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81. 发明申请

US20060241648A1 Methods and apparatus for tissue modification 有权
标题翻译：组织修复的方法和装置
公开(公告)号：US20060241648A1
公开(公告)日：2006-10-26
申请号：US11375265
申请日：2006-03-13
申请人： Jeffery Bleich , Vahid Saadat , Steven Spisak , John Ashley
发明人： Jeffery Bleich , Vahid Saadat , Steven Spisak , John Ashley
IPC分类号： A61B17/58
CPC分类号： A61B17/1659 , A61B17/00234 , A61B17/02 , A61B17/1671 , A61B17/1757 , A61B17/320016 , A61B17/32002 , A61B17/3421 , A61B2017/00261 , A61B2017/00867 , A61B2017/32006 , A61B2017/3488 , A61B2090/08021
摘要： A method for modifying tissue in a patient may involve one or more of the following steps: advancing at least a distal portion of at least one elongate, at least partially flexible tissue modification device into a patient and between one or more target tissues and one or more non-target tissues; positioning at least one tissue modifying member of the tissue modification device adjacent the target tissue such that the tissue modifying member(s) face the target tissue and do not face the non-target tissue; applying an anchoring force to the tissue modification device at or near the distal portion or a proximal portion of the device; applying a tensioning force to the tissue modification device at or near an opposite end of the device relative to the end to which anchoring force is applied, while maintaining the anchoring force, to urge the tissue modifying member(s) against the target tissue; and modifying the target tissue, using the tissue modifying member(s), while preventing the tissue modifying member(s) from extending significantly beyond the target tissue toward the proximal or distal portion of the tissue modification device during tissue modification.
摘要翻译：用于修改患者组织的方法可以涉及一个或多个以下步骤：将至少一个细长的，至少部分柔性的组织改变装置的至少远端部分推进到患者体内，并将一个或多个靶组织与一个或多个靶组织更多的非靶组织; 将所述组织改变装置的至少一个组织修改构件定位成邻近所述目标组织，使得所述组织修改构件面向所述靶组织并且不面向所述非靶组织; 在组件修改装置的远端部分或近端部分处或附近施加锚定力; 在保持锚固力的同时相对于施加锚定力的端部在装置的相对端处或附近施加张力，以促使组织修改构件抵靠目标组织; 以及在组织改变期间，使组织改变部件改变目标组织，同时防止组织改变部件显着地超出目标组织向组织改变装置的近端或远端部分延伸。

82. 发明申请

US20060020276A1 Apparatus and methods for achieving prolonged maintenance of gastrointestinal tissue folds 审中-公开
标题翻译：用于实现胃肠组织折叠的长期维持的装置和方法
公开(公告)号：US20060020276A1
公开(公告)日：2006-01-26
申请号：US10898683
申请日：2004-07-23
申请人： Vahid Saadat , Desmond Birkett
发明人： Vahid Saadat , Desmond Birkett
IPC分类号： A61B17/08
CPC分类号： A61B17/0401 , A61B17/08 , A61B18/1492 , A61B2017/0417 , A61B2017/0454 , A61B2017/0458 , A61B2017/0464 , A61B2017/081 , A61B2018/00291
摘要： Apparatus and methods are provided for achieving prolonged maintenance of gastrointestinal (“GI”) tissue folds. The apparatus and methods are adapted to form, secure, approximate and promote healing of tissue folds. Such healing may comprise remodeling the tissue folds along region(s) of opposing tissue contact to facilitate prolonged maintenance of the folds. In one variation, the apparatus and methods may be utilized to achieve gastric reduction. The apparatus may be provided as a system of tools.
摘要翻译：提供了用于实现胃肠（“GI”）组织折叠的延长维持的装置和方法。该装置和方法适于形成，固定，近似和促进组织折叠的愈合。这种愈合可以包括沿着相对的组织接触区域重塑组织褶皱，以便于折叠的延长维持。在一个变型中，可以利用该装置和方法来实现胃的减少。该装置可以被提供为工具系统。

