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81. 发明申请

US20090215117A1 Site specific incorporation of keto amino acids into proteins 有权
公开(公告)号：US20090215117A1
公开(公告)日：2009-08-27
申请号：US12228146
申请日：2008-08-07
申请人： Peter G. Schultz , Lei Wang
发明人： Peter G. Schultz , Lei Wang
IPC分类号： C12P21/00
CPC分类号： C12N15/67 , C12N9/93 , C12N15/10 , C12P21/005
摘要： Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate keto amino acids into proteins are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with keto amino acids using these orthogonal pairs.

82. 发明申请

US20090116427A1 ADVANCED TECHNOLOGY FRAME STRUCTURE WITH BACKWARD COMPATIBILITY 有权
标题翻译：具有后向兼容性的高级技术框架结构
公开(公告)号：US20090116427A1
公开(公告)日：2009-05-07
申请号：US12265435
申请日：2008-11-05
申请人： Roger Marks , Lei Wang , Yair Bourlas , Srikanth Gummadi , Kenneth Stanwood , Ron Porat
发明人： Roger Marks , Lei Wang , Yair Bourlas , Srikanth Gummadi , Kenneth Stanwood , Ron Porat
IPC分类号： H04W40/00
CPC分类号： H04W72/0453 , H04L5/0007 , H04L5/14 , H04W16/14 , H04W72/04 , H04W72/0446
摘要： An advanced technology frame structure is described herein. The advanced technology frame structure can enhance a first technology frame structure in dimensions of time, frequency, or a combination of time and frequency. A second technology frame structure time division multiplexes second technology subframes with the first technology downlink and uplink subframes. The first technology downlink subframe can be divided into a first technology downlink subframe and one or more second technology downlink subframes. Similarly, the first technology uplink subframe can be divided into a first uplink subframe and one or more second technology uplink subframes. These principles can be expanded upon and can be applied in many communication systems.
摘要翻译：这里描述了一种先进的技术框架结构。先进的技术框架结构可以在时间，频率或时间和频率的组合方面增强第一技术框架结构。第二技术帧结构时分复用第二技术子帧与第一技术下行链路和上行链路子帧。第一技术下行链路子帧可以被划分为第一技术下行链路子帧和一个或多个第二技术下行链路子帧。类似地，第一技术上行链路子帧可以被划分为第一上行链路子帧和一个或多个第二技术上行链路子帧。这些原则可以扩展并且可以应用于许多通信系统。

83. 发明授权

US07493688B1 Method of manufacturing a magnetic recording transducer 失效
标题翻译：制造磁记录传感器的方法
公开(公告)号：US07493688B1
公开(公告)日：2009-02-24
申请号：US11352536
申请日：2006-02-13
申请人： Lei Wang , Liping Ren , Yingjian Chen , Christopher T. Ngo , Ming Zhao
发明人： Lei Wang , Liping Ren , Yingjian Chen , Christopher T. Ngo , Ming Zhao
IPC分类号： G11B5/127 , H04R31/00
CPC分类号： G11B5/3163 , G11B5/3116 , Y10T29/49041 , Y10T29/49043 , Y10T29/49046 , Y10T29/49048 , Y10T29/49052
摘要： A method for providing a magnetic recording transducer is disclosed. The method includes providing a first pole having front and rear portions and a back gap on the rear portion. The method also includes providing an insulator on the first pole. The method includes providing a write gap and providing a portion of a second pole on at least the write gap. A portion of the write gap resides on the front portion of the first pole. A portion of the insulator covers a portion of the first pole between the portion of the second pole and the back gap. The method also includes providing a mask that covers the back gap and exposes the portion of the second pole and the insulator. The method also includes performing a pole trim that can substantially remove the portion of the insulator covering the remaining portion of the first pole.
摘要翻译：公开了一种用于提供磁记录换能器的方法。该方法包括提供具有前部和后部的第一极和后部上的后部间隙。该方法还包括在第一极上提供绝缘体。所述方法包括提供写入间隙并且在至少所述写入间隙上提供第二极点的一部分。写入间隙的一部分位于第一极的前部。绝缘体的一部分覆盖第二极的部分和后间隙之间的第一极的一部分。该方法还包括提供覆盖后隙并且暴露第二极和绝缘体的部分的掩模。该方法还包括执行极性修剪，其可以基本上去除覆盖第一极的剩余部分的绝缘体的部分。

