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81. 发明专利

BR112013002150A2 lentes de hidrogel de silicone com um revestimento hidrofílico reticulado 未知
公开(公告)号：BR112013002150A2
公开(公告)日：2016-05-31
申请号：BR112013002150
申请日：2011-07-29
申请人： NOVARTIS AG
发明人： MEDINA ARTURO N , KOLLURU CHANDANA , WU DAQING , NELSON JARED , PRUITT JOHN DALLAS , WINTERTON LYNN COOK , SAMUEL NEWTON T , QIAN XINMING , QIU YONGXING
IPC分类号： B05D5/06 , B29D11/00 , G02C7/04
摘要： lentes de hidrogel de silicone com um revestimento hidrofólico reticulado. a presente invenção refere-se a um processo eficiente em relação ao custo para a produção de uma lente de contato de hidrogel de silicone que possui um revestimento hidrofilíco reticulado sobre a mesma. um processo da invenção envolve o aquecimento da lente de contato de hidrogel de silicone em uma solução aquosa na presença de um material polimérico hidrofílico reticulável termicamente altamente ramificado solúvel em água que possui grupos azetidínio carregados positivamente, até uma temperatura desde 40 c até 140 c durante um período de tempo suficiente para ligar covalentemente o material polimérico hidrofílico reticulável termicamente sobre a superfície da lente de contato de hidrogel de silicone através de ligações covalentes cada uma formada entre um grupo azetidínio e um dos grupos funcionais reativos sobre e/ou próximos à superfície da lente de contato de hidrogel de silicone, formando assim um revestimento hidrofílico reticulado sobre a lente de contato de hidrogel de silicone. tal processo pode ser vantajosamente implementado diretamente em uma embalagem de lente selada durante tratamento em autoclave.

82. 发明专利

PL2185951T3 Wyrób soczewek kontaktowych 未知
公开(公告)号：PL2185951T3
公开(公告)日：2016-03-31
申请号：PL08795634
申请日：2008-08-27
申请人： NOVARTIS AG
发明人： PRUITT JOHN DALLAS , WINTERTON LYNN COOK
IPC分类号： G02B1/04 , A61K9/00 , A61L12/04 , A61L12/08 , B29D11/00

83. 发明专利

PT2185951E PRODUTOS PARA LENTES DE CONTACTO 未知
公开(公告)号：PT2185951E
公开(公告)日：2015-12-18
申请号：PT08795634
申请日：2008-08-27
申请人： NOVARTIS AG
发明人： WINTERTON LYNN COOK , PRUITT JOHN DALLAS

84. 发明专利

SG11201504592YA METHOD FOR APPLYING A COATING ONTO A SILICONE HYDROGEL LENS 未知
公开(公告)号：SG11201504592YA
公开(公告)日：2015-07-30
申请号：SG11201504592Y
申请日：2013-12-10
申请人： NOVARTIS AG
发明人： QIU YONGXING , MEDINA ARTURO NORBERTO , PRUITT JOHN DALLAS
IPC分类号： B29D11/00 , G02B11/04
摘要： The present invention generally relates to a method for applying a coating of hydrophilic polymers onto silicone hydrogel contact lenses to improve hydrophilicity and lubricity. In particular, the present invention is directed to a method for forming a coating on a contact lens, preferably a silicone hydrogel contact lens, directly in the primary package and maintaining the coated contact lens within said primary package until insertion of the coated contact lens in the eye of the contact lens user. The resultant silicone hydrogel contact lens has a coating with good hydrophilicity, improved lubricity and good durability and also can be used directly from the lens package by a patient without washing and/or rising.

85. 发明专利

AU2015201805A1 A silicone hydrogel lens with a crosslinked hydrophilic coating 未知
公开(公告)号：AU2015201805A1
公开(公告)日：2015-04-30
申请号：AU2015201805
申请日：2015-04-10
申请人： NOVARTIS AG
发明人： QIU YONGXING , SAMUEL NEWTON T , PRUITT JOHN DALLAS , KOLLURU CHANDANA , MEDINA ARTURO N , WINTERTON LYNN COOK , WU DAQING , QIAN XINMING , NELSON JARED
IPC分类号： G02C7/04 , B05D5/06 , B29D11/00
摘要： The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from 40C to 140*C for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogen contact lens through covalent linkages each formed between one azetidiniurn group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.

86. 发明专利

SG10201500807PA CONTACT LENS PRODUCTS 未知
公开(公告)号：SG10201500807PA
公开(公告)日：2015-04-29
申请号：SG10201500807P
申请日：2008-08-27
申请人： NOVARTIS AG
发明人： PRUITT JOHN DALLAS , WINTERTON LYNN COOK
摘要： The present invention relates to improved contact lens products which not only have initial insertion comfort but also are comfortable to wear for more than about 6 hours. The invention is achieved by packaging and storing a hydrogel lens with two or more leachable polymeric lubricants incorporated therein in a relatively viscous packaging solution including a relatively low molecular weight polyethylene glycol (PEG) and a viscosity-enhancing hydrophilic polymer. The present invention also provides methods for making contact lens products of the invention.