83. 发明申请

US20050277981A1 Apparatus and methods for optimizing anchoring force 有权
标题翻译：用于优化锚固力的装置和方法
公开(公告)号：US20050277981A1
公开(公告)日：2005-12-15
申请号：US10865243
申请日：2004-06-09
申请人： Tracy Maahs , Richard Ewers , Vahid Saadat , Alex Khairkhahan , Kenneth Michlitsch
发明人： Tracy Maahs , Richard Ewers , Vahid Saadat , Alex Khairkhahan , Kenneth Michlitsch
IPC分类号： A61B17/00 , A61B17/04 , A61B17/06 , A61B17/064 , A61B17/08 , A61B19/00
CPC分类号： A61B17/0482 , A61B17/0401 , A61B17/0469 , A61B17/0644 , A61B2017/00867 , A61B2017/0454 , A61B2017/0464 , A61B2017/0496 , A61B2017/06052 , A61B2090/037
摘要： Apparatus and methods for optimizing anchoring force are described herein. In securing tissue folds, over-compression of the tissue directly underlying the anchors is avoided by utilizing tissue anchors having expandable arms configured to minimize contact area between the anchor and tissue. When the anchor is in its expanded configuration, a load is applied to the anchor until it is optimally configured to accommodate a range of deflections while the anchor itself exerts a substantially constant force against the tissue. Various devices, e.g., stops, spring members, fuses, strain gauges, etc., can be used to indicate when the anchor has been deflected to a predetermined level within the optimal range. Moreover, other factors to affect the anchor characteristics include, e.g., varying the number of arms or struts of the anchor, positioning of the arms, configuration of the arms, the length of the collars, etc.
摘要翻译：本文描述了用于优化锚固力的装置和方法。在固定组织褶皱时，通过利用具有可扩张臂的组织锚来避免直接位于锚固件正下方的组织的过度压缩，所述组织锚构造成使锚和组织之间的接触面积最小化。当锚固件处于其膨胀构型时，将负载施加到锚固件，直到其被最佳地构造成适应一定范围的偏转，同时锚固件本身对组织施加基本恒定的力。可以使用各种装置，例如止动件，弹簧构件，保险丝，应变计等来指示锚固件何时被偏转到最佳范围内的预定水平。此外，影响锚固特征的其他因素包括例如改变锚的臂或支柱的数量，臂的定位，臂的构型，套环的长度等。

84. 发明申请

US20050251209A1 Apparatus and methods for positioning and securing anchors 有权
标题翻译：用于定位和固定锚固件的装置和方法
公开(公告)号：US20050251209A1
公开(公告)日：2005-11-10
申请号：US11036866
申请日：2005-01-14
申请人： Vahid Saadat , Marvin Elmer
发明人： Vahid Saadat , Marvin Elmer
IPC分类号： A61B17/00 , A61B17/04 , A61B17/06 , A61B17/064 , A61B17/08 , A61B17/10 , A61B17/28 , A61B17/34
CPC分类号： A61B17/0401 , A61B17/0469 , A61B17/0487 , A61B17/06066 , A61B17/064 , A61B17/08 , A61B17/10 , A61B17/29 , A61B2017/00349 , A61B2017/00818 , A61B2017/00867 , A61B2017/0404 , A61B2017/0409 , A61B2017/0417 , A61B2017/0419 , A61B2017/0441 , A61B2017/0445 , A61B2017/0446 , A61B2017/045 , A61B2017/0451 , A61B2017/0454 , A61B2017/0456 , A61B2017/0458 , A61B2017/0459 , A61B2017/0461 , A61B2017/0462 , A61B2017/0464 , A61B2017/0475 , A61B2017/0488 , A61B2017/0496 , A61B2017/06052 , A61B2017/081 , A61B2017/3488
摘要： Apparatus and methods for positioning and securing anchors are disclosed herein. The anchors are adapted to be delivered and implanted into or upon tissue, particularly tissue within the gastrointestinal system of a patient. The anchor is adapted to slide uni-directionally over suture such that a tissue plication may be cinched between anchors. A locking mechanism, either within the anchor itself or positioned proximally of the anchor, may allow for the uni-directional translation of the anchor while enabling the anchor to be locked onto the suture if the anchor is pulled, pushed, or otherwise urged in the opposite direction along the suture. This uni-directional anchor locking mechanism facilitates cinching of the tissue plication between the anchors, and it may be utilized in one or several anchors in cinching a tissue fold.
摘要翻译：本文公开了用于定位和固定锚固件的装置和方法。锚固件适于被递送并植入到组织中，特别是患者胃肠系统内的组织中。锚固件适于在缝合线上单向滑动，使得组织褶皱可以在锚固件之间束紧。在锚固件本身内或定位在近端处的锁定机构可以允许锚固件的单向平移，同时使锚固件被锁定在缝合线上，如果锚被拉动，推动或以其他方式被推入沿缝合方向相反。这种单向锚定锁定机构有助于锚定器之间的组织褶皱的收缩，并且可以在一个或多个锚定器中用于收紧组织褶皱。

