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81. 发明申请

US20090258029A1 Heparin Prodrugs and Drug Delivery Stents Formed Therefrom 审中-公开
标题翻译：肝素前药和药物输送支架
公开(公告)号：US20090258029A1
公开(公告)日：2009-10-15
申请号：US12489205
申请日：2009-06-22
申请人： Syed Faiyaz Ahmed Hossainy , Ni Ding
发明人： Syed Faiyaz Ahmed Hossainy , Ni Ding
IPC分类号： A61K39/44 , C08B37/10 , C07K17/08 , C08L39/06 , A61P7/02
CPC分类号： A61K31/727 , A61K47/61 , A61L31/10 , A61L31/16 , A61L2300/236 , A61L2300/606 , A61L2300/80 , C08B37/0075 , C09D105/10
摘要： A prodrug comprising a heparin and a drug is provided. The prodrug can be used to form a coating on a medical device. The prodrug can also be used with a polymeric material to form a coating on a medical device. The polymeric material can be a hydrophobic polymer, a hydrophilic polymer, a non-fouling polymer, or combinations thereof. The medical device can be implanted in a human being for the treatment of a disease such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.
摘要翻译：提供了包含肝素和药物的前药。前药可用于在医疗装置上形成涂层。前药还可以与聚合物材料一起使用以在医疗装置上形成涂层。聚合物材料可以是疏水性聚合物，亲水性聚合物，非结垢聚合物，或其组合。医疗器械可以植入人类用于治疗动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等疾病，胆管阻塞，输尿管阻塞，肿瘤阻塞或其组合。

82. 发明授权

US07560492B1 Polysulfone block copolymers as drug-eluting coating material 失效
标题翻译：聚砜嵌段共聚物作为药物洗脱涂料
公开(公告)号：US07560492B1
公开(公告)日：2009-07-14
申请号：US10723137
申请日：2003-11-25
申请人： Charles D. Claude , Ni Ding , Yeung Siu Yu
发明人： Charles D. Claude , Ni Ding , Yeung Siu Yu
IPC分类号： A61K47/00
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/606 , C08L81/06
摘要： A polymeric composition comprising a polysulfone polymer and an elastomeric polymer for use as a coating composition for coating an implantable device, such as a DES, and methods of making and using the implantable device are provided.
摘要翻译：提供了一种聚合物组合物，其包含聚砜聚合物和用作涂覆可植入装置（例如DES）的涂料组合物的弹性体聚合物，以及制造和使用可植入装置的方法。

83. 发明申请

US20080262606A1 POLYMERS CONTAINING SILOXANE MONOMERS 有权
标题翻译：含硅氧烷单体的聚合物
公开(公告)号：US20080262606A1
公开(公告)日：2008-10-23
申请号：US12135921
申请日：2008-06-09
申请人： Ni Ding , Stephen D. Pacetti
发明人： Ni Ding , Stephen D. Pacetti
IPC分类号： A61F2/82 , C08G77/04 , A61F2/00
CPC分类号： C08G77/442 , A61L31/10 , A61L31/16 , A61L2300/00 , C08L83/04
摘要： A polymer of siloxanes as flexibility monomers and strength monomers is provided. It is also provided a polymer blend that contains a polymer formed of siloxane monomers and strength monomers and another biocompatible polymer. The biocompatible polymer or polymer blend described herein and optionally a bioactive agent can form a coating on an implantable device such as a drug-delivery stent. The implantable device can be used for treating or preventing a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.
摘要翻译：提供了作为柔性单体和强度单体的硅氧烷的聚合物。还提供了一种聚合物共混物，其包含由硅氧烷单体和强度单体形成的聚合物和另一种生物相容性聚合物。本文所述的生物相容性聚合物或聚合物共混物和任选的生物活性剂可以在可植入装置如药物递送支架上形成涂层。可植入装置可用于治疗或预防动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等障碍，胆管阻塞，输尿管阻塞，肿瘤阻塞或其组合。

84. 发明申请

US20080234810A1 Amorphous Glass-Coated Drug Delivery Medical Device 审中-公开
标题翻译：无定形玻璃涂层药物输送医疗器械
公开(公告)号：US20080234810A1
公开(公告)日：2008-09-25
申请号：US11769581
申请日：2007-06-27
申请人： James M. Carlson , Ni Ding
发明人： James M. Carlson , Ni Ding
IPC分类号： A61F2/82 , C23C16/453
CPC分类号： A61L31/022 , A61L31/082 , A61L31/10 , A61L31/16 , A61L2300/608 , A61L2400/12 , A61L2420/08
摘要： An implantable medical device that can include an amorphous glass primer layer, an amorphous glass drug-containing layer and a nanoporous amorphous glass top-coat layer is disclosed.
摘要翻译：公开了可包括非晶玻璃底漆层，非晶玻璃药物含量层和纳米多孔无定形玻璃顶涂层的可植入医疗装置。

85. 发明申请

US20070198080A1 Coatings including an antioxidant 审中-公开
标题翻译：涂层包括抗氧化剂
公开(公告)号：US20070198080A1
公开(公告)日：2007-08-23
申请号：US11528891
申请日：2006-09-27
申请人： Ni Ding , Leslie Coleman
发明人： Ni Ding , Leslie Coleman
IPC分类号： A61L33/00 , B05D3/00 , A61F2/06 , A61F2/02 , A61F2/82
CPC分类号： A61L31/10 , Y10T428/1307
摘要： A coating including an antioxidant or a combination of antioxidant and another bioactive agent on a medical device is described.
摘要翻译：描述了包括抗氧化剂或抗氧化剂和另一种生物活性剂在医疗装置上的组合的涂层。

