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81. 发明申请

WO1997043301A2 IDENTIFICATION OF MEMBERS OF COMBINATORIAL LIBRARIES BY MASS SPECTROMETRY 审中-公开
标题翻译：通过质谱鉴定组合图书馆的成员
公开(公告)号：WO1997043301A2
公开(公告)日：1997-11-20
申请号：PCT/EP1997002215
申请日：1997-04-30
申请人： NOVARTIS AG , WENNOGLE, Lawrence Paul , KELLY, Michele, Ann , LIANG, Hongbin , GOELLER, Christine , THOMA, Hans, Mathis
发明人： NOVARTIS AG
IPC分类号： C07K01/04
CPC分类号： C40B30/04 , C07K1/047 , G01N33/6845 , H01J49/00
摘要： The present invention is drawn to methods for characterizing the members of a combinatorial library which bind to a domain of interest. The method utilizes affinity selection in combination with mass spectrometry to provide rapid and efficient screening. The method provides information on relative affinities and molecular weights of affinity-selected compounds. The methods find use in analyzing all types of combinatorial libraries.
摘要翻译：本发明涉及用于表征结合到感兴趣域的组合文库的成员的方法。该方法利用亲和力选择与质谱联用，提供快速有效的筛选。该方法提供了亲和力选择化合物的相对亲和力和分子量的信息。该方法可用于分析所有类型的组合库。

82. 发明申请

WO1997041221A1 METASTASIS-ASSOCIATED ANTIGEN AND ANTIBODIES THERETO 审中-公开
标题翻译： METASTASIS相关抗原和抗体
公开(公告)号：WO1997041221A1
公开(公告)日：1997-11-06
申请号：PCT/EP1997001963
申请日：1997-04-18
申请人： NOVARTIS AG , BACHMANN, Felix
发明人： NOVARTIS AG
IPC分类号： C12N15/12
CPC分类号： G01N33/57407 , A61K38/00 , C07K14/47 , C07K16/30 , C07K2317/76 , G01N33/57492
摘要： There are provided membrane-associated polypeptides having the sequence shown in SEQ ID Nos. 1 and 9. Also provided are immunogenic determinants derived from said polypeptides and antibodies raised thereto. The polypeptides, their derived antigenic determinants and the antibodies are useful for the diagnosis and treatment of metastatic potential in tumors.
摘要翻译：提供具有SEQ ID No.1和9所示序列的膜相关多肽。还提供衍生自所述多肽的免疫原性决定簇和对其产生的抗体。多肽，其衍生的抗原决定簇和抗体可用于诊断和治疗肿瘤中的转移潜能。

83. 发明申请

WO1997037211A1 INTEGRATED OPTICAL LUMINESCENCE SENSOR 审中-公开
标题翻译：集成的光致发光
公开(公告)号：WO1997037211A1
公开(公告)日：1997-10-09
申请号：PCT/EP1997001468
申请日：1997-03-22
申请人： NOVARTIS AG , DANIELZIK, Burkhard , NEUSCHÄFER, Dieter , PAWLAK, Michael , DUVENECK, Gert, Ludwig
发明人： NOVARTIS AG
IPC分类号： G01N21/77
CPC分类号： G01N21/648 , G01N21/7703
摘要： An integrated optical luminescence sensor with an exciting light beam with a first optical axis (Kein), a planar waveguide (1), a sample interacting with its evanescent field and a detection beam path running from the waveguide with a second optical axis and/or a decoupling grid (7) to decouple the part of the luminescent light conducted in the waveguide, in which the luminescence light to be detected is spatially separated from the exciting light.
摘要翻译：具有第一光轴的激发光光束的集成光学发光传感器（否），与平面波导（1），（与渐逝场样品和出射波导检测光束路径与第二光轴的交互和/或与输出耦合光栅 7），用于耦合出在发光光的波导部分的导波的，其特征在于，要被检测的发光光在空间上与激发光分开。