85. 发明申请

US20050251162A1 Apparatus and methods for manipulating and securing tissue 有权
标题翻译：用于操纵和固定组织的装置和方法
公开(公告)号：US20050251162A1
公开(公告)日：2005-11-10
申请号：US10955245
申请日：2004-09-29
申请人： Chris Rothe , Richard Ewers , Cang Lam , Vahid Saadat , Kenneth Michlitsch
发明人： Chris Rothe , Richard Ewers , Cang Lam , Vahid Saadat , Kenneth Michlitsch
IPC分类号： A61B1/00 , A61B17/00 , A61B17/04 , A61B17/06 , A61B17/08 , A61B17/28 , A61B17/34 , A61B19/00
CPC分类号： A61B1/0014 , A61B17/0401 , A61B17/06066 , A61B17/29 , A61B17/295 , A61B2017/00867 , A61B2017/00876 , A61B2017/0409 , A61B2017/0417 , A61B2017/0419 , A61B2017/0496 , A61B2017/06052 , A61B2017/06076 , A61B2017/3488 , A61B2090/037
摘要： Apparatus and methods for manipulating and securing tissue are described herein. In creating tissue folds within the body of a patient, a tissue manipulation assembly may generally have an elongate tubular member, an engagement member slidably disposed through the tubular member and a distal end adapted to engage tissue via a helical member, tissue stabilizing members positioned at the tubular member distal end which are adapted to stabilize tissue therebetween, and a delivery tube pivotable about the tissue stabilizer. The stabilizing members can be adapted to become angled relative to a longitudinal axis of the elongate tubular member. Moreover, one or all the articulation controls and functions can be integrated into a singular handle assembly connectable to the tissue manipulation assembly via a rigid or flexible tubular body.
摘要翻译：本文描述了用于操纵和固定组织的装置和方法。在组织折叠在患者体内产生时，组织操作组件通常可以具有细长的管状构件，可滑动地设置穿过管状构件的接合构件和适于通过螺旋构件接合组织的远端，位于所述管状构件远端适于在其间稳定组织，以及可围绕所述组织稳定器枢转的输送管。稳定构件可以适于相对于细长管状构件的纵向轴线成角度。此外，一个或所有关节运动控制和功能可以集成到通过刚性或柔性管状体连接到组织操作组件的单个手柄组件中。

86. 发明申请

US20050251161A1 Needle assembly for tissue manipulation 有权
标题翻译：用于组织操作的针组件
公开(公告)号：US20050251161A1
公开(公告)日：2005-11-10
申请号：US10955243
申请日：2004-09-30
申请人： Vahid Saadat , Chris Rothe , Richard Ewers
发明人： Vahid Saadat , Chris Rothe , Richard Ewers
IPC分类号： A61B17/00 , A61B17/04 , A61B17/06 , A61B17/064 , A61B17/08 , A61B17/10 , A61B17/28 , A61B17/34
CPC分类号： A61B17/0401 , A61B17/0469 , A61B17/0487 , A61B17/06066 , A61B17/064 , A61B17/08 , A61B17/10 , A61B17/29 , A61B2017/00349 , A61B2017/00867 , A61B2017/0404 , A61B2017/0409 , A61B2017/0417 , A61B2017/0419 , A61B2017/0445 , A61B2017/0446 , A61B2017/045 , A61B2017/0451 , A61B2017/0454 , A61B2017/0456 , A61B2017/0458 , A61B2017/0459 , A61B2017/0461 , A61B2017/0462 , A61B2017/0464 , A61B2017/0475 , A61B2017/0488 , A61B2017/0496 , A61B2017/06052 , A61B2017/081 , A61B2017/3488
摘要： Needle assemblies for tissue manipulation are described herein. In creating tissue folds within the body of a patient, a tissue manipulation assembly may generally have an elongate tubular member, an engagement member slidably disposed through the tubular member and a distal end adapted to engage tissue via a helical member, tissue stabilizing members positioned at the tubular member distal end which are adapted to stabilize tissue therebetween, and a delivery tube pivotable about the tissue stabilizer. A needle deployment assembly is deployable through the tissue manipulation assembly via a handle assembly, through the tubular member, and into or through tissue. An elongate pusher is translationally disposed within a sheath of the needle deployment assembly and can be urged distally for deploying an anchor assembly from the sheath distal end. The anchor assembly is positioned distally of the pusher within the sheath.
摘要翻译：用于组织操作的针组件在本文中描述。在组织折叠在患者体内产生时，组织操作组件通常可以具有细长的管状构件，可滑动地设置穿过管状构件的接合构件和适于通过螺旋构件接合组织的远端，位于所述管状构件远端适于在其间稳定组织，以及可围绕所述组织稳定器枢转的输送管。针部署组件可经由手柄组件穿过组织操纵组件展开，穿过管状构件，并且进入或穿过组织。细长的推动器平移地设置在针展开组件的护套内，并且可以向远侧推动以从护套远端展开锚固组件。锚固组件位于鞘内的推动器的远侧。

