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81. 发明申请

US20050202983A1 Prevention of loss of tight cell junctions using carbohydrate-containing compositions 审中-公开
标题翻译：使用含碳水化合物的组合物预防紧密细胞连接的损失
公开(公告)号：US20050202983A1
公开(公告)日：2005-09-15
申请号：US10799521
申请日：2004-03-12
申请人： Erning Xia , Joseph Salamone , David McCanna
发明人： Erning Xia , Joseph Salamone , David McCanna
IPC分类号： A61K9/00 , A61K31/70 , A61K31/7004 , A61K31/7016 , A61K31/702 , A61K31/715 , A61K31/717 , A61K31/721 , A61K31/723 , A61K31/726 , A61K31/728 , A61K31/729 , A61K31/731 , A61K31/732 , A61K31/734 , A61K31/736 , C11D3/00 , C11D3/22 , G02B1/12
CPC分类号： A61K31/70 , A61K31/7004 , A61K31/7016 , A61K31/702 , A61K31/715 , A61K31/717 , A61K31/721 , A61K31/723 , A61K31/726 , A61K31/728 , A61K31/729 , A61K31/731 , A61K31/732 , A61K31/734 , A61K31/736 , C11D3/0078 , C11D3/222
摘要： Compositions are described which are useful in preventing the loss of tight epithelial cell junctions upon topical application. Such compositions include one or more carbohydrates in an amount effective to prevent the loss of tight cell junctions and hence improve the management of tissue health.
摘要翻译：描述了可用于在局部施用时防止紧密上皮细胞连接丧失的组合物。这样的组合物包括一种或多种碳水化合物，其量有效地防止紧密细胞连接的丧失，从而改善组织健康的管理。

82. 发明申请

US20050118058A1 Gentle preservative compositions for self-preserving solutions 审中-公开
标题翻译：用于自我保护溶液的温和防腐剂组合物
公开(公告)号：US20050118058A1
公开(公告)日：2005-06-02
申请号：US10725049
申请日：2003-12-01
申请人： Erning Xia , Joseph Salamone
发明人： Erning Xia , Joseph Salamone
IPC分类号： A01N43/16 , A61L12/08 , A61L12/14 , C11D3/00 , C11D3/22 , C11D3/48
CPC分类号： C11D3/48 , A01N43/16 , A61L12/08 , A61L12/143 , C11D3/0078 , C11D3/227
摘要： Compositions are described which are useful in preserving any topically applied solution. Compositions including one or more cationic polysaccharides in solution in an amount effective to preserve contact lenses are also described, as well as methods of making and using such solutions.
摘要翻译：描述了可用于保存任何局部施用的溶液的组合物。还描述了包含一种或多种有效保护隐形眼镜的量的溶液中的阳离子多糖的组合物，以及制备和使用这些溶液的方法。

83. 发明授权

US08829053B2 Biocidal compositions and methods of using the same 有权
标题翻译：杀生物组合物及其使用方法
公开(公告)号：US08829053B2
公开(公告)日：2014-09-09
申请号：US13313880
申请日：2011-12-07
申请人： Joseph Salamone , Ann Beal Salamone
发明人： Joseph Salamone , Ann Beal Salamone
IPC分类号： A61K31/155 , A61K31/14 , A61K31/08 , A61K31/045
CPC分类号： A01N47/44 , A61K31/155 , Y02A50/473 , A01N31/02 , A01N37/12
摘要： An antimicrobial composition with synergistic biocidal activity is described which comprises at least one antimicrobial polymeric biguanide and at least one antimicrobial vicinal diol, said vicinal diol comprises at least one monoalkyl glycol, monoalkyl glycerol, or monoacyl glycerol, to diminish or eliminate biofilm communities. Such synergistic interaction is effective in wound treatment, particularly for chronic wounds, burns and battlefield-induced wounds, as well as for disinfecting non-biological surfaces. The antimicrobial composition can also be prepared as viscous solutions or as gels. The antimicrobial composition may be added to a substrate and dried, such as to a catheter, or to a foam, or to a fiber wound dressing, or coated as a viscous solution or gel upon such devices, to provide controlled release antimicrobial activity.
摘要翻译：描述了具有协同杀生物活性的抗微生物组合物，其包含至少一种抗微生物聚合双胍和至少一种抗微生物连位二醇，所述连位二醇包含至少一种单烷基二醇，单烷基甘油或单酰基甘油，以减少或消除生物膜群落。这种协同相互作用在伤口治疗中是有效的，特别是对于慢性伤口，烧伤和战场引起的伤口以及用于消毒非生物表面。抗微生物组合物也可以制备成粘稠溶液或凝胶。可以将抗微生物组合物加入到基质中并干燥，例如导管，或泡沫，或纤维伤口敷料，或在这些装置上作为粘性溶液或凝胶涂覆，以提供受控释放的抗微生物活性。

