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81. 发明授权

US09877781B2 Electrode catheter device with indifferent electrode for direct current tissue therapies 有权
公开(公告)号：US09877781B2
公开(公告)日：2018-01-30
申请号：US13885776
申请日：2011-11-18
申请人： Martin M. Grasse , Richard E. Stehr , Israel A. Byrd , Lynn E. Gilmour , D. Curtis Deno , Troy T. Tegg , James V. Kauphusman , Saurav Paul , Jeffrey A. Schweitzer
发明人： Martin M. Grasse , Richard E. Stehr , Israel A. Byrd , Lynn E. Gilmour , D. Curtis Deno , Troy T. Tegg , James V. Kauphusman , Saurav Paul , Jeffrey A. Schweitzer
IPC分类号： A61N1/00 , A61B5/04 , A61B18/16 , A61B5/042 , A61B18/14 , A61B18/00 , A61M25/01 , A61M25/06
CPC分类号： A61B18/16 , A61B5/042 , A61B18/1492 , A61B2018/00357 , A61B2018/00613 , A61B2018/00791 , A61B2018/1435 , A61B2018/162 , A61M25/0147 , A61M2025/0681
摘要： An electrode catheter device with indifferent electrode for direct current tissue therapies is disclosed. An example of the catheter device has a flexible tubing with at least one ablation electrode. The catheter device also may also be used with a sheath for introducing the flexible tubing inside a patient's body. An indifferent electrode on the sheath can provide a ground for a direct current (DC) pulse to deliver electrical energy and create an electrical field adjacent a tissue. Various other embodiments are also disclosed.

82. 发明申请

US20130172874A1 FLEXIBLE CONDUCTIVE POLYMER BASED CONFORMABLE DEVICE AND METHOD TO CREATE LINEAR ENDOCARDIAL LESIONS 审中-公开
标题翻译：基于柔性导电聚合物的一致性装置和产生线性内分泌的方法
公开(公告)号：US20130172874A1
公开(公告)日：2013-07-04
申请号：US13340127
申请日：2011-12-29
申请人： Saurav Paul , Riki Chou Thao
发明人： Saurav Paul , Riki Chou Thao
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2017/00039 , A61B2017/00053 , A61B2018/00357 , A61B2018/00577 , A61B2018/00875 , A61B2018/1407 , A61B2090/065
摘要： An ablation device for creating linear lesions comprises a flexible support structure defining at least a partial curve; and an electrode disposed on the flexible support structure. The electrode comprises a pressure sensitive conductive composite that is configured for electrical communication with an electrical conductor and a flexible conductive outer covering that covers at least a portion of the pressure sensitive conductive composite. Electrical resistance of the pressure sensitive conductive composite varies inversely in proportion to pressure that is applied to the pressure sensitive conductive composite. Methods of creating linear lesions are also provided.
摘要翻译：用于产生线性损伤的消融装置包括限定至少部分曲线的柔性支撑结构; 以及设置在柔性支撑结构上的电极。电极包括压敏导电复合材料，其被配置为与电导体电连通，并且柔性导电外覆层覆盖至少一部分压敏导电复合材料。压敏导电复合材料的电阻与施加在压敏导电复合材料上的压力成反比。还提供了创建线性损伤的方法。

83. 发明申请

US20130131669A1 Accelerometer-based contact sensing assembly and system 有权
公开(公告)号：US20130131669A1
公开(公告)日：2013-05-23
申请号：US13740624
申请日：2013-01-14
申请人： Troy T. Tegg , Saurav Paul
发明人： Troy T. Tegg , Saurav Paul
IPC分类号： A61B18/14
CPC分类号： A61M25/0054 , A61B5/067 , A61B2034/2048 , A61B2562/0219 , A61M25/00 , A61M2025/0166 , A61N1/36542 , A61N1/36578
摘要： A catheter system including an accelerometer-based sensing assembly is provided. In particular the present teachings relate to an accelerometer based assembly used to determine contact between a catheter and surrounding proximate tissue, such as cardiac tissue. An embodiment of such a system may, for example, be used for visualization, mapping, ablation, or other methods of diagnosis and treatment of tissue and/or surrounding areas.

