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81. 发明授权

US07288540B2 Phenylalkynes 有权
标题翻译：苯基炔
公开(公告)号：US07288540B2
公开(公告)日：2007-10-30
申请号：US11490394
申请日：2006-07-20
申请人： Richard Apodaca , Xiaohu Deng , Jill A. Jablonowski , Neelakandha Mani , Chennagiri R. Pandit , Wei Xiao
发明人： Richard Apodaca , Xiaohu Deng , Jill A. Jablonowski , Neelakandha Mani , Chennagiri R. Pandit , Wei Xiao
IPC分类号： C07D413/06 , A61K31/5377
CPC分类号： C07D239/42 , A61K31/444 , A61K31/4453 , A61K31/4709 , A61K31/5355 , A61K31/5377 , A61K31/541 , C07D203/12 , C07D209/14 , C07D209/16 , C07D211/14 , C07D211/22 , C07D211/44 , C07D211/46 , C07D211/60 , C07D211/62 , C07D211/78 , C07D213/38 , C07D215/06 , C07D273/00 , C07D273/01 , C07D277/04 , C07D295/02 , C07D295/03 , C07D295/073 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/205 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D413/10 , C07D417/10 , C07D471/10 , C07D491/10 , C07D491/113
摘要： Substituted phenylalkynes of formula (I) compositions containing them and their methods of use to treat histamine related disorders are described, wherein R1, R2, R3, R4, R5 and n are as defined.
摘要翻译：描述了含有它们的式（I）的组合物的取代苯炔基及其用于治疗组胺相关病症的方法，其中R 1，R 2，R 3， R 4，R 4，R 5和n如上所定义。

82. 发明授权

US07241778B2 Non-imidazole aryloxypiperidines 有权
标题翻译：非咪唑芳氧基哌啶
公开(公告)号：US07241778B2
公开(公告)日：2007-07-10
申请号：US11138631
申请日：2005-05-26
申请人： Richard Apodaca , Nicholas I. Carruthers , Curt A. Dvorak , Chandravadan R. Shah , Wei Xiao
发明人： Richard Apodaca , Nicholas I. Carruthers , Curt A. Dvorak , Chandravadan R. Shah , Wei Xiao
IPC分类号： A61K31/445 , C07D211/06
CPC分类号： C07D207/325 , A61K31/4402 , A61K31/4465 , A61K45/06 , C07C217/22 , C07C323/25 , C07C335/32 , C07D207/335 , C07D211/22 , C07D211/46 , C07D211/58 , C07D213/36 , C07D213/74 , C07D215/06 , C07D231/12 , C07D233/42 , C07D233/54 , C07D233/56 , C07D233/84 , C07D233/88 , C07D235/06 , C07D235/26 , C07D239/34 , C07D249/08 , C07D257/04 , C07D277/36 , C07D295/088 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/205 , C07D307/52 , C07D317/28 , C07D333/20 , C07D401/12 , C07D401/14 , C07D471/08 , A61K2300/00
摘要： Substituted non-imidazole aryloxypiperidine compounds, compositions containing them, and methods of making and using them to treat or prevent histamine-mediated conditions.
摘要翻译：取代的非咪唑芳氧基哌啶化合物，含有它们的组合物，以及制备和使用它们来治疗或预防组胺介导的病症的方法。

83. 发明申请

US20060235049A1 Non-imidazole aryloxyalkylamines 有权
公开(公告)号：US20060235049A1
公开(公告)日：2006-10-19
申请号：US11453422
申请日：2006-06-15
申请人： Richard Apodaca , Nicholas Carruthers , Curt Dvorak , Dale Rudolph , Chandravadan Shah , Wei Xiao
发明人： Richard Apodaca , Nicholas Carruthers , Curt Dvorak , Dale Rudolph , Chandravadan Shah , Wei Xiao
IPC分类号： C07D211/20 , A61K31/445 , A61K31/40 , C07D207/04 , A61K31/138
CPC分类号： C07D207/325 , A61K31/4402 , A61K31/4465 , A61K45/06 , C07C217/22 , C07C323/25 , C07C335/32 , C07D207/335 , C07D211/22 , C07D211/46 , C07D211/58 , C07D213/36 , C07D213/74 , C07D215/06 , C07D231/12 , C07D233/42 , C07D233/54 , C07D233/56 , C07D233/84 , C07D233/88 , C07D235/06 , C07D235/26 , C07D239/34 , C07D249/08 , C07D257/04 , C07D277/36 , C07D295/088 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/205 , C07D307/52 , C07D317/28 , C07D333/20 , C07D401/04 , C07D401/12 , C07D401/14 , C07D471/08 , A61K2300/00
摘要： Substituted aryloxyalkylamines of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.

