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81. 发明专利

IL156405D0 INHIBITORS OF SPERMIDINE SYNTHASE FOR THE TREATMENT OF OSTEOARTHRITIS AND CARTILAGE REHABILITATION 未知
公开(公告)号：IL156405D0
公开(公告)日：2004-01-04
申请号：IL15640501
申请日：2001-12-12
申请人： QUARK BIOTECH INC , SHIONOGI & CO
IPC分类号： G01N33/50 , A61K31/13 , A61K31/155 , A61K31/16 , A61K31/275 , A61K31/52 , A61K31/70 , A61K31/7076 , A61K45/00 , A61P19/02 , A61P43/00 , C12N9/99 , C12Q1/02 , C12Q1/48 , C12Q1/527 , G01N33/15 , A61K
摘要： This invention provides a method for the treatment of a subject in need of treatment for osteoarthritis comprising administering to said subject an amount of an inhibitor of spermidine biosynthesis sufficient to effect a substantial inhibition of spermidine biosynthesis. This invention also provides the use of an inhibitor of spermidine biosynthesis in the treatment of a subject in need of treatment of osteoarthritis in an amount sufficient to effect a substantial inhibition of spermidine biosynthesis This invention further provides a method of preparing a therapeutic composition for the treatment of a subject in need of a treatment for osteoarthritis and the invention further provides a method identifying an inhibitor of spermidine biosynthesis, whereby the inhibitor is a spermidine synthesis inhibitor.

84. 发明专利

AU2003223172A1 USE OF THE AXL RECEPTOR FOR DIAGNOSIS AND TREATMENT OF RENAL DISEASE 未知
公开(公告)号：AU2003223172A1
公开(公告)日：2003-09-04
申请号：AU2003223172
申请日：2003-02-12
申请人： QUARK BIOTECH INC
发明人： MOR ORNA
IPC分类号： G01N33/50 , A61K45/00 , A61P13/12 , C12N15/09 , C12Q1/02 , C12Q1/48 , G01N33/15 , G01N33/68 , C12Q1/00 , C12Q1/68 , C07H21/04 , C07K14/00
摘要： The invention is directed to a process of identifying a compound capable of inhibiting the activity of a human Ax1 receptor that comprises contacting the Ax1 receptor or cells expressing the Ax1 receptor with the compound; measuring the Ax1 receptor activity in the presence of the compound; and comparing the activity measured to that measured in the absence of the compound under controlled conditions, wherein a decrease identifies the compound as being capable of inhibiting the activity. Therapeutic and diagnostic applications are also described.

86. 发明专利

AU2002316201A1 Methods of using colony stimulating factors in the treatment of tissue damage and ischemia 未知
公开(公告)号：AU2002316201A1
公开(公告)日：2002-12-16
申请号：AU2002316201
申请日：2002-06-07
申请人： QUARK BIOTECH INC
发明人： CHAJUT AYELET
IPC分类号： A61K38/18 , A61K38/19 , A61K38/20 , A61K38/22
摘要： The present invention relates to novel uses of growth factors, particularly colony stimulating factors (CSFs), that stimulate migration and differentiation of stem cells in order to promote and enhance recovery from tissue trauma and ischemic events, including ischemia of the central nervous system, as well as for use in preventing or alleviating chronic degenerative processes, including neuronal degeneration

87. 发明专利

IL148922D0 METHOD FOR ENRICHMENT OF NATURAL ANTISENSE MESSENGER RNA 未知
公开(公告)号：IL148922D0
公开(公告)日：2002-09-12
申请号：IL14892200
申请日：2000-10-06
申请人： QUARK BIOTECH INC
IPC分类号： C12N15/113 , C12Q1/68 , C12Q1/6809 , C12Q
摘要： A method for enrichment of natural antisense mRNA which involves hybridization of cDNA obtained from sense RNA with cDNA obtained from antisense RNA, followed by DNA polymerase treatment of the sense-antisense hybrid DNA molecule. A natural antisense library can be generated by cloning of sense-antisense hybrid DNA molecules in a vector.

88. 发明专利

AU7998901A Sequence specific and sequence non-specific methods and materials for cdna normalization and subtraction 未知
公开(公告)号：AU7998901A
公开(公告)日：2002-06-18
申请号：AU7998901
申请日：2001-07-11
申请人： QUARK BIOTECH INC
发明人： MUGASIMANGALAM RAJA C
IPC分类号： C12N15/10
摘要： This invention provides methods for constructing a normalized cDNA library, constructing a low copy gene library, preparing a probe from a biological sample and a kit for constructing a normalized cDNA library.

90. 发明专利

IL133673D0 METHOD FOR IDENTIFYING GENES 未知
公开(公告)号：IL133673D0
公开(公告)日：2001-04-30
申请号：IL13367399
申请日：1999-05-11
申请人： QUARK BIOTECH INC
IPC分类号： C12N15/09 , C12P19/34 , C12Q1/68 , C12Q1/6806 , C12Q1/6809 , C12N
摘要： A method for identifying genes regulated at the RNA level by cue-induced gene expression. The invention relates to the rapid isolation of differentially expressed or developmentally regulated gene sequences through analysis of mRNAs obtained from specific cellular compartments and comparing the changes in the relative abundance of the mRNA in these compartments as a result of applying a cue to the tested biological sample. The cellular compartments include polysomal and nonpolysomal fractions, nuclear fractions, cytoplasmic fractions, and spliceosomal fractions. Genes that are differentially expressed due to regulation on any one or more of a number of levels, may be characterized. Regulation levels include translational regulation, transcriptional regulation, mRNA stability regulation, and mRNA transport regulation. A method for identifying gene sequences coding for internal ribosome entry sites is also provided, which includes inhibiting 5' cap-dependant mRNA translation in a cell, collecting a pool of mRNA from the cells, and differentially analyzing the pool of mRNA to identify genes with sequences coding for internal ribosome entry sites.

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