84. 发明申请

WO1997035905A1 PROCESS FOR MANUFACTURE OF A POROUS POLYMER BY USE OF A POROGEN 审中-公开
标题翻译：通过使用多孔聚合物制备多孔聚合物的方法
公开(公告)号：WO1997035905A1
公开(公告)日：1997-10-02
申请号：PCT/EP1997001409
申请日：1997-03-20
申请人： NOVARTIS AG , COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION , CHAOUK, Hassan , MEIJS, Gordon, Francis
发明人： NOVARTIS AG , COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION
IPC分类号： C08G65/00
CPC分类号： B01D67/0006 , B01D67/003 , B01D71/32 , B01D2323/18 , B01D2325/02 , B01D2325/026 , B01D2325/22 , B01D2325/28 , B01D2325/30 , C08G65/007 , C08J9/286 , C08J2371/00 , C08L71/02 , G02B1/043 , C08L63/00
摘要： The invention is directed to a process for producing a porous polymer comprising the steps of: (1) dispersing a porogen in a continuous monomer component phase wherein said continuous monomer component phase comprises at least one monomer having at least one perfluoropolyether unit and wherein said porogen is an optionally substituted poly(alkylene)glycol; (2) thereafter polymerising the continuous monomer phase; and (3) removing the porogen from the porous polymer.
摘要翻译：本发明涉及一种生产多孔聚合物的方法，包括以下步骤：（1）将致孔剂分散在连续单体组分相中，其中所述连续单体组分相包含至少一种具有至少一个全氟聚醚单元的单体，并且其中所述致孔剂是任选取代的聚（亚烷基）二醇; （2）然后使连续单体相聚合; 和（3）从多孔聚合物中除去致孔剂。

85. 发明申请

WO1997035904A1 PROCESS FOR MANUFACTURE OF A POROUS POLYMER FROM A MIXTURE 审中-公开
标题翻译：从混合物制备多孔聚合物的方法
公开(公告)号：WO1997035904A1
公开(公告)日：1997-10-02
申请号：PCT/EP1997001408
申请日：1997-03-20
申请人： NOVARTIS AG , COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION , CHAOUK, Hassan , MEIJS, Gordon, Francis , LAYCOCK, Bronwyn, Glenice
发明人： NOVARTIS AG , COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION
IPC分类号： C08G65/00
CPC分类号： B01D67/0006 , B01D67/003 , B01D71/32 , B01D2323/18 , B01D2325/02 , B01D2325/026 , B01D2325/22 , B01D2325/28 , B01D2325/30 , C08G65/007 , C08J9/286 , C08J2371/00 , C08L71/02 , G02B1/043 , Y10T428/24 , Y10T428/24504 , Y10T428/249921 , Y10T428/249953 , Y10T428/249958 , C08L63/00
摘要： The present invention is directed to a process for the production of a porous polymer comprising the steps of: i) forming a mixture comprising a polymerizable component and an organic solvent wherein the polymerizable component comprises at least one macromonomer having at least one perfluoropolyether unit; ii) polymerizing said mixture wherein immediately after the polymerization of said mixture at least a substantial proportion of said organic solvent is in the form of a discrete phase and wherein said discrete organic solvent phase forms an interpenetrating network throughout the mixture or is dispersed throughout the mixture; and iii) removing the discrete organic solvent phase.
摘要翻译：本发明涉及生产多孔聚合物的方法，包括以下步骤：i）形成包含可聚合组分和有机溶剂的混合物，其中可聚合组分包含至少一种具有至少一个全氟聚醚单元的大分子单体; ii）使所述混合物聚合，其中在所述混合物的聚合之后立即至少相当比例的所述有机溶剂是离散相的形式，并且其中所述离散的有机溶剂相在整个混合物中形成互穿网络，或者分散在整个混合物中 ; 和iii）除去离散的有机溶剂相。

