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81. 发明申请

US20090131263A1 Normalization methods for G-protein coupled receptor membrane array 审中-公开
标题翻译： G蛋白偶联受体膜阵列的归一化方法
公开(公告)号：US20090131263A1
公开(公告)日：2009-05-21
申请号：US11985990
申请日：2007-11-19
申请人： Longying Dong , Yulong Hong , Joydeep Lahiri , Fang Lai , Li Liu , Jeffrey G. Lynn
发明人： Longying Dong , Yulong Hong , Joydeep Lahiri , Fang Lai , Li Liu , Jeffrey G. Lynn
IPC分类号： C40B20/04 , C40B40/10 , C40B50/14
CPC分类号： G01N33/554 , G01N2333/726 , G01N2500/10
摘要： Reference membrane components are either pre-labeled or labeled during assays for purposes of normalizing signals associated with binding or functional assays employing G-protein coupled receptor microarrays. A reference component may be included in a membrane in which the target GPCR is embedded or may be present in another membrane printed in conjunction with the target membrane on a microspot. Or, a GPCR microarray may be pre-labeled by incorporating a label on an exposed substrate in a defect in the printed microspot.
摘要翻译：参考膜组分在测定期间被预标记或标记，目的是使与G-蛋白偶联受体微阵列的结合或功能测定相关的信号归一化。参考组分可以包括在其中嵌入目标GPCR的膜中，或者可以存在于与微孔上的靶膜结合印刷的另一膜中。或者，GPCR微阵列可以通过在印刷的微点的缺陷中的暴露的基底上并入标签来进行预标记。

82. 发明申请

US20090064120A1 Method and apparatus to achieve maximum outer level parallelism of a loop 有权
标题翻译：实现环路最大外层平行度的方法和装置
公开(公告)号：US20090064120A1
公开(公告)日：2009-03-05
申请号：US11897468
申请日：2007-08-30
申请人： Li Liu , Buqi Cheng , Gansha Wu
发明人： Li Liu , Buqi Cheng , Gansha Wu
IPC分类号： G06F9/45
CPC分类号： G06F8/452
摘要： In one embodiment, the present invention includes a method for constructing a data dependency graph (DDG) for a loop to be transformed, performing statement shifting to transform the loop into a first transformed loop according to at least one of first and second algorithms, performing unimodular and echelon transformations of a selected one of the first or second transformed loops, partitioning the selected transformed loop to obtain maximum outer level parallelism (MOLP), and partitioning the selected transformed loop into multiple sub-loops. Other embodiments are described and claimed.
摘要翻译：在一个实施例中，本发明包括一种用于构造要变换的循环的数据依赖图（DDG）的方法，执行语句移位以根据第一和第二算法中的至少一个将循环变换为第一变换循环，执行对所选择的第一或第二变换循环中的一个进行单模和梯形变换，分割所选择的变换循环以获得最大外部水平并行度（MOLP），以及将所选择的变换循环分割成多个子循环。描述和要求保护其他实施例。

83. 发明申请

US20090042871A1 Tricyclic Delta-Opioid Modulators 失效
标题翻译：三环三角洲阿片样物质调节剂
公开(公告)号：US20090042871A1
公开(公告)日：2009-02-12
申请号：US12248150
申请日：2008-10-09
申请人： Steven J. Coats , Scott L. Dax , Bart DeCorte , Li Liu , Mark McDonnell , James J. McNally
发明人： Steven J. Coats , Scott L. Dax , Bart DeCorte , Li Liu , Mark McDonnell , James J. McNally
IPC分类号： A61K31/5415 , C07D471/08 , A61P25/00 , A61K31/538
CPC分类号： C07D451/04
摘要： The invention is directed to delta opioid receptor modulators. More specifically, the invention relates to tricyclic δ-opioid modulators. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described.
摘要翻译：本发明涉及Δ阿片样物质受体调节剂。更具体地，本发明涉及三环类阿片样物质调节剂。还描述了使用本发明的化合物治疗轻度至重度疼痛和各种疾病的药物和兽医组合物和方法。

84. 发明授权

US07432257B2 Piperdinyl-phenoxazine and phenothiazine derivatives as δ-opioid modulators 失效
标题翻译：哌嗪基 - 吩恶嗪和吩噻嗪衍生物作为δ-阿片样物质调节剂
公开(公告)号：US07432257B2
公开(公告)日：2008-10-07
申请号：US11326084
申请日：2006-01-05
申请人： Steve J. Coats , Scott L. Dax , Bart DeCorte , Li Liu , Mark McDonnell , James J. McNally
发明人： Steve J. Coats , Scott L. Dax , Bart DeCorte , Li Liu , Mark McDonnell , James J. McNally
IPC分类号： A61K31/535 , A61K31/54 , C07D265/38 , C07D417/00
CPC分类号： C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： The invention is directed to delta opioid receptor modulators. More specifically, the invention relates to tricyclic δ-opioid modulators. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described.
摘要翻译：本发明涉及Δ阿片样物质受体调节剂。更具体地，本发明涉及三环类阿片样物质调节剂。还描述了使用本发明的化合物治疗轻度至重度疼痛和各种疾病的药物和兽医组合物和方法。

