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81. 发明授权

US5759172A Balloon catheter with lobed balloon and method for manufacturing such a catheter 失效
标题翻译：气囊导管带有裂片气囊和制造这种导管的方法
公开(公告)号：US5759172A
公开(公告)日：1998-06-02
申请号：US629720
申请日：1996-04-09
申请人： Jan Weber , Johannes Gerardus Maria Van Muiden
发明人： Jan Weber , Johannes Gerardus Maria Van Muiden
IPC分类号： A61F2/958 , A61M25/00 , A61M29/02 , A61M29/00
CPC分类号： A61M25/1029 , A61M25/1002 , A61M25/1038 , A61M2025/1072 , A61M25/0043 , A61M25/104
摘要： The invention relates to a catheter comprising a tube-like basic body with a proximal and a distal end and an expandable balloon member arranged close to the distal end to the basic body. The balloon member comprises a number of relatively stiff sections extending on a small diameter in a longitudinal direction of the basic body and relatively pliable sections extending inbetween, wherein the relatively pliable sections form lobes in an expanded state of the balloon member. The invention furthermore relates to a method for manufacturing a catheter according to the invention, wherein a piece of tube-like basic material is provided and, by blow molding, a balloon member is made in a mold, which is arranged to the bias material. The balloon member is manufactured in the mold cavity of a mold, the cross-section of which is lobated, by receiving a tube-like partial manufacture inside it and deforming it by blow molding into a shape corresponding to that of the shape of the mold cavity.
摘要翻译：本发明涉及一种导管，其包括具有近端和远端的管状基体，以及靠近基体的远端设置的可膨胀气囊构件。球囊构件包括在基体的纵向方向上以小直径延伸的多个相对刚性的部分和在其间延伸的相对柔韧的部分，其中相对柔韧的部分形成为球囊构件的展开状态的凸角。本发明还涉及一种根据本发明的制造导管的方法，其中提供了一块管状基材，并且通过吹塑成型，将气囊构件制成设置在偏置材料上的模具中。气囊构件通过在其内部容纳管状的部分制造而在模具的模腔中制造，其横截面为叶形，并通过吹塑成型为与模具形状相对应的形状腔。

82. 发明授权

US09463103B2 Medical devices comprising nanocomposites 有权
标题翻译：包含纳米复合材料的医疗器械
公开(公告)号：US09463103B2
公开(公告)日：2016-10-11
申请号：US13402141
申请日：2012-02-22
申请人： Edward Parsonage , Daniel J. Horn , John J. Chen , Paul J. Miller , Douglas A. Devens, Jr. , Jan Weber
发明人： Edward Parsonage , Daniel J. Horn , John J. Chen , Paul J. Miller , Douglas A. Devens, Jr. , Jan Weber
IPC分类号： A61L29/00 , A61F2/95 , A61F2/01 , A61F2/02 , A61F2/958 , A61L29/12 , A61L31/12
CPC分类号： A61F2/95 , A61F2/01 , A61F2/02 , A61F2/958 , A61F2002/018 , A61F2230/0006 , A61F2230/005 , A61F2230/0067 , A61L29/126 , A61L31/125 , Y10S623/90 , Y10S977/905
摘要： The present invention provides medical devices comprising nanocomposite materials. By utilizing nanocomposites in the production thereof, the inventive medical devices can be produced with various advantageous properties. Methods of producing the inventive medical devices are also provided. Inasmuch as the inventive devices are expected to provide certain advantages in their use, there is also provided a method of medical care including methods of treatment or diagnosis, wherein the inventive devices are brought into therapeutic contact with a body to be treated or diagnosed thereby.
摘要翻译：本发明提供包含纳米复合材料的医疗装置。通过在其生产中利用纳米复合材料，本发明的医疗装置可以以各种有利的性质生产。还提供了制造本发明的医疗装置的方法。由于本发明的装置预期在使用中提供某些优点，还提供了包括治疗或诊断方法的医疗护理方法，其中本发明的装置与被治疗或被诊断的身体进行治疗接触。

83. 发明授权

US08876772B2 Variable stiffness shaft 有权
标题翻译：可变刚度轴
公开(公告)号：US08876772B2
公开(公告)日：2014-11-04
申请号：US11280120
申请日：2005-11-16
申请人： Jan Weber , Tracee E. J. Eidenschink
发明人： Jan Weber , Tracee E. J. Eidenschink
IPC分类号： A61M5/178 , A61L29/14 , A61L29/04 , A61B17/00 , A61M25/09 , A61M25/00
CPC分类号： A61M25/0054 , A61B2017/00398 , A61B2017/00871 , A61L29/041 , A61L29/14 , A61M25/0045 , A61M2025/0058 , A61M2025/0059 , A61M2025/006 , A61M2025/0063 , A61M2025/09133 , A61M2025/0915 , C08L39/04
摘要： Medical devices may include structure or provision that permit a physician or other health care professional to adjust particular parameters such as flexibility, stiffness and compressive strength of at least a portion of the medical device. In some instances, the medical device may be adjusted prior to inserting the medical device into a patient. In some cases, the medical device may be adjusted while in use within the patient.
摘要翻译：医疗设备可以包括允许医师或其他保健专业人员调整医疗设备的至少一部分的特定参数，例如柔性，刚度和抗压强度的结构或规定。在一些情况下，可以在将医疗装置插入病人之前调整医疗装置。在一些情况下，医疗装置可在患者使用期间进行调整。