86. 发明申请

WO1997035869A1 DINUCLEOTIDE AND OLIGONUCLEOTIDE ANALOGUES 审中-公开
标题翻译：胆固醇和寡核苷酸类似物
公开(公告)号：WO1997035869A1
公开(公告)日：1997-10-02
申请号：PCT/GB1997000651
申请日：1997-03-11
申请人： NOVARTIS AG , BAXTER, Anthony, David , BAYLIS, Eric, Keith , COLLINGWOOD, Stephen, Paul , FAIRHURST, Robin, Alec , TAYLOR, Roger, John
发明人： NOVARTIS AG
IPC分类号： C07H21/00
CPC分类号： C07H19/06 , C07H21/00 , Y02P20/55
摘要： A compound which is a dinucleotide analogue of formula (I) or a salt thereof, where B an B are each independently a monovalent nucleoside base radical, R is hydrogen or Y , R and R are each independently hydrogen, halogen, hydroxy or -OY , R is hydrogen, halogen, hydroxy, -OY or R , R is hydrogen, halogen or R , R is hydrogen, Y or a phosphoramidyl group, Z is a group of formula (II), (III) or (IV), where R is hydrogen, halogen, hydroxy, -OY or R , R is hydrogen, halogen or R , R is hydroxy, R or -OR where R is a C1 to C10 aliphatic group, a C3 to C8 cycloaliphatic group, a C6 to C10 aromatic group or a C7 to C13 araliphatic group, and R is hydrogen, R a or -OCOR a where R a is C1 to C10 aliphatic, a C3 to C8 cycloaliphatic group, a C6 to C10 aromatic group or a C7 to C13 araliphatic group, Y , Y , Y , Y , and Y are each independently a hydroxy-protecting group, and R , R , R , R are each independently a C1 to C10 aliphatic group, a C3 to C8 cycloaliphatic group, a C6 to C10 aromatic group or a C7 to C13 araliphatic group.
摘要翻译：作为式（I）的二核苷酸类似物或其盐的化合物，其中B 1和B 2各自独立地为一价核苷碱基，R 1为氢或Y 1， 2>和R 3各自独立地为氢，卤素，羟基或-OY 2，R 4为氢，卤素，羟基，-OY 3或R 7，R 5为氢，卤素或R 8，R 6为氢，Y 4或亚磷酰基，Z为式（II），（III）或（IV）的基团，其中R 9为氢，卤素，羟基，-OY 5或R 13，R 10是氢，卤素或R 14，R 11是羟基，R 15或-OR 15，其中R 15 >为C1至C10脂族基团，C3至C8脂环族基团，C6至C10芳族基团或C7至C13芳脂族基团，R12为氢，R12a或-OCOR12 其中R 12是C 1至C 10脂族基，C 3至C 8脂环族基团，C 6至C 10芳族基团或C 7至C 13芳脂基基团，Y 1，Y 2，Y 3， 4＆gt;和Y 5各自独立地为羟基保护基，R 7，R 8，R 13，R 14，Ar 各自独立地为C1至C10脂族基团，C3至C8脂环族基团，C6至C10芳族基团或C7至C13芳脂肪族基团。

87. 发明申请

WO1997035575A1 USE OF RAPAMYCIN DERIVATIVES IN VASCULOPATHIES AND XENOTRANSPLANTATION 审中-公开
标题翻译： RAPAMYCIN衍生物在血管造影和XENOTRANSPLANTATION中的应用
公开(公告)号：WO1997035575A1
公开(公告)日：1997-10-02
申请号：PCT/EP1997001548
申请日：1997-03-26
申请人： NOVARTIS AG , SCHULER, Walter , SCHUURMAN, Hendrik , WECKBECKER, Gisbert , ZERWES, Hans-Günter
发明人： NOVARTIS AG
IPC分类号： A61K31/435
CPC分类号： A61K31/436
摘要： Use of a rapamycin derivative of formula (I) as defined in the claims for preventing or treating vasculopathies and manifestations of xenotransplantation.
摘要翻译：在权利要求中定义的式（I）雷帕霉素衍生物用于预防或治疗血管病变和异种移植的表现的用途。

88. 发明申请

WO1997034752A1 METHOD OF MUTUALLY POSITIONING A PAIR OF SHAPING-TOOL HALVES FACING EACH OTHER, AND SHAPING TOOL FOR THE MANUFACTURE OF PRECISION-MADE ARTICLES, IN PARTICULAR CONTACT LENSES 审中-公开
标题翻译： METHOD FOR相反FORM的相互定位对确定模具部分和模精密元件的生产，特别是接触镜
公开(公告)号：WO1997034752A1
公开(公告)日：1997-09-25
申请号：PCT/EP1997001105
申请日：1997-03-05
申请人： NOVARTIS AG , BAUR, Karl-Albert , BICKERT, Stefan , REINISCH, Hubert
发明人： NOVARTIS AG
IPC分类号： B29C33/56
CPC分类号： B29C33/303 , B29D11/00432 , B29K2909/08
摘要： Proposed is a shaping tool for manufacturing precision-made articles, in particular contact lenses, said shaping tool comprising two halves fitted with inserts (18, 38) and with a cavity (50) between them. The tool is made of ceramic glass with negligible thermal expansion in a given work range. On each side of the cavity (50) is a ceramic-glass insert which defines the shape of the part being manufactured and which is positively held round its circumference in a positioning plate (16, 36) also made of ceramic glass. The positioning plates (16, 36) are each mounted on a ceramic-glass mounting plate (14, 34).