84. 发明申请

US20120035460A1 MOVABLE MAGNET FOR MAGNETICALLY GUIDED CATHETER 有权
标题翻译：用于磁导管的可变磁铁
公开(公告)号：US20120035460A1
公开(公告)日：2012-02-09
申请号：US12851407
申请日：2010-08-05
申请人： Todd R. Stangenes , Saurav Paul , James V. Kauphusman , Troy T. Tegg , Jeffrey A. Schweitzer
发明人： Todd R. Stangenes , Saurav Paul , James V. Kauphusman , Troy T. Tegg , Jeffrey A. Schweitzer
IPC分类号： A61M25/092 , A61B5/055 , A61B6/12
CPC分类号： A61M25/0127 , A61B5/0422 , A61B5/055 , A61B5/062 , A61B5/6857 , A61B6/12 , A61B6/487 , A61B18/1492 , A61B34/32 , A61B34/73 , A61B2018/00375 , A61B2018/00577 , A61B2018/00791 , A61B2034/301 , A61B2034/303 , A61B2034/731 , A61B2034/732 , A61B2562/0271 , A61M25/0158
摘要： A catheter is disclosed having a flexible tubing with a proximal end and a distal end. The catheter comprising at least one movable magnet provided within the distal end of the flexible tubing. A control mechanism is operable to selectively activate the at least one movable magnet from the proximal end of the flexible tubing. The at least one movable magnet is responsive to an external magnetic field to position and guide the distal end of the flexible tubing within a body of a patient.
摘要翻译：公开了一种具有近端和远端的柔性管的导管。导管包括设置在柔性管的远端内的至少一个可动磁体。控制机构可操作以从柔性管的近端选择性地启动至少一个可动磁体。所述至少一个可移动磁体响应外部磁场来定位和引导患者体内的柔性管的远端。

85. 发明申请

US20110270191A1 Fast-acting or rotating transseptal needle 有权
标题翻译：快速或旋转经口针
公开(公告)号：US20110270191A1
公开(公告)日：2011-11-03
申请号：US13142957
申请日：2009-12-23
申请人： Saurav Paul , Todd R. Stangenes , Reer R. Heimbecher
发明人： Saurav Paul , Todd R. Stangenes , Reer R. Heimbecher
IPC分类号： A61B17/34
CPC分类号： A61B17/3403 , A61B17/3478 , A61B17/3498 , A61B2017/00243 , A61B2017/3405 , A61M29/00
摘要： A transseptal medical device (10, 110) is provided including a dilator (12, 112), a needle (14, 114), and a needle control mechanism (22, 122). The needle (14, 114) may be disposed within the dilator (12, 112), and the needle control mechanism (22, 122) may be operably connected to a proximal end (24, 124, 16, 116) of the needle (14, 114) or the dilator (12, 112) for selective adjustment of the distal end (26, 126) of the needle (14, 114) from a first position within the dilator (12, 112) to a second position external to the dilator (12, 112). The needle control mechanism (22) may include an actuator (32) configured for rotation within the dilator in one embodiment.
摘要翻译：提供了一种经血管医疗装置（10,110），其包括扩张器（12,112），针（14,114）和针控制机构（22,122）。针（14,114）可以设置在扩张器（12,112）内，并且针控制机构（22,122）可以可操作地连接到针的近端（24,124,16,116） 14,114）或扩张器（12,112），用于选择性地将针（14,114）的远端（26,126）从扩张器（12,112）内的第一位置调节到第二位置扩张器（12,112）。针控制机构（22）可以包括在一个实施例中构造成用于在扩张器内旋转的致动器（32）。