84. 发明申请

US20090030293A1 SENSING DEVICE, APPARATUS AND SYSTEM, AND METHOD FOR OPERATING THE SAME 审中-公开
标题翻译：传感装置，装置和系统及其操作方法
公开(公告)号：US20090030293A1
公开(公告)日：2009-01-29
申请号：US11815841
申请日：2006-02-10
申请人： Jonathan Mark Cooper , David Robert Sime Cumming , Nicholas Wood , Lei Wang
发明人： Jonathan Mark Cooper , David Robert Sime Cumming , Nicholas Wood , Lei Wang
IPC分类号： A61B5/07 , A61B5/055 , H04L5/16 , A61B5/1455
CPC分类号： A61B1/041 , A61B1/00016 , A61B1/00036 , A61B5/0028 , A61B5/0031 , A61B5/14539 , A61B5/447 , A61B2560/0209 , A61B2560/0271
摘要： A sensing device, apparatus and system, and method for operating the same are provided. The sensing apparatus includes a first module and a second module. The first module includes a controller, a transmitter and an array of sensor elements. The controller is capable of activating one or more sensor elements in the array independently of others in the array, in order to obtain a sensor output from the array at different times by using different sensor elements in said array. The transmitter is configured to transmit sensor data derived from the sensor output from the first module to a receiver of the second module. Each sensor element is a biological sensor for detecting the presence of the same analyte in the environment in which the sensor array is to be deployed.
摘要翻译：提供了一种感测装置，装置和系统及其操作方法。感测装置包括第一模块和第二模块。第一模块包括控制器，发射器和传感器元件阵列。控制器能够独立于阵列中的其他阵列激活阵列中的一个或多个传感器元件，以便通过在所述阵列中使用不同的传感器元件在不同时间从阵列获得传感器输出。发射器被配置为将从第一模块的传感器输出得到的传感器数据传送到第二模块的接收器。每个传感器元件是用于检测传感器阵列将要部署的环境中相同分析物的存在的生物传感器。

85. 发明申请

US20080261311A1 In vivo incorporation of unnatural amino acids 有权
公开(公告)号：US20080261311A1
公开(公告)日：2008-10-23
申请号：US11978108
申请日：2007-10-26
申请人： Peter Schultz , Lei Wang , John Christopher Anderson , Jason William Chin , David R. Liu , Thomas J. Magliery , Eric L. Meggers , Ryan A. Mehl , Miro Pastrnak , Stephen William Santoro , Zhiwen Zhang
发明人： Peter Schultz , Lei Wang , John Christopher Anderson , Jason William Chin , David R. Liu , Thomas J. Magliery , Eric L. Meggers , Ryan A. Mehl , Miro Pastrnak , Stephen William Santoro , Zhiwen Zhang
IPC分类号： C12N15/63 , C12N15/87 , C12N15/82 , C07K7/00 , C07K14/00
CPC分类号： C12P21/00 , C07K14/00 , C07K14/505 , C12N9/93 , C12N15/67 , C12P13/00 , C12P13/005 , C12P13/04 , C12P13/22 , C12P19/26 , C12P21/02
摘要： The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.

86. 发明申请

US20080254540A1 METHODS OF GENETICALLY ENCODING UNNATURAL AMINO ACIDS IN EUKARYOTIC CELLS USING ORTHOGONAL tRNA/SYNTHETASE PAIRS 失效
标题翻译：使用正交tRNA /合成酶对真核细胞进行遗传性氨基酸的编码方法
公开(公告)号：US20080254540A1
公开(公告)日：2008-10-16
申请号：US12098395
申请日：2008-04-04
申请人： Lei Wang
发明人： Lei Wang
IPC分类号： C12N15/06 , C12N15/04 , C12N15/00 , C12N5/00 , C12N1/00
CPC分类号： C12N15/67 , C12N15/1086
摘要： This disclosure concerns compositions and methods for genetically encoding and expressing prokaryotic tRNAs in eukaryotic cells. In some embodiments, the disclosure concerns methods and compositions for expressing unnatural amino acids in eukaryotic cells using orthogonal tRNA/synthetase pairs. In certain embodiments, the methods involve expressing prokaryotic tRNA/synthetase pairs in eukaryotic cells, for instance mammalian cells or yeast cells (such as those that are NMD-deficient), under the control of a pol III promoter, for instance a type-3 pol III promoter or an internal leader promoter. Also provided are cell lines that are NMD-deficient and methods of increasing the efficiency of UAA incorporation in a cell that include de-activating the NMD pathway in the cell. Also provided are methods increasing the efficiency of incorporation of an unnatural amino acid in a cell by disrupting a Nonsense-Mediated mRNA Decay—(NMD) pathway in the cell.
摘要翻译：本公开涉及用于在真核细胞中遗传编码和表达原核生物tRNA的组合物和方法。在一些实施方案中，本公开涉及使用正交的tRNA /合成酶对在真核细胞中表达非天然氨基酸的方法和组合物。在某些实施方案中，所述方法包括在pol III启动子的控制下，在真核细胞中表达原核生物tRNA /合成酶对，例如哺乳动物细胞或酵母细胞（例如NMD缺陷的那些），例如3型 pol III启动子或内部前导启动子。还提供了NMD缺陷的细胞系和提高UAA并入细胞中包括去激活细胞中的NMD途径的效率的方法。还提供了通过破坏细胞中的无义介导的mRNA衰变（NMD）途径来增加非天然氨基酸掺入细胞的效率的方法。

