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81. 发明授权

US07993677B2 Density-controlled particulate suspensions for foodstuff, cosmetic, pharmaceutical and other uses 有权
标题翻译：用于食品，化妆品，药物和其他用途的密度可控颗粒悬浮液
公开(公告)号：US07993677B2
公开(公告)日：2011-08-09
申请号：US10722968
申请日：2003-11-26
申请人： Li Ding , Stephanie Morar , David Schlossman
发明人： Li Ding , Stephanie Morar , David Schlossman
IPC分类号： A61K9/14 , A61K9/50 , A61K9/56
CPC分类号： A61Q5/02 , A61K8/0283 , A61K8/8152 , A61K9/0014 , A61K2800/56 , A61Q19/00
摘要： Stable and uniform distribution of gel beads or other particulate material, dispersed in a liquid medium can be obtained by including a density-reducing agent within the gel beads to provide the particle with a desired bulk density, for example a density close to that of the disperse liquid medium. Suitable density control can prevent migration due to gravity leading to settling in storage. Gel beads formulated with agar are suitable for use in cosmetics and for inclusion in cosmetics formulating processes which may employ modestly elevated temperatures. Attractive and novel cosmetics bead suspensions are described. Additional to cosmetics, pharmaceutical, foodstuff and other applications are disclosed. Examples of suitable density-reducing agents include very low density hollow polymeric microspheres and temperature-sensitive expandable thermoplastic microspheres.
摘要翻译：分散在液体介质中的凝胶珠或其它颗粒材料的稳定和均匀分布可以通过在凝胶珠内包含密度降低剂来提供颗粒以获得所需的堆积密度，例如接近于分散液体介质。合适的密度控制可以防止由重力引起的迁移导致储存沉降。用琼脂配制的凝胶珠适用于化妆品和包含在可能采用温和升高的温度的化妆品配方中。描述了有吸引力和新颖的化妆品珠悬浮液。披露了化妆品，制药，食品和其他应用的附加物。合适的减密剂的实例包括非常低密度的中空聚合物微球和温度敏感的可发性热塑性微球。

82. 发明授权

US07943902B2 Method for introducing ions into an ion trap and an ion storage apparatus 有权
标题翻译：将离子引入离子阱和离子存储装置的方法
公开(公告)号：US07943902B2
公开(公告)日：2011-05-17
申请号：US11916355
申请日：2006-05-26
申请人： Li Ding , Alan Joseph Smith , Evgenij Nikolaevich Nikolaev
发明人： Li Ding , Alan Joseph Smith , Evgenij Nikolaevich Nikolaev
IPC分类号： H01J49/04 , H01J49/26
CPC分类号： H01J49/4295 , H01J49/0072 , H01J49/0095 , H01J49/062
摘要： A method of introducing ions into an ion trap and an ion storage apparatus are described. Introduction means are used to introduce first ions into an ion trap through an entrance aperture to the ion trap. An operating condition of the introduction means is adjusted to cause second ions, of different polarity to the first ions to be introduced into the ion trap through the same entrance aperture.
摘要翻译：描述了将离子引入离子阱和离子存储装置的方法。引入装置用于通过离子阱的入口将第一离子引入离子阱。引入装置的操作条件被调整以使得与第一离子不同的第二离子通过相同的入口孔引入离子阱。

83. 发明申请

US20090055797A1 METHOD AND COMPUTER PROGRAM PRODUCT FOR VIEWING EXTENDIBLE MODELS FOR LEGACY APPLICATIONS 有权
标题翻译：用于查看可扩展应用程序的方法和计算机程序产品
公开(公告)号：US20090055797A1
公开(公告)日：2009-02-26
申请号：US11844121
申请日：2007-08-23
申请人： Li Ding , Donald J. Yantzi
发明人： Li Ding , Donald J. Yantzi
IPC分类号： G06F9/44
CPC分类号： G06F8/00
摘要： A method and computer program product of incrementally visualizing graphical extensible models for legacy software applications via a user interface are provided. A graph of nodes and connections showing only the highest level of details are presented. Each node that contains additional, lower level, details is shown with an expansion icon that may be selected to see additional levels of detail for the node. When selected, the user interface drills down to show the next lowest level of details for that artifact within a visual boundary of the original artifact that was expanded. Because of the nested, hierarchical nature of the model, relationships between higher level artifacts can be inferred from explicit relationships between lower level artifacts. When the node is expanded, any connections that previously connected to the higher level artifact are updated to connect to the appropriate artifact in the lower level details.
摘要翻译：提供了一种通过用户界面逐步可视化传统软件应用程序的图形可扩展模型的方法和计算机程序产品。提出了仅显示最高级别细节的节点和连接图。包含附加，较低级别的详细信息的每个节点都会显示一个扩展图标，该图标可能被选择以查看该节点的附加级别的详细信息。当选择时，用户界面向下钻取，以便在扩展的原始工件的视觉边界内显示该工件的下一个最低级别的细节。由于模型的嵌套层次性，可以从较低级别的工件之间的显式关系推断出较高级的工件之间的关系。当节点扩展时，先前连接到较高级别工件的任何连接都将被更新，以连接到较低级别详细信息中的相应工件。