86. 发明授权

US07824377B2 Tissue anchoring catheter systems and methods 有权
标题翻译：组织锚固导管系统及方法
公开(公告)号：US07824377B2
公开(公告)日：2010-11-02
申请号：US11962512
申请日：2007-12-21
申请人： James V. Kauphusman , Israel A. Byrd , Saurav Paul
发明人： James V. Kauphusman , Israel A. Byrd , Saurav Paul
IPC分类号： A61M5/178
CPC分类号： A61M25/04 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2090/065 , A61M25/0084 , A61M2025/0089 , A61M2025/0095
摘要： Catheter systems and methods are disclosed for anchoring the catheter system to tissue, e.g., for delivery of biologic or chemical agents, or other therapeutic fluid during various procedures. An exemplary tissue anchoring catheter comprises an outer catheter shaft connected to a catheter handle. A delivery sheath is provided within the outer catheter shaft, the delivery sheath housing a needle. At least one anchor is operatively associated with the delivery sheath, the at least one anchor operable at the catheter handle to secure the delivery sheath to tissue for conveying biologic or chemical agents, or other therapeutic fluid from the needle to the tissue. The tissue anchoring catheter may further comprise sensing means such as piezoelectric, pressure, thermistor, thermocouple, or ultrasound sensors.
摘要翻译：公开了用于将导管系统锚定到组织的导管系统和方法，例如用于在各种程序期间递送生物或化学试剂或其它治疗性流体。示例性组织锚定导管包括连接到导管手柄的外导管轴。输送护套设置在外导管轴内，输送护套容纳针。至少一个锚定件与输送护套可操作地相关联，所述至少一个锚固件可在导管手柄处操作以将输送护套固定到组织，用于将生物或化学试剂或其它治疗流体从针输送到组织。组织锚定导管还可以包括诸如压电，压力，热敏电阻，热电偶或超声波传感器的感测装置。

87. 发明申请

US20090163904A1 System and Method for Assessing Coupling Between an Electrode and Tissue 有权
标题翻译：用于评估电极和组织之间耦合的系统和方法
公开(公告)号：US20090163904A1
公开(公告)日：2009-06-25
申请号：US12253637
申请日：2008-10-17
申请人： Stephan P. Miller , Don Curtis Deno , Saurav Paul
发明人： Stephan P. Miller , Don Curtis Deno , Saurav Paul
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B5/053 , A61B18/1233 , A61B18/14 , A61B2018/00178 , A61B2018/00875 , A61B2090/065
摘要： A system and method for assessing a degree of coupling between an electrode and tissue in a body is provided. Values for first and second components of a complex impedance (e.g., resistance and reactance or impedance magnitude and phase angle) between the electrode and the tissue are obtained. From these values, a coupling index is calculated that that is indicative of a degree of coupling between the electrode and the tissue. The coupling index may be displayed to a clinician in a variety of ways to indicate the degree of coupling to the clinician. The system and method find particular application in ablation of tissue by permitting a clinician to create lesions in the tissue more effectively and safely.
摘要翻译：提供了一种用于评估身体中电极和组织之间的耦合程度的系统和方法。获得电极和组织之间的复阻抗的第一和第二分量的值（例如，电阻和电抗或阻抗幅度和相位角）。根据这些值，计算出表示电极和组织之间的耦合程度的耦合指数。耦合指数可以以各种方式显示给临床医生以指示与临床医生的耦合程度。该系统和方法通过允许临床医生更有效和安全地在组织中产生损伤来发现组织消融中的特定应用。

88. 发明授权

US09579483B2 Pressure-sensitive conductive composite contact sensor and method for contact sensing 有权
标题翻译：压敏导电复合接触传感器和接触感应方法
公开(公告)号：US09579483B2
公开(公告)日：2017-02-28
申请号：US11647314
申请日：2006-12-29
申请人： Kedar Ravindra Belhe , Saurav Paul
发明人： Kedar Ravindra Belhe , Saurav Paul
IPC分类号： A61B5/00 , A61M25/00 , A61B18/14
CPC分类号： A61B18/1492 , A61B5/6885 , A61B2018/00083 , A61B2018/00577 , A61B2018/00875 , A61B2018/00988 , A61B2090/064 , A61B2090/065 , A61B2562/0209 , A61M25/00 , A61M2025/0002 , G01L1/20
摘要： A catheter assembly for assessing contact between the catheter assembly and tissue is disclosed. The assembly includes a catheter shaft and a pressure sensitive conductive composite member whose electrical resistance varies with pressure applied to the catheter assembly. The assembly also includes at least one measurement terminal to permit the measurement of changes in the electrical characteristics of the pressure sensitive conductive composite member. The assembly may optionally include a measurement device to measure resistance, impedance and/or other electrical characteristics. The assembly may utilize a reference electrode secured to the patient's tissue, which permits the measurement device to measure changes between the reference electrode and the at least one measurement terminal. Optionally, the assembly may include a conductive outer layer. Also disclosed are sensor assemblies, contact sensor, methods of contact sensing, and methods of manufacturing relating to the use of pressure sensitive conductive composites.
摘要翻译：公开了一种用于评估导管组件和组织之间的接触的导管组件。组件包括导管轴和压力敏感的导电复合构件，其电阻随着施加到导管组件的压力而变化。组件还包括至少一个测量端子，以允许测量压敏导电复合构件的电特性的变化。组件可以可选地包括测量电阻，阻抗和/或其他电特性的测量装置。组件可以利用固定到患者组织的参考电极，其允许测量装置测量参考电极和至少一个测量终端之间的变化。可选地，组件可以包括导电外层。还公开了传感器组件，接触传感器，接触感测方法以及与使用压敏导电复合材料有关的制造方法。

