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81. 发明专利

CY1117084T1 ΘΡΑΥΣΜΑΤΑ ΠΕΠΤΙΔΙΟΥ ΓΙΑ ΤΗΝ ΕΠΑΓΩΓΗ ΣΥΝΘΕΣΗΣ ΠΡΩΤΕΪΝΩΝ ΕΞΩΚΥΤΤΑΡΙΑΣ ΜΗΤΡΑΣ 未知
公开(公告)号：CY1117084T1
公开(公告)日：2017-04-05
申请号：CY151101181
申请日：2015-12-22
申请人： HELIX BIOMEDIX INC
发明人： HARRIS SCOTT , FALLA TIMOTHY , ZHANG LIJUAN
IPC分类号： C07K5/10
摘要： Ένατετραπεπτίδιοπεριλαμβάνει SEQ ID ΝΟ:1, SEQ ID ΝΟ:10 ή SEQ ID ΝΟ:9. Ένατετραπεπτίδιοπεριλαμβάνει SEQ ID ΝΟ:3, SEQ ID ΝΟ:6 ή SEQ ID ΝΟ:7. Ένατετραπεπτίδιοπεριλαμβάνει SEQ ID NO: 14. Μίασύνθεσηπεριλαμβάνειέναμίγματωντετραπεπτιδίων SEQ ID ΝΟ:5, SEQ ID ΝΟ:6, SEQ ID ΝΟ:7 και SEQ ID ΝΟ:8. Μία in vitro μέθοδοςγιατηδιέγερσητηςπαραγωγήςκολλαγόνουδιαενόςκυττάρου, όπουη μέθοδοςπεριλαμβάνειέκθεσηενόςκυττάρουειςένατετραπεπτίδιοτοοποίοπεριλαμβάνει SEQ ID ΝΟ:1, SEQ ID ΝΟ:10, SEQ ID ΝΟ:9, SEQ ID ΝΟ:3, SEQ ID ΝΟ:6, SEQ ID ΝΟ:7 ή SEQ ID ΝΟ:14 ήέναμίγμαεξαυτώνή μίασύνθεσηη οποίαπεριλαμβάνειέναμίγματωντετραπεπτιδίων SEQ ID ΝΟ:5, SEQ ID ΝΟ:6, SEQ ID ΝΟ:7 και SEQ ID ΝΟ:8, επάγονταςτοιουτοτρόπωςτηνπαραγωγήκολλαγόνουαπότοκύτταρο.

82. 发明专利

CA2835369C PEPTIDE FRAGMENTS FOR INDUCING SYNTHESIS OF EXTRACELLULAR MATRIX PROTEINS 未知
公开(公告)号：CA2835369C
公开(公告)日：2017-01-31
申请号：CA2835369
申请日：2007-06-12
申请人： HELIX BIOMEDIX INC
发明人： HARRIS SCOTT M , FALLA TIMOTHY J , ZHANG LIJUAN
IPC分类号： C07K5/117 , A61K8/64 , A61K38/17 , A61P17/00 , A61P17/02 , A61Q19/00 , A61Q19/08
摘要： Short biologically active tetrapeptides are disclosed that are comprised of the sequences GxxG and PxxP where G (glycine) and P (proline) are maintained and x is a variable amino acid. The peptides can be used singly or in combination to stimulate production of extracellular matrix proteins in skin. A rapid, low-cost method of producing heterogenous formulations of tetrapeptides is disclosed.

83. 发明专利

CA2655116C PEPTIDE FRAGMENTS FOR INDUCING SYNTHESIS OF EXTRACELLULAR MATRIX PROTEINS 未知
公开(公告)号：CA2655116C
公开(公告)日：2016-12-13
申请号：CA2655116
申请日：2007-06-12
申请人： HELIX BIOMEDIX INC
发明人： HARRIS SCOTT M , FALLA TIMOTHY J , ZHANG LIJUAN
IPC分类号： C07K14/78 , A61K8/64 , A61K38/07 , A61P17/02 , A61Q19/08 , C07K5/10 , C07K5/103 , C07K5/117
摘要： [0049] Short biologically active tetrapeptides are disclosed that are comprised of the sequences GxxG and PxxP where G (glycine) and P (proline) are maintained and x is a variable amino acid. The peptides can be used singly or in combination to stimulate production of extracellular matrix proteins in skin. A rapid, low-cost method of producing heterogenous formulations of tetrapeptides is disclosed.

84. 发明专利

PL2402369T3 Fragmenty peptydów do indukowania syntezy białek macierzy zewnątrzkomórkowej 未知
公开(公告)号：PL2402369T3
公开(公告)日：2016-05-31
申请号：PL11175264
申请日：2007-06-12
申请人： HELIX BIOMEDIX INC
发明人： HARRIS SCOTT , FALLA TIMOTHY , ZHANG LIJUAN
IPC分类号： C07K5/10

85. 发明专利

ES2567706T3 Tetrapéptidos protectores para cuidado cutáneo 未知
公开(公告)号：ES2567706T3
公开(公告)日：2016-04-26
申请号：ES08844747
申请日：2008-10-28
申请人： HELIX BIOMEDIX INC
发明人： ZHANG LIJUAN , HARRIS SCOTT , FALLA TIMOTHY
IPC分类号： C07K5/10
摘要： Un péptido aislado, en el que la secuencia de aminoácidos del péptido consiste en prolina-glutamina-glutamato-X (P-Q-E-X), en la que X es lisina (K) o isoleucina (I).