86. 发明授权

US07247313B2 Polyacrylates coatings for implantable medical devices 有权
标题翻译：用于可植入医疗器械的聚丙烯酸酯涂层
公开(公告)号：US07247313B2
公开(公告)日：2007-07-24
申请号：US10176504
申请日：2002-06-21
申请人： Wouter E. Roorda , Ni Ding , Stephen D. Pacetti , Eugene T. Michal , Ashok A. Shah , Syed F. A. Hossainy
发明人： Wouter E. Roorda , Ni Ding , Stephen D. Pacetti , Eugene T. Michal , Ashok A. Shah , Syed F. A. Hossainy
IPC分类号： A61F2/02 , A61K9/00
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/608 , A61L2420/08 , C08L33/10 , C08L33/06
摘要： A coating for a medical device, particularly for a drug eluting stent, is described. The coating can include a polyacrylate, a blend of polyacrylates, or a blend of the polyacrylate with other polymers, for example, poly(ethylene-co-vinyl alcohol).
摘要翻译：描述了用于医疗装置的涂层，特别是用于药物洗脱支架的涂层。涂层可以包括聚丙烯酸酯，聚丙烯酸酯的共混物或聚丙烯酸酯与其它聚合物的共混物，例如聚（乙烯 - 共 - 乙烯醇）。

87. 发明申请

US20060177482A1 Stent with coatings containing self-assembled monolayers 审中-公开
标题翻译：支架与含有自组装单层的涂层
公开(公告)号：US20060177482A1
公开(公告)日：2006-08-10
申请号：US11400433
申请日：2006-04-06
申请人： Ni Ding
发明人： Ni Ding
IPC分类号： A61K31/4745 , A61F2/00
CPC分类号： A61K31/4745 , A61L31/10 , A61L31/16 , A61L2300/416 , B82Y30/00 , B82Y40/00 , Y10T428/24
摘要： A medical device with a coating, particularly a drug eluting stent, is described. The coating includes a self-assembled monolayer.
摘要翻译：描述了具有涂层的医疗装置，特别是药物洗脱支架。涂层包括自组装单层。

88. 发明授权

US07033602B1 Polycationic peptide coatings and methods of coating implantable medical devices 失效
标题翻译：聚阳离子肽涂层和涂覆可植入医疗器械的方法
公开(公告)号：US07033602B1
公开(公告)日：2006-04-25
申请号：US10177116
申请日：2002-06-21
申请人： Stephen D. Pacetti , Eugene T Michal , Syed F A Hossainy , Ni Ding , Wouter E Roorda
发明人： Stephen D. Pacetti , Eugene T Michal , Syed F A Hossainy , Ni Ding , Wouter E Roorda
IPC分类号： A61F2/02
CPC分类号： A61K31/727 , A61K31/728 , A61K31/737 , A61L31/10 , C08L89/00
摘要： Coatings for medical devices which include polycationic peptides such as L-arginine and methods for fabricating the coatings are disclosed.
摘要翻译：公开了包括聚阳离子肽如L-精氨酸的医疗器械用涂层和制造涂层的方法。

89. 发明申请

US20060062821A1 Polycationic peptide coatings and methods of making the same 有权
公开(公告)号：US20060062821A1
公开(公告)日：2006-03-23
申请号：US11218654
申请日：2005-09-02
申请人： Murthy Simhambhatla , Ni Ding , Stephen Pacetti
发明人： Murthy Simhambhatla , Ni Ding , Stephen Pacetti
IPC分类号： A61F13/00
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/114 , A61L2300/606 , A61L2300/622 , A61L2300/626 , C08L77/04
摘要： Polycationic peptide coatings for implantable medical devices and methods of making the same are described. The methods include applying an emulsion on the device, the emulsion including a polymer and a polycationic peptide. Other methods include incorporation of the polycationic peptide in microspheres and liposomes.

90. 发明申请

US20050175666A1 High-density lipoprotein coated medical devices 有权
标题翻译：高密度脂蛋白包被的医疗器械
公开(公告)号：US20050175666A1
公开(公告)日：2005-08-11
申请号：US11027822
申请日：2004-12-29
申请人： Ni Ding
发明人： Ni Ding
IPC分类号： A61K38/17 , A61K48/00 , A61L31/10 , A61L31/16 , A61F2/00
CPC分类号： A61L31/16 , A61F2/82 , A61K38/1709 , A61L31/10 , A61L2300/252 , A61L2300/416
摘要： An implantable medical device is disclosed comprising a high-density lipoprotein (HDL), recombinant HDL, high-density lipoprotein mimics (HDLm), or a combination thereof. Method are also disclosed for local and systemic administration HDL, recombinant HDL or HDLm for the prevention, treatment, or amelioration of a vascular disorder, disease or occlusion such as restenosis or vulnerable plaque.
摘要翻译：公开了一种植入式医疗装置，其包括高密度脂蛋白（HDL），重组HDL，高密度脂蛋白模拟物（HDLm）或其组合。还公开了局部和全身给药HDL，重组HDL或HDLm用于预防，治疗或改善血管疾病，疾病或闭塞如再狭窄或易损斑块的方法。

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