84. 发明授权

US08862203B2 Medical device with temperature modulator for use in magnetic resonance imaging 有权
标题翻译：具有用于磁共振成像的温度调制器的医疗设备
公开(公告)号：US08862203B2
公开(公告)日：2014-10-14
申请号：US10401227
申请日：2003-03-27
申请人： Jan Weber
发明人： Jan Weber
IPC分类号： A61B5/00 , A61B5/055 , A61M25/01 , G01R33/56 , G01R33/28 , A61M25/00 , A61B19/00
CPC分类号： A61B5/055 , A61B90/39 , A61B2090/3954 , A61F7/12 , A61F2007/126 , A61M25/0009 , A61M25/0045 , A61M25/0127 , G01R33/281 , G01R33/285 , G01R33/287 , G01R33/5601
摘要： This disclosure employs temperature, magnetism and Curie point transition to construct and use catheters and other medical devices that can be visualized using magnetic resonance imaging (MRI). Accordingly, this disclosure includes, but is not limited to, medical devices, means of constructing medical devices, and methods of imaging medical devices using magnetic resonance and other technologies.
摘要翻译：本公开采用温度，磁力和居里点过渡来构建和使用可以使用磁共振成像（MRI）可视化的导管和其他医疗装置。因此，本公开包括但不限于医疗设备，构建医疗设备的手段，以及使用磁共振和其他技术对医疗设备成像的方法。

85. 发明授权

US08771343B2 Medical devices with selective titanium oxide coatings 有权
标题翻译：具有选择性氧化钛涂层的医疗设备
公开(公告)号：US08771343B2
公开(公告)日：2014-07-08
申请号：US11763770
申请日：2007-06-15
申请人： Jan Weber , Liliana Atanasoska , James Lee Shippy, III , Edward E. Parsonage
发明人： Jan Weber , Liliana Atanasoska , James Lee Shippy, III , Edward E. Parsonage
IPC分类号： A61F2/82
CPC分类号： A61F2/82 , A61F2/91 , A61F2002/30322 , A61F2250/0026 , A61F2250/0056 , A61F2310/00616 , A61F2310/0097 , A61L31/088 , A61L31/10 , A61L31/16 , A61L2300/00 , B05D1/32
摘要： Medical devices, such as endoprostheses, and methods of making the devices are described. In some embodiments, a medical device includes a body of interconnected bands and connectors forming an elongated tubular structure having an inner luminal wall surface and an outer abluminal wall surface and defining a central lumen or passageway. The inner luminal wall surface and side wall surface of the bands and connectors forming transverse passageways through the elongated tubular structure can bear a coating of hydrophilic material and the outer abluminal wall surface of the tubular structure can bear a coating of hydrophobic material.
摘要翻译：描述医疗装置，例如内用假体，以及制造装置的方法。在一些实施例中，医疗装置包括互连带的主体和形成细长管状结构的连接器，其具有内管腔壁表面和外侧腔壁表面，并限定中央腔或通道。形成穿过细长管状结构的横向通道的带和连接件的内腔壁表面和侧壁表面可以承受亲水材料的涂层，并且管状结构的外侧壁面可承受疏水材料的涂层。

86. 发明申请

US20140128991A1 BIOERODIBLE NANO-FIBROUS AND NANO-POROUS CONDUCTIVE COMPOSITES 有权
标题翻译：可生物降解的纳米纤维和纳米多孔导电复合材料
公开(公告)号：US20140128991A1
公开(公告)日：2014-05-08
申请号：US11694436
申请日：2007-03-30
申请人： Liliana Atanasoska , James Q. Feng , Jan Weber , James Lee Shippy, III
发明人： Liliana Atanasoska , James Q. Feng , Jan Weber , James Lee Shippy, III
IPC分类号： A61L27/40
CPC分类号： A61L27/40 , A61L27/14 , A61L27/50 , A61L27/58 , A61L2400/12
摘要： A bioerodible conductive tissue scaffold that can provide, e.g., improved tissue growth.
摘要翻译：可以提供例如改善的组织生长的生物蚀蚀性导电组织支架。

