenbach , Lesley Greene
发明人： Karl H. Schoenbach , Lesley Greene
IPC分类号： A61B18/18
CPC分类号： A61B18/12 , A61B18/1492 , A61B2018/00446 , A61N1/205 , A61N1/327
摘要： A method and device for treating a condition aggravated by the presence of amyloid fibrils is disclosed. The method includes applying a plurality of ultra-short pulses to target tissue comprising amyloid fibrils. The plurality of ultra-short pulses produce an electric field in the target tissue sufficient to change a molecular structure of the amyloid fibrils without causing the death, destruction, or serious injury of healthy cells surrounding the target tissue. For example, the plurality of ultra-short pulses can be sufficient to change the molecular structure of amyloid fibrils without causing apoptosis or necrosis of surrounding cells. The ultra-short pulses can be applied using an electrode device or a wideband antenna. The ultra-short pulses can have a duration ranging from 1 ps to 10 ns, an amplitude ranging from 100 V to 1 MV, and can apply an electrical field to the target tissue ranging from 1 kV/cm to 1 MV/cm.
摘要翻译：公开了一种用于治疗由淀粉样蛋白原纤维存在而加重的病症的方法和装置。该方法包括将多个超短脉冲应用于包含淀粉样蛋白原纤维的靶组织。多个超短脉冲在目标组织中产生足以改变淀粉样蛋白原纤维的分子结构的电场，而不会导致靶组织周围的健康细胞的死亡，破坏或严重损伤。例如，多个超短脉冲可以足以改变淀粉样蛋白原纤维的分子结构，而不引起周围细胞的凋亡或坏死。可以使用电极装置或宽带天线来施加超短脉冲。超短脉冲可以具有1ps至10ns的持续时间，振幅范围为100V至1MV，并且可以向1KV / cm至1MV / cm的目标组织施加电场。

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