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81. 发明授权

US07018217B2 Structurally integrable electrode and associated assembly and fabrication method 有权
标题翻译：结构可积分电极及相关装配及制造方法
公开(公告)号：US07018217B2
公开(公告)日：2006-03-28
申请号：US10848655
申请日：2004-05-19
申请人： Joseph A. Marshall , David M. Anderson
发明人： Joseph A. Marshall , David M. Anderson
IPC分类号： H01R12/00 , H05K1/00
CPC分类号： B32B3/08 , B32B7/12 , B32B27/08 , B32B27/281 , B32B2250/24 , B32B2307/206 , B32B2457/00 , B64D43/00 , H05K3/10 , H05K3/28 , H05K2201/029
摘要： A structurally integrable electrode, an assembly with an integrated electrode, and an associated method are provided. The electrode is configured to provide an electrically conductive path between nodes of an electrical circuit of a structural member. In particular, the electrode includes at least one conductive tow having a core and a conductive coating thereon. Electrically conductive contacts are connected to the ends of the tow, and at least one dielectric ply extends parallel to the tow to at least partially insulate the tow. Thus, the first and second contacts can be connected to the nodes of the circuit, and the tow can be structurally integrated with the structural member so that the tow provides an electrically conductive path between the nodes.
摘要翻译：提供了结构可积分电极，具有集成电极的组件和相关联的方法。电极被配置为在结构构件的电路的节点之间提供导电路径。特别地，电极包括至少一个具有芯和其上的导电涂层的导电丝束。导电触点连接到丝束的端部，并且至少一个电介质层平行于丝束延伸以使丝束至少部分绝缘。因此，第一和第二触点可以连接到电路的节点，并且丝束可以在结构上与结构构件一体化，使得丝束在节点之间提供导电路径。

82. 发明授权

US06624344B1 Transformation of cotton plants 失效
标题翻译：棉花植物转化
公开(公告)号：US06624344B1
公开(公告)日：2003-09-23
申请号：US08480186
申请日：1995-06-07
申请人： Thirumale S. Rangan , David M. Anderson , Kanniah Rajasekaran , John W. Grula , Richard Lorne Hudspeth , Richard L. Yenofsky
发明人： Thirumale S. Rangan , David M. Anderson , Kanniah Rajasekaran , John W. Grula , Richard Lorne Hudspeth , Richard L. Yenofsky
IPC分类号： C12N1582
CPC分类号： A01H5/10 , A01H1/02 , A01H4/001 , A01H4/005 , A01H4/008 , C07K14/325 , C12N5/04 , C12N15/8205 , C12N15/8222 , C12N15/8223 , C12N15/8275 , C12N15/8286 , Y02A40/162
摘要： A method for producing transformed cotton plants. The method comprising providing cotton explants, incubating the cotton explant in the presence of a vector comprising a selectable marker to produce treated explants, growing the treated explants to produce callus and selecting transformed callus.
摘要翻译：一种生产转化棉花植物的方法。该方法包括提供棉花外植体，在包含选择性标记的载体存在下孵育棉花外植体以产生经处理的外植体，培养经处理的外植体以产生愈伤组织并选择转化的愈伤组织。

83. 发明授权

US06620990B1 Transformation of cotton plants 失效
公开(公告)号：US06620990B1
公开(公告)日：2003-09-16
申请号：US08122090
申请日：1993-09-14
申请人： Thirumale S. Rangan , David M. Anderson , Kanniah Rajasekaran , John W. Grula , Richard Lorne Hudspeth , Richard L. Yenofsky
发明人： Thirumale S. Rangan , David M. Anderson , Kanniah Rajasekaran , John W. Grula , Richard Lorne Hudspeth , Richard L. Yenofsky
IPC分类号： C12N1582
CPC分类号： A01H5/10 , A01H1/02 , A01H4/001 , A01H4/005 , A01H4/008 , C07K14/325 , C12N5/04 , C12N15/8205 , C12N15/8222 , C12N15/8223 , C12N15/8275 , C12N15/8286 , Y02A40/162
摘要： A method for producing transformed cotton plants. The method comprising providing cotton explants, incubating the cotton explant in the presence of a vector comprising a selectable marker to produce treated explants, growing the treated explants to produce callus and selecting transformed callus.

