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81. 发明申请

US20070129712A1 Benign prostate hyperplasia treatment using photosensitizer and laser ablation 审中-公开
标题翻译：良性前列腺增生治疗使用光敏剂和激光消融
公开(公告)号：US20070129712A1
公开(公告)日：2007-06-07
申请号：US11598401
申请日：2006-11-13
申请人： Wolfgang Neuberger
发明人： Wolfgang Neuberger
IPC分类号： A61B18/18 , A61N5/06
CPC分类号： A61B18/24 , A61B2017/00274 , A61B2018/00547 , A61B2018/2272 , A61K9/0034 , A61K9/127 , A61K41/0071 , A61N5/0601 , A61N5/062 , A61N2005/061
摘要： A method and apparatus are disclosed to employ a combination of laser ablation/coagulation and photosensitizers (PS) to treat benign prostate hyperplasia (BPH). According to this method a photosensitizer is administered locally to the prostate zone, which is to be treated, using a suitable device to ensure an adequately uniform distribution of the photosensitizer in the hyperplasic prostate tissue to be treated. In one embodiment enlarged prostate tissue is laser irradiated using an optical fiber inserted through an endoscope to ablate and coagulate tissue nearby and to activate the photosensitizer to destroy tissue deeper into the prostate. In another embodiment a suitable laser wavelength is used to photoactivate the photosensitizer in the presensitized prostate tissue to enhance ablation, photo-coagulation and destruction of diseased prostate tissues. Additional wavelengths may be employed that would target different areas of the prostate. Generally laser ablation is done in pulsed or continuous irradiations where the photosensitizer can be activated before, during, or after this radiation. Multiple wavelength laser sources can also be used to achieve laser ablation, photo-coagulation and absorption by the photosensitizer. The photosensitizer used in the invention may be formulated in a liposomal or other drug carrier system to achieve an enhanced effect of the drug.
摘要翻译：公开了采用激光烧蚀/凝固和光敏剂（PS）的组合来治疗良性前列腺增生（BPH）的方法和装置。根据该方法，使用合适的装置将光敏剂局部施用于待治疗的前列腺区域，以确保光敏剂在待治疗的增生性前列腺组织中的均匀分布。在一个实施方案中，使用插入通过内窥镜的光纤激光照射放大的前列腺组织以消融和凝结附近的组织并激活光敏剂以将组织深入到前列腺中。在另一个实施方案中，使用合适的激光波长来光敏化未化学前列腺组织中的光敏剂，以增强患病前列腺组织的消融，光凝和破坏。可以采用靶向前列腺的不同区域的附加波长。通常在脉冲或连续照射下进行激光烧蚀，其中光敏剂可以在该辐射之前，期间或之后被激活。多波长激光源也可用于实现光敏剂的激光烧蚀，光凝和吸收。本发明中使用的光敏剂可以配制在脂质体或其它药物载体体系中以实现药物的增强作用。

82. 发明申请

US20060217692A1 Power regulated medical underskin irradiation treatment system for manual movement 有权
公开(公告)号：US20060217692A1
公开(公告)日：2006-09-28
申请号：US11443143
申请日：2006-05-30
申请人： Wolfgang Neuberger
发明人： Wolfgang Neuberger
IPC分类号： A61B18/18
CPC分类号： A61B18/24 , A61B18/20 , A61B2017/00075 , A61B2018/00196 , A61B2018/00636
摘要： A system and method for controllably releasing radiation in percutaneous radiation treatment is provided. In a preferred embodiment, a laser is coupled to an optical fiber that is inserted below the skin or into a vascular lumen to a predetermined point. The fiber is connected to a source of electromagnetic radiation such as a laser, non-coherent radiation source, high power laser diode, LED, and an ultrasonic source. Radiation is then delivered to the treatment site while the fiber is simultaneously drawn out to the entry point. The fiber is manually withdrawn and during this time the radiation is administered in a manner appropriate for the vein being treating in regards to power or energy level. To maintain a constant proper energy density, the speed of withdrawal is measured and sent to a controlling mechanism. The controlling mechanism modifies the power emitted, pulse length or pulse rate to ensure that the vein or tissue receives a consistent dose of energy during manual withdrawal. In one preferred embodiment, an imaging device provides the controlling device with position and time information so that speed information from fiber or catheter surface textural properties or based on one or more bar code like markings. In another preferred embodiment, additional information is collected, such as vein diameter prior to treatment, position of the distal end of the fiber, and/or impact measurements such as vibration or temperature during treatment, and the controlling mechanism adjusts output power or pulse rate in response to measurements to maintain a desired power density at all position during the manual withdrawal.

