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    • 82. 发明授权
    • HIV coreceptor mutants
    • HIV共同受体突变体
    • US6057102A
    • 2000-05-02
    • US907468
    • 1997-08-08
    • Nathaniel R. LandauRichard A. KoupRong LiuWilliam Paxton
    • Nathaniel R. LandauRichard A. KoupRong LiuWilliam Paxton
    • C07K14/715C12Q1/70C12Q1/68
    • C12Q1/703C07K14/7158A01K2217/05C12Q2600/156
    • Entry of HIV-1 into target cells requires cell surface CD4 as well as additional host cell cofactors. A cofactor required for infection with virus adapted for growth in transformed T cell lines was recently identified and named fusin. Fusin, however, does not promote entry of macrophage-tropic viruses that are believed to be the key pathogenic strains in vivo. It has now been determined that the principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage-tropic strains of HIV-1 is CC-CKR5, a receptor for the .beta.-chemokines RANTES, MIP-1.alpha., and MIP-1.beta.. It has also been found that individuals who are homozygous for a mutation of the CKR-5 receptor are resistent to HIV infection; in vitro infection requires a 1000-fold higher dose of HIV than normal cells. The mutation results in complete suppression of CKR-5 expression.
    • HIV-1进入靶细胞需要细胞表面CD4以及额外的宿主细胞辅因子。 最近鉴定了一种在转化的T细胞系中适应生长的病毒感染所需的辅因子,并命名为fusin。 然而,Fusin不促进被认为是体内关键致病菌株的巨噬细胞 - 嗜性病毒的进入。 现在已经确定,由HIV-1的初级巨噬细胞 - 热带菌株的包膜糖蛋白引入的主要辅助因子是CC-CKR5,β-chemokines RANTES,MIP-1α和MIP-1β的受体 。 还发现对CKR-5受体的突变是纯合的个体对HIV感染是抗性的; 体外感染需要比正常细胞高1000倍的HIV。 突变导致CKR-5表达的完全抑制。
    • 86. 发明授权
    • Paper processing tool with three-lever actuation
    • 纸张加工工具,三杠杆致动
    • US08122805B2
    • 2012-02-28
    • US11954605
    • 2007-12-12
    • Rong Liu
    • Rong Liu
    • B26D5/08B26D5/18B26F1/14B26F1/00B26B19/02B26B19/12
    • B26F1/02B26D5/10Y10T83/8809Y10T83/8828Y10T83/8845Y10T83/885Y10T83/9423Y10T83/943
    • A paper processing tool includes a base having a receiving area for selectively receiving a sheet of paper. The tool further includes a first lever having a handle portion, the first lever being pivotable relative to the base about a first axis. An intermediate lever is pivotable relative to the base about a second axis in response to movement of the first lever. At least one cutting element is arranged along a cutting plane, the at least one cutting element being configured to selectively engage the sheet of paper. A drive lever is actuable by the intermediate lever to move the at least one cutting element relative to the base. The drive lever is pivotable relative to the base about a third axis parallel to the cutting plane.
    • 纸张处理工具包括具有用于选择性地接收纸张的接收区域的底座。 所述工具还包括具有手柄部分的第一杠杆,所述第一杠杆可围绕第一轴线相对于所述基座枢转。 响应于第一杆的移动,中间杆可相对于基座围绕第二轴线枢转。 沿着切割平面布置至少一个切割元件,所述至少一个切割元件构造成选择性地接合纸张。 驱动杆可由中间杆致动以使至少一个切割元件相对于底座移动。 驱动杆可相对于平行于切割平面的第三轴线相对于基座枢转。
    • 87. 发明申请
    • DERIVING ENTITY-CENTRIC SOLUTION MODELS FROM INDUSTRY REFERENCE PROCESS AND DATA MODELS
    • 从行业参考流程和数据模型中获取实体中心解决方案模型
    • US20120011079A1
    • 2012-01-12
    • US12834389
    • 2010-07-12
    • Santhosh KumaranRong LiuYashodhara M. PatnaikFrederick Y. Wu
    • Santhosh KumaranRong LiuYashodhara M. PatnaikFrederick Y. Wu
    • G06Q10/00
    • G06Q10/067
    • A mechanism is provided for forming a business entity model. A selection of business components is received from a business function model to be selected business components. Activities are found in an industry reference model to be selected activities corresponding to selected business components. Based on the selected activities, industry reference model is scoped to be a scoped industry reference model, which includes reducing business process models in the industry reference model to selected business process models corresponding to selected activities, reducing data models in the industry reference model to selected data models corresponding to use cases of selected activities, and reducing service operations in the industry reference model to selected service operations corresponding to the selected activities. Selected activities and scoped industry reference model are customized. Based on a business entity template, selected activities, and scoped industry reference model, business entities are generated to form a business entity model.