84. 发明授权

US06428512B1 Guidewire with improved lesion measurement 有权
标题翻译：导丝具有改善的病变测量
公开(公告)号：US06428512B1
公开(公告)日：2002-08-06
申请号：US09686143
申请日：2000-10-10
申请人： David M. Anderson , Mark T. Richardson , Gina Eileen Stephens
发明人： David M. Anderson , Mark T. Richardson , Gina Eileen Stephens
IPC分类号： A61M2500
CPC分类号： A61M25/09 , A61M2025/0008 , A61M2025/09083 , A61M2025/09166
摘要： A guidewire having an elongated core having a radiopaque marker on a distal portion of the core and a plurality of indicia on the proximal extremity of the core to facilitate measurement of an intracorporeal location such as a stenotic region within a patient's coronary artery. The guidewire is first positioned within the patient with the distal radiopaque marker at one end of the intracorporeal location and an indicia representing a base reference point is noted on the proximal portion of the guidewire which extends out of the patient. The guidewire is then moved so that the distal radiopaque marker is located at or adjacent to the other end of the intracorporeal location and another indicia on the proximal portion of the guidewire adjacent to the reference point. The distance between the two indicia on the proximal extremity of the guidewire is a measurement of intracorporeal length.
摘要翻译：具有细长芯的导丝，其具有在芯的远侧部分上的不透射线的标记，以及在芯的近端上的多个标记，以便于测量体内位置，例如患者冠状动脉内的狭窄区域。首先将导丝线定位在患者体内，在体内位置的一端具有远端不透射线的标记，并且在延伸出患者的导丝的近端部分上注意到表示基准参考点的标记。导线然后被移动，使得远端不透射线的标记物位于或邻近体内位置的另一端，并且在引导线的邻近参考点的近端部分上的另一个标记。导线近端两个标记之间的距离是体内长度的测量。

85. 发明授权

US6146339A Guide wire with operator controllable tip stiffness 有权
标题翻译：导线，操作者可控尖端刚度
公开(公告)号：US6146339A
公开(公告)日：2000-11-14
申请号：US317574
申请日：1999-05-24
申请人： Emmanuel Biagtan , David M. Anderson
发明人： Emmanuel Biagtan , David M. Anderson
IPC分类号： A61B5/00 , A61M25/09
CPC分类号： A61M25/09 , A61M2025/09008 , A61M2025/09133 , A61M2025/0915 , A61M2025/09175
摘要： An improved method and apparatus for providing a readily insertable guide wire that is also accurately steerable. One embodiment of the present invention comprises one or more thin diameter, liquid filled, polymer balloons enclosed by the guide wire coils and connected through a hypotube lumen to a pressure transducer. The pressure transducer exerts pressure via a fluid medium to the balloon(s), which then expand and exert pressure onto the inner surface of the coils, thereby stiffening the distal section of the guide wire. In operation, the guide wire will typically be inserted with the balloons deflated, hence the distal tip is very flexible. Once the distal tip reaches its destination, the balloons are inflated and expanded to stiffen and/or reorient the distal tip to allow it to perform as required, typically by aiding in the positioning of a catheter or stent in the desired location.
摘要翻译：一种改进的方法和设备，用于提供也是可精确控制的易于插入的导丝。本发明的一个实施例包括由导丝线圈包围并通过海波管腔连接到压力传感器的一个或多个细直径的，液体填充的聚合物球。压力传感器通过流体介质将压力施加到球囊上，然后膨胀并施加压力到线圈的内表面上，从而加强导丝的远端部分。在操作中，导丝通常将气囊放气，因此远端尖端非常柔软。一旦远端顶端到达其目的地，气囊就被膨胀和膨胀以加强和/或重新定向远侧末端，以允许其根据需要执行，通常通过辅助将导管或支架定位在期望的位置。