83. 发明授权

US07005623B2 Autocalibrating medical diode laser system 失效
标题翻译：自动校准医用二极管激光系统
公开(公告)号：US07005623B2
公开(公告)日：2006-02-28
申请号：US10438513
申请日：2003-05-15
申请人： Wolfgang Neuberger , Stefan Spaniol
发明人： Wolfgang Neuberger , Stefan Spaniol
IPC分类号： G01J1/32
CPC分类号： G01J1/08 , G01J1/04 , G01J1/0425 , G01J1/0474 , G01J1/32 , G01J1/42 , G01J2001/4247
摘要： Briefly stated, the present invention discloses a novel device that automatically calibrates and adjusts the intensity, dosage, and other parameters of a radiation delivery system and radiation source based on selected or detected radiation delivery systems. Such radiation delivery systems include optical fiber systems, and any type of diffuser, as well as bare fiber tips. The functions of a radiation source and a calibration device are combined by storing the characteristics of a wide variety of delivery system types and brands and calibrating the radiation based on those stored characteristics. In a preferred embodiment, a calibration sheath is provided that fits over a delivery system, such as a bare fiber tip or a diffuser at the distal end of a fiber, to both protect the system during calibration and direct output radiation to a detector. In another embodiment, one or more detectors are situated on the interior surface of the calibration sheath to directly measure at least a preselected portion of the emitted radiation. Power readings are directed to a calibration subsystem from the detector or detectors, which then adjusts the emitted power to conform to desired treatment parameters. The need for different calibration devices based on the characteristics of the delivery system is alleviated.
摘要翻译：简而言之，本发明公开了一种基于选定或检测的辐射传播系统自动校准和调整辐射传播系统和辐射源的强度，剂量和其它参数的新型装置。这种辐射递送系统包括光纤系统和任何类型的扩散器以及裸光纤尖端。辐射源和校准装置的功能通过存储各种传送系统类型和品牌的特性并基于这些存储的特性来校准辐射来组合。在优选实施例中，提供了一种校准护套，其配合在诸如光纤末端处的裸光纤尖端或扩散器之类的传送系统上，以在校准期间保护系统并且将直接输出辐射传输到检测器。在另一个实施例中，一个或多个检测器位于校准护套的内表面上，以直接测量所发射的辐射的至少预选部分。功率读数从检测器或检测器引导到校准子系统，然后检测器或检测器调整发射功率以符合所需的治疗参数。基于输送系统的特性对不同校准装置的需求得到缓解。

84. 发明授权

US06984229B2 Device and method for minimizing restenosis after angioplasty treatment 失效
公开(公告)号：US06984229B2
公开(公告)日：2006-01-10
申请号：US10103234
申请日：2002-03-21
申请人： Wolfgang Neuberger
发明人： Wolfgang Neuberger
IPC分类号： A61B18/18
CPC分类号： A61N5/062 , A61B18/245 , A61B2017/22002 , A61B2018/2261 , A61N5/0601
摘要： A novel device and method for preventing restenosis and streamlining the angioplasty procedure. The device and method provide a fiberoptic guidewire, or, alternatively, a light-conducting catheter, to decrease the size of the angioplasty device, decrease the overall time of the procedure, and increase the safety of the procedure. The present invention delivers radiation to a sclerotized area after balloon angioplasty treatment to prevent restenosis Radiation delivered via the catheter or fiberoptic guidewire discourages the cell proliferation and cell growth after angioplasty, thereby improving the chances of avoiding restenosis.

