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81. 发明专利

AT440595T 未知
公开(公告)号：AT440595T
公开(公告)日：2009-09-15
申请号：AT04704837
申请日：2004-01-23
申请人： PSIVIDA INC
发明人： ASHTON PAUL , GUO HONG
IPC分类号： A61K9/22 , A61K9/00 , A61K9/50 , A61K31/382 , A61K31/485 , A61K31/542 , A61L27/34 , A61L27/54 , A61L31/10 , A61L31/16
摘要： The invention provides a device and method for treating and/or preventing raised intraocular pressure, such as that associated with glaucoma or the use of corticosteroids with adrenergic agents. The invention provides insertable sustained-release devices adapted to maintain a therapeutically effective concentration of one or more adrenergic agents for an extended period of time, and a method of use thereof.

82. 发明专利

NZ547619A Injectable sustained release implant having a bioerodible matrix core and a bioerodible skin 未知
公开(公告)号：NZ547619A
公开(公告)日：2009-06-26
申请号：NZ54761904
申请日：2004-10-26
申请人： PSIVIDA INC
发明人： CHOU KANG-JYE , GUO HONG , ASHTON PAUL , SHIMIZU ROBERT W , WATSON DAVID A
IPC分类号： A61K9/00 , A61K9/20
摘要： Provided is a drug delivery device shaped and sized for injection in a needle or cannula ranging in size from 30 gauge to 15 gauge, comprising: a core including one or more drugs; and a polymeric skin at least partially, but not completely surrounding the core, the skin comprising a fIrst one or more polymers, impermeable to the passage of drug; wherein the device provides sustained release of the one or more drugs when exposed to a biological medium. Further provided are devices with specified polymers and drugs.

83. 发明专利

SI1276462T1 Priprava za dajanje zdravila z zadrĹľevanim sproĹˇÄŤanjem, postopki za uporabo in postopki za njihovo izdelavo 未知
公开(公告)号：SI1276462T1
公开(公告)日：2009-02-28
申请号：SI200130887
申请日：2001-04-19
申请人： PSIVIDA INC
发明人： GUO HONG , ASHTON PAUL
IPC分类号： A61F9/007 , A61K9/00 , A61K9/22 , A61K31/4422 , A61K31/58 , A61M37/00 , A61P9/12 , A61P27/02 , A61P29/00

84. 发明专利

DK1635875T3 未知
公开(公告)号：DK1635875T3
公开(公告)日：2009-01-12
申请号：DK04756068
申请日：2004-06-25
申请人： PSIVIDA INC
发明人： ASHTON PAUL , CHEN JIANBING , SU DONGLING
IPC分类号： A61K47/34 , A61K9/00 , A61K31/382 , A61K31/485 , A61K31/542 , A61K47/48
摘要： The invention relates to an injectable pharmaceutical composition comprising: (a) a drug substance; (b) a polyethylene glycol; and (c) a biocompatible and bioerodable poly(DL-lactide-glycolide) (PLGA) polymer; (d) wherein the polyethylene glycol serves as a solvent for the PLGA polymer; and (e) wherein the composition forms a gel phase when said composition comes into contact with water or bodily fluids.

85. 发明专利

PT1276462E DISPOSITIVOS DE DISTRIBUIÇÃO DE FÁRMACO DE LIBERTAÇÃO PROLONGADA, MÉTODOS DE UTILIZAÇÃO E SEUS PROCESSOS DE FABRICO 未知
公开(公告)号：PT1276462E
公开(公告)日：2009-01-08
申请号：PT01927200
申请日：2001-04-19
申请人： PSIVIDA INC
发明人： GUO HONG , ASHTON PAUL
IPC分类号： A61F9/007 , A61K9/00 , A61K9/22 , A61K31/4422 , A61K31/58 , A61M37/00 , A61P9/12 , A61P27/02 , A61P29/00

86. 发明专利

DE60135907D1 未知
公开(公告)号：DE60135907D1
公开(公告)日：2008-11-06
申请号：DE60135907
申请日：2001-04-19
申请人： PSIVIDA INC
发明人： GUO HONG , ASHTON PAUL
IPC分类号： A61F9/007 , A61K9/00 , A61K9/22 , A61K31/4422 , A61K31/58 , A61M37/00 , A61P9/12 , A61P27/02 , A61P29/00
摘要： A method and device for treating a mammalian organism to obtain a desired local or systemic physiological or pharmacological effect is provided. The method includes administering a sustained release drug delivery system to mammalian organism in need of such treatment at an area wherein release of an effective agent is desired and allowing the effective agent to pass through the device in a controlled manner. The device includes an inner core or reservoir including the effective agent, an impermeable tube which encloses portions of the reservoir, and a permeable member at the end of the tube.

