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81. 发明专利

BRPI0712430A2 未知
公开(公告)号：BRPI0712430A2
公开(公告)日：2012-07-03
申请号：BRPI0712430
申请日：2007-06-07
申请人： SPEEDEL EXPERIMENTA AG
发明人： HEROLD PETER , MAH ROBERT , STUTZ STEFAN , TSCHINKE VINCENZO , LYOTHIER ISABELLE , JELAKOVIC STJEPAN , QUIRMBACH MICHAEL , MARTI CHRISTIANE
IPC分类号： C07D405/12 , A61K31/538 , A61P9/12 , C07D405/14 , C07D413/12 , C07D413/14

82. 发明专利

BRPI0710614A2 未知
公开(公告)号：BRPI0710614A2
公开(公告)日：2011-08-16
申请号：BRPI0710614
申请日：2007-04-12
申请人： SPEEDEL EXPERIMENTA AG
发明人： HEROLD PETER , MAH ROBERT , TSCHINKE VINCENZO , STOJANOVIC ALEKSANDAR , MARTI CHRISTIANE , JELAKOVIC STJEPAN , STUTZ STEFAN
IPC分类号： C07D498/04 , A61K31/4188 , A61P5/40 , C07D513/04

83. 发明专利

BRPI0709695A2 未知
公开(公告)号：BRPI0709695A2
公开(公告)日：2011-07-19
申请号：BRPI0709695
申请日：2007-03-30
申请人： SPEEDEL EXPERIMENTA AG
发明人： MARTIN PIERRE , BOUDIER ANDREAS , QUIRMBACH MICHAEL , MAH ROBERT , JOTTERAND NATHALIE
IPC分类号： C07D213/65 , C07D233/22 , C07D471/04 , C07F7/08 , C07F7/18
摘要： 6,7-Dihydro-5H-imidazo[1,5-a]pyridin-8-one (I), is obtainable in high yields by: 1) a process which proceeds from a suitably protected C-(3-hydroxypyridin-2-yl)methylamine whose amine is converted to the formamide which is then cyclized to the imidazo[1,5-a]pyridine and hydrogenated to the 6,7-dihydro-5H-imidazo[1,5-a]pyridin-8-one, and suitably protected C-(3-hydroxypyridin-2-yl)methylamines can be prepared either in 2 steps proceeding from commercially available 3-hydroxy-2-cyanopyridine [932-35-4] or in 3 steps proceeding from commercially available 2-hydroxymethylpyridin-3-ol [14173-30-9]; 2) a process for preparing 4-hydroxy-1-(1H-imidazol-4-yl)butan-1-one, an intermediate from the synthesis of 6,7-dihydro-5H-imidazo[1,5-a]pyridin-8-one (formula I), as described in WO 2002/040484, proceeding from N,N-dimethyl-2-(trialkylsilanyl)imidazole-1-sulphonamide by lithiation and subsequent reaction with a suitably protected 4-hydroxybutyraldehyde, followed by oxidation of the secondary alcohol, acid-induced deprotection of the imidazole and deprotection of the alcohol functionality; 3) a process which proceeds from 5,6,7,8-tetrahydroimidazo[1,5-a]pyridine [38666-30-7], which is oxidized.

84. 发明专利

BRPI0611313A2 未知
公开(公告)号：BRPI0611313A2
公开(公告)日：2011-02-22
申请号：BRPI0611313
申请日：2006-05-30
申请人： SPEEDEL EXPERIMENTA AG
发明人： HEROLD PETER , MAH ROBERT , TSCHINKE VINCENZO , STOJANOVIC ALEKSANDAR , MARTI CHRISTIANE , JOTTERAND NATHALIE , SCHUMACHER CHRISTOPH , QUIRMBACH MICHAEL
IPC分类号： C07D491/20 , A61P5/00 , C07D471/10 , C07D471/20 , C07D491/10
摘要： The patent application relates to new heterocyclic compounds of the general formula (I) in which A, R, R1, R2, U, V, W, X, Y, Z, n and p have the definitions elucidated in more detail in the description, to a process for preparing them and to the use of these compounds as medicaments, particularly as aldosterone synthase inhibitors.