85. 发明授权

US06975791B2 Fiber laser pumping device 失效
标题翻译：光纤激光泵送装置
公开(公告)号：US06975791B2
公开(公告)日：2005-12-13
申请号：US10202990
申请日：2002-07-25
申请人： Wolfgang Neuberger
发明人： Wolfgang Neuberger
IPC分类号： G02B6/42 , H01S3/067 , H01S3/094 , H01S3/0941 , G02B6/26 , H01S3/091 , H04B10/12
CPC分类号： H01S3/094003 , G02B6/429 , H01S3/067 , H01S3/094015 , H01S3/094019 , H01S3/0941
摘要： An improved device and method to pump fiber lasers in order to enhance performance and reliability is provided. A fiber laser is bent into a coil having a moderate curvature so as to avoid radiation losses. A cladding is partly polished to produce coupling surfaces along the length of the spring-like coil. Radiation emitters are imaged with one or more micro lenses that are attached to the coupling surface. In a preferred embodiment, banks of high power laser diodes are utilized as pump sources. Coupling surfaces are preferably created along the length of the fiber at intervals where pump radiation from the previous pump edge has been absorbed. Although the system may be used to pump single mode fibers, the preferred application is to pump multimode fibers, having greater core diameters and higher luminescent capacity, wherein only a single cladding can be used. When a core dopant is included that can convert infrared to visible wavelengths, the device is particularly useful as a light source for homogeneously illuminated and partially illuminated fibers that diffuse light along their lengths.
摘要翻译：提供了一种用于泵浦光纤激光器以提高性能和可靠性的改进的装置和方法。光纤激光器弯曲成具有中等曲率的线圈，以避免辐射损失。部分抛光包层以产生沿弹簧状线圈的长度的耦合表面。辐射发射器用附接到耦合表面的一个或多个微透镜成像。在优选实施例中，使用大功率激光二极管组作为泵浦源。优选地，沿着纤维的长度以间隔从先前的泵边缘的泵浦辐射被吸收的间隔来创建耦合表面。虽然该系统可以用于泵送单模光纤，但是优选的应用是泵浦多模光纤，具有更大的芯径和更高的发光容量，其中仅可以使用单个包层。当包括可以将红外线转换成可见波长的核掺杂剂时，该器件特别可用作用于均匀照明和部分照射的纤维的光源，其沿着其长度扩散光。

86. 发明授权

US06951630B2 Method and substance for obtaining surfaces with antimicrobial properties 有权
标题翻译：用于获得具有抗菌性能的表面的方法和物质
公开(公告)号：US06951630B2
公开(公告)日：2005-10-04
申请号：US09931265
申请日：2001-08-16
申请人： Wolfgang Neuberger
发明人： Wolfgang Neuberger
IPC分类号： B65F1/00 , A01N25/04 , A01N25/06 , A01N25/18 , A61L2/08 , A61L2/16 , A61L2/00
CPC分类号： A61L2/088 , A61L2/16
摘要： The present invention involves the use of photosensitizers to provide antibacterial surfaces on consumer and industrial items. This approach avoids the used of chemicals and solutions that may be toxic. The inventions also avoids the use of chemical compositions that might form degradation products which may be unacceptable to healthy persons or irritating to persons who may have allergies or are otherwise sensitized. According to the invention, photosensitizers with specific properties and specific design features are selected to make practical use of photosensitizers in the consumer and industrial market place. It is important to select a photosensitizer with an activation spectrum that is matched to the environmental conditions under which the surface to be protected is required to exhibit its antimicrobial properties. This means that the illumination energy and intensity levels expected need to yield enough singlet oxygen to destroy the targeted microbes. It is also possible to select photosensitizers that are activated only by wavelengths prominently present in certain illumination lamps, such as those lamps commonly present in a laboratories, medical offices, pharmacies and food service areas, thereby making the surfaces antimicrobial only on demand when the illumination lamps are turned on.
摘要翻译：本发明涉及使用光敏剂以在消费品和工业物品上提供抗菌表面。这种方法避免使用可能有毒的化学品和溶液。本发明还避免使用可能形成降解产物的化学组合物，其可能对健康人不能接受或刺激可能具有过敏或其他敏化剂的人。根据本发明，选择具有特定性质和特定设计特征的光敏剂以在消费者和工业市场中实际使用光敏剂。选择具有与需要保护的表面需要展现其抗微生物性质的环境条件匹配的激活光谱的光敏剂是重要的。这意味着预期的照明能量和强度水平需要产生足够的单线态氧来破坏目标微生物。还可以选择仅由某些照明灯具中显着存在的波长激活的光敏剂，例如通常存在于实验室，医疗机构，药店和食品服务区域中的那些灯，从而使表面仅在照射灯已打开。