89. 发明申请

WO1997033890A1 PYRIMIDIN-4-ONE DERIVATIVES AS PESTICIDE 审中-公开
标题翻译： PYRIMIDIN-4-ONE衍生物作为杀菌剂
公开(公告)号：WO1997033890A1
公开(公告)日：1997-09-18
申请号：PCT/EP1997001056
申请日：1997-03-03
申请人： NOVARTIS AG , WALTER, Harald
发明人： NOVARTIS AG
IPC分类号： C07D495/04
CPC分类号： C07D487/04 , A01N43/90 , C07D491/04 , C07D495/04 , C07D513/04
摘要： Novel pyrimidin-4-one derivatives of formula (I), wherein: R1=C1-C8alkyl, C2-C8alkenyl, C2-C8alkynyl, C3-C6cycloalkyl, each of which is unsubstituted or substituted by halogen, O-C1-C4alkyl, O-C1-C4haloalky, O-C1-C4alkoxy, S-C1-C4alkyl, SO-C1-C4alkyl, SO2-C1-C4alkyl, CO-C1C4alkyl, N=C1-C4alkyl, NH-C1-C4alkyl, N(C1-C4alkyl)2, COO-C1-C4alkyl, COO-aryl, cyano, nitro, Si-(C1-C4alkyl)3, phenyl, halophenyl, phenoxyphenyl, halophenoxyphenyl, naphthyl; R2=OR5, SR6, NR7R8; R3 and R4 are each independently of the other hydrogen, halogen, C1-C4alkyl, C1-C4haloalkyl, C2-C4alkenyl, C2-C4haloalkenyl, C2-C4alkynyl, C2-C4haloalkynyl, Si-(C1-C6alkyl)3, COO-C1-C4alkyl, COO-aryl, COOH, CH=N-C1-C4alkyl, C(CH3)=N-C1-C4alkyl, SO-C1-C4alkyl, SO2-C1-C4alkyl, OR5, SR6, NR7R8, COR9; R9=hydrogen, C1-C4alkyl, phenyl, benzyl; R5 and R6 are each independently of the other C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C3-C6cycloalkyl, each of which is unsubstituted or substituted by halogen, O-C1-C4alkyl, O-C1-C4haloalkyl, O-C1-C4alkoxy, S-C1-C4alkyl, SO-C1-C4alkyl, SO2-C1-C4alkyl, CO-C1-C4alkyl, N=C1-C4alkyl, NH-C1-C4alkyl, N(C1-C4alkyl)2, COO-C1-C4alkyl, COO-aryl, cyano, nitro, Si-(C1-C4alkyl)3, phenyl, halophenyl, phenoxyphenyl, halophenoxyphenyl, naphthyl; R7 and R8 are each independently of the other C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C3-C6cycloalkyl, each of which is unsubstituted or substituted by halogen, O-C1-C4alkyl, O-C1-C4haloalkyl, O-C1-C4alkoxy, S-C1-C4alkyl, SO-C1-C4alkyl, SO2-C1-C4alkyl, CO-C1-C4-alkyl, N=C1-C4alkyl, NH-C1-C4alkyl, N(C1-C4alkyl)2, COO-C1-C4alkyl, COO-aryl, cyano, nitro, Si-(C1-C4alkyl)3, phenyl, halophenyl, phenoxyphenyl, halophenoxyphenyl, naphthyl; A = is a 5-membered heterocyclic ring which may be saturated or unsaturated, aromatic or non-aromatic and which may contain one or two hetero atoms O, S and/or N, each in the free form or in salt form. The novel compounds have plant-protective properties and are suitable for protecting plants against infestation by phytopathogenic micro-organisms, in particular fungi.
摘要翻译：式（I）的新型嘧啶-4-酮衍生物，其中：R1 = C1-C8烷基，C2-C8链烯基，C2-C8炔基，C3-C6环烷基，其各自为未取代或被卤素，O-C1-C4烷基，O C 1 -C 4卤代烷基，O-C 1 -C 4烷氧基，S-C 1 -C 4烷基，SO-C 1 -C 4烷基，SO 2 -C 1 -C 4烷基，CO-C 1 -C 4烷基，N = C 1 -C 4烷基，NH-C 1 -C 4烷基，）2，COO-C 1 -C 4烷基，COO-芳基，氰基，硝基，Si-（C 1 -C 4烷基）3，苯基，卤代苯基，苯氧基苯基，卤代苯氧基苯基， R2 = OR5，SR6，NR7R8; R3和R4分别独立地为氢，卤素，C1-C4烷基，C1-C4卤代烷基，C2-C4链烯基，C2-C4卤代烯基，C2-C4炔基，C2-C4卤代炔基，Si-（C1-C6烷基）3，COO-C1- C4烷基，COO-芳基，COOH，CH = N-C1-C4烷基，C（CH3）= N-C1-C4烷基，SO-C1-C4烷基，SO2-C1-C4烷基，OR5，SR6，NR7R8，COR9; R9 =氢，C1-C4烷基，苯基，苄基; R 5和R 6各自独立地为C 1 -C 6烷基，C 2 -C 6烯基，C 2 -C 6炔基，C 3 -C 6环烷基，其各自未被取代或被卤素，O-C 1 -C 4烷基，O-C 1 -C 4卤代烷基，O-C 1 C 1-4烷氧基，S-C 1 -C 4烷基，SO-C 1 -C 4烷基，SO 2 -C 1 -C 4烷基，CO-C 1 -C 4烷基，N = C 1 -C 4烷基，NH-C 1 -C 4烷基，N（C 1 -C 4烷基）2，COO- -C 1-4烷基，COO-芳基，氰基，硝基，Si-（C 1 -C 4烷基）3，苯基，卤代苯基，苯氧基苯基，卤代苯氧基苯基，萘基; R 1和R 2各自独立地为C 1 -C 6烷基，C 2 -C 6烯基，C 2 -C 6炔基，C 3 -C 6环烷基，其各自未被取代或被卤素，O-C 1 -C 4烷基，O-C 1 -C 4卤代烷基，O-C 1 C 1-4烷氧基，S-C 1 -C 4烷基，SO-C 1 -C 4烷基，SO 2 -C 1 -C 4烷基，CO-C 1 -C 4烷基，N = C 1 -C 4烷基，NH-C 1 -C 4烷基，N（C 1 -C 4烷基）2，COO C 1 -C 4烷基，COO-芳基，氰基，硝基，Si-（C 1 -C 4烷基）3，苯基，卤代苯基，苯氧基苯基，卤代苯氧基苯基，萘基; A =是可以是饱和或不饱和的，芳族或非芳族的5元杂环，并且可以含有一个或两个以游离形式或盐形式的一个或两个杂原子O，S和/或N。新化合物具有植物保护性质，并且适合于保护植物免受植物病原微生物特别是真菌的侵袭。