85. 发明专利

BRPI0609656A2 未知
公开(公告)号：BRPI0609656A2
公开(公告)日：2010-04-20
申请号：BRPI0609656
申请日：2006-03-30
申请人： SPEEDEL EXPERIMENTA AG
发明人： HEROLD PETER , MAH ROBERT , TSCHINKE VINCENZO , BEHNKE DIRK , MARTI CHRISTIANE , JOTTERAND NATHALIE , STUTZ STEFAN , QUIRMBACH MICHAEL
IPC分类号： C07D413/12 , A61K31/538 , A61P9/00 , A61P27/06 , C07D413/14

86. 发明专利

MX2009001404A ESTERES DE NITRATO DE PIPERIDINAS. 未知
公开(公告)号：MX2009001404A
公开(公告)日：2009-05-13
申请号：MX2009001404
申请日：2007-08-07
申请人： SPEEDEL EXPERIMENTA AG
发明人： HEROLD PETER , MAH ROBERT , STUTZ STEFAN , TSCHINKE VICENZO , LYOTHIER ISABELLE , SCHUMACHER CHRISTOPH , MARTI CHRISTIANE , JOTTERAND NATHALIE
IPC分类号： C07D401/04 , A61K31/445 , A61P9/00 , C07D405/04 , C07D405/12 , C07D413/04
摘要： La solicitud se refiere a a nuevos derivados de éster de nitrato de piperidinas sustituidas de la fórmula general (I), en donde R1, R2, R3, X, y Z0, y m, n, p, y q tienen los significados explicados en más detalle en la descripción, un proceso para su preparación y el uso de estos compuestos como un agente curativo en enfermedades cardiovasculares, en particular alta presión sanguínea y daño vascular y de órganos que acompaña la alta presión sanguínea.

87. 发明专利

AT421501T 未知
公开(公告)号：AT421501T
公开(公告)日：2009-02-15
申请号：AT06117363
申请日：2005-03-17
申请人： SPEEDEL EXPERIMENTA AG
发明人： HEROLD PETER , STUTZ STEFAN , MAH ROBERT , TSCHINKE VINCENZO , STOJANOVIC ALEKSANDAR , JOTTERAND NATHALIE , QUIRMBACH MICHAEL , BEHNKE DIRK , MARTI CHRISTIANE
IPC分类号： C07D209/12 , A61K31/405 , A61P9/04 , A61P9/10 , A61P9/12 , A61P27/06 , A61P31/12 , C07C237/06 , C07C237/22 , C07D209/20 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： The application relates to novel alkanamides of the general formula where X, R 1 , R 2 , R 3 , R 4 and R 5 are each as defined in detail in the description, to a process for their preparation and to the use of these compounds as medicines, especially as renin inhibitors.

88. 发明专利

BRPI0518998A2 未知
公开(公告)号：BRPI0518998A2
公开(公告)日：2008-12-23
申请号：BRPI0518998
申请日：2005-12-09
申请人： SPEEDEL EXPERIMENTA AG
发明人： HEROLD PETER , STUTZ STEFAN , MAH ROBERT , TSCHINKE VINCENZO , MARTI CHRISTIANE
IPC分类号： C07C237/20 , A61K31/165

89. 发明专利

HK1110065A1 OMEGA-PHENYLOCTANAMIDES 未知
公开(公告)号：HK1110065A1
公开(公告)日：2008-07-04
申请号：HK08100623
申请日：2008-01-17
申请人： SPEEDEL EXPERIMENTA AG
发明人： HEROLD PETER , STUTZ STEFAN , MAH ROBERT , TSCHINKE VINCENZO , MARTI CHRISTIANE
IPC分类号： A61K20090101 , C07C20090101

90. 发明专利

BRPI0513199A 未知
公开(公告)号：BRPI0513199A
公开(公告)日：2008-04-29
申请号：BRPI0513199
申请日：2005-07-11
申请人： SPEEDEL EXPERIMENTA AG
发明人： HEROLD PETER , MAH ROBERT , STUTZ STEFAN , STOJANOVIC ALEKSANDAR , TSCHINKE VICENZO , JOTTERAND NATHALIE , BEHNKE DIRK
IPC分类号： C07D413/14 , A61K31/538 , C07D413/12
摘要： The application relates to novel substituted piperidines of the general formula (I) in which R 1 , R 2 , R 3 , R 4 , W, X, Z, m and n are each as defined in detail in the description, to a process for their preparation and to the use of these compounds as medicines, in particular as renin inhibitors.

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