84. 发明申请

US20080300147A1 Detection and Treatment of Fibrotic Disorders 审中-公开
标题翻译：纤维性疾病的检测与治疗
公开(公告)号：US20080300147A1
公开(公告)日：2008-12-04
申请号：US10590675
申请日：2005-03-28
申请人： Nasser Chegini , Xiaoping Luo , Li Ding , R. Stan Williams
发明人： Nasser Chegini , Xiaoping Luo , Li Ding , R. Stan Williams
IPC分类号： C40B40/06 , C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , G01N2800/364
摘要： The present invention provides a method for detecting a fibrotic disorder in a subject by: (a) providing a biological sample obtained from the subject (such as endometrium, peritoneal fluid, and/or smooth muscle cells); (b) analyzing the expression of at least one gene that is differentially expressed in the fibrotic disorder of interest; and (c) correlating the expression of the gene(s) with the presence or absence of the fibrotic disorder in the subject. The present invention also provides a method and compositions for modulating the expression of genes that are differentially expressed in fibrotic tissues, compared to normal tissues. Restoration of gene expression to levels associated with normal tissue is expected to ameliorate at least some of the symptoms of the fibrotic disorder. This method includes the step of contacting the tissue with an agent that modulates expression of one or more differentially expressed genes in the tissue. The present invention also includes arrays, such as microfluidic cards, for detecting differential gene expression in samples of fibrotic tissue.
摘要翻译：本发明提供一种通过以下方法检测受试者中的纤维化病症的方法：（a）提供从受试者获得的生物样品（例如子宫内膜，腹膜液和/或平滑肌细胞）; （b）分析在感兴趣的纤维化疾病中差异表达的至少一种基因的表达; 和（c）将基因的表达与受试者中是否存在纤维化病症相关联。本发明还提供了与正常组织相比调节在纤维组织中差异表达的基因表达的方法和组合物。将基因表达恢复到与正常组织相关的水平，预期可以改善纤维化病症的至少一些症状。该方法包括使组织与调节组织中一种或多种差异表达基因的表达的试剂接触的步骤。本发明还包括用于检测纤维组织样品中差异基因表达的阵列，例如微流控卡。

85. 发明授权

US07326924B2 Method for obtaining high accuracy mass spectra using an ion trap mass analyser and a method for determining and/or reducing chemical shift in mass analysis using an ion trap mass analyser 失效
标题翻译：使用离子阱质量分析仪获得高精度质谱的方法和使用离子阱质量分析仪测定和/或减少质量分析中的化学位移的方法
公开(公告)号：US07326924B2
公开(公告)日：2008-02-05
申请号：US10558474
申请日：2004-06-02
申请人： Li Ding , Francesco Lorenzo Brancia
发明人： Li Ding , Francesco Lorenzo Brancia
IPC分类号： H01J49/42 , H01J49/00 , B01D59/44
CPC分类号： H01J49/424 , H01J49/429
摘要： A method for obtaining high accuracy mass spectra using an ion trap mass analyzer includes adjusting operating parameters of the analyser to enable a reverse mass scan in a mass selective resonance ejection mode and setting the trapping field to trap ions in a mass-to-charge ratio which has a lower limit close to the mass-to-charge ratio of an ion of interest. A method of determining chemical shift includes adjusting operating parameters of the analyzer to enable forward and reverse mass scans and calibrating the spectra obtained from the forward and reverse mass scans.
摘要翻译：使用离子阱质量分析仪获得高精度质谱的方法包括：调节分析仪的工作参数，使得能够以质量选择共振喷射模式进行反向质谱扫描，并设置捕获场以捕集质荷比其具有接近感兴趣的离子的质荷比的下限。确定化学位移的方法包括调整分析仪的操作参数，以进行正向和反向质量扫描并校准从正向和反向质量扫描获得的光谱。