84. 发明授权

US06569878B1 Substituted 4-amino-thiazol-2-yl compounds as cyclin-dependent kinase inhibitors 失效
标题翻译：取代的4-氨基 - 噻唑-2-基化合物作为细胞周期蛋白依赖性激酶抑制剂
公开(公告)号：US06569878B1
公开(公告)日：2003-05-27
申请号：US09179744
申请日：1998-10-27
申请人： Wesley K. M. Chong , Shao Song Chu , Lin Li , Rohit K. Duvadie , Yi Yang , Wei Xiao
发明人： Wesley K. M. Chong , Shao Song Chu , Lin Li , Rohit K. Duvadie , Yi Yang , Wei Xiao
IPC分类号： A61K31425
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D277/42 , C07D417/06 , C07D417/12 , C07D417/14
摘要： Pharmaceutical compositions containing effective amounts of CDK-inhibiting diaminothiazole compounds of the following formula (where R1 and R2 are as defined in the specification) or their salts, or prodrugs or active metabolites of such compounds or salts, are useful for treating disorders and diseases such as cancer: In preferred embodiments, R1 and R2 are independently unsubstituted or substituted carbocyclic or heterocyclic aryl ring structures. Compounds where R2 is ortho-substituted aryl are especially potent inhibitors of CDKs such as CDK4.
摘要翻译：含有有效量的下式（其中R1和R2如本说明书中所定义）的有效量的CDK抑制性二氨基噻唑化合物或其盐或这些化合物或其盐的前体药物或活性代谢物可用于治疗疾病和疾病，例如作为癌症：在优选的实施方案中，R 1和R 2独立地是未取代或取代的碳环或杂环芳环结构。其中R2是邻位取代的芳基的化合物是CDK如CDK4的特别有效的抑制剂。

85. 发明授权

US09991905B2 Encoding method, decoding method, encoder and decoder 有权
公开(公告)号：US09991905B2
公开(公告)日：2018-06-05
申请号：US13572980
申请日：2012-08-13
申请人： Wei Xiao , Qing Zhang
发明人： Wei Xiao , Qing Zhang
IPC分类号： H04N7/12 , H03M7/30
CPC分类号： H03M7/3082
摘要： An encoding method, decoding method, encoder, and decoder are provided in embodiments of this invention. The encoding method comprises: selecting at least one dimension vector from at least two dimension vectors to partition the coefficients to be encoded into vectors, according to the number of the coefficients to be encoded contained in a current subband; quantizing the vectors partitioned from the coefficients to be encoded into lattice vectors according to the selected dimension, and then mapping the lattice vectors to lattice index vectors; performing lossless encoding on the lattice index vectors.

86. 发明授权

US09187459B2 Quinazoline-7-ether compounds and methods of use 有权
标题翻译：喹唑啉-7-醚化合物及其使用方法
公开(公告)号：US09187459B2
公开(公告)日：2015-11-17
申请号：US14118200
申请日：2012-05-17
申请人： Wang Shen , Wei Xiao , Jack Maung , Aimin Zhang , Xiaoling Zheng , Zhenzhong Wang , Qingming Guo , Yingguang Li
发明人： Wang Shen , Wei Xiao , Jack Maung , Aimin Zhang , Xiaoling Zheng , Zhenzhong Wang , Qingming Guo , Yingguang Li
IPC分类号： A01N43/54 , A61K31/517 , C07D401/00 , C07D239/72 , C07D405/12 , C07D493/04
CPC分类号： C07D405/12 , C07D493/04
摘要： The invention provides quinazoline-7-ether derivatives, particularly 4-anilinyl-6-butenamido-quinazoline-7-ether derivatives that are inhibitors of the receptor protein tyrosine kinases (RTK). The compounds are useful in the treatment of diseases and disorders where RTK activity is implicated such as a hyperproliferative diseases (e.g., cancer). Also provided are methods of preparation of the quinazoline derivatives and methods of use as therapeutic agents alone or in a drug combination.
摘要翻译：本发明提供了喹唑啉-7-醚衍生物，特别是作为受体蛋白酪氨酸激酶（RTK）抑制剂的4-苯乙烯基-6-丁烯酰氨基 - 喹唑啉-7-醚衍生物。所述化合物可用于治疗涉及RTK活性的疾病和病症，例如过度增殖性疾病（例如癌症）。还提供了制备喹唑啉衍生物的方法和单独使用或作为药物组合用作治疗剂的方法。

87. 发明授权

US08119141B2 Cinnamomi and poria composition, method to prepare same and uses thereof 有权
标题翻译：肉桂和茯苓的组成，制备方法及其用途
公开(公告)号：US08119141B2
公开(公告)日：2012-02-21
申请号：US12581466
申请日：2009-10-19
申请人： Wei Xiao
发明人： Wei Xiao
IPC分类号： A61K36/84 , A61K36/736 , A61K36/05 , A61K36/00
CPC分类号： A61K36/54 , A61K36/076 , A61K36/23 , A61K36/65 , A61K36/736 , G01N30/02 , A61K2300/00
摘要： This invention provides a method for identifying a composition of Cinnamomi and Poria. This invention further provides a composition comprising: Ramulus Cinnamomi, Poria Cortex, Moutan Radicis, Radix Paeonize Alba, and Semen Persicae. This invention provides various uses of these compositions.
摘要翻译：本发明提供了一种鉴定肉桂和茯苓的组成的方法。本发明进一步提供了一种组合物，其包含：樟子松，茯苓皮，Moutan Radicis，芍药芍药和Semen Persicae。本发明提供了这些组合物的各种用途。