87. 发明专利

MX2014015424A COPOLIMEROS QUE CONTIENEN AZETIDINIO Y USOS DE LOS MISMOS. 未知
公开(公告)号：MX2014015424A
公开(公告)日：2015-03-05
申请号：MX2014015424
申请日：2013-06-10
申请人： NOVARTIS AG
发明人： HOLLAND TROY VERNON , CHANG FRANK , QIU YONGXING , PRUITT JOHN DALLAS , CHIANG CHUNG-YUAN , SHANKERNARAYANAN MANIVAKKAM J , SCOTT ROBERT , KAPOOR YASH
IPC分类号： B29D11/00 , B05D3/10 , C07D205/04 , C08F20/00 , C08F26/00 , G02C7/04
摘要： La invención se refiere a copolímeros y monómeros vinílicos que contienen azetidinio, y a sus usos en la formación de recubrimientos de hidrogel sin silicona sobre lentes de contacto de hidrogel de silicona.

88. 发明专利

BRPI0816104A2 未知
公开(公告)号：BRPI0816104A2
公开(公告)日：2015-03-03
申请号：BRPI0816104
申请日：2008-08-27
申请人： NOVARTIS AG
发明人： PRUITT JOHN DALLAS , WINTERTON LYNN COOK
IPC分类号： G02B1/04 , A61L12/08
摘要： The present invention relates to improved contact lens products which not only have initial insertion comfort but also are comfortable to wear for more than about 6 hours. The invention is achieved by packaging and storing a hydrogel lens with two or more leachable polymeric lubricants incorporated therein in a relatively viscous packaging solution including a relatively low molecular weight polyethylene glycol (PEG) and a viscosity-enhancing hydrophilic polymer. The present invention also provides methods for making contact lens products of the invention.

89. 发明专利

CA2802793C SILICONE HYDROGEL LENSES WITH WATER-RICH SURFACES 未知
公开(公告)号：CA2802793C
公开(公告)日：2014-10-21
申请号：CA2802793
申请日：2011-07-29
申请人： NOVARTIS AG
发明人： QIU YONGXING , PRUITT JOHN DALLAS , THEKVELI SIBICHEN J , TUCKER ROBERT CAREY , NELSON JARED
IPC分类号： G02B1/04 , G02C7/04
摘要： The invention is related to a hydrated silicone hydrogel contact lens having a layered structural configuration: a low water content silicone hydrogel core (or bulk material) completely covered with a layer of a water-rich (e.g., a water content greater than 80%), hydrogel totally or substantially free of silicone. A hydrated silicone hydrogel contact lens of the invention possesses high oxygen permeability for maintaining the corneal health and a soft, water-rich, lubricious surface for wearing comfort.

90. 发明专利

CA2747355C METHOD FOR MAKING SILICONE HYDROGEL CONTACT LENSES 未知
公开(公告)号：CA2747355C
公开(公告)日：2014-10-21
申请号：CA2747355
申请日：2009-06-16
申请人： NOVARTIS AG
发明人： CHANG FRANK , VOGT JURGEN , PRUITT JOHN DALLAS , QIAN XINMING , DOMSCHKE ANGELIKA MARIA , HOLLAND TROY VERNON , TUREK RICHARD CHARLES , WU DAQING , SMITH DAWN A
IPC分类号： G02B1/04
摘要： A method for producing silicone hydrogel contact lenses and silicon hydrogel contact lens thereof. The method comprising the steps of: providing a mold for making a soft contact lens, wherein the mold has a first mold half with a first molding surface defining the anterior surface of a contact lens and a second mold half with a second molding surface defining the posterior surface of the contact lens, wherein said first and second mold halves are configured to receive each other such that a cavity is formed between said first and second molding surfaces; introduce a monomer mixture of lens-forming materials into the cavity, wherein the monomer mixture comprises at least one hydrophilic amide-type vinylic monomer, at least one siloxane-containing (meth)acrylamide monomer, at least one polysiloxane vinylic monomer or macromer, and from about 0.05 % to about 1.5 % by weight of a photoinitiator, wherein the lens forming material is characterized by having an ability to be cured by a UV light having an UV-intensity of about 4.1 mW/cm2 within about 100 seconds; and irradiating, under a spatial limitation of actinic radiation, the lens-forming material in the mold for a time period of about 120 seconds or less, so as to crosslink the lens-forming material to form the silicone hydrogel contact lens, wherein the produced contact lens comprises an anterior surface defined by the first molding surface, an opposite posterior surface defined by the second molding surface, and a lens edge defined by the spatial limitation of actinic radiation.

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