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    • 81. 发明申请
    • Fine mapping and application of dna markers linked to a gall midge resistance gene for marker-aided selection in rice
    • US20050183173A1
    • 2005-08-18
    • US10493001
    • 2002-10-16
    • Nagesh SardesaiArvind KumarSuresh Nair
    • Nagesh SardesaiArvind KumarSuresh Nair
    • A01H1/04C07K14/415C12Q1/68C12Q1/6895A01H5/00C12N15/82
    • C07K14/415A01H1/04C12Q1/6811C12Q1/6895C12Q2600/13C12Q2600/156
    • The present invention relates to fine mapping and potential application of dna markers linked to a gall midge resistance gene gm7 for marker-aided selection in rice. Towards this, the present invention discloses a combination of novel sequence characterized amplified region (SCAR) primers for use in assay with the DNA of Rice plants in question. A cross between the gall midge resistant parent, RP2333 carrying the Gm7 gene and susceptible parent Shyamala, is developed and a F5 progeny is raised. A polymorphic band is identified from the F5 progeny, using AFLP that cosegregates with the susceptible phenotype. This band is eluted from the gel and cloned. The cloned AFLP fragment is sequenced and primers are developed for selectively amplifying DNA of susceptible phenotypes, thus differentiating them from the resistant phenotypes. This Gm7 gene linked marker is mapped onto chromosome 4 of rice and is also shown to be linked to Gm2 gene and the blight resistance gene, Xal through fine mapping using Yeast Artificial Chromosomes (YACS) and cosmids. This marker is present in a single copy in the susceptible parent, Shyamala. Primers developed from this marker are able to differentiate between the resistant and susceptible phenotypes in different crosses carrying different gall midge resistance genes. A number of screenings of resistant and susceptible varieties of rice with these primers show consistent polymorphism between them. The use of primers for PCR amplification of DNAs from F3 progenies derived from crosses between three different parental lines and the primers also differentiates the resistant phenotypes from the susceptible one. The primers of the present invention therefore have a great use in marker assisted selection as they show polymorphism between resistant and susceptible plants and therefore between plants with or without gall midge resistance genes.
    • 84. 发明授权
    • Methods of treating Giardia lamblia
    • 治疗贾第鞭毛虫的方法
    • US5627184A
    • 1997-05-06
    • US454838
    • 1995-05-31
    • David W. BoykinChristine C. DykstraRichard R. TidwellJames E. HallW. David WilsonArvind Kumar
    • David W. BoykinChristine C. DykstraRichard R. TidwellJames E. HallW. David WilsonArvind Kumar
    • G01N33/50A61K31/505A61K31/506C07D239/26C07D307/52C07D307/54C07D307/58C07D403/10C07D403/14C07D405/14C09B23/01C12Q1/68G01N21/78G01N33/52G01N33/58
    • C07D239/26A61K31/505A61K31/506C07D307/54C07D403/10C07D403/14C07D405/14C09B23/0075G01N33/52
    • The present invention provides methods for treating Pneumocystis carinii pneumonia and Giardia lamblia in a subject in need of such treatment. The methods comprises administering to the subject a compound of Formula I: ##STR1## wherein: X and Y are located in the para or meta positions and are selected from the group consisting of H, loweralkyl, loweralkoxy, and ##STR2## wherein: each R.sub.1 is independently selected from the group consisting of H, loweralkyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, cycloalkyl, aryl, or alkylaryl or two R.sub.1 groups together represent C.sub.2 -C.sub.10 alkyl, hydroxyalkyl, or alkylene, or two R.sub.1 groups together represent ##STR3## wherein m is from 1-3 and R.sub.7 is H or --CONHCR.sub.8 NR.sub.9 R.sub.10, wherein R.sub.8 is loweralkyl, and R.sub.9 and R.sub.10 are each independently selected from the group consisting of H and lower alkyl;R.sub.2 is H, hydroxy, loweralkyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, cycloalkyl, aryl, or alkylaryl;n is a number from 0 to 2;R.sub.3 and R.sub.4 are each independently selected from the group consisting of H, loweralkyl, loweralkoxy, alkylaryl, aryl, oxyaryl, aminoalkyl, aminoaryl, or halogen; andR.sub.5 and R.sub.6 are each independently selected from the group consisting of H, loweralkyl, aryl, alkylaryl, aminoalkyl, aminoaryl, halogen, oxyalkyl, oxyaryl, or oxyarylalkyl; or a phamaceutically acceptable salt thereof. The compound of Formula I is administered in an amount effective to treat the condition.The present invention also provides compounds useful for the treatment of Pneumocystis carinii pneumonia and Giardia lamblia.
