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81. 发明申请

US20090093549A1 Aqueous Pharmaceutical Compositions Of 2,6-Diisopropylphenol (Propofol) And Their Uses 有权
标题翻译： 2,6-二异丙基苯酚（异丙酚）的水性药物组合物及其用途
公开(公告)号：US20090093549A1
公开(公告)日：2009-04-09
申请号：US12333887
申请日：2008-12-12
申请人： Zhong Zhang , Orn Almarsson , Hongming Chen
发明人： Zhong Zhang , Orn Almarsson , Hongming Chen
IPC分类号： A61K31/05
CPC分类号： A61K31/56 , A61K9/0019 , A61K9/10 , A61K31/05 , A61K31/74 , A61K45/06 , A61K47/10 , A61K47/12 , A61K47/186 , A61K47/26 , A61K47/34 , A61K2300/00
摘要： The present invention provides aqueous pharmaceutical compositions containing a lipophilic therapeutic agent. In particular, the invention provides aqueous pharmaceutical compositions containing the compound 2,6-diisopropylphenol (propofol). Preferred compositions of the invention contain propofol in the presence of at least one block copolymer (for example, P188 or another poloxamer) and a polyethylene glycol (PEG). Compositions of the invention are preferably sterile or are readily sterilized (e.g., by autoclaving) and are suitable for parenteral administration to any animal, including humans. The compositions are also chemically and physically stable over a wide range of environmental conditions and for extended periods of time.
摘要翻译：本发明提供含有亲脂性治疗剂的含水药物组合物。特别地，本发明提供含有化合物2,6-二异丙基苯酚（丙泊酚）的含水药物组合物。在至少一种嵌段共聚物（例如P188或其他泊洛沙姆）和聚乙二醇（PEG）的存在下，本发明的优选组合物含有异丙酚。本发明的组合物优选是无菌的或容易灭菌（例如通过高压灭菌），并且适用于对包括人在内的任何动物肠胃外给药。组合物在宽范围的环境条件下和长时间内也是化学和物理稳定的。

82. 发明授权

US07431935B2 Proteins within the type E botulinum neurotoxin complex 有权
标题翻译： E型肉毒杆菌神经毒素复合物中的蛋白质
公开(公告)号：US07431935B2
公开(公告)日：2008-10-07
申请号：US10766283
申请日：2004-01-27
申请人： Bal Ram Singh , Zhong Zhang
发明人： Bal Ram Singh , Zhong Zhang
IPC分类号： C07K14/00 , A61K38/00 , A61K38/43
CPC分类号： C07K14/33 , A61K38/00 , Y02A50/469
摘要： The invention features a polypeptide complex synthesized by bacteria of the genus Clostridia that contains the serotype E botulinum neurotoxin and five neurotoxin associated polypeptides having molecular weights of about 118, 80, 65, 40, and 18 kDa. respectively. The complex is useful in the treatment of diseases or conditions that are caused by excessive release of acetylcholine from presynaptic nerve terminals.
摘要翻译：本发明的特征在于由梭菌属细菌合成的多肽复合物，其包含血清型E肉毒杆菌神经毒素和五种具有约118,80,65,40和18kDa分子量的神经毒素相关多肽。分别。该复合物可用于治疗由突触前神经末梢过度释放乙酰胆碱引起的疾病或病症。