86. 发明授权

US5551515A Hemicellulase active at extremes of Ph and temperature and utilizing the enzyme in oil wells 失效
标题翻译：半纤维素酶在极端的Ph和温度下活跃，并在油井中利用酶
公开(公告)号：US5551515A
公开(公告)日：1996-09-03
申请号：US450899
申请日：1995-05-26
申请人： Douglas W. Fodge , David M. Anderson , Thomas M. Pettey
发明人： Douglas W. Fodge , David M. Anderson , Thomas M. Pettey
IPC分类号： C09K8/90 , C12N1/21 , C12N9/24 , C12N9/00 , C12N9/42 , E21B43/267
CPC分类号： C09K8/905 , C12N9/2437 , C12N9/2488 , C12Y302/01025 , C12Y302/01078 , C12Y302/01101 , Y10S435/832 , Y10S435/835 , Y10S507/921 , Y10S507/922
摘要： Soil bacteria can be isolated which produce an enzyme capable of catalyzing the degradation of mannan-containing hemicellulose under conditions combining high pH and high temperature. Such bacteria can be cultured or used as sources of genetic information with which to engineer other microorganisms to produce the enzyme. Commercially useful quantities of native or recombinant hemicellulase can thus be produced by cultures consisting essentially of microorganisms capable of producing the enzyme.
摘要翻译：可以分离出能够在高pH和高温条件下结合的能够催化含甘露聚糖的半纤维素降解的酶的土壤细菌。这样的细菌可以被培养或用作遗传信息的来源，用于设计其他微生物以产生酶。因此，商业上有用量的天然或重组半纤维素酶可以由基本上由能够产生酶的微生物组成的培养物产生。

87. 发明授权

US5213972A Fermentation process for the production of pyrimidine deoxyribonucleosides 失效
标题翻译：用于生产吡咯烷酮脱氧核糖核酸酶的发酵方法
公开(公告)号：US5213972A
公开(公告)日：1993-05-25
申请号：US448158
申请日：1989-12-08
申请人： Russell J. McCandliss , David M. Anderson
发明人： Russell J. McCandliss , David M. Anderson
IPC分类号： C12N1/21 , C12N9/00 , C12N9/02 , C12N9/10 , C12N9/12 , C12N9/16 , C12N15/09 , C12P19/38 , C12R1/19
CPC分类号： C12N9/0004 , C12N9/00 , C12N9/10 , C12N9/12 , C12N9/16 , C12P19/385 , C12R1/19
摘要： DNA coding for at least one enzyme that causes the accumulation of a pyrimidine deoxyribonucleoside is used, in conjunction with metabolic mutations or heterologous DNA coding for metabolic enzymes that also increase pyrimidine deoxyribonucleoside production, to engineer cultured cells to express a pyrimidine deoxyribonucleoside (PdN) in recoverable quantities, providing a commercially useful fermentation source for PdNs.
摘要翻译：使用编码导致嘧啶脱氧核糖核苷的积累的至少一种酶的DNA，连同代谢突变或编码也增加嘧啶脱氧核糖核苷产生的代谢酶的异源DNA，以设计培养的细胞以在嘧啶脱氧核糖核苷（PdN）中表达嘧啶脱氧核糖核苷可回收量，为PdN提供商业上有用的发酵源。

