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81. 发明申请

US20080294073A1 METHOD AND SYSEM FOR NON-ABLATIVE ACNE TREATMENT AND PREVENTION 有权
标题翻译：非侵入性ACNE治疗和预防的方法和系统
公开(公告)号：US20080294073A1
公开(公告)日：2008-11-27
申请号：US11738682
申请日：2007-04-23
申请人： Peter G. Barthe , Michael H. Slayton , Inder Raj S. Makin
发明人： Peter G. Barthe , Michael H. Slayton , Inder Raj S. Makin
IPC分类号： A61N7/02
CPC分类号： A61N7/02 , A61B8/4272 , A61B2017/00747 , A61B2017/22008 , A61B2018/00666 , A61M37/0092 , A61N7/00 , A61N2007/0008 , A61N2007/0078
摘要： A method and system for non-ablative acne treatment and prevention is disclosed. The method utilizes ultrasound energy which is targeted at a region of interest to treat existing acne and prevent future acne from forming. The application of ultrasound energy causes numerous physiological effects that treat acne. Some of these physiological effects comprise reducing sebum, increasing perfusion at the region of interest, denaturing proteins at the region of interest, creating an uninhabitable environment at the region of interest, initiating programmed cell death at the region of interest and the initiation of mechanical effects at the region of interest.
摘要翻译：公开了一种用于非烧蚀性痤疮治疗和预防的方法和系统。该方法利用针对感兴趣区域的超声能量来治疗现有的痤疮并防止将来的痤疮形成。超声能量的应用导致许多治疗痤疮的生理效应。这些生理作用中的一些包括减少皮脂，增加感兴趣区域的灌注，在感兴趣的区域变性蛋白质，在感兴趣的区域产生不适宜的环境，在感兴趣的区域启动程序性细胞死亡并引发机械效应在感兴趣的地区。

82. 发明申请

US20080275342A1 METHOD AND SYSTEM FOR ULTRASOUND TREATMENT WITH A MULTI-DIRECTIONAL TRANSDUCER 有权
标题翻译：用于多方向传感器超声处理的方法和系统
公开(公告)号：US20080275342A1
公开(公告)日：2008-11-06
申请号：US12135962
申请日：2008-06-09
申请人： Peter G. Barthe , Michael H. Slayton
发明人： Peter G. Barthe , Michael H. Slayton
IPC分类号： A61N7/00 , A61B8/00
CPC分类号： A61N7/022 , A61B8/4272 , A61B2017/00084 , A61B2090/378 , A61N2007/0078
摘要： A method and system for ultrasound treatment utilizing a multi-directional transducer to facilitate treatment, such as therapy and/or imaging or other tissue parameter monitoring, in two or more directions. In accordance with an exemplary embodiment, a multi-directional transducer comprises at least two transduction elements configured to provide for ultrasound energy, such as radiation, acoustical energy, heat energy, imaging, positional information and/or tissue parameter monitoring signals in two or more directions. The transduction elements can comprise various materials for providing ultrasound energy or radiation, such as piezoelectric materials, with and without matching layers. In addition, the transduction elements can be configured for substantially uniform, focused and/or defocused radiation patterns, as well as for single, multiple-element and/or multiple-element array configurations. In addition, an exemplary multi-directional transducer can comprise multiple elements, either side by side, stacked or in an array.
摘要翻译：一种利用多向换能器来促进诸如在两个或更多个方向上的治疗和/或成像或其它组织参数监测的治疗的超声治疗的方法和系统。根据示例性实施例，多方向换能器包括至少两个换能元件，所述至少两个换能元件被配置为提供两个或更多个超声波能量，例如辐射，声能，热能，成像，位置信息和/或组织参数监测信号方向。转导元件可以包括用于提供超声能量或辐射的各种材料，例如具有和不具有匹配层的压电材料。此外，转导元件可以被配置为基本上均匀的，聚焦的和/或散焦的辐射图，以及用于单个，多元件和/或多元件阵列配置。此外，示例性多向换能器可以包括多个元件，并排，堆叠或阵列。