87. 发明申请

US20050251091A1 Apparatus and methods for transgastric tissue manipulation 审中-公开
标题翻译：用于经胃组织操作的装置和方法
公开(公告)号：US20050251091A1
公开(公告)日：2005-11-10
申请号：US10843682
申请日：2004-05-10
申请人： Vahid Saadat , Richard Ewers
发明人： Vahid Saadat , Richard Ewers
IPC分类号： A61B1/00 , A61B1/04 , A61B17/04 , A61B17/068 , A61B17/28 , A61B17/34 , A61M5/178 , A61M25/04 , A61M29/00
CPC分类号： A61B17/29 , A61B17/0469 , A61B17/068 , A61B17/3415 , A61B17/3421 , A61B2017/2927 , A61B2017/3445 , A61B2017/3488 , A61M25/04
摘要： Apparatus and methods for transgastric tissue manipulation are described herein. Procedures are performed transgastrically through a trocar or insert, e.g., to create tissue plications and approximating those plications towards one another for accomplishing gastroplasty procedures. The trocar is positioned through the abdominal wall of the patient and into the stomach. A multi-lumen insertion tool is positioned within the trocar and comprises one or several channels, e.g., two, three, or more channels as practicable, through the single insertion tool. Each of the channels is aligned and individually sealable with a reversible seal which allows for insertion or removal of a tool therethrough without comprising sealing of the entire trocar or port. A proximal section of the shafts comprise a flexible section to allow for the flexing of each respective control handle away from one another such that the surgeon can manipulate the tools without interference between the handles.
摘要翻译：本文描述了用于经胃组织操作的装置和方法。手术通过套管针或插入物经腹部进行，例如，以产生组织淤积，并将其彼此近似，以实现成形术程序。套针针穿过患者的腹壁并进入胃。多腔插入工具定位在套管针内，并且通过单个插入工具包括一个或多个通道，例如两个，三个或更多个通道。每个通道都可对准并且可单独地密封，可逆的密封件允许插入或移除工具，而不需要将整个套管针或端口密封。轴的近侧部分包括柔性部分，以允许每个相应的控制手柄彼此远离地弯曲，使得外科医生可以操纵工具而不会在手柄之间产生干涉。

88. 发明申请

US20050250986A1 Removable apparatus and methods for manipulating and securing tissue 审中-公开
公开(公告)号：US20050250986A1
公开(公告)日：2005-11-10
申请号：US11002404
申请日：2004-12-01
申请人： Chris Rothe , Richard Ewers , Vahid Saadat , Cang Lam
发明人： Chris Rothe , Richard Ewers , Vahid Saadat , Cang Lam
IPC分类号： A61B1/00 , A61B17/00 , A61B17/04 , A61B17/06 , A61B17/08 , A61B17/28 , A61B17/34 , A61B19/00
CPC分类号： A61B17/0401 , A61B1/0014 , A61B17/06066 , A61B17/29 , A61B17/295 , A61B2017/00867 , A61B2017/00876 , A61B2017/0409 , A61B2017/0417 , A61B2017/0419 , A61B2017/0496 , A61B2017/06052 , A61B2017/06076 , A61B2017/3488 , A61B2090/037
摘要： Removable apparatus and methods for manipulating and securing tissue are described herein. In creating tissue folds within the body of a patient, a tissue manipulation assembly may generally have tissue stabilizing members adapted to stabilize tissue therebetween, an engagement member slidably disposed through the stabilizing members and having a distal end adapted to engage tissue, and a delivery tube pivotable about the tissue stabilizing members. The tissue manipulation assembly optionally may be configured for removable attachment to an endoscope.