89. 发明授权

US09198726B2 Photodynamic-based cardiac ablation device and method via the esophagus 有权
标题翻译：基于光动力学的心脏消融装置和通过食道的方法
公开(公告)号：US09198726B2
公开(公告)日：2015-12-01
申请号：US11967350
申请日：2007-12-31
申请人： Saurav Paul , Israel A. Byrd
发明人： Saurav Paul , Israel A. Byrd
IPC分类号： A61B18/18 , A61B18/24 , A61N5/06 , A61B18/22
CPC分类号： A61B18/24 , A61B2018/2272 , A61N5/0601 , A61N5/062
摘要： A method and system for ablation of cardiac tissue in a living being via the esophagus is provided. The method includes the step of introducing a photodynamic substance to the cardiac tissue. A deformable, elongated body defining a proximal end and a distal end is inserted into an esophagus of the living being. The distal end of the elongated body is located proximate the cardiac tissue. A first set of electromagnetic radiation is then directed from the distal end of the elongated body towards the cardiac tissue. Reflective and opaque surfaces at the distal end of the elongated body may be used to direct the electromagnetic radiation and an expandable membrane at the distal end may be used to urge the distal end of the elongated body to a predetermined position within the esophagus.
摘要翻译：提供了一种通过食道消融心脏组织的方法和系统。该方法包括将光动力学物质引入心脏组织的步骤。限定近端和远端的可变形的细长主体被插入到生命的食道中。细长体的远端位于心脏组织附近。然后将第一组电磁辐射从细长体的远端引向心脏组织。在细长体的远端处的反射和不透明表面可以用于引导电磁辐射，并且在远端处的可扩张膜可以用于将细长体的远端推动到食道内的预定位置。

90. 发明授权

US08449535B2 System and method for assessing coupling between an electrode and tissue 有权
标题翻译：用于评估电极和组织之间的耦合的系统和方法
公开(公告)号：US08449535B2
公开(公告)日：2013-05-28
申请号：US12253637
申请日：2008-10-17
申请人： Don Curtis Deno , Stephan Paul Miller , Saurav Paul
发明人： Don Curtis Deno , Stephan Paul Miller , Saurav Paul
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B5/053 , A61B18/1233 , A61B18/14 , A61B2018/00178 , A61B2018/00875 , A61B2090/065
摘要： A system and method for assessing a degree of coupling between an electrode and tissue in a body is provided. Values for first and second components of a complex impedance (e.g., resistance and reactance or impedance magnitude and phase angle) between the electrode and the tissue are obtained. From these values, a coupling index is calculated that is indicative of a degree of coupling between the electrode and the tissue. The coupling index may be displayed to a clinician in a variety of ways to indicate the degree of coupling to the clinician. The system and method find particular application in ablation of tissue by permitting a clinician to create lesions in the tissue more effectively and safely.
摘要翻译：提供了一种用于评估身体中电极和组织之间的耦合程度的系统和方法。获得电极和组织之间的复阻抗的第一和第二分量的值（例如，电阻和电抗或阻抗幅度和相位角）。根据这些值，计算表示电极和组织之间的耦合程度的耦合指数。耦合指数可以以各种方式显示给临床医生以指示与临床医生的耦合程度。该系统和方法通过允许临床医生更有效和安全地在组织中产生损伤来发现组织消融中的特定应用。

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