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81. 发明专利

DK2489743T3 Aptamerer med 5-(N-naphthyl)-substituerede uridiner 未知
公开(公告)号：DK2489743T3
公开(公告)日：2015-03-02
申请号：DK12160299
申请日：2008-07-17
申请人： SOMALOGIC INC
发明人： WILCOX SHERI K , BOCK CHRIS , ZICHI DOMINIC , SCHNEIDER DANIEL J , EATON BRUCE , GOLD LARRY
IPC分类号： C12Q1/68

82. 发明专利

AU2010271271B2 Method for generating aptamers with improved off-rates 未知
公开(公告)号：AU2010271271B2
公开(公告)日：2015-01-29
申请号：AU2010271271
申请日：2010-07-09
申请人： SOMALOGIC INC
发明人： ZICHI DOMINIC , WILCOX SHERI K , BOCK CHRIS , SCHNEIDER DANIEL J , EATON BRUCE , GOLD LARRY , JARVIS THALE C , CARTER JEFFREY D
IPC分类号： C12Q1/68
摘要： The present disclosure describes the identification and use of aptamers and photoaptamers having slower dissociation rate constants than those obtained using previously described methods. Specifically, the present disclosure describes methods for the identification and use of aptamers to one or more targets within a histological or cytological sample, which have slow rates of dissociation. The aptamers may be used to assess localization, relative density, and presence or absence of one or more targets in cytological and histological samples. Targets may be selected that are specific and diagnostic of a given disease state for which the sample was collected. The aptamers may also be used to introduce target specific signal moieties. In addition to target identification, the aptamers may be used to amplify signal generation through a variety of methods.

83. 发明专利

AU2013248169A1 MULTIPLEXED ANALYSES OF TEST SAMPLES 未知
公开(公告)号：AU2013248169A1
公开(公告)日：2014-01-30
申请号：AU2013248169
申请日：2013-11-29
申请人： SOMALOGIC INC
发明人： HEIL JAMES R , SCHNEIDER DANIEL J , NIEUWLANDT DANIEL T , WILLCOX SHERI K , ZICHI DOMINIC , GANDER TODD , EATON BRUCE , GOLD LARRY
IPC分类号： C12Q1/68
摘要： The present disclosure describe methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. In one embodiment, a test sample is contacted with an aptamer that includes a tag and has a specific affinity for a target molecule. An aptamer affinity complex that includes an aptamer bound to its target molecule is allowed to form. If the test sample contains the target molecule, an aptamer affinity complex will generally form in the test sample. The aptamer affinity complex is optionally converted to an aptamer covalent complex that includes an aptamer covalently bound to its target molecule. The aptamer affinity complex (or optional aptamer covalent complex) can then be detected and/or quantified using any of a variety of methods known to one skilled in the art, including using a solid support, using mass spectrometry, and using quantitative polymerase chain reaction (Q-PCR). - 62a-

84. 发明专利

AT530665T 未知
公开(公告)号：AT530665T
公开(公告)日：2011-11-15
申请号：AT98963150
申请日：1998-12-14
申请人： SOMALOGIC INC
发明人： GOLD LARRY , DROLET DANIEL , ZICHI DOMINIC , JAYASENA SUMEDHA , CREIGHTON STEVE , GILL STANLEY
IPC分类号： C12Q1/68 , G01N33/53 , C07B61/00 , C07H21/04 , C12M1/00 , C12N15/09 , C12P19/34 , G01N33/543 , G01N33/566 , G01N37/00
摘要： A nucleic acid ligand "biochip" is disclosed, consisting of a solid support to which one or more specific nucleic acid ligands is attached in a spatially defined manner. Each nucleic acid ligand binds specifically and avidly to a particular target molecule contained within a test mixture, such as a bodily fluid. The target molecules include, but are not limited to, proteins (cellular, viral, bacterial, etc.) hormones, sugars, metabolic byproducts, cofactor, and intermediates, drugs, and toxins. Contacting the test mixture with the biochip leads to the binding of a target molecule to its cognate nucleic acid ligand. Binding of target to the nucleic acid ligand results in a detectable change at each specific location on the biochip. The detectable change can include, but is not limited to, a change in fluorescence, or a change in a physical parameter, such as electrical conductance or refractive index, at each location on the biochip. The biochip will then be read by a device, such as a fluorescence scanner or a surface plasmon resonance detector, that can measure the magnitude of the change at each location on the biochip. The location of the change reveals what target molecule has been detected, and the magnitude of the change indicates how much of it is present. The combination of these two pieces of information will yield diagnostic and prognostic medical information when signal patterns are compared with those obtained from bodily fluids of individuals with diagnosed disorders. In principle, the biochip could be used to test any chemically complex mixture provided that nucleic acid ligands to components suspected of being present in the mixture are attached to the biochip. Thus, the nucleic acid ligand biochip will have a wider use in environmental testing, etc.