87. 发明专利

AT409023T 未知
公开(公告)号：AT409023T
公开(公告)日：2008-10-15
申请号：AT01927200
申请日：2001-04-19
申请人： PSIVIDA INC
发明人： GUO HONG , ASHTON PAUL
IPC分类号： A61F9/007 , A61K9/00 , A61K9/22 , A61K31/4422 , A61K31/58 , A61M37/00 , A61P9/12 , A61P27/02 , A61P29/00
摘要： A method and device for treating a mammalian organism to obtain a desired local or systemic physiological or pharmacological effect is provided. The method includes administering a sustained release drug delivery system to mammalian organism in need of such treatment at an area wherein release of an effective agent is desired and allowing the effective agent to pass through the device in a controlled manner. The device includes an inner core or reservoir including the effective agent, an impermeable tube which encloses portions of the reservoir, and a permeable member at the end of the tube.

88. 发明专利

AU2002259045B2 Sustained release drug delivery system containing codrugs 未知
公开(公告)号：AU2002259045B2
公开(公告)日：2008-05-22
申请号：AU2002259045
申请日：2002-04-26
申请人： PSIVIDA INC
发明人： SMITH THOMAS J , CHEN JIANBING , ASHTON PAUL
IPC分类号： A61K47/48 , A61F2/84 , A61K9/00 , A61K9/10 , A61K9/22 , A61K9/52 , A61K9/70 , A61K31/192 , A61K31/496 , A61K31/513 , A61K45/00 , A61K47/30 , A61K47/32 , A61K47/34 , A61L17/00 , A61L29/00 , A61L29/16 , A61L31/00 , A61L31/10 , A61L31/16 , A61P27/06 , A61P29/00 , A61P31/00 , A61P31/04 , A61P31/12 , A61P33/10 , A61P35/00 , A61P37/00 , A61P43/00 , C08K5/00 , C08L101/00
摘要： Disclosed is a sustained release system that includes a polymer and a prodrug having a solubility less than about 1 mg/ml dispersed in the polymer. Advantageously, the polymer is permeable to the prodrug and may be non-release rate limiting with respect to the rate of release of the prodrug from the polymer. This permits improved drug delivery within a body in the vicinity of a surgery via sustained release rate kinetics over a prolonged period of time, while not requiring complicated manufacturing processes.

89. 发明专利

NO20062362L 未知
公开(公告)号：NO20062362L
公开(公告)日：2006-08-13
申请号：NO20062362
申请日：2006-05-23
申请人： PSIVIDA INC
发明人： GUO HONG , ASHTON PAUL , SHIMIZU ROBERT W , WATSON DAVID A , CHOU KANG-JYE
IPC分类号： A61K9/58 , A61K9/00 , A61K9/20

90. 发明专利

NO20062362A 未知
公开(公告)号：NO20062362A
公开(公告)日：2006-08-13
申请号：NO20062362
申请日：2006-05-23
申请人： PSIVIDA INC
发明人： GUO HONG , ASHTON PAUL , SHIMIZU ROBERT W , WATSON DAVID A , CHOU KANG-JYE
IPC分类号： A61K9/58 , A61K9/00 , A61K9/20
CPC分类号： A61K9/0024 , A61K9/0051 , A61K9/2095 , Y02A50/385
摘要： An injectable drug delivery device includes a core containing one or more drugs and one or more polymers. The core may be surrounded by one or more polymer outer layers (referred to as "coatings", "skins", or "outer layers"). In certain embodiments, the device is formed by extruding or otherwise preforming a polymeric skin for a drug core. The drug core may be co-extruded with the skin, or inserted into the skin after the skin has been extruded, and possibly cured. In other embodiments, the drug core may be coated with one or more polymer coatings. These techniques may be usefully applied to fabricate devices having a wide array of drug formulations and skins that can be selected to control the release rate profile and various other properties of the drugs in the drug core in a form suitable for injection using standard or non-standard gauge needles. The device may be formed by combining at least one polymer, at least one drug, and at least one liquid solvent to form a liquid suspension or solution wherein, upon injection, such suspension or solution undergoes a phase change and forms a gel. The configuration may provide for controlled release of the drug(s) for an extended period.

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