83. 发明申请

US20080221491A1 METHOD AND SYSTEM FOR COMBINED ENERGY THERAPY PROFILE 有权
标题翻译：用于组合能量治疗概况的方法和系统
公开(公告)号：US20080221491A1
公开(公告)日：2008-09-11
申请号：US12116845
申请日：2008-05-07
申请人： Michael H. Slayton , Peter G. Barthe , Inder Raj S. Makin
发明人： Michael H. Slayton , Peter G. Barthe , Inder Raj S. Makin
IPC分类号： A61N5/06 , A61N7/02 , A61B18/18
CPC分类号： A61N7/022 , A61B8/4281 , A61B18/14 , A61B18/20 , A61B34/30 , A61B2017/22024 , A61B2017/22028 , A61N7/00 , A61N7/02 , A61N2007/0008 , A61N2007/0052 , A61N2007/0078
摘要： A method and system for treating tissue with a combined therapy profile is disclosed. In one exemplary embodiment, ultrasound energy is used to treat numerous depths of tissue within a region of interest and the spatial and temporal properties of the ultrasound energy are varied for more effective treatment. The method and system of the present invention are configured to treat all of the tissue from the surface on down and not spare intervening tissue.
摘要翻译：公开了一种用组合治疗方案处理组织的方法和系统。在一个示例性实施例中，使用超声能量来治疗感兴趣区域内的组织的许多深度，并且改变超声能量的空间和时间属性以进行更有效的治疗。本发明的方法和系统被配置为从表面上向下处理所有的组织，而不是备用的中间组织。

84. 发明授权

US06623430B1 Method and apparatus for safety delivering medicants to a region of tissue using imaging, therapy and temperature monitoring ultrasonic system 有权
标题翻译：使用成像，治疗和温度监测超声波系统将药物安全地输送到组织区域的方法和装置
公开(公告)号：US06623430B1
公开(公告)日：2003-09-23
申请号：US09502175
申请日：2000-02-10
申请人： Michael H. Slayton , Peter G. Barthe , Valeryi Lishko
发明人： Michael H. Slayton , Peter G. Barthe , Valeryi Lishko
IPC分类号： A61B800
CPC分类号： A61N7/02 , A61B5/01 , A61B8/0833 , A61B8/5223 , A61B2017/22028
摘要： A method and apparatus for controlling the safe delivery of thermosensitive liposomes containing medicant to a targeted tissue region using ultrasound. Thermosensitive liposomes containing medicants are delivered to a region of interest, the region of interest is located using ultrasound imaging, ultrasound therapy is applied to heat the region of interest, and the temperature of the region is monitored to determine whether a designated threshold temperature has been reached which allows for the release of medicants from the liposomes. If the threshold temperature is reached, and the liposomes are melted, the treatment stops. If the threshold temperature has not been reached, the application of ultrasound therapy and ultrasound imaging are alternated until the threshold temperature is reached. The ultrasound imaging, temperature monitoring and ultrasound therapy are preferably performed with a single transducer.
摘要翻译：一种使用超声波控制含有药物的热敏脂质体到目标组织区域的安全递送的方法和装置。将含有药物的热敏脂质体输送到感兴趣的区域，利用超声成像定位感兴趣区域，应用超声波治疗来加热感兴趣区域，并监测该区域的温度，以确定是否已经指定的阈值温度达到了允许从脂质体释放药物。如果达到阈值温度，并且脂质体熔化，则停止处理。如果尚未达到阈值温度，则交替使用超声波治疗和超声成像直到达到阈值温度。超声成像，温度监测和超声治疗优选用单个换能器进行。

85. 发明授权

US06540679B2 Visual imaging system for ultrasonic probe 有权
公开(公告)号：US06540679B2
公开(公告)日：2003-04-01
申请号：US09750816
申请日：2000-12-28
申请人： Michael H. Slayton , Peter G. Barthe
发明人： Michael H. Slayton , Peter G. Barthe
IPC分类号： A61B800
CPC分类号： A61B8/42 , A61B8/00 , A61B8/463
摘要： A non-invasive visual imaging system is provided, wherein the imaging system procures an image of a transducer position during diagnostic or therapeutic treatment. In addition, the system suitably provides for the transducer to capture patient information, such as acoustic, temperature, or ultrasonic images. For example, an ultrasonic image captured by the transducer can be correlated, fused or otherwise combined with the corresponding positional transducer image, such that the corresponding images represent not only the location of the transducer with respect to the patient, but also the ultrasonic image of the region of interest being scanned. Further, a system is provided wherein the information relating to the transducer position on a single patient may be used to capture similar imaging planes on the same patient, or with subsequent patients. Moreover, the imaging information can be effectively utilized as a training tool for medical practitioners.

