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81. 发明授权

US5980921A Topical compositions for regulating the oily/shiny appearance of skin 失效
标题翻译：用于调节皮肤油性/光泽外观的局部组合物
公开(公告)号：US5980921A
公开(公告)日：1999-11-09
申请号：US134025
申请日：1998-08-14
申请人： Kimberly Ann Biedermann , George Endel Deckner
发明人： Kimberly Ann Biedermann , George Endel Deckner
IPC分类号： A61K8/30 , A61K8/00 , A61K8/42 , A61K8/49 , A61K8/67 , A61Q1/00 , A61Q1/02 , A61Q1/12 , A61Q5/00 , A61Q5/02 , A61Q5/12 , A61Q19/00 , A61Q19/10 , A61K7/48
CPC分类号： A61Q19/10 , A61K8/42 , A61K8/673 , A61K8/675 , A61Q19/00 , A61Q1/02 , A61Q5/02 , A61Q5/12 , Y10S514/844 , Y10S514/846 , Y10S514/944
摘要： The present invention is directed to topical compositions for regulating the oil and/or shiny appearance of mammalian skin which comprise: a) from about 1% to about 10% of an active for regulating the oil and/or shiny appearance of mammalian skin which consists essentially of one or more compounds selected from the group consisting of niacinamide, panthenol, and pantothenic acid; and b) a cosmetically acceptable carrier for the active.
摘要翻译：本发明涉及用于调节哺乳动物皮肤的油和/或光泽外观的局部组合物，其包含：a）约1％至约10％的用于调节哺乳动物皮肤的油和/或光泽外观的活性物质，其包含基本上是一种或多种选自烟酰胺，泛醇和泛酸的化合物; 和b）活性物质的化妆品可接受载体。

82. 发明授权

US5948416A Stable topical compositions 失效
标题翻译：稳定的局部组合物
公开(公告)号：US5948416A
公开(公告)日：1999-09-07
申请号：US647083
申请日：1996-05-08
申请人： Julie Ann Wagner , Joseph Michael Zukowski , Larry Richard Robinson , George Endel Deckner , Marie Antoinette Rinaldi , Victoria Claire Szymanski
发明人： Julie Ann Wagner , Joseph Michael Zukowski , Larry Richard Robinson , George Endel Deckner , Marie Antoinette Rinaldi , Victoria Claire Szymanski
IPC分类号： A61K9/107 , A61K8/00 , A61K8/33 , A61K8/34 , A61K8/35 , A61K8/36 , A61K8/362 , A61K8/365 , A61K8/368 , A61K8/39 , A61K8/40 , A61K8/44 , A61K8/49 , A61K8/86 , A61K47/30 , A61Q17/04 , A61Q19/00 , A61K7/48
CPC分类号： A61K8/342 , A61K8/368 , A61K8/39 , A61K8/447 , A61K8/86 , A61Q19/00 , A61Q17/04 , A61Q19/007 , A61Q19/08 , Y10S514/844 , Y10S514/845 , Y10S514/846 , Y10S514/847
摘要： The present invention relates to leave on, skin care compositions, comprising: (A) from about 0.001% to about 20% of an active ingredient, (B) from about 1% to about 20% of a stable, hydrophobic, structuring agent selected from the group consisting of saturated C.sub.16 to C.sub.30 fatty alcohols, saturated C.sub.16 to C.sub.30 fatty alcohols containing from about 1 to about 5 moles of ethylene oxide, saturated C.sub.16 to C.sub.30 diols, saturated C.sub.16 to C.sub.30 monoglycerol ethers, saturated C.sub.16 to C.sub.30 hydroxy fatty acids, and mixtures thereof, having a melting point of at least about 45.degree. C.; and (C) from about 0.05% to about 10% of a hydrophilic surfactant selected from the group consisting of anionic surfactants, cationic surfactants, zwitterionic surfactants, and mixtures thereof, and (D) from about 25% to about 98.949% water. These compositions are useful for delivering a wide variety of active ingredients to the skin.
摘要翻译：本发明涉及皮肤护理组合物，其包含：（A）约0.001％至约20％的活性成分，（B）约1％至约20％的稳定的疏水性结构剂，其选自由饱和C16至C30脂肪醇组成的组，含有约1至约5摩尔环氧乙烷的饱和C16至C30脂肪醇，饱和C16至C30二醇，饱和C16至C30单甘油醚，饱和C16至C30羟基脂肪酸，及其混合物，其熔点至少为约45℃。和（C）约0.05％至约10％的选自阴离子表面活性剂，阳离子表面活性剂，两性离子表面活性剂及其混合物的亲水性表面活性剂，（D）约25％至约98.949％的水。这些组合物可用于将多种活性成分递送至皮肤。