83. 发明申请

US20070143206A1 Method and system for generating an auction using a product catalog in an integrated internal auction system 有权
标题翻译：在综合内部拍卖系统中使用产品目录生成拍卖的方法和系统
公开(公告)号：US20070143206A1
公开(公告)日：2007-06-21
申请号：US11591150
申请日：2006-10-31
申请人： Yan Cui , Rowell Sotto , Lenin Subramanian , Anisha Dadhia , Yue Fang , Zhong Zhang
发明人： Yan Cui , Rowell Sotto , Lenin Subramanian , Anisha Dadhia , Yue Fang , Zhong Zhang
IPC分类号： G06Q40/00
CPC分类号： G06Q30/08 , G06Q30/0617 , G06Q30/0619 , G06Q40/04
摘要： A seller may use an existing product catalog in a seller business information management system to generate an auction and populate auction parameters to expedite and facilitate the auction creation process. The information in the product catalog may be used to provide auction parameters (populate auction fields) in addition to adding a product and/or service to the auction. An auction profile may also be defined for a seller and may contain data or rules for generating an auction that may be used to provide additional default values for the auction. One or more auction profiles may be associated with a seller. The seller selects a product from the catalog and chooses a create auction option resulting in an auction being generated from the product information and the profile, if one exists. The seller may then modify the auction parameters and add or drop products before saving the auction.
摘要翻译：卖方可以使用卖家业务信息管理系统中的现有产品目录来生成拍卖并填充拍卖参数，以加快和促进拍卖创作过程。除了向拍卖添加产品和/或服务之外，产品目录中的信息可用于提供拍卖参数（填充拍卖领域）。也可以为卖方定义拍卖简档，并且可以包含用于生成拍卖的数据或规则，该拍卖可用于为拍卖提供附加的默认值。一个或多个拍卖简档可以与卖家相关联。卖方从目录中选择产品，并选择创建拍卖选项，导致从产品信息和配置文件生成的拍卖（如果存在）。卖方可以在保存拍卖之前修改拍卖参数并添加或删除产品。

84. 发明申请

US20070117851A1 Liquid pharmaceutical compositions of nimodipine 审中-公开
标题翻译：尼莫地平液体药物组合物
公开(公告)号：US20070117851A1
公开(公告)日：2007-05-24
申请号：US11548880
申请日：2006-10-12
申请人： Julius Remenar , Zhong Zhang
发明人： Julius Remenar , Zhong Zhang
IPC分类号： A61K31/455
CPC分类号： A61K31/4422 , A61K9/0019 , A61K9/0043 , A61K9/08 , A61K31/455 , A61K47/10 , A61K47/26 , A61K47/44
摘要： The present invention relates to liquid compositions of nimodipine and administration of said compositions. New stable liquid compositions of nimodipine can be used to treat conditions such as, but not limited to, aneurysms, subarachnoid hemorrhage, vasospastic angina, Prenzmetal's angina, stable angina, acute myocardial infarction, myocardial arrest, arrhythmia, systemic hypertension, pulmonary hypertension, congestive heart failure, and hypertrophic cardiomyopathy.
摘要翻译：本发明涉及尼莫地平的液体组合物和所述组合物的施用。新的稳定的尼莫地平液体组合物可用于治疗诸如动脉瘤，蛛网膜下腔出血，血管痉挛性心绞痛，普伦茨金氏心绞痛，稳定性心绞痛，急性心肌梗死，心肌停搏，心律失常，全身性高血压，肺动脉高压，充血性心力衰竭和肥厚型心肌病。

85. 发明申请

US20060161901A1 System and method for automatically generating flow diagrams 有权
标题翻译：自动生成流程图的系统和方法
公开(公告)号：US20060161901A1
公开(公告)日：2006-07-20
申请号：US11037150
申请日：2005-01-19
申请人： Guruprasad Srinivasamurthy , Yue Fang , Zhong Zhang , Pavan Bayyapu
发明人： Guruprasad Srinivasamurthy , Yue Fang , Zhong Zhang , Pavan Bayyapu
IPC分类号： G06F9/44
CPC分类号： G06F8/10 , G06Q10/06
摘要： A method and system automatically generate a flow diagram displaying a process flow between configuration files and application files in a predefined process. An indication of a location of the configuration files and the application files is received. Flow information is extracted from the configuration files and from the application files. The flow diagram displaying a process flow between the configuration files and the application files is then generated.
摘要翻译：方法和系统自动生成流程图，显示在预定义的过程中配置文件和应用程序文件之间的过程流程。接收到配置文件和应用程序文件的位置的指示。从配置文件和应用文件中提取流信息。然后生成显示配置文件和应用程序文件之间的过程流程的流程图。

86. 发明申请

US20050203185A1 Pharmaceutical compositions and method of using levodopa and carbidopa 有权
公开(公告)号：US20050203185A1
公开(公告)日：2005-09-15
申请号：US11083168
申请日：2005-03-17
申请人： Julius Remenar , Orn Almarsson , Anthony Meehan , Zhong Zhang
发明人： Julius Remenar , Orn Almarsson , Anthony Meehan , Zhong Zhang
IPC分类号： A61K31/19 , A61K31/198
CPC分类号： A61K31/195 , A61K31/198 , A61K2300/00
摘要： The present invention relates to stable compositions of levodopa and carbidopa, methods of treating patients with these compositions, and methods of preparing these compositions.