    • 本发明提供了在需要这种治疗的受试者中治疗卡氏肺囊虫肺炎和贾第鞭毛虫的方法。 所述方法包括向受试者施用式I化合物:其中:X和Y位于对位或间位,并且选自H,低级烷基,低级烷氧基和低级烷氧基, 其中:每个R 1独立地选自H,低级烷基,烷氧基烷基,羟基烷基,氨基烷基,烷基氨基烷基,环烷基,芳基或烷基芳基,或两个R 1基团一起表示C 2 -C 10烷基,羟基烷基或亚烷基或两个R 1基团 一起代表,其中m为1-3,R7为H或-CONHCR8NR9R10,其中R8为低级烷基,R9和R10各自独立地选自H和低级烷基; R2是H,羟基,低级烷基,烷氧基烷基,羟基烷基,氨基烷基,烷基氨基烷基,环烷基,芳基或烷基芳基; n是从0到2的数字; R 3和R 4各自独立地选自H,低级烷基,低级烷氧基,烷基芳基,芳基,氧芳基,氨基烷基,氨基芳基或卤素; 并且R 5和R 6各自独立地选自H,低级烷基,芳基,烷基芳基,氨基烷基,氨基芳基,卤素,氧烷基,氧芳基或氧芳基烷基; 或其药学上可接受的盐。 以有效治疗病症的量施用式I化合物。 本发明还提供了可用于治疗卡氏肺囊虫肺炎和贾第鞭毛虫的化合物。
    • 86. 发明授权
    • Methods of inhibiting Pneumocystis carinii pneumonia, Giardia lamblia,
and Cryptosporidium and compounds useful therefor
    • 抑制卡氏肺囊虫肺炎,贾第鞭毛虫和隐孢子虫的方法及其有用的化合物
    • US5602172A
    • 1997-02-11
    • US453276
    • 1995-05-30
    • David W. BoykinChristine C. DykstraRichard R. TidwellJames E. HallW. David WilsonArvind KumarByron L. Blagburn
    • David W. BoykinChristine C. DykstraRichard R. TidwellJames E. HallW. David WilsonArvind KumarByron L. Blagburn
    • A61K31/341A61K31/4178A61K31/505A61K31/506C07D307/54C07D307/58C07D403/10C07D403/14C07D405/14G01N33/52A61K31/34
    • G01N33/52A61K31/341A61K31/4178A61K31/505A61K31/506C07D307/54C07D307/58C07D403/10C07D403/14C07D405/14
    • The present invention provides methods for treating Pneumocystis carinii pneumonia, Giardia lamblia, and Cryptosporidium parvum in a subject in need of such treatment. The methods comprise adminstering to the subject a compound of Formula (I): ##STR1## wherein: R.sub.1 and R.sub.2 are each independently selected from the group consisting of H, loweralkyl, aryl, alkylaryl, aminoalkyl, aminoaryl, halogen, oxyalkyl, oxyaryl, or oxyarylalkyl;R.sub.3 and R.sub.4 are each independently selected from the group consisting of H, loweralkyl, oxyalkyl, alkylaryl, aryl, oxyaryl, aminoalkyl, aminoaryl, or halogen; andX and Y are located in the para or meta positions and are selected from the group consisting of H, loweralkyl, oxyalkyl, and ##STR2## wherein: each R.sub.5 is independently selected from the group consisting of H, loweralkyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, cycloalkyl, aryl, or alkylaryl or two R.sub.5 groups together represent C.sub.2 -C.sub.10 alkyl, hydroxyalkyl, or alkylene; andR.sub.6 is H, hydroxy, loweralkyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylamino, alkylaminoalkyl, cycloalkyl, hydroxycycloalkyl, alkoxycycloalkyl, aryl, or alkylaryl;or a phamaceutically acceptable salt thereof. The compounds ar administered in an amount effective to treat the condition. The present invention also includes novel compounds useful in the treatment of Pneumocystis carinii pneumonia, Giardia lamblia, and Cryptosporidium parvum.