83. 发明授权

US5932228A Dermatological compositions and method of treatment of skin lesions therewith 失效
公开(公告)号：US5932228A
公开(公告)日：1999-08-03
申请号：US652083
申请日：1996-05-23
申请人： Bonnie Joy Hall , Julie Anne Baur , George Endel Deckner
发明人： Bonnie Joy Hall , Julie Anne Baur , George Endel Deckner
IPC分类号： A61K8/27 , A61K8/38 , A61K8/42 , A61K8/67 , A61K31/16 , A61K31/185 , A61K31/19 , A61K31/195 , A61K31/355 , A61K31/415 , A61K33/30 , A61K33/40 , A61Q17/00 , A61Q19/00 , A61K7/48
CPC分类号： A61K8/673 , A61K8/27 , A61K8/38 , A61K8/42 , A61Q17/00 , A61Q19/00 , A61K2800/75 , Y10S514/859 , Y10S514/864 , Y10S514/944
摘要： The present invention relates to compositions for treating acne and other skin lesions and also to methods of treatment utilizing these compositions. These compositions and methods of treatment employ benzoyl peroxide, a compound for reducing the skin irritation associated therewith, and a topical carrier.

84. 发明授权

US5874095A Enhanced skin penetration system for improved topical delivery of drugs 失效
标题翻译：增强皮肤渗透系统，改善药物的局部给药
公开(公告)号：US5874095A
公开(公告)日：1999-02-23
申请号：US49367
申请日：1998-03-27
申请人： George Endel Deckner , Brian Scott Lombardo
发明人： George Endel Deckner , Brian Scott Lombardo
IPC分类号： A61K8/35 , A61K8/36 , A61K8/368 , A61K8/81 , A61K9/00 , A61K9/107 , A61K9/113 , A61K31/78 , A61K45/08 , A61K47/32 , A61Q19/00 , A61Q19/04
CPC分类号： A61K8/36 , A61K47/32 , A61K8/35 , A61K8/368 , A61K8/8158 , A61K9/0014 , A61Q19/00 , A61Q19/04 , Y10S514/938 , Y10S514/944 , Y10S514/946 , Y10S514/969
摘要： The invention involves pharmaceutical compositions for topical application comprising:(a) a safe and effective amount of a pharmaceutical active; and(b) from about 0.05% to about 5% of a non-ionic polyacrylamide having a molecular wight of from about 1,000,000 to about 30,000,000.
摘要翻译：本发明涉及用于局部应用的药物组合物，其包括：（a）安全有效量的药物活性物质; 和（b）约0.05％至约5％的分子量约为1,000,000至约30,000,000的非离子聚丙烯酰胺。

85. 发明授权

US5780049A Enhanced skin penetration system for improved topical delivery of drugs 失效
公开(公告)号：US5780049A
公开(公告)日：1998-07-14
申请号：US464991
申请日：1995-06-05
申请人： George Endel Deckner , Brian Scott Lombardo
发明人： George Endel Deckner , Brian Scott Lombardo
IPC分类号： A61K8/35 , A61K8/36 , A61K8/368 , A61K8/81 , A61K9/00 , A61K9/107 , A61K9/113 , A61K31/78 , A61K45/08 , A61K47/32 , A61Q19/00 , A61Q19/04 , A61K47/44
CPC分类号： A61K8/36 , A61K47/32 , A61K8/35 , A61K8/368 , A61K8/8158 , A61K9/0014 , A61Q19/00 , A61Q19/04 , Y10S514/938 , Y10S514/944 , Y10S514/946 , Y10S514/969
摘要： The invention involves pharmaceutical compositions for topical application comprising: (a) a safe and effective amount of a pharmaceutical active; and (b) from about 0.05% to about 5% of a non-ionic polyacrylamide having a molecular wight of from about 1,000,000 to about 30,000,000.

86. 发明授权

US5756119A Enhanced skin penetration system for improved topical delivery of drugs 失效
公开(公告)号：US5756119A
公开(公告)日：1998-05-26
申请号：US462376
申请日：1995-06-05
申请人： George Endel Deckner , Brian Scott Lombardo
发明人： George Endel Deckner , Brian Scott Lombardo
IPC分类号： A61K8/35 , A61K8/36 , A61K8/368 , A61K8/81 , A61K9/00 , A61K9/107 , A61K9/113 , A61K31/78 , A61K45/08 , A61K47/32 , A61Q19/00 , A61Q19/04 , A61K9/07 , A61K47/44
CPC分类号： A61K8/36 , A61K47/32 , A61K8/35 , A61K8/368 , A61K8/8158 , A61K9/0014 , A61Q19/00 , A61Q19/04 , Y10S514/938 , Y10S514/944 , Y10S514/946 , Y10S514/969
摘要： The invention involves pharmaceutical compositions for topical application comprising: (a) a safe and effective amount of a pharmaceutical active; and (b) from about 0.05% to about 5% of a non-ionic polyacrylamide having a molecular weight of from about 1,000,000 to about 30,000,000.