86. 发明授权

US07272807B2 Determining equivalent waveforms for distorted waveforms 有权
标题翻译：确定失真波形的等效波形
公开(公告)号：US07272807B2
公开(公告)日：2007-09-18
申请号：US11071121
申请日：2005-03-02
申请人： Li Ding , Peivand Fallah Tehrani , Alireza Kasnavi
发明人： Li Ding , Peivand Fallah Tehrani , Alireza Kasnavi
IPC分类号： G06F17/50
CPC分类号： G06F17/5036 , G06F17/5031
摘要： An equivalent waveform for a distorted waveform used in timing and signal integrity analysis in the design of an integrated circuit is automatically generated. The equivalent waveform is produced by calculating the transition quantity of a first non-distorted waveform. The transition quantity is the amount of transition of the first non-distorted waveform that is required for the cell to produce an output waveform with a predetermined end voltage. The end point of the transition period for the distorted waveform is then determined based on when the distorted waveform has accumulated the same transition quantity. The equivalent waveform can then be formed by computing a second non-distorted waveform such that the end point of the transition period for the second non-distorted waveform coincides with the end point of the transition period for the distorted waveform.
摘要翻译：自动生成在集成电路设计中用于定时和信号完整性分析的失真波形的等效波形。通过计算第一非失真波形的转移量来产生等效波形。转换量是单元格产生具有预定端电压的输出波形所需的第一非失真波形的转变量。然后，基于失真波形累积相同过渡量的时间来确定失真波形的转换周期的终点。然后可以通过计算第二非失真波形来形成等效波形，使得第二非失真波形的转换周期的终点与失真波形的过渡周期的终点重合。

87. 发明申请

US20070092885A1 Secreted proteins 失效
公开(公告)号：US20070092885A1
公开(公告)日：2007-04-26
申请号：US11378616
申请日：2006-03-20
申请人： Henry Yue , Monique Yao , Ameena Gandhi , Mariah Baughn , Anita Swarnakar , Narinder Chawla , Madhusudan Sanjanwala , Michael Thornton , Vicki Elliott , Yan Lu , Kimberly Gietzen , Neil Burford , Li Ding , April Hafalia , Y. Tang , Olga Bandman , Bridget Warren , Cynthia Honchell , Dyung Lu , Kavitha Thangavelu , Sally Lee , Yuming Xu , Junming Yang , Preeti Lal , Bao Tran , Craig Ison , Brendan Duggan , Stephanie Sapperstein
发明人： Henry Yue , Monique Yao , Ameena Gandhi , Mariah Baughn , Anita Swarnakar , Narinder Chawla , Madhusudan Sanjanwala , Michael Thornton , Vicki Elliott , Yan Lu , Kimberly Gietzen , Neil Burford , Li Ding , April Hafalia , Y. Tang , Olga Bandman , Bridget Warren , Cynthia Honchell , Dyung Lu , Kavitha Thangavelu , Sally Lee , Yuming Xu , Junming Yang , Preeti Lal , Bao Tran , Craig Ison , Brendan Duggan , Stephanie Sapperstein
IPC分类号： C12Q1/68 , G01N33/53 , C07H21/04 , C12P21/06 , C12P21/04 , C07K14/705
CPC分类号： C12N15/1055 , A61K39/3955 , A61K47/64 , A61K47/643 , A61K2039/505 , C07K14/47 , C07K14/4711 , C07K14/4713 , C07K16/18 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/622 , C07K2317/75 , C07K2317/76 , G01N33/5023
摘要： The invention provides human secreted proteins (SECP) and polynucleotides which identify and encode SECP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of SECP.

88. 发明申请

US20070075239A1 Method for obtaining high accuracy mass spectra using an ion trap mass analyser and a method for determining and/or reducing chemical shift in mass analysis using an ion trap mass analyser 失效
标题翻译：使用离子阱质量分析仪获得高精度质谱的方法和使用离子阱质量分析仪测定和/或减少质量分析中的化学位移的方法
公开(公告)号：US20070075239A1
公开(公告)日：2007-04-05
申请号：US10558474
申请日：2004-06-02
申请人： Li Ding , Francesco Brancia
发明人： Li Ding , Francesco Brancia
IPC分类号： H01J49/42
CPC分类号： H01J49/424 , H01J49/429
摘要： A method for obtaining high accuracy mass spectra using an ion trap mass analyzer includes adjusting operating parameters of the analyser to enable a reverse mass scan in a mass selective resonance ejection mode and setting the trapping field to trap ions in a mass-to-charge ratio which has a lower limit close to the mass-to-charge ratio of an ion of interest. A method of determining chemical shift includes adjusting operating parameters of the analyzer to enable forward and reverse mass scans and calibrating the spectra obtained from the forward and reverse mass scans.
摘要翻译：使用离子阱质量分析仪获得高精度质谱的方法包括：调节分析仪的工作参数，使得能够以质量选择共振喷射模式进行反向质谱扫描，并设置捕获场以捕集质荷比其具有接近感兴趣的离子的质荷比的下限。确定化学位移的方法包括调整分析仪的操作参数，以进行正向和反向质量扫描并校准从正向和反向质量扫描获得的光谱。