    • 本发明提供了在需要这种治疗的受试者中治疗卡氏肺囊虫肺炎,贾第鞭毛虫和隐孢子虫的方法。 所述方法包括给予受试者式(I)的化合物:其中:R 1和R 2各自独立地选自H,低级烷基,芳基,烷基芳基,氨基烷基,氨基芳基,卤素,烷氧基烷基 ,芳氧基或氧芳基烷基; R 3和R 4各自独立地选自H,低级烷基,烷氧基烷基,烷基芳基,芳基,氧芳基,氨基烷基,氨基芳基或卤素; 并且X和Y位于对位或间位,并且选自H,低级烷基,氧烷基和其中:每个R 5独立地选自H,低级烷基,烷氧基烷基,羟基烷基, 氨基烷基,烷基氨基烷基,环烷基,芳基或烷基芳基或两个R 5基团一起表示C 2 -C 10烷基,羟基烷基或亚烷基; 烷基氨基,烷基氨基烷基,环烷基,羟基环烷基,烷氧基环烷基,芳基或烷基芳基; R 6是H,羟基,低级烷基,烷氧基烷基,羟基烷基, 或其药学上可接受的盐。 以有效治疗病症的量施用化合物。 本发明还包括可用于治疗卡氏肺囊虫肺炎,贾第鞭毛虫和隐孢子虫的新型化合物。
    • 89. 发明授权
    • Write-leveling system and method
    • 写平整系统和方法
    • US08737161B1
    • 2014-05-27
    • US13769172
    • 2013-02-15
    • Arvind KumarShobhit SinghalVikas Lakhanpal
    • Arvind KumarShobhit SinghalVikas Lakhanpal
    • G11C8/00G11C7/22G11C7/10
    • G11C8/18G11C5/04G11C7/1093
    • A system is provided for use with a DRAM, a DQS signal provider, a clock signal provider, a DQS line and a clock line. The DQS line can provide the DQS signal from the DQS signal provider to the DRAM. The clock line can provide the clock signal from the clock signal provider to the DRAM. The system includes a clock delay determining portion, a DQS delay determining portion, and adjustment portion and a controlling portion. The clock delay determining portion can determine a clock delay. The DQS delay determining portion can determine a DQS delay. The adjustment portion can generate an adjustment value based on the clock delay and the DQS delay. The controlling portion can instruct the DQS signal provider to adjust a time of providing a second DQS signal based on the adjustment value, wherein the clock delay is less than the DQS delay.
    • 提供了一种与DRAM,DQS信号提供器,时钟信号提供器,DQS线和时钟线一起使用的系统。 DQS线路可以将来自DQS信号提供器的DQS信号提供给DRAM。 时钟线可以将来自时钟信号提供器的时钟信号提供给DRAM。 该系统包括时钟延迟确定部分,DQS延迟确定部分和调整部分以及​​控制部分。 时钟延迟确定部分可以确定时钟延迟。 DQS延迟确定部分可以确定DQS延迟。 调整部分可以基于时钟延迟和DQS延迟生成调整值。 控制部分可以指示DQS信号提供者基于调整值来调整提供第二DQS信号的时间,其中时钟延迟小于DQS延迟。
    • 90. 发明申请
    • MECHANISM FOR FACILITATING CONTEXT-AWARE MODEL-BASED IMAGE COMPOSITION AND RENDERING AT COMPUTING DEVICES
    • 促进基于模式的图像组合和计算设备渲染的机制
    • US20130271452A1
    • 2013-10-17
    • US13977657
    • 2011-09-30
    • Arvind KumarMark D. YarvisChristopher J. Lord
    • Arvind KumarMark D. YarvisChristopher J. Lord
    • G06T17/00
    • G06F3/14G06F3/04815G06T17/00G09G5/00G09G2320/0693G09G2340/02G09G2354/00G09G2360/121
    • A mechanism is described for facilitating context-aware composition and rendering of virtual models and/or images of physical objects computationally composited and rendered at computing devices according to one embodiment of the invention. A method of embodiments of the invention includes performing initial calibration of a plurality of computing devices to provide point of view positions of a scene according to a location of each of the plurality of computing devices with respect to the scene, where computing devices of the plurality of computing devices are in communication with each other over a network. The method may further include generating context-aware views of the scene based on the point of view positions of the plurality of computing devices, where each context-aware view corresponds to a computing device. The method may further include generating images of the scene based on the context-aware views of the scene, where each image corresponds to a computing device, and displaying each image at its corresponding computing device.
    • 描述了一种机制,用于促进根据本发明的一个实施例的在计算设备处计算地合成和呈现的物理对象的虚拟模型和/或图像的上下文感知组合和呈现。 本发明的实施例的方法包括执行多个计算设备的初始校准,以根据多个计算设备中的每一个相对于场景的位置来提供场景的位置,其中多个计算设备的计算设备 的计算设备通过网络彼此通信。 该方法还可以包括基于多个计算设备的观点位置来生成场景的上下文感知视图,其中每个上下文感知视图对应于计算设备。 该方法还可以包括基于场景的上下文感知视图来生成场景的图像,其中每个图像对应于计算设备,并且在其相应的计算设备处显示每个图像。