87. 发明授权

US08226932B2 Prophy paste and weekly oral care compositions 有权
标题翻译： Prophy酱和每周口腔护理组合物
公开(公告)号：US08226932B2
公开(公告)日：2012-07-24
申请号：US12625223
申请日：2009-11-24
申请人： John Christian Haught , George Endel Deckner , Arif Ali Baig , Iain Allan Hughes
发明人： John Christian Haught , George Endel Deckner , Arif Ali Baig , Iain Allan Hughes
IPC分类号： A61K8/00 , A61K8/18 , A61Q11/00
CPC分类号： A61Q11/00 , A61K8/25 , A61K8/922 , A61K2800/28 , Y10T428/2982
摘要： An oral care composition comprising a fused silica abrasive, wherein the fused silica has a median particle size of at least about 7 microns and wherein the composition has a PCR of at least about 100.
摘要翻译：一种包含熔融二氧化硅研磨剂的口腔护理组合物，其中所述熔融二氧化硅具有至少约7微米的中值粒度，并且其中所述组合物具有至少约100的PCR。

88. 发明授权

US08211411B2 Oral care compositions comprising fused silica 有权
标题翻译：包含熔融二氧化硅的口腔护理组合物
公开(公告)号：US08211411B2
公开(公告)日：2012-07-03
申请号：US12625164
申请日：2009-11-24
申请人： George Endel Deckner , Arif Ali Baig , Iain Allan Hughes , John Christian Haught
发明人： George Endel Deckner , Arif Ali Baig , Iain Allan Hughes , John Christian Haught
IPC分类号： A61K8/00 , A61K8/18 , A61Q11/00
CPC分类号： A61Q11/00 , A61K8/25 , A61K8/922 , A61K2800/28 , Y10T428/2982
摘要： An oral care composition comprising a fused silica abrasive and an orally-acceptable carrier.
摘要翻译：一种口腔护理组合物，其包含熔融二氧化硅磨料和口服可接受的载体。

89. 发明授权

US08211406B2 Oral care compositions with fused silica 有权
标题翻译：口腔护理组合物与熔融二氧化硅
公开(公告)号：US08211406B2
公开(公告)日：2012-07-03
申请号：US12624617
申请日：2009-11-24
申请人： Arif Ali Baig , George Endel Deckner , Iain Allan Hughes , Erica Marie Kincaid
发明人： Arif Ali Baig , George Endel Deckner , Iain Allan Hughes , Erica Marie Kincaid
IPC分类号： A61K8/00 , A61K8/18 , A61K8/46 , A61Q11/00
CPC分类号： A61Q11/00 , A61K8/25 , A61K8/922 , A61K2800/28 , Y10T428/2982
摘要： An oral care composition comprising a fused silica abrasive and a stannous ion source.
摘要翻译：一种包含熔融石英磨料和亚锡离子源的口腔护理组合物。

90. 发明申请

US20110089073A1 Methods And Compositions For Hydrophobic Modification Of Oral Cavity Surfaces 审中-公开
标题翻译：口腔表面疏水改性的方法和组合物
公开(公告)号：US20110089073A1
公开(公告)日：2011-04-21
申请号：US12879214
申请日：2010-09-10
申请人： Arif Ali Baig , Jayanth Rajaiah , George Endel Deckner , William Michael Glandorf
发明人： Arif Ali Baig , Jayanth Rajaiah , George Endel Deckner , William Michael Glandorf
IPC分类号： B65D85/00 , A61K8/46 , A61Q11/00
CPC分类号： A61Q11/00 , A61K8/24 , A61K8/55 , A61K8/556 , A61Q11/02
摘要： Oral care compositions containing agents that are effective for treating and modifying teeth and mucosal surfaces to be hydrophobic are disclosed. Hydrophobic modification of teeth and other oral cavity surfaces imparts a variety of end use benefits including prevention of caries, erosion, wear, staining, sensitivity and desquamation as well as providing shine, smoothness and positive tooth feel benefits. The compositions contain selected surface active organophosphate compounds that deposit and adhere to teeth and other oral cavity surfaces forming a hydrophobic coating having prolonged retention thereon. By forming a “hydrophobic coating” on the oral cavity surface is meant that the hydrophobic character of the surface is increased as measured, for example, by an increase of at least about 10 degrees in the water contact angle of the surface after treatment. The increased hydrophobic character of the surface is maintained for a period of at least about 5 minutes and desirably longer such as at least about 10, at least about 20 or at least about 30 minutes. The compositions may contain additional hydrophobic materials to further increase hydrophobicity of the surface and/or functionality of the coating to provide surface protection and many other benefits.
摘要翻译：公开了含有有效治疗和改变牙齿和粘膜表面是疏水性的试剂的口腔护理组合物。牙齿和其他口腔表面的疏水改性赋予各种最终用途益处，包括预防龋齿，侵蚀，磨损，染色，敏感性和脱屑，以及提供光泽，光滑度和积极的牙齿感受益处。组合物含有选择的表面活性有机磷酸盐化合物，其沉积并粘附到牙齿和其它口腔表面上，形成具有延长的保留性的疏水涂层。通过在口腔表面上形成“疏水性涂层”是指表面的疏水特性例如通过在处理后表面的水接触角增加至少约10度来测量而增加。表面增加的疏水特性保持至少约5分钟，期望更长，例如至少约10，至少约20或至少约30分钟。组合物可以含有另外的疏水材料以进一步增加涂层的表面和/或功能性的疏水性，以提供表面保护和许多其它益处。

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