88. 发明授权

US08067040B2 Cinnamomi and poria composition and uses thereof 有权
标题翻译：肉桂和茯苓的组成及用途
公开(公告)号：US08067040B2
公开(公告)日：2011-11-29
申请号：US12376601
申请日：2007-10-17
申请人： Wei Xiao , Xiang Ling Dai , Ya Ling , Zhen Zhong Wang , Yu An Bi , Zheng Kuan Wang
发明人： Wei Xiao , Xiang Ling Dai , Ya Ling , Zhen Zhong Wang , Yu An Bi , Zheng Kuan Wang
IPC分类号： A01N65/00
CPC分类号： A61K36/54 , A61K36/076 , A61K36/65 , A61K36/73 , A61K2236/00 , A61K2300/00
摘要： A composition comprising Chinese herbal medicines Ramulus cinnamomi and Poria cocos is provided, wherein the composition is defined by a fingerprint profile obtained from an improved chromatographic method. Various uses of such compositions are also provided.
摘要翻译：提供了包含中草药樟脑和茯苓的组合物，其中所述组合物由通过改进的色谱法获得的指纹图谱定义。还提供了这些组合物的各种用途。

89. 发明申请

US20110286549A1 Method, Device And System For Signal Encoding And Decoding 有权
标题翻译：用于信号编码和解码的方法，装置和系统
公开(公告)号：US20110286549A1
公开(公告)日：2011-11-24
申请号：US13210127
申请日：2011-08-15
申请人： Chen Hu , Zexin Liu , Lei Miao , Longyin Chen , Qing Zhang , Wei Xiao , Herve Marcel Taddei
发明人： Chen Hu , Zexin Liu , Lei Miao , Longyin Chen , Qing Zhang , Wei Xiao , Herve Marcel Taddei
IPC分类号： H04L27/00
CPC分类号： G10L21/00 , G10L19/24
摘要： A method, device and system for signal encoding and decoding, the method comprising: encoding a core layer signal to obtain a core layer signal code; selecting an enhancement sample point that requires enhancement layer signal encoding according to the core layer signal code and the number of bits that can be used by an enhancement layer; obtaining an enhancement layer signal code of the enhancement sample point; and outputting a bit stream, where the bit stream includes the core layer signal code and the enhancement layer signal code. In embodiments of the present invention, according to the number of bits that can be used by the enhancement layer, the enhancement sample point that requires enhancement layer signal encoding is selected; the enhancement layer signal of the selected enhancement sample point is encoded and decoded; when no sufficient bits are available for the enhancement layer, the enhancement quality of the core layer can be improved.
摘要翻译：一种用于信号编码和解码的方法，装置和系统，所述方法包括：对核心层信号进行编码以获得核心层信号码; 选择需要根据核心层信号码的增强层信号编码和增强层可以使用的位数的增强采样点; 获得增强采样点的增强层信号码; 并输出比特流，其中比特流包括核心层信号码和增强层信号码。在本发明的实施例中，根据增强层可以使用的比特数，选择需要增强层信号编码的增强采样点; 所选择的增强采样点的增强层信号被编码和解码; 当没有足够的比特可用于增强层时，可以提高核心层的增强质量。

90. 发明授权

US08063809B2 Transient signal encoding method and device, decoding method and device, and processing system 有权
标题翻译：瞬态信号编码方法及装置，解码方法及装置及处理系统
公开(公告)号：US08063809B2
公开(公告)日：2011-11-22
申请号：US13172652
申请日：2011-06-29
申请人： Zexin Liu , Longyin Chen , Lei Miao , Chen Hu , Wei Xiao , Herve Marcel Taddei , Qing Zhang
发明人： Zexin Liu , Longyin Chen , Lei Miao , Chen Hu , Wei Xiao , Herve Marcel Taddei , Qing Zhang
IPC分类号： H03M1/12
CPC分类号： G10L19/025
摘要： A transient signal encoding method and device, decoding method and device, and processing system, where the transient signal encoding method includes: obtaining a reference sub-frame where a maximal time envelope having a maximal amplitude value is located from time envelopes of all sub-frames of an input transient signal; adjusting an amplitude value of the time envelope of each sub-frame before the reference sub-frame in such a way that a first difference is greater than a preset first threshold, in which the first difference is a difference between the amplitude value of the time envelope of each sub-frame before the reference sub-frame and the amplitude value of the maximal time envelope; and writing the adjusted time envelope into bitstream.
摘要翻译：一种瞬态信号编码方法和装置，解码方法和装置以及处理系统，其中瞬态信号编码方法包括：获得参考子帧，其中具有最大振幅值的最大时间包络位于所有子帧的时间包络上，输入瞬态信号的帧; 在所述参考子帧之前调整每个子帧的时间包络的幅度值，使得所述第一差值大于预设的第一阈值，其中所述第一差值是所述时间的振幅值参考子帧之前的每个子帧的包络和最大时间包络的振幅值; 并将经调整的时间包络写入比特流。

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