85. 发明专利

CA2765857A1 METHOD FOR GENERATING APTAMERS WITH IMPROVED OFF-RATES 未知
公开(公告)号：CA2765857A1
公开(公告)日：2011-01-13
申请号：CA2765857
申请日：2010-07-09
申请人： SOMALOGIC INC
发明人： ZICHI DOMINIC , WILCOX SHERI K , BOCK CHRIS , SCHNEIDER DANIEL J , EATON BRUCE , GOLD LARRY , JARVIS THALE C , CARTER JEFFREY D
IPC分类号： C12Q1/68 , C07H21/00 , C12N15/115 , C40B30/04 , G01N33/50
摘要： The present disclosure describes the identification and use of aptamers and photoaptamers having slower dissociation rate constants than those obtained using previously described methods. Specifically, the present disclosure describes methods for the identification and use of aptamers to one or more targets within a histological or cytological sample, which have slow rates of dissociation. The aptamers may be used to assess localization, relative density, and presence or absence of one or more targets in cytological and histological samples. Targets may be selected that are specific and diagnostic of a given disease state for which the sample was collected. The aptamers may also be used to introduce target specific signal moieties. In addition to target identification, the aptamers may be used to amplify signal generation through a variety of methods.

86. 发明专利

CA3011730A1 LUNG CANCER BIOMARKERS AND USES THEREOF 未知
公开(公告)号：CA3011730A1
公开(公告)日：2010-03-18
申请号：CA3011730
申请日：2009-09-09
申请人： SOMALOGIC INC
发明人： GOLD LARRY , STANTON MARTY , BRODY EDWARD N , OSTROFF RACHEL M , ZICHI DOMINIC , STEWART ALEX A
IPC分类号： C12Q1/6813 , C12Q1/6809 , C12Q1/6886 , C40B30/04 , G01N33/53 , G06F19/20
摘要： The present application includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of lung cancer. In one aspect, the application provides biomarkers that can be used alone or in various combinations to diagnose lung cancer or permit the differential diagnosis of pulmonary nodules as benign or malignant. In another aspect, methods are provided for diagnosing lung cancer in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 1, Co1. 2, wherein the individual is classified as having lung cancer, or the likelihood of the individual having lung cancer is determined, based on the at least one biomarker value.

87. 发明专利

CA2734535A1 LUNG CANCER BIOMARKERS AND USES THEREOF 未知
公开(公告)号：CA2734535A1
公开(公告)日：2010-03-18
申请号：CA2734535
申请日：2009-09-09
申请人： SOMALOGIC INC
发明人： GOLD LARRY , STANTON MARTY , BRODY EDWARD N , OSTROFF RACHEL M , ZICHI DOMINIC , STEWART ALEX A E
IPC分类号： G06G7/58 , G01N33/50
摘要： The present application includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of lung cancer. In one aspect, the application provides biomarkers that can be used alone or in various combinations to diagnose lung cancer or permit the differential diagnosis of pulmonary nodules as benign or malignant. In another aspect, methods are provided for diagnosing lung cancer in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 1, Col. 2, wherein the individual is classified as having lung cancer, or the likelihood of the individual having lung cancer is determined, based on the at least one biomarker value.

88. 发明专利

AU2009291811A1 Lung cancer biomarkers and uses thereof 未知
公开(公告)号：AU2009291811A1
公开(公告)日：2010-03-18
申请号：AU2009291811
申请日：2009-09-09
申请人： SOMALOGIC INC
发明人： GOLD LARRY , STANTON MARTY , BRODY EDWARD N , OSTROFF RACHEL M , ZICHI DOMINIC , STEWART ALEX A E
IPC分类号： G06G7/58 , G01N33/50
摘要： The present application includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of lung cancer. In one aspect, the application provides biomarkers that can be used alone or in various combinations to diagnose lung cancer or permit the differential diagnosis of pulmonary nodules as benign or malignant. In another aspect, methods are provided for diagnosing lung cancer in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 1, Co1. 2, wherein the individual is classified as having lung cancer, or the likelihood of the individual having lung cancer is determined, based on the at least one biomarker value.

89. 发明专利

HK1132012A1 測試樣本的分析未知
公开(公告)号：HK1132012A1
公开(公告)日：2010-02-12
申请号：HK09111557
申请日：2009-12-10
申请人： SOMALOGIC INC
发明人： SCHNEIDER DANIEL J , NIEUWLANDT DAN , EATON BRUCE , STANTON MARTY , GUPTA SHASHI , KRAEMER STEPHAN , ZICHI DOMINIC , GOLD LARRY
IPC分类号： C12Q20060101 , C07H20060101

90. 发明专利

CA3022666A1 MULTIPLEXED ANALYSES OF TEST SAMPLES 未知
公开(公告)号：CA3022666A1
公开(公告)日：2009-01-22
申请号：CA3022666
申请日：2008-07-17
申请人： SOMALOGIC INC
发明人： SCHNEIDER DANIEL J , NIEUWLANDT DAN , EATON BRUCE , STANTON MARTY , GUPTA SHASHI , KRAEMER STEPHAN , ZICHI DOMINIC , GOLD LARRY
IPC分类号： C12Q1/6813 , C12Q1/68 , C12Q1/6876 , C40B30/04 , G01N33/53
摘要： The present disclosure describes improved SELEX methods for producing aptamers that are capable of binding to target molecules and improved photoSELEX methods for producing photoreactive aptamers that are capable of both binding and covalently cross linking to target molecules. Specifically, the present disclosure describes methods for producing aptamers and photoaptamers having slower dissociation rate constants than are obtained using prior SELEX and photoSELEX methods. The disclosure further describes aptamers and photoaptamers having slower dissociation rate constants than those obtained using prior methods. In addition, the disclosure describes aptamer constructs that include a variety of functionalities, including a cleavable element, a detection element, and a capture or immobilization element.

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