86. 发明授权

US6120452A Apparatus for three dimensional imaging 有权
标题翻译：三维成像装置
公开(公告)号：US6120452A
公开(公告)日：2000-09-19
申请号：US434078
申请日：1999-11-05
申请人： Peter G. Barthe , Michael H. Slayton
发明人： Peter G. Barthe , Michael H. Slayton
IPC分类号： A61B8/00 , A61B8/14
CPC分类号： A61B8/483 , A61B8/00 , A61B8/14 , A61B8/4461 , Y10S128/916
摘要： A method and apparatus for medical diagnostic ultrasound imaging that utilizes a one, one and one-half or two dimensional scanhead for performing three dimensional imaging. The method and apparatus limits acoustic reverberations by swinging or rotating an array of ultrasound transducer elements about the longitudinal axis of the probe of an ultrasound transducer apparatus to enable the transducers to maintain a constant and concentric position with the acoustic membrane of the probe.
摘要翻译：一种用于医学诊断超声成像的方法和装置，其利用一个一个或二个或二维扫描头进行三维成像。该方法和装置通过围绕超声换能器装置的探针的纵向轴线摆动或旋转超声波换能器元件阵列来限制声学混响，以使换能器能够与探针的声膜保持恒定和同心的位置。

87. 发明授权

US6050943A Imaging, therapy, and temperature monitoring ultrasonic system 失效
标题翻译：成像，治疗和温度监测超声系统
公开(公告)号：US6050943A
公开(公告)日：2000-04-18
申请号：US950353
申请日：1997-10-14
申请人： Michael H. Slayton , Peter G. Barthe
发明人： Michael H. Slayton , Peter G. Barthe
IPC分类号： A61B8/08 , A61B17/22 , A61N7/02 , A61B8/00
CPC分类号： A61N7/02 , A61B5/01 , A61B5/015 , A61B5/4836 , A61B8/0833 , A61B8/15 , A61B8/5223 , A61B2017/22028
摘要： An ultrasonic system useful for providing imaging, therapy and temperature monitoring generally comprises an acoustic transducer assembly configured to enable the ultrasound system to perform the imaging, therapy and temperature monitoring functions. The acoustic transducer assembly comprises a single transducer that is operatively connected to an imaging subsystem, a therapy subsystem and a temperature monitoring subsystem. The ultrasound systems may also include a display for imaging and temperature monitoring functions. An exemplary single transducer is configured such that when connected to the subsystems, the imaging subsystem can generate all image of a treatment region on the display, the therapy subsystem can generate high power acoustic energy to heat the treatment region, and the temperature monitoring subsystem can map and monitor the temperature of the treatment region and display the temperature on the display, an through the use of the single transducer. Moreover, the acoustic transducer assembly is configured such that the imaging, therapeutic heating and temperature monitoring of the treatment region can be conducted substantially simultaneously.
摘要翻译：用于提供成像，治疗和温度监测的超声系统通常包括声学换能器组件，其被配置为使超声系统能够执行成像，治疗和温度监测功能。声换能器组件包括可操作地连接到成像子系统，治疗子系统和温度监控子系统的单个换能器。超声系统还可以包括用于成像和温度监测功能的显示器。示例性的单个换能器被配置为使得当连接到子系统时，成像子系统可以在显示器上产生治疗区域的所有图像，治疗子系统可以产生高功率声能来加热治疗区域，并且温度监测子系统可以映射和监控处理区域的温度，并通过使用单个传感器显示显示器上的温度。此外，声学换能器组件被配置成使得治疗区域的成像，治疗加热和温度监测可以基本上同时进行。