90. 发明申请

WO1997033568A1 FILLED GELATIN CAPSULES HAVING A REDUCED DEGREE OF CROSS-LINKING 审中-公开
标题翻译：具有减少交联度的填充凝胶胶囊
公开(公告)号：WO1997033568A1
公开(公告)日：1997-09-18
申请号：PCT/EP1997001108
申请日：1997-03-05
申请人： NOVARTIS AG
发明人： NOVARTIS AG , ADESUNLOYE, Adedotun, Tony , STACH, Paul, Edward
IPC分类号： A61K09/48
CPC分类号： A61K9/4858 , C09H5/00 , C09H7/00 , Y10S514/962
摘要： Disclosed is a method of reducing cross-linking in gelatin capsules wherein an amino acid and a carboxylic acid are incorporated into the capsule fill, as well as filled gelatin capsules that utilize the disclosed method. The inventive method is especially useful for pharmaceutical formulations which include hydrochlorothiazide, triamterene, gemfibrozil, chloramphenicol, etodolac, piroxicam, nifedipine, tetracycline, diphenhydramine, hydroflumethiazide and rifampin, or a combination thereof as active ingredient.
摘要翻译：公开了一种降低明胶胶囊中的交联的方法，其中将氨基酸和羧酸掺入胶囊填充物中，以及使用所公开的方法的填充的明胶胶囊。本发明的方法对于药物制剂特别有用，其中包括氢氯噻嗪，氨苯蝶胺，吉非贝齐，氯霉素，依托度酸，吡罗昔康，硝苯地平，四环素，苯海拉明，氢氟噻嗪和利福平或其组合作为活性成分。

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