87. 发明授权

US09157133B2 Hydrothermal oxidation method for production of alkali metal dichromate from carbon ferrochrome 有权
标题翻译：从碳铬铁生产碱金属重铬酸盐的水热氧化法
公开(公告)号：US09157133B2
公开(公告)日：2015-10-13
申请号：US13882354
申请日：2010-11-02
申请人： Zhu Ji , Jinsong Wang , Zhong Zhang , Yuqing Yang , Aishan Wang , Weiguo Song , Xinjian Yin , Qingting Wei , Hongwei Ru , Wenwen Zhang , Haijun Mei
发明人： Zhu Ji , Jinsong Wang , Zhong Zhang , Yuqing Yang , Aishan Wang , Weiguo Song , Xinjian Yin , Qingting Wei , Hongwei Ru , Wenwen Zhang , Haijun Mei
IPC分类号： C22B34/32 , C01G37/14 , C01G49/02
CPC分类号： C22B34/32 , C01G37/14 , C01G49/02
摘要： The present invention provides a hydrothermal oxidation method for producing alkali metal dichromate from carbon ferrochrome, and the method comprises the following steps: formulating an initial reaction liquid by mixing carbon ferrochrome, an alkaline substance and water, in which the actual addition amount of the alkali is controlled smaller than the theoretically required amount; adding the initial reaction liquid into a reaction kettle, charging an oxidizing gas into the reaction kettle, and allowing the reaction to proceed for 0.5 to 3 h at a temperature of 150° C. to 370° C. and a pressure of 2 Mpa to 24 MPa; carrying out solid-liquid separation, cooling the resultant filtrate to a temperature of −12° C. to −20° C. to precipitate crystals, and carrying out separation by centrifuge to obtain alkali metal dichromate solution; adding CrO3 to the alkali metal dichromate solution until the degree of acidification reaches 100% or greater, concentrating the solution by evaporation, and cooling it to precipitate crystals, so as to afford alkali metal dichromate. The method has a simple process, is easy to control, and can directly produce sodium dichromate under hydrothermal conditions.
摘要翻译：本发明提供一种从碳铬铁制备碱金属重铬酸盐的水热氧化方法，其方法包括以下步骤：通过混合碳铬铁，碱性物质和水，配制初始反应液，其中碱的实际添加量控制小于理论要求量; 将初始反应液加入反应釜中，将氧化气体加入到反应釜中，并使反应在150℃至370℃的温度和2Mpa的压力下进行0.5至3小时， 24 MPa; 进行固液分离，将得到的滤液冷却至-12℃〜-20℃的温度，析出结晶，通过离心分离，得到重金属碱金属溶液; 将CrO 3加入到碱金属重铬酸盐溶液中直至酸化度达到100％以上，蒸发浓缩溶液，冷却析出晶体，得到碱金属重铬酸盐。该方法工艺简单，易于控制，可在水热条件下直接生成重铬酸钠。