    • 提供了一种形成业务实体模型的机制。 从业务功能模型接收到业务组件的选择,以便被选中的业务组件。 行业参考模型中可以找到活动,以选择与所选业务组件相对应的活动。 基于选定的活动,行业参考模型被定义为行业参考模型,其中包括将行业参考模型中的业务流程模型减少到与选定活动相对应的选定业务流程模型,减少行业参考模型中的数据模型选择 数据模型对应于选定活动的用例,并将行业参考模型中的服务操作减少为与所选活动相对应的选定服务操作。 选定的活动和范围的行业参考模型是定制的。 基于业务实体模板,选定活动和范围行业参考模型,生成业务实体以形成业务实体模型。
    • 88. 发明申请
    • SYSTEM AND METHOD FOR EXTENDING VCO OUTPUT VOLTAGE SWING
    • 用于扩展VCO输出电压振荡的系统和方法
    • US20120001699A1
    • 2012-01-05
    • US12872195
    • 2010-08-31
    • Yu YangXuechu LiRong LiuPeiqi Xuan
    • Yu YangXuechu LiRong LiuPeiqi Xuan
    • H03B5/12
    • H03B5/1228H03B5/1212H03B5/1243
    • Voltage controlled oscillator (VCO) has been widely used in radio frequency communication systems. In a typical VCO implementation, a pair of directly cross-coupled MOS transistors is used as a switching device and an LC resonant circuit is used to tune the desired frequency. The direct cross coupling of the MOS transistor pair will result in limited output voltage swing since a large swing may cause the MOS transistors into a linear region to increase phase noise. The VCO system to increase the output voltage swing according to one embodiment of the present invention includes DC-blocking capacitors to avoid direct cross coupling of the MOS pair. The VCO further includes circuit to provide bias for the gate voltage of the MOS pair. A method for increasing the output voltage swing is disclosed for a VCO system having LC resonant circuit. The method includes providing DC-blocked cross coupling from the drains of the cross-coupled transistor pair to the gates of the cross-coupled transistor pair. The method also includes providing an offset voltage to the gates of the cross-coupled transistor pair to reduce the maximum gate-to-drain voltage of a cross-coupled NMOS transistor pair or maximum drain-to-gate voltage of a cross-coupled PMOS transistor pair so that the cross-coupled transistor pair will work in a saturation region when the output voltage swing is increased.
    • 压控振荡器(VCO)已广泛应用于射频通信系统。 在典型的VCO实现中,使用一对直接交叉耦合的MOS晶体管作为开关器件,并且使用LC谐振电路来调谐期望的频率。 MOS晶体管对的直接交叉耦合将导致有限的输出电压摆幅,因为大的摆幅可能导致MOS晶体管进入线性区域以增加相位噪声。 根据本发明的一个实施例的用于增加输出电压摆幅的VCO系统包括隔直电容器以避免MOS对的直接交叉耦合。 VCO还包括为MOS对的栅极电压提供偏置的电路。 对于具有LC谐振电路的VCO系统,公开了一种用于增加输出电压摆幅的方法。 该方法包括从交叉耦合晶体管对的漏极到交叉耦合晶体管对的栅极提供DC阻塞的交叉耦合。 该方法还包括向交叉耦合晶体管对的栅极提供偏移电压以减小交叉耦合NMOS晶体管对的最大栅极至漏极电压或交叉耦合PMOS的最大漏极 - 栅极电压 晶体管对,使得当输出电压摆幅增加时,交叉耦合晶体管对将在饱和区域中工作。
    • 89. 发明申请
    • SHAVING TRAY FOR PENCIL SHARPENER
    • 用于笔记本的SHAVING托盘
    • US20110179654A1
    • 2011-07-28
    • US12692901
    • 2010-01-25
    • Rong LiuMichael L. Parrish
    • Rong LiuMichael L. Parrish
    • B43L23/00
    • B43L23/008B43K23/001
    • A pencil sharpener includes a base containing a sharpening mechanism, and a shaving tray coupled to the base and movable between an installed position and an uninstalled position relative to the base. The shaving tray defines a chamber configured to receive and hold shavings produced during a sharpening operation. The shaving tray includes a body, an aperture in the body configured to receive shavings for passage into the chamber, a movable member configured to selectively cover the aperture to inhibit shavings from leaving the chamber through the aperture, and a biasing member coupled to the body and to the movable member to bias the movable member into a closed position covering the aperture.
    • 一种铅笔刀包括一个包含磨刀机构的基座和一个与基座相连的剃须盘,可在安装位置和相对于底座的卸载位置之间移动。 剃须托盘限定了一个构造成容纳和保持在磨削操作期间产生的切屑的腔室。 剃须托盘包括主体,主体中的孔,构造成接收用于通过腔室的切屑;可移动构件,构造成选择性地覆盖孔,以阻止切屑离开腔室通过孔;以及偏压构件,其联接到主体 以及可动构件,以将可动构件偏压到覆盖该孔的关闭位置。
    • 90. 发明授权
    • Enhanced monitoring of laser output power in electro-optical readers
    • 增强电光读取器激光输出功率的监控
    • US07963447B2
    • 2011-06-21
    • US11998555
    • 2007-11-30
    • Ming YuRong Liu
    • Ming YuRong Liu
    • G06K7/10
    • G06K7/10584G06K7/10732
    • Laser power monitoring arrangements interrupt power to a laser used in electro-optical readers upon detection of operating conditions not conforming to preestablished standards. An auxiliary light detector independently monitors the output power of a laser beam, and directly receives a portion of the laser beam reflected from a diffractive optical lens surface of an optical assembly for optically modifying the laser beam, or from a coated or uncoated inclined surface of a split collimating lens of the optical assembly. The split collimating lens may have its lens portions in mutual contact or separated by an air gap.
    • 激光功率监测装置在检测到不符合预先建立的标准的操作条件时,会中断电光读取器中使用的激光的电源。 辅助光检测器独立地监视激光束的输出功率,并且直接接收从光学组件的衍射光学透镜表面反射的激光束的一部分,以光学地修改激光束,或者从涂覆或未涂覆的倾斜表面 光学组件的分割准直透镜。 分割准直透镜可以使其透镜部分相互接触或由气隙分开。