85. 发明申请

US20080085871A1 Novel polysaccharide pro-drug 5-fluorouracil (5-FU) with enhanced target specificity for colorectal cancer and its preparation methods 审中-公开
公开(公告)号：US20080085871A1
公开(公告)日：2008-04-10
申请号：US11657753
申请日：2007-09-17
申请人： Joemy Tam , Qi Mei , Li Liu , Qing Wang
发明人： Joemy Tam , Qi Mei , Li Liu , Qing Wang
IPC分类号： A61K31/7072 , A61P35/00 , C07H1/00 , C07H19/06 , C07H3/00
CPC分类号： A61K31/716 , A61K47/61 , C08B37/0036 , C08B37/0045 , C08B37/0096
摘要： This invention describes a novel polysaccharide prodrug of 5-fluorouracil (5-FU) with enhanced target specificity for colorectal cancer treatment, and its preparation methods. The prodrug is synthesized by chemically linking anti-cancer drug 5-fluorouracil (5-FU) with a specially selected polysaccharide with molecular weight of 105˜107 Da containing galactose residues. Its distinctive characteristics are that it is a prodrug synthesized by chemically linking polysaccharides with 5-FU through different bridge links for the targeted treatment of colorectal cancer; that the polysaccharides in the chemical compound contain galactose residues; and that these polysaccharides are prepared from natural gums or plant materials. Due to these unique characteristics, as an oral preparation, the polysaccharide component of this novel prodrug can protect the active agent 5-FU from absorption (or metabolism) in the upper gastrointestinal tract and deliver a high concentration of the 5-FU to the colorectal area. Upon reaching the colorectal area, the 5-FU-galactose portion of the prodrug will bind to galectin-3, a-galactoside-binding protein implicated in tumor progression by interactions with its ligands, such as TF (Thomsen-Friedenreich, Galb3GalNAc), Tn (GalNAcaThr/Ser), and Sialy-Tn with galactose residues, which are highly expressed among colorectal cancer cells. Finally, the active 5-FU component will be released locally from the polysaccharide via enzymatic hydrolysis from the local bacterial flora, allowing it to actively kill the colorectal cancer cells. In summary, this novel target-specific prodrug can enhance the selectivity of 5-FU and increase its therapeutic effects in the treatment of colorectal cancer. In addition, with this enhanced target specificity, it is possible to maximize the 5-FU efficacy in cancer patients by having either less toxicity with the same or higher therapeutic dose, and/or administer a lower dosage (if so desired) to achieve the same therapeutic effects, but with much less toxicity. Multiple examples of various approaches to synthesize this novel prodrug are enclosed herein along with several animal model experiments to substantiate the claims as stated above.

86. 发明申请

US20070015207A1 Triazolopyrimidine derivatives 有权
标题翻译：三唑并嘧啶衍生物
公开(公告)号：US20070015207A1
公开(公告)日：2007-01-18
申请号：US11329642
申请日：2006-01-11
申请人： Donald Ludovici , Richard Connors , Steven Coats , Li Liu , Bart De Corte , Dana Johnson , Mark Schulz
发明人： Donald Ludovici , Richard Connors , Steven Coats , Li Liu , Bart De Corte , Dana Johnson , Mark Schulz
IPC分类号： G01N33/53 , C07H21/04 , C12P21/06 , C12N5/06 , C07D487/02 , C07K16/40 , C12N9/12
CPC分类号： C07K14/4738 , C07D487/04 , C12N9/1205 , C12Q1/485 , G01N2500/02
摘要： The invention relates to the discovery of triazolopyrimidine derivatives of formula (I), which have been found to exhibit inhibitory activity against the serine-tyrosine and tyrosine kinases.
摘要翻译：本发明涉及已发现对丝氨酸 - 酪氨酸和酪氨酸激酶具有抑制活性的式（I）三唑并嘧啶衍生物的发现。