89. 发明授权

US6057689A Apparatus and method for leak detection in a fluid-filled balloon useful to treat body tissue 失效
标题翻译：用于治疗身体组织的流体填充球囊中的泄漏检测装置和方法
公开(公告)号：US6057689A
公开(公告)日：2000-05-02
申请号：US905367
申请日：1997-08-04
申请人： Vahid Saadat
发明人： Vahid Saadat
IPC分类号： A61M25/00 , A61F2/958 , G01M3/18 , G01R31/12 , G01N27/00
CPC分类号： G01M3/187
摘要： An apparatus for detecting leaks in a fluid-filled device used to treat a patient's tissue includes an catheter having an expandable device defining a fluid reservoir about the distal end of the catheter. An internal electrode is in electrical contact with a conductive fluid within the fluid reservoir. A grounding electrode is outside of the fluid reservoir, in electrical contact with the patient's tissue. Voltage is supplied to the internal electrode and the grounding electrode. Where a leak occurs in the expandable device, conductive fluid will contact the patient's tissue, thus creating an electrical current path between the internal electrode and the grounding electrode. This so-called "leak current" is used to generate a leak alarm signal.
摘要翻译：用于检测用于治疗患者组织的流体填充装置中的泄漏的装置包括具有可扩张装置的导管，该可扩张装置围绕导管的远端界定流体储存器。内部电极与流体储存器内的导电流体电接触。接地电极位于流体储存器的外部，与患者的组织电接触。电压被提供给内部电极和接地电极。在可扩张装置中发生泄漏的情况下，导电流体将接触病人的组织，从而在内部电极和接地电极之间产生电流通路。这种所谓的“泄漏电流”用于产生泄漏报警信号。

90. 发明授权

US5972012A Cutting apparatus having articulable tip 失效
标题翻译：切割装置具有铰接尖端
公开(公告)号：US5972012A
公开(公告)日：1999-10-26
申请号：US27828
申请日：1998-02-19
申请人： John H. Ream , Vahid Saadat
发明人： John H. Ream , Vahid Saadat
IPC分类号： A61B17/00 , A61B17/22 , A61B17/28 , A61B17/30 , A61B17/32 , A61B17/34 , A61B18/14 , A61B19/00
CPC分类号： A61B17/32002 , A61B17/3207 , A61B17/320758 , A61B18/148 , A61B17/3478 , A61B18/1492 , A61B2017/00022 , A61B2017/00026 , A61B2017/00247 , A61B2017/003 , A61B2017/00398 , A61B2017/00685 , A61B2017/00703 , A61B2017/22077 , A61B2017/2927 , A61B2017/308 , A61B2017/320028 , A61B2017/320084 , A61B2017/3445 , A61B2017/3488 , A61B2018/00196 , A61B2018/00208 , A61B2018/00267 , A61B2018/00279 , A61B2018/00291 , A61B2018/00392 , A61B2018/00738 , A61B2018/00761 , A61B2018/00839 , A61B2018/00916 , A61B2018/124 , A61B2018/1435 , A61B2018/1437 , A61B2018/1861 , A61B2090/064 , A61B2090/3782 , A61B2090/3784 , A61B2218/002 , A61B2218/007 , A61B34/20 , A61B90/37
摘要： Apparatus and methods for intraoperatively performing surgery to create transmural channels in tissue, for example, as in transmyocardial revascularization, are provided using apparatus having an end region containing a mechanical cutting head and means for articulating the end-region to access hard-to-reach portions of the anatomy. The handpiece is coupled by a disposable cable to a controller that houses a vacuum pump and mechanisms for driving the cutting head. The cutting head is adapted to cooperate with the vacuum pump to evacuate tissue severed during the channel forming process.
摘要翻译：用于在手术中进行手术以在组织中产生透壁通道的装置和方法，例如在心肌血运重建中，使用具有包含机械切割头的端部区域的装置和用于铰接末端区域以访问难以到达的装置部分解剖结构。手持件通过一次性电缆连接到容纳真空泵的控制器和用于驱动切割头的机构。切割头适于与真空泵配合以排出在通道形成过程中切断的组织。

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