88. 发明授权

US5202256A Bioadhesive precursor protein expression vectors 失效
标题翻译：生物粘附前体蛋白表达载体
公开(公告)号：US5202256A
公开(公告)日：1993-04-13
申请号：US745695
申请日：1991-08-16
申请人： Kathy J. Maugh , David M. Anderson , Robert Strausberg , Susan L. Strausberg , Russ McCandliss , Tena Wei , David Filpula
发明人： Kathy J. Maugh , David M. Anderson , Robert Strausberg , Susan L. Strausberg , Russ McCandliss , Tena Wei , David Filpula
IPC分类号： C07K14/435 , C09J189/00 , C12N1/21 , C12N9/16 , C12N9/64 , C12N15/12 , C12N15/71 , C12N15/81
CPC分类号： C12N9/6481 , C07K14/435 , C09J189/00 , C12N15/71 , C12N15/81 , C12N9/16
摘要： Vectors are provided that are capable of expressing, in microbial transformants, a protein having the native amino acid sequence of a bioadhesive precursor protein of a marine animal selected from the group consisting of mussels, barnacles, and oysters. The bioadhesive precursor protein can be expressed in transformants, recovered and converted to a bioadhesive protein by hydroxylation.
摘要翻译：提供能够在微生物转化体中表达具有选自贻贝，藤壶和牡蛎的海洋动物的生物粘附前体蛋白的天然氨基酸序列的蛋白质的载体。生物粘附前体蛋白可以在转化体中表达，回收并通过羟基化转化成生物粘附蛋白。

89. 发明授权

US5151353A Process of using bacteria that metabolize phenylacetate through mandelate 失效
标题翻译：使用通过扁桃酸代谢苯乙酸酯的细菌的过程
公开(公告)号：US5151353A
公开(公告)日：1992-09-29
申请号：US667661
申请日：1991-03-11
申请人： Steven D. Geusz , David M. Anderson
发明人： Steven D. Geusz , David M. Anderson
IPC分类号： C12N15/00 , C12P7/24
CPC分类号： C12N15/00 , C12P7/24 , Y10S435/877
摘要： Bacteria that metabolize phenylacetate along a mandelate-to-cis,cis-muconate pathway are disclosed. Bacteria that express the pathway for metabolizing phenylacetate through a mandelate intermediate can be isolated reproducibly by first selecting bacteria that can utilize both L-phenylalanine and mandelate as the sole carbon source and then blocking alternate pathways for the degradation of L-phenylalanine. The activity of selected enzymes along the mandelate-to-cis,cis-muconate pathway can be blocked in these bacteria to effect the accumulation of selected intermediates.
摘要翻译：公开了沿着扁桃酸酯 - 顺式，顺式 - 粘蛋白途径代谢苯乙酸酯的细菌。表达通过扁桃酸酯中间体代谢苯乙酸盐的途径的细菌可以通过首先选择可以利用L-苯丙氨酸和扁桃酸酯作为唯一碳源的细菌然后阻断用于降解L-苯丙氨酸的替代途径的方法来重复分离。沿着扁桃体对顺式，顺式 - 粘蛋白途径的选择的酶的活性可以在这些细菌中被阻断以影响所选择的中间体的积累。

90. 发明授权

US4798791A Vector for high level gene expression 失效
标题翻译：用于高水平基因表达的载体
公开(公告)号：US4798791A
公开(公告)日：1989-01-17
申请号：US671967
申请日：1984-11-16
申请人： David M. Anderson , Jeffrey C. McGuire
发明人： David M. Anderson , Jeffrey C. McGuire
IPC分类号： C12N15/09 , C12N1/20 , C12N9/52 , C12N9/64 , C12N15/71 , C12P21/02 , C12R1/19 , C12P21/00 , C12N5/00 , C12N7/00 , C12P19/34
CPC分类号： C12N9/6481 , C12N15/71
摘要： Methods and vectors for high level expression of genes in bacteria are disclosed. A terminal mRNA sequence from a gene coding for a stable bacterial protein mRNA is ligated to a gene coding for the desired protein adjacent the translation termination codon of the gene. The gene for the desired protein and the terminal mRNA sequence are situated in an expression vector in which the gene is operably linked to a transcription promoter.
摘要翻译：公开了在细菌中高水平表达基因的方法和载体。从编码稳定的细菌蛋白质mRNA的基因的末端mRNA序列连接到编码与该基因的翻译终止密码子相邻的所需蛋白质的基因。所需蛋白质的基因和末端mRNA序列位于表达载体中，其中该基因与转录启动子可操作地连接。

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