88. 发明授权

US10183182B2 Methods and systems for treating plantar fascia 有权
公开(公告)号：US10183182B2
公开(公告)日：2019-01-22
申请号：US13136541
申请日：2011-08-02
申请人： Michael H. Slayton , Peter G. Barthe
发明人： Michael H. Slayton , Peter G. Barthe
IPC分类号： A61N7/00 , A61N7/02 , A61B8/14 , A61B8/00 , A61B8/13 , A61B17/32 , A61B18/00 , A61B8/08 , A61B90/00
摘要： Various embodiments, described herein, provide methods and systems for the treatment of plantar fascia. In some embodiments, a method of non-invasive treatment of plantar fasciacan include the steps of identifying a damage location comprising a planter fascia; directing a conformal distribution of ultrasound energy to the plantar fascia at the damage location; creating a plurality of micro lesions in the plantar fascia at the damage location; initiating healing of a plurality of micro tears in the plantar fascia at the damage location; and sparing intervening tissue between the plantar fascia and a surface of a sole of a foot.

89. 发明授权

US09504446B2 Systems and methods for coupling an ultrasound source to tissue 有权
标题翻译：用于将超声源耦合到组织的系统和方法
公开(公告)号：US09504446B2
公开(公告)日：2016-11-29
申请号：US13547023
申请日：2012-07-11
申请人： Paul Jaeger , Peter G. Barthe , Michael H. Slayton
发明人： Paul Jaeger , Peter G. Barthe , Michael H. Slayton
IPC分类号： A61B8/00 , A61N7/02 , A61B18/00 , A61N7/00
CPC分类号： A61N7/02 , A61B8/429 , A61B8/56 , A61B2018/00642 , A61B2018/00898 , A61B2090/378 , A61N2007/0034 , A61N2007/006 , A61N2007/0091 , A61N2007/0095 , A61N2007/027
摘要： This disclosure provides systems and methods for sensing coupling of an ultrasound source to a target and for providing a constant average output of power from an ultrasound source. The systems and methods can include a frequency sweep function. The systems and methods can also include receiving reflected energy from an acoustic window and determining a feedback using the reflected energy. The systems and methods can also include comparing the feedback with a threshold level and using the comparison to determine if the ultrasound source is coupled with a target.
摘要翻译：本公开提供用于感测超声源与目标的耦合并用于从超声源提供恒定的平均功率输出的系统和方法。系统和方法可以包括频率扫描功能。系统和方法还可以包括从声窗口接收反射的能量并且使用反射的能量来确定反馈。系统和方法还可以包括将反馈与阈值水平进行比较，并且使用比较来确定超声源是否与目标耦合。

90. 发明授权

US09149658B2 Systems and methods for ultrasound treatment 有权
标题翻译：超声治疗的系统和方法
公开(公告)号：US09149658B2
公开(公告)日：2015-10-06
申请号：US13136544
申请日：2011-08-02
申请人： Peter G. Barthe , Michael H. Slayton
发明人： Peter G. Barthe , Michael H. Slayton
IPC分类号： A61B8/00 , A61N7/02 , A61B8/14 , A61N7/00 , A61B18/00 , A61B19/00 , A61B8/08
CPC分类号： A61N7/00 , A61B8/13 , A61B8/14 , A61B8/4254 , A61B8/4272 , A61B8/485 , A61B8/5246 , A61B17/320068 , A61B2018/00642 , A61B2018/00898 , A61B2090/378 , A61N7/02 , A61N2007/0013 , A61N2007/0034 , A61N2007/0052 , A61N2007/006 , A61N2007/0065 , A61N2007/0091 , A61N2007/0095 , A61N2007/027
摘要： Various embodiments provide a method for an extended field of view treatment. The method can include the steps of imaging a region; targeting a region with directed ultrasound energy; monitoring the region; moving the imaging, treatment, and monitoring region while spatially correlating to one or more prior regions via imaging and/or position sensing; continuing the extended field of view treatment; and, achieving an ultrasound induced biological effect in the extended field of view treatment region.
摘要翻译：各种实施例提供了一种用于扩展视野处理的方法。该方法可以包括对区域进行成像的步骤; 针对具有定向超声能量的区域; 监测该地区; 移动成像，处理和监视区域，同时通过成像和/或位置感测与一个或多个先前区域空间相关; 继续扩大视野治疗; 并在扩展视野区域实现超声诱导生物学效应。

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