86. 发明专利

PT2402369E FRAGMENTOS PEPTÍDICOS PARA INDUZIR A SÍNTESE DE PROTEÍNAS DA MATRIZ EXTRACELULAR 未知
公开(公告)号：PT2402369E
公开(公告)日：2016-02-19
申请号：PT11175264
申请日：2007-06-12
申请人： HELIX BIOMEDIX INC
发明人： HARRIS SCOTT , FALLA TIMOTHY , ZHANG LIJUAN

87. 发明专利

HK1204453A1 SHORT ANTIMICROBIAL LIPOPEPTIDES 未知
公开(公告)号：HK1204453A1
公开(公告)日：2015-11-20
申请号：HK15105035
申请日：2015-05-27
申请人： HELIX BIOMEDIX INC
发明人： ZHANG LIJUAN , CARMICHAEL ROBIN
IPC分类号： A61K20060101 , C07K20060101
摘要： Disclosed are peptides having biological and therapeutic activity. Particularly disclosed are lipidated di- or tri-peptides analogs of KPV or KdPT that exhibit antimicrobial activity. In particular, the peptides of this invention provide enhanced anti-microbial activity over the base tri-peptides, lysine-proline-valine and lysine-d-proline-tyrosine. The disclosed peptides have the general formula of C12-18 lipid-KXZ-NH2i wherein K is lysine; X is proline, d-proline, histidine or arginine; Z is optional and if present Z is valine, threonine, alanine or leucine; and the terminal COOH is NH2 amidated. The C12-18 lipid is preferably the lipid moiety of lauric acid (C12), myristic acid (C14), pentadecanoic acid (C15), palmitic acid (C16), or stearic acid (C18). The invention is further related to methods of using of these peptides to treat various insults, inflammations or bacterial infections affecting the skin and other related mucosal body surfaces such as the oral cavity.

88. 发明专利

DK2409988T3 Peptidfragmenter til induktion af syntese af ekstracellulære matrixproteiner 未知
公开(公告)号：DK2409988T3
公开(公告)日：2015-09-14
申请号：DK11175263
申请日：2007-06-12
申请人： HELIX BIOMEDIX INC
发明人： HARRIS SCOTT , FALLA TIMOTHY , ZHANG LIJUAN
IPC分类号： C07K14/78 , C07K5/10

89. 发明专利

MX2014011290A LIPOPEPTIDOS ANTIMICROBIANOS CORTOS. 未知
公开(公告)号：MX2014011290A
公开(公告)日：2014-10-13
申请号：MX2014011290
申请日：2013-03-07
申请人： HELIX BIOMEDIX INC
发明人： ZHANG LIJUAN , CARMICHAEL ROBIN
IPC分类号： A61K47/48 , A61K38/34 , C07K5/09
摘要： Péptidos que presentan actividad biológica y terapéutica, que en particular, son dipéptidos o tripéptidos lipidados que son análogos de los péptidos KPV y KdPT y que presentan actividad antimicrobiana. Más precisamente, los péptidos de acuerdo con la presente invención presentan una actividad antimicrobiana que es superior a la de los tripéptidos originales lisina-prolina-valina y lisina-d-prolina-tirosina. Los péptidos que se describen presentan la fórmula general lípido C12-18-KXZ-NH2, donde K es lisina, X es prolina, d-prolina, histidina o arginina, Z es opcional, y si está presente, es valina, treonina, alanina o leucina, y el grupo COOH en el extremo está amidado con NH2. El lípido C12-18 preferiblemente es una unidad lipidica que se selecciona entre el ácido láurico (C12), el ácido mirístico (C14), el ácido pentadecanoico (C15), el ácido palmítico (C16) y el ácido esteárico (C18). Métodos para usar estos péptidos en el tratamiento de diversas lesiones, inflamaciones o infecciones que son provocadas por bacterias en la piel o en otras superficies mucosas del cuerpo, como es el caso de la cavidad oral.

90. 发明专利

CA2864179A1 SHORT ANTIMICROBIAL LIPOPEPTIDES 未知
公开(公告)号：CA2864179A1
公开(公告)日：2013-09-26
申请号：CA2864179
申请日：2013-03-07
申请人： HELIX BIOMEDIX INC
发明人： ZHANG LIJUAN , CARMICHAEL ROBIN
IPC分类号： A61K47/48 , A61K38/34 , C07K5/09
摘要： Disclosed are peptides having biological and therapeutic activity. Particularly disclosed are lipidated di- or tri- peptides analogs of KPV or KdPT that exhibit antimicrobial activity. In particular, the peptides of this invention provide enhanced anti-microbial activity over the base tri -peptides, lysine -proline- valine and lysine-d-proline-tyrosine. The disclosed peptides have the general formula of C12-18 lipid KXZ-NH2i wherein K is lysine; X is proline, d-proline, histidine or arginine; Z is optional and if present Z is valine, threonine, alanine or leucine; and the terminal COOH is NH2 amidated. The C12-18 lipid is preferably the lipid moiety of lauric acid (C12), myristic acid (C14), pentadecanoic acid (C15), palmitic acid (C16), or stearic acid (C18). The invention is further related to methods of using of these peptides to treat various insults, inflammations or bacterial infections affecting the skin and other related mucosal body surfaces such as the oral cavity.

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