84. 发明授权

US08263720B1 Sacrificial adhesive coatings 有权
标题翻译：牺牲粘合剂涂层
公开(公告)号：US08263720B1
公开(公告)日：2012-09-11
申请号：US13253348
申请日：2011-10-05
申请人： Joseph Salamone , Ann Beal Salamone , Xiang Yu , Levi J. Irwin
发明人： Joseph Salamone , Ann Beal Salamone , Xiang Yu , Levi J. Irwin
IPC分类号： C08F30/08 , A61F13/00 , C08L15/00
CPC分类号： A61L26/0019 , C08F230/08 , C09D183/00 , C09J143/04 , C08L83/04 , C08F220/14 , C08F2230/085 , C08F2220/1858 , C08F220/54 , C08F2222/1013
摘要： Combinations of solubilized, covalently crosslinked, siloxy-containing polymers in a solvent system of a volatile hydrophobic (non-polar) liquid that is non-stinging to a user are excellent non-irritating liquid coating materials for forming films, which, after solvent evaporation, are water insoluble but water-vapor permeable and lightly adherent to surfaces such as skin and mucous membranes. The crosslinking content is greater than 1 weight % and can be as much as 16 weight %. In comparison to non-crosslinked polysiloxy films, or crosslinked films of 1 weight % or less, the enhanced crosslinked polysiloxy films, while continuing to be soluble in the solvent, have reduced tack and reduced adhesion to skin and can act as sacrificial coatings under strongly adherent pressure sensitive adhesives.
摘要翻译：在非用户使用的挥发性疏水（非极性）液体的溶剂系统中，溶解，共价交联的含甲硅烷氧基聚合物的组合是用于形成膜的非刺激性液体涂料，其在溶剂蒸发之后是水不溶性的，但水蒸气可透过并且轻微粘附于表面如皮肤和粘膜。交联含量大于1重量％，可高达16重量％。与未交联的聚硅氧烷膜或1重量％以下的交联膜相比，增强的交联聚硅氧烷膜在继续溶于溶剂的同时具有降低的粘着性和降低的对皮肤的粘附性，并且可以在强烈的作用下作为牺牲涂层粘附压敏粘合剂。

85. 发明申请

US20070004866A1 Biomedical devices 失效
标题翻译：生物医学装置
公开(公告)号：US20070004866A1
公开(公告)日：2007-01-04
申请号：US11173703
申请日：2005-07-01
申请人： Derek Schorzman , Joseph Salamone
发明人： Derek Schorzman , Joseph Salamone
IPC分类号： C08F114/18
CPC分类号： C08F214/18 , C08F216/125 , C08G77/385 , G02B1/043 , C08L27/12
摘要： Biomedical devices formed from a polymerization product of a monomeric mixture comprising one or more monomers comprising at least two trifluorovinyl groups are provided. Also provided are biomedical devices formed from a network of a polymer comprising one or more perfluorocyclobutane rings in the polymer backbone wherein the network is formed by crosslinks in the polymer.
摘要翻译：提供由包含一种或多种包含至少两个三氟乙烯基的单体的单体混合物的聚合产物形成的生物医学装置。还提供了由在聚合物主链中包含一个或多个全氟环丁烷环的聚合物网络形成的生物医学装置，其中网络由聚合物中的交联形成。