87. 发明申请

US20060176977A1 Method and apparatus for use of space time trellis codes based on channel phase feedback 有权
标题翻译：基于信道相位反馈的空时格码编码方法和装置
公开(公告)号：US20060176977A1
公开(公告)日：2006-08-10
申请号：US11332019
申请日：2006-01-12
申请人： Hamid Jafarkhani , Li Liu
发明人： Hamid Jafarkhani , Li Liu
IPC分类号： H04L27/36 , H04L27/04 , H04L23/02
CPC分类号： H04B7/0626 , B63B35/03 , H04B7/0669 , H04L1/0026 , H04L1/006 , H04L1/0065 , H04L1/0662 , H04L1/0681 , H04L1/0693
摘要： A method for MIMO wireless communication comprises the steps of generating inner and outer codes based on channel state information available at a transmitter and concatenating different inner codes with different outer codes; and using the generated concatenated inner and outer codes for wireless communication. The inner and outer codes are based on channel phase information at the transmitter or channel feedback. High-performance trellis codes or block codes for use in cellular networks are illustratively described. The space-time trellis codes are generated by set partitioning on a plurality of classes of signal designs to generate a series of inner codes, each of the series of inner codes being optimized by channel phase feedback, and concatenating each inner code with a multiple trellis coded modulated outer code to provide a complete space-time trellis code as a cophase space-time trellis code.
摘要翻译：一种用于MIMO无线通信的方法包括以下步骤：基于在发射机处可用的信道状态信息产生内部和外部码，并且将不同的内部码与不同的外部码相连; 并使用生成的级联的内部和外部代码进行无线通信。内部和外部代码基于发射机或信道反馈的信道相位信息。说明性地描述了用于蜂窝网络中的高性能网格码或块码。时空网格码通过在多个信号设计类别上的集合划分来生成，以生成一系列内部码，每个内部码的一系列通过信道相位反馈进行优化，并且将每个内部码与多个网格连接起来编码调制外码，以提供完整的时空格码作为同相时空网格码。

88. 发明申请

US20060135522A1 Tricyclic delta-opioid modulators 审中-公开
公开(公告)号：US20060135522A1
公开(公告)日：2006-06-22
申请号：US11314300
申请日：2005-12-21
申请人： John Carson , Scott Dax , Bart DeCorte , Li Liu , Mark McDonnell , James McNally
发明人： John Carson , Scott Dax , Bart DeCorte , Li Liu , Mark McDonnell , James McNally
IPC分类号： A61K31/53 , A61K31/506 , A61K31/452 , C07D409/14 , C07D405/14
CPC分类号： C07D405/14 , C07D405/04 , C07D409/14 , C07D413/14
摘要： The invention is directed to delta opioid receptor modulators. More specifically, the invention relates to tricyclic δ-opioid modulators. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described.

89. 外观设计

USD496365S1 Coreless inductor magnetic strip simulacrum for right angle transaction acceptance systems 失效
标题翻译：用于直角交易验收系统的无芯电感磁条模拟
公开(公告)号：USD496365S1
公开(公告)日：2004-09-21
申请号：US29201574
申请日：2004-03-16
申请人： Li Liu , Theodore J. Colburn , Xu Zhang
设计人： Li Liu , Theodore J. Colburn , Xu Zhang

90. 发明授权

US06179889B2 Vacuum cleaner tank assembly 有权
标题翻译：真空吸尘器组件
公开(公告)号：US06179889B2
公开(公告)日：2001-01-30
申请号：US09348893
申请日：1999-07-07
申请人： Li Liu
发明人： Li Liu
IPC分类号： B01D4602
CPC分类号： A47L9/1427 , Y10S55/02 , Y10S55/03
摘要： A vacuum cleaner filter bag retainer includes slots on each side which receive a cardboard plate attached to a filter bag. The plate is slid into the slots of the filter bag retainer such that openings in the plate and bag match with an opening in the filter bag retainer. The retainer is attached to a tank through an opening in the tank, and an inlet fitting extends from outside the tank, through the retainer, and into the bag. The inlet fitting, therefore, prevents the bag from sliding out of the slots in the retainer. A swivel fitting loosely traps the inlet fitting adjacent the filter bag retainer through threads on the swivel fitting and the retainer. The inlet fitting also holds a hose to the inlet fitting.
摘要翻译：真空吸尘器过滤袋保持器包括在每一侧上的槽，其接收附接到过滤袋的纸板板。板被滑入过滤袋保持器的槽中，使得板和袋中的开口与过滤袋保持器中的开口相匹配。保持器通过罐中的开口附接到罐，并且入口配件从罐的外部延伸通过保持器并进入袋中。因此，入口配件防止袋从保持器中的槽中滑出。旋转接头通过旋转接头和保持器上的螺纹松动地将靠近过滤袋保持器的入口接头捕获。入口接头还将软管保持在入口接头上。

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