88. 发明申请

US20120171247A1 NOVEL PROTEINS WITHIN THE TYPE E BOTULINUM NEUROTOXIN COMPLEX 审中-公开
标题翻译： E型胆碱酯神经毒素复合物中的新蛋白
公开(公告)号：US20120171247A1
公开(公告)日：2012-07-05
申请号：US13184995
申请日：2011-07-18
申请人： Bal Ram Singh , Zhong Zhang
发明人： Bal Ram Singh , Zhong Zhang
IPC分类号： A61K39/08 , G01N33/566 , A61P25/14 , A61P25/00 , C07K7/06 , C07K16/12
CPC分类号： C07K14/33 , A61K38/00 , Y02A50/469
摘要： The invention features a polypeptide complex synthesized by bacteria of the genus Clostridia that contains the serotype E botulinum neurotoxin and five neurotoxin associated polypeptides having molecular weights of about 118, 80, 65, 40, and 18 kDa, respectively. The complex is useful in the treatment of diseases or conditions that are caused by excessive release of acetylcholine from presynaptic nerve terminals.
摘要翻译：本发明的特征在于一种由梭菌属细菌合成的多肽复合物，其分别含有分子量分别为约118,80,65,40和18kDa的血清型E肉毒杆菌神经毒素和五种神经毒素相关多肽。该复合物可用于治疗由突触前神经末梢过度释放乙酰胆碱引起的疾病或病症。

89. 发明授权

US08195942B2 Network security authentication method 有权
标题翻译：网络安全认证方式
公开(公告)号：US08195942B2
公开(公告)日：2012-06-05
申请号：US10531569
申请日：2003-09-22
申请人： Tao Zhang , Zhong Zhang
发明人： Tao Zhang , Zhong Zhang
IPC分类号： H04L29/06
CPC分类号： H04L63/062 , H04L63/08 , H04L63/0823
摘要： An authentication method for network security includes: configuring a Media Gateway (MG) with an authentication key and setting a security data package on a network protocol by a Media Gateway Controller (MGC); during a security authentication, sending, by the MGC, security authentication request data to the MG using the data package; receiving by the MGC a calculation result obtained by performing an encryption calculation on the request data using the authentication key by the MG; and determining by the MGC whether the MG is legal according to the calculation result.
摘要翻译：一种用于网络安全的认证方法包括：使用认证密钥配置媒体网关（MG），并通过媒体网关控制器（MGC）在网络协议上设置安全数据包; 在安全认证过程中，由MGC使用数据包向MG发送安全认证请求数据; 由MGC接收通过使用MG的认证密钥对请求数据执行加密计算而获得的计算结果; 并由MGC根据计算结果确定MG是否合法。

90. 发明授权

US08133918B2 Aqueous pharmaceutical compositions of 2,6-diisopropylphenol (propofol) and their uses 有权
标题翻译： 2,6-二异丙基苯酚（丙泊酚）的水性药物组合物及其用途
公开(公告)号：US08133918B2
公开(公告)日：2012-03-13
申请号：US12333887
申请日：2008-12-12
申请人： Zhong Zhang , Orn Almarsson , Hongming Chen
发明人： Zhong Zhang , Orn Almarsson , Hongming Chen
IPC分类号： A61K31/05 , A61K31/14
CPC分类号： A61K31/56 , A61K9/0019 , A61K9/10 , A61K31/05 , A61K31/74 , A61K45/06 , A61K47/10 , A61K47/12 , A61K47/186 , A61K47/26 , A61K47/34 , A61K2300/00
摘要： The present invention provides aqueous pharmaceutical compositions containing a lipophilic therapeutic agent. In particular, the invention provides aqueous pharmaceutical compositions containing the compound 2,6-diisopropylphenol (propofol). Preferred compositions of the invention contain propofol in the presence of at least one block copolymer (for example, P188 or another poloxamer) and a polyethylene glycol (PEG). Compositions of the invention are preferably sterile or are readily sterilized (e.g., by autoclaving) and are suitable for parenteral administration to any animal, including humans. The compositions are also chemically and physically stable over a wide range of environmental conditions and for extended periods of time.
摘要翻译：本发明提供含有亲脂性治疗剂的含水药物组合物。特别地，本发明提供含有化合物2,6-二异丙基苯酚（丙泊酚）的含水药物组合物。在至少一种嵌段共聚物（例如P188或其他泊洛沙姆）和聚乙二醇（PEG）的存在下，本发明的优选组合物含有异丙酚。本发明的组合物优选是无菌的或容易灭菌（例如通过高压灭菌），并且适用于对包括人在内的任何动物肠胃外给药。组合物在宽范围的环境条件下和长时间内也是化学和物理稳定的。

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