86. 发明申请

US20060223727A1 Polysaccharide and polyol composition for treating dry eye and related methods of manufacture and methods of use 审中-公开
标题翻译：用于治疗干眼的多糖和多元醇组合物及其制备方法和使用方法
公开(公告)号：US20060223727A1
公开(公告)日：2006-10-05
申请号：US11391060
申请日：2006-03-28
申请人： Joseph Salamone , Erning Xia , X. Liu
发明人： Joseph Salamone , Erning Xia , X. Liu
IPC分类号： C11D3/00
CPC分类号： A61K47/10 , A61K9/0048 , A61K47/38
摘要： The present invention is directed to a composition for treating dry eye comprising, in one embodiment, carboxymethylcellulose and a polyol. Such compositions have been found to alleviate the symptoms of dry eye and remain in the eye for a long period of time.
摘要翻译：本发明涉及一种用于治疗干眼症的组合物，在一个实施方案中包括羧甲基纤维素和多元醇。已经发现这样的组合物可以缓解干眼症状并长期保留在眼睛中。

87. 发明申请

US20060057222A1 Method for the production of polymerized nanoparticles and microparticles by ternary agent concentration and temperature alteration induced immiscibility 失效
公开(公告)号：US20060057222A1
公开(公告)日：2006-03-16
申请号：US10941163
申请日：2004-09-15
申请人： Jeffrey Linhardt , Adrian Raiche , Joseph Salamone
发明人： Jeffrey Linhardt , Adrian Raiche , Joseph Salamone
IPC分类号： A61K9/50 , A61K9/16 , B01J13/02
CPC分类号： C08F2/22 , A61K9/1682 , A61K9/5089
摘要： Polymerized drug delivery devices are described. Additionally, methods are described for producing and for using polymerized particles for use as drug delivery devices.

88. 发明申请

US20060057215A1 Method for the production of nanoparticles and microparticles by ternary agent concentration and temperature alteration induced immiscibility 审中-公开
标题翻译：通过三元试剂浓度和温度变化诱导不混溶性制备纳米颗粒和微粒的方法
公开(公告)号：US20060057215A1
公开(公告)日：2006-03-16
申请号：US10941156
申请日：2004-09-15
申请人： Adrian Raiche , Joseph Salamone
发明人： Adrian Raiche , Joseph Salamone
IPC分类号： A61K9/14
CPC分类号： A61K9/5146 , A61K9/5089 , A61K9/5153 , A61K9/5192 , C08J3/14
摘要： Methods are described for forming nanoparticle- and microparticle-sized drug delivery agents. Also described are methods for incorporating one or more active therapeutic agents uniformly or non-uniformly within the particles and uses thereof.
摘要翻译：描述了形成纳米颗粒和微粒尺寸的药物递送剂的方法。还描述了将一种或多种活性治疗剂均匀或不均匀地掺入颗粒内及其用途的方法。

89. 发明申请

US20050266095A1 Gentle preservative compositions 审中-公开
标题翻译：温和的防腐剂组合物
公开(公告)号：US20050266095A1
公开(公告)日：2005-12-01
申请号：US10858116
申请日：2004-06-01
申请人： Erning Xia , Joseph Salamone
发明人： Erning Xia , Joseph Salamone
IPC分类号： A61K33/40 , A61L2/18 , A61L12/12 , A61L12/14 , C01B15/037 , C11D3/00 , C11D3/32 , C11D3/39
CPC分类号： A61L2/186 , A61L12/124 , A61L12/143 , A61L2202/24 , C01B15/037 , C11D3/0078 , C11D3/323 , C11D3/3947
摘要： Compositions are described which are useful in preserving any topically applied solution. Compositions including urea-hydrogen peroxide complex in solution in an amount effective to preserve contact lenses are also described, as well as methods of making and using such solutions. A hydrogen peroxide component of such solutions, when introduced into the eye, is converted to oxygen and water, leaving only the natural product, urea.
摘要翻译：描述了可用于保存任何局部施用的溶液的组合物。还描述了包括有效保护隐形眼镜的量的溶液中的脲 - 过氧化氢络合物的组合物，以及制备和使用这些溶液的方法。这种溶液的过氧化氢组分当被引入眼睛时被转化成氧和水，只剩下天然产物尿素。

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