89. 发明授权

US07088143B2 Dynamic circuits having improved noise tolerance and method for designing same 有权
标题翻译：具有改进的噪声容限的动态电路及其设计方法
公开(公告)号：US07088143B2
公开(公告)日：2006-08-08
申请号：US10847018
申请日：2004-05-17
申请人： Li Ding , Pinaki Mazumder
发明人： Li Ding , Pinaki Mazumder
IPC分类号： H03K19/096 , H03K19/00 , H03K19/20 , H03K19/094
CPC分类号： H03K19/0963
摘要： A number of different dynamic circuits having improved noise tolerance and a method for designing same are provided. The circuits include a power supply node and a precharge node. Keeper circuitry is connected to the nodes and has a current-voltage characteristic that exhibits a negative differential resistance property to improve noise tolerance of the circuits.
摘要翻译：提供了许多具有改进的噪声容限的不同动态电路及其设计方法。电路包括电源节点和预充电节点。 Keeper电路连接到节点，并具有呈现负差分电阻特性的电流 - 电压特性，以改善电路的噪声容限。

90. 发明授权

US06927056B2 Proteases 失效
标题翻译：蛋白酶
公开(公告)号：US06927056B2
公开(公告)日：2005-08-09
申请号：US10363937
申请日：2001-09-06
申请人： Stephen Todd , Angelo M. Delegeane , Ameena R. Gandhi , Danniel B. Nguyen , April J. A. Hafalia , Liam Kearney , Yan Lu , Ernestine A. Lee , Narinder K. Chawla , Debopriya Das , Chandra S. Arvizu , Monique G. Yao , Deborah A. Kallick , Vicki S. Elliott , Li Ding , Henry Yue , Roopa M. Reddy , Dyung Aina M. Lu , Jayalaxmi Ramkumar , Junming Yang , Catherine M. Tribouley , Neil Burford , Mariah R. Baughn , Preeti G. Lal , Mark L. Borowsky , Farrah A. Khan , Rajagopal Gururajan , Y. Tom Tang , Janice K. Au-Young , Bridget A. Warren , Roberto Hernandez , Brendan M. Duggan
发明人： Stephen Todd , Angelo M. Delegeane , Ameena R. Gandhi , Danniel B. Nguyen , April J. A. Hafalia , Liam Kearney , Yan Lu , Ernestine A. Lee , Narinder K. Chawla , Debopriya Das , Chandra S. Arvizu , Monique G. Yao , Deborah A. Kallick , Vicki S. Elliott , Li Ding , Henry Yue , Roopa M. Reddy , Dyung Aina M. Lu , Jayalaxmi Ramkumar , Junming Yang , Catherine M. Tribouley , Neil Burford , Mariah R. Baughn , Preeti G. Lal , Mark L. Borowsky , Farrah A. Khan , Rajagopal Gururajan , Y. Tom Tang , Janice K. Au-Young , Bridget A. Warren , Roberto Hernandez , Brendan M. Duggan
IPC分类号： A01K67/00 , C07H21/04 , C12N9/64 , C12N15/09 , C12P21/06 , C12Q1/68 , C12N1/20 , C12N15/00 , C12N15/63
CPC分类号： C12N9/6421 , A01K2217/05 , A01K2217/075 , C07H21/04 , C12N9/6472 , C12Q1/6837 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , Y02A50/52
摘要： The invention provides a human cysteine proteases and polynucleotides which encode those proteases. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists, as well as methods for diagnosing, treating, or preventing disorders associated with aberrant expression of cysteine proteases.
摘要翻译：本发明提供编码这些蛋白酶的人半胱氨酸蛋白酶和多核苷酸。本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂，以及用于诊断，治疗或预防与半胱氨酸蛋白酶异常表达相关的紊乱的方法。

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