87. 发明申请

US20050024583A1 Laser safety contact lenses 失效
标题翻译：激光安全隐形眼镜
公开(公告)号：US20050024583A1
公开(公告)日：2005-02-03
申请号：US10628522
申请日：2003-07-28
申请人： Wolfgang Neuberger
发明人： Wolfgang Neuberger
IPC分类号： A61F9/02 , G02C7/04
CPC分类号： G02C7/021 , A61F9/022 , G02C7/04
摘要： Individually marked contact lenses for protection of one's eyes from harmful radiation are provided. Contact lenses are coated or treated to be absorptive or reflective to a preselected wavelength or wavelength range. The lenses are for protection and generally do not provide vision correction. Because different lenses may protect against different wavelengths and are thus suitable only for certain applications, and because it is desirable to be able to visually confirm that all those in vicinity of the radiation are wearing the proper lenses, the lenses contain one or more identification areas on each lens to demonstrate that the lenses are being worn and to indicate the proper applications with which the lenses should be used. The identification area, which should be visible when worn to third parties and/or the person wearing the lenses, consists of markings such as colored bands or shaded areas in the region around the iris. Different colors or color patterns indicate which wavelengths the lens protects against. Other safety features are contemplated, such as fluorescent markers, added features and devices to facilitate placement in the eye, pick-up or release and to prevent the lens from accidentally dropping out.
摘要翻译：提供单独标记的隐形眼镜，用于保护人眼免受有害辐射。隐形眼镜被涂覆或处理成吸收或反射到预选的波长或波长范围。镜片用于保护，一般不提供视力矫正。因为不同的透镜可以防止不同的波长，并且因此仅适用于某些应用，并且因为期望能够目视地确认辐射附近的所有那些都佩戴适当的透镜，所以透镜包含一个或多个识别区域在每个镜头上，以证明镜片被磨损，并指出应使用镜片的适当应用。当佩戴到第三方和/或戴着镜片的人员时，识别区域应该可见，包括虹膜周围区域的彩色条纹或阴影区域等标记。不同的颜色或颜色图案表示镜头防止哪些波长。可以考虑其他安全特征，例如荧光标记，附加特征和装置，以便于放置在眼睛中，拾取或释放并防止镜片意外脱落。

88. 发明授权

US06758844B2 System and method for oral treatments 失效
标题翻译：口服治疗的系统和方法
公开(公告)号：US06758844B2
公开(公告)日：2004-07-06
申请号：US10056130
申请日：2002-01-24
申请人： Wolfgang Neuberger
发明人： Wolfgang Neuberger
IPC分类号： A61B1822
CPC分类号： A61B18/20 , A61B2018/00029
摘要： A system and method is disclosed for improved treatment of oral tissues using 980 nm laser radiation and a handpiece with means for concurrently delivering the laser radiation and a liquid/gas spray onto the treatment area to improve the treatment effects. Unwanted heating and carbonization of surrounding tissues is reduced. The liquid/gas spray may be mixed inside the handpiece or in a separate device. The combination of cooling sprays with radiation wavelengths having high absorption in water has previously been avoided due to the thought that energy absorption by the cooling fluid would render the energy delivered to the tissue uncontrollable and of minimal benefit. Preferably, pulsed laser light provides a localized energy deposition and heating to avoid unwanted heating of underlying tissue. The liquid spray flushes away tissue debris in addition to cooling the treated tissue.
摘要翻译：公开了一种用于使用980nm激光辐射改善口腔组织治疗的系统和方法，以及具有用于同时递送激光辐射和液体/气体喷雾到处理区域以提高治疗效果的手段的手持件。周围组织的不需要的加热和碳化减少。液体/气体喷雾可以在机头内部或在单独的装置中混合。由于认为冷却流体的能量吸收将使能量传递给组织的能量不受控制并且具有最小的益处，所以先前已经避免了冷却喷雾与具有在水中的高吸收的辐射波长的组合。优选地，脉冲激光提供局部能量沉积和加热以避免下层组织的不期望的加热。除了冷却经处理的组织之外，液体喷雾还冲掉组织碎片。