87. 发明授权

US08668732B2 Surface treated bioerodible metal endoprostheses 失效
标题翻译：表面处理的生物腐蚀性金属内假体
公开(公告)号：US08668732B2
公开(公告)日：2014-03-11
申请号：US13053791
申请日：2011-03-22
申请人： Torsten Scheuermann , Jan Weber , Charles Deng , Jonathan S. Stinson , Steven R. Larsen , Dennis A. Boismier , Jacob D. Edick
发明人： Torsten Scheuermann , Jan Weber , Charles Deng , Jonathan S. Stinson , Steven R. Larsen , Dennis A. Boismier , Jacob D. Edick
IPC分类号： A61F2/82
CPC分类号： A61L31/148 , A61F2/91 , A61F2210/0004 , A61L31/022 , A61L31/088
摘要： An endoprosthesis includes an expandable tubular body defined by a plurality of struts. In some embodiments, the expandable tubular body includes a bioerodible metal that has at least a first surface region and a second surface region. The first and second surface regions can have different surface oxide compositions. In some embodiments, the first portion has a thermally altered microstructure and the second portion has a wrought microstructure. The thermally altered microstructure can be a cast microstructure comprising dendritic grains. The first portion forms at least a portion of an outer surface of the expandable tubular body. In some embodiments, the expandable tubular body includes iron or a bioerodible iron alloy and at least one surface of the expandable tubular body includes a substantially uniform coating of iron(III) oxide.
摘要翻译：内假体包括由多个支柱限定的可扩张管状体。在一些实施例中，可扩张管状体包括具有至少第一表面区域和第二表面区域的生物浸渍金属。第一和第二表面区域可以具有不同的表面氧化物组成。在一些实施例中，第一部分具有热改变的微结构，第二部分具有锻造微结构。热改变的微结构可以是包含树枝状晶粒的铸造微结构。第一部分形成可扩张管状体的外表面的至少一部分。在一些实施例中，可膨胀管状体包括铁或生物腐蚀性铁合金，并且可膨胀管体的至少一个表面包括基本均匀的氧化铁（III）涂层。

88. 发明授权

US08562566B2 Stent delivery and guidewire guidance system 有权
标题翻译：支架输送和导丝引导系统
公开(公告)号：US08562566B2
公开(公告)日：2013-10-22
申请号：US11068330
申请日：2005-02-28
申请人： Jan Weber , Raed Rizq
发明人： Jan Weber , Raed Rizq
IPC分类号： A61M5/178
CPC分类号： A61F2/95 , A61M2025/0188
摘要： A system for controlling multiple guidewires comprises a guiderail, which has a housing that defines a first guidewire lumen and a second guidewire lumen. The guidewire lumens extend through the entire length of the guiderail. The guiderail housing further defines a first longitudinal opening that extends from the first guidewire lumen to the exterior of the guiderail, and a second longitudinal opening that extends from the second guidewire lumen to the exterior of the guiderail.
摘要翻译：一种用于控制多条导线的系统包括一个导轨，其具有限定第一导丝管腔和第二导丝管腔的外壳。导丝流道延伸穿过导轨的整个长度。导轨壳体进一步限定了从第一导丝内腔延伸到导轨外部的第一纵向开口，以及从第二导丝管腔延伸到导轨外部的第二纵向开口。

89. 发明授权

US08516871B2 Crimper 有权
标题翻译：卷边机
公开(公告)号：US08516871B2
公开(公告)日：2013-08-27
申请号：US12987587
申请日：2011-01-10
申请人： Jan Weber , Tracee Eidenschink
发明人： Jan Weber , Tracee Eidenschink
IPC分类号： B21D39/00
CPC分类号： A61F2/958 , A61F2002/9522 , B25B27/10 , Y10T29/49913 , Y10T29/49925 , Y10T29/53065 , Y10T29/53652 , Y10T29/53987 , Y10T29/53996
摘要： In one embodiment, an apparatus for shaping an article may comprise a plurality of movable dies arranged to form a chamber whose size may be varied by moving the dies. Each of the dies may have a contacting surface for contacting the article to be shaped. The chamber may have a first portion having a first cross-section and a second portion having a second cross-section. Either portion may include a taper. The first portion may have a differently shaped cross-section than the second portion. The first portion may have a cross-section of greater area than the second portion. The longitudinal axis of the first portion may be offset from the longitudinal axis of the second portion.
摘要翻译：在一个实施例中，用于成型物品的装置可以包括多个可移动模具，其被设置成形成其尺寸可以通过移动模具而改变的腔室。每个模具可以具有用于接触待成形制品的接触表面。腔室可以具有第一部分和第二部分，第一部分具有第一横截面，第二部分具有第二横截面。任一部分可以包括锥形。第一部分可以具有与第二部分不同的形状的横截面。第一部分可以具有比第二部分更大的面积的横截面。第一部分的纵向轴线可以偏离第二部分的纵向轴线。

90. 发明授权

US08449603B2 Endoprosthesis coating 有权
标题翻译：内置假体涂层
公开(公告)号：US08449603B2
公开(公告)日：2013-05-28
申请号：US12486295
申请日：2009-06-17
申请人： Jan Weber , Liliana Atanasoska , Michele Zoromski
发明人： Jan Weber , Liliana Atanasoska , Michele Zoromski
IPC分类号： A61F2/82
CPC分类号： A61F2/82 , A61L31/088 , A61L31/146
摘要： An endoprosthesis, e.g., a stent (e.g., a drug eluting stent), that includes a porous surface and hollow elements integrated with a coating on the surface and a method of making the same are disclosed.
摘要翻译：公开了一种内置假体，例如支架（例如，药物洗脱支架），其包括多孔表面和与表面上的涂层成一体的中空元件及其制造方法。

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