87. 发明申请

US20080220787A1 Channel Aggregation 有权
标题翻译：频道聚合
公开(公告)号：US20080220787A1
公开(公告)日：2008-09-11
申请号：US11683274
申请日：2007-03-07
申请人： Kenneth L. Stanwood , Ramon Khalona , Lei Wang , Yair Bourlas , Gene W. Marsh , Robert P. Gilmore , Ron Porat , Paul W. Piggin
发明人： Kenneth L. Stanwood , Ramon Khalona , Lei Wang , Yair Bourlas , Gene W. Marsh , Robert P. Gilmore , Ron Porat , Paul W. Piggin
IPC分类号： H04Q7/20 , H04M1/00
CPC分类号： H04L5/06 , H04B7/02 , H04L5/0003 , H04L5/0007 , H04L5/0016 , H04W72/04 , H04W72/12
摘要： Multiple channels are aggregated. In an example embodiment, first data is transmitted on a first channel to a wireless device, and second data is simultaneously transmitted on a second channel to the wireless device. The first data and the second data are transmitted in a coordinated manner by aggregating the first channel and the second channel. Various example channel characteristics and combinations thereof are described. Different data allocation options for aggregated channels are described. Other alternative implementations are also presented herein.
摘要翻译：多个频道被聚合。在示例实施例中，第一数据在第一信道上发送到无线设备，并且第二数据在第二信道上同时发送到无线设备。通过聚合第一信道和第二信道以协调的方式发送第一数据和第二数据。描述各种示例信道特性及其组合。描述了聚合通道的不同数据分配选项。本文还介绍了其他替代实施方式。

88. 发明申请

US20080176284A1 Site specific incorporation of keto amino acids into proteins 有权
公开(公告)号：US20080176284A1
公开(公告)日：2008-07-24
申请号：US11978160
申请日：2007-10-26
申请人： Peter G. Schultz , Lei Wang
发明人： Peter G. Schultz , Lei Wang
IPC分类号： C12P21/02
CPC分类号： C12N15/67 , C12N9/93 , C12N15/10 , C12P21/005
摘要： Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate keto amino acids into proteins are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with keto amino acids using these orthogonal pairs.

89. 发明申请

US20080167243A1 In vivo incorporation of unnatural amino acids 有权
公开(公告)号：US20080167243A1
公开(公告)日：2008-07-10
申请号：US11978188
申请日：2007-10-26
申请人： Peter Schultz , Lei Wang , John Christopher Anderson , Jason William Chin , David R. Liu , Thomas J. Magliery , Eric L. Meggers , Ryan Aaron Mehl , Miro Pastrnak , Stephen William Santoro , Zhiwen Zhang
发明人： Peter Schultz , Lei Wang , John Christopher Anderson , Jason William Chin , David R. Liu , Thomas J. Magliery , Eric L. Meggers , Ryan Aaron Mehl , Miro Pastrnak , Stephen William Santoro , Zhiwen Zhang
IPC分类号： A61K38/00
CPC分类号： C12P21/00 , C07K14/00 , C07K14/505 , C12N9/93 , C12N15/67 , C12P13/00 , C12P13/005 , C12P13/04 , C12P13/22 , C12P19/26 , C12P21/02
摘要： The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.

90. 发明授权

US07393923B2 Red-shifted fluorescent proteins mPlum and mRaspberry and polynucleotides encoding the same 有权
标题翻译：红移荧光蛋白mPlum和mRaspberry以及编码相同的多核苷酸
公开(公告)号：US07393923B2
公开(公告)日：2008-07-01
申请号：US10984694
申请日：2004-11-08
申请人： Roger Y. Tsien , Lei Wang
发明人： Roger Y. Tsien , Lei Wang
IPC分类号： C07K14/00 , C07H21/04 , C12N15/00
CPC分类号： C12P21/02
摘要： Methods using somatic hypermutation (SHM) for producing polypeptide and nucleic acid variants, and nucleic acids encoding such polypeptide variants are disclosed. Such variants may have desired properties. Also disclosed are novel polypeptides, such as improved fluorescent proteins, produced by the novel methods, and nucleic acids, vectors, and host cells comprising such vectors.
摘要翻译：公开了使用体细胞超突变（SHM）用于产生多肽和核酸变体的方法，以及编码这种多肽变体的核酸。这样的变体可以具有期望的性质。还公开了通过新方法产生的新型多肽，例如改良的荧光蛋白，以及包含这种载体的核酸，载体和宿主细胞。

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