89. 发明授权

US06660000B2 Device for application of radiation 有权
标题翻译：辐射装置
公开(公告)号：US06660000B2
公开(公告)日：2003-12-09
申请号：US10115662
申请日：2002-04-04
申请人： Wolfgang Neuberger , Michael Quade
发明人： Wolfgang Neuberger , Michael Quade
IPC分类号： A61B1818
CPC分类号： A61B18/203 , A61B2017/00199 , A61B2018/00452 , A61C19/004 , A61C19/066
摘要： A photonic scanning and delivery system capable of controllable transmission of light energy to an irregularly shaped treatment area are disclosed. The desired uniformity (controllability) of light energy application is ensured by a tracking device, which monitors the position of the radiation applicator and thereby prevents over- or under-radiation. The system employs a light energy delivery hand-piece. By these means, structures in the lower dermis are irradiated. Because of the large size of the treatment area, damage to surface tissue is avoided. The hand-piece can operate while in contact with the treatment surface. Treatment surfaces include non-medical work sites. Alternatively, the hand-piece can operate in a non-contact mode. The system can also be used in non-medical applications such as UV curing.
摘要翻译：公开了一种能够将光能可控地传输到不规则形状的处理区域的光子扫描和传送系统。通过跟踪装置确保光能施加的期望的均匀性（可控制性），跟踪装置监测辐射施加器的位置，从而防止辐射或辐射不足。该系统采用光能传递手段。通过这些方式，照射下层真皮中的结构。由于治疗面积大，避免了表面组织的损伤。手柄可以在与治疗表面接触的同时进行操作。治疗表面包括非医疗工作场所。或者，手持件可以以非接触模式操作。该系统也可用于非医疗应用，如紫外线固化。

90. 发明授权

US06485414B1 Color video diagnostic system for mini-endoscopes 有权
标题翻译：迷你内窥镜彩色视频诊断系统
公开(公告)号：US06485414B1
公开(公告)日：2002-11-26
申请号：US09525625
申请日：2000-03-14
申请人： Wolfgang Neuberger
发明人： Wolfgang Neuberger
IPC分类号： A61B107
CPC分类号： A61B1/05 , A61B1/063 , A61B1/0638 , A61B1/07
摘要： A color video diagnostic system for mini-endoscopes for viewing features of objects where access to the object is limited or where minimally invasive techniques are preferable, such as in medical or industrial applications. A black-and-white video chip mounted at the distal end of an endoscope body images an object sequentially illuminated by laser diode light sources having different wavelengths. More than one laser diode may be used within a color region to provide truer color representations. A controller controls the laser diode light sources for sequentially illuminating the object by color, and a video processor responsive to the controller receives signals from the black-and-white video chip for producing a color data signal. A display displays a color image of the object. At least one diagnostic laser diode light source, which can be tunable, may be included for enhancing selected features of the object being viewed, and it may emit in the visible, near infrared, or infrared wavelength regions. A beam-combining element can be included for combining the light beams from the laser diode light sources for provision to a fiber light transport element for transporting the light to illuminate the object.
摘要翻译：用于微型内窥镜的彩色视频诊断系统，用于观察对象的访问受限的物体的特征，或者在诸如医疗或工业应用中的最佳侵入技术中。安装在内窥镜主体的远端的黑白视频芯片对由具有不同波长的激光二极管光源顺序照射的物体进行成像。可以在颜色区域内使用多于一个的激光二极管，以提供更真实的颜色表示。控制器控制激光二极管光源以用颜色顺序照亮物体，并且响应于控制器的视频处理器接收来自黑白视频芯片的信号以产生彩色数据信号。显示器显示对象的彩色图像。可以包括至少一个可调谐的诊断激光二极管光源，用于增强被观察物体的选定特征，并且其可以在可见光，近红外或红外波长区域中发射。可以包括光束组合元件，用于组合来自激光二极管光源的光束用于提供用于传输光以照亮物体的光纤传输元件。

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