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    • 82. 发明申请
    • PESTICIDAL COMPOSITIONS
    • 农药组合物
    • WO1997040692A1
    • 1997-11-06
    • PCT/EP1997001926
    • 1997-04-17
    • NOVARTIS AGSENN, RobertMAIENFISCH, PeterWYSS, Peter
    • NOVARTIS AG
    • A01N51/00
    • A01N53/00A01N43/88A01N47/40A01N51/00A01N43/56A01N43/40A01N43/30A01N2300/00A01N57/12
    • Composition for controlling insects and representatives of the order Acarina, which comprises a combination of variable amounts of one or more compounds of formula (A), in which A is an unsubstituted or, depending on the possibility of substitution on the ring system, mono- to tetrasubstituted, aromatic or non-aromatic monocyclic or bicyclic heterocyclic radical, in which the substituents of A can be chosen from the group consisting of C1-C3alkyl, C1-C3alkoxy, halogen, halo-C1-C3alkyl, cyclopropyl, halocyclopropyl, C2-C3alkenyl, C2-C3alkynyl, halo-C2-C3alkenyl, halo-C2-C3alkynyl, halo-C1-C3alkoxy, C1-C3alkylthio, halo-C1-C3alkylthio, allyloxy, propargyloxy, allylthio, propargylthio, haloallyloxy, haloallylthio, cyano and nitro; R is hydrogen, C1-C6alkyl, phenyl-C1-C4alkyl, C3-C6cycloalkyl, C2-C6alkenyl or C2-C6alkynyl; and X is N-NO2 or N-CN, in the free form or in the salt form, if appropriate tautomers, in the free form or salt form, and one or more of the compounds (I to CLXXXIV) mentioned according to the invention and at least one auxiliary. A method of controlling pests, a process for the preparation of the composition, its use and plant propagation material treated with it, and the use of the compound of formula (A) for the preparation of the composition, are described.
    • 用于防治昆虫的组合物和Acarina序列的代表,其包含可变量的一种或多种式(A)化合物的组合,其中A是未取代的,或者根据在环系上取代的可能性, 其中A的取代基可以选自C 1 -C 3烷基,C 1 -C 3烷氧基,卤素,卤代-C 1 -C 3烷基,环丙基,卤代环丙基,C 2 -C 3烷氧基, C 3链烯基,C 2 -C 3炔基,卤代-C 2 -C 3烯基,卤代-C 2 -C 3炔基,卤代-C 1 -C 3烷氧基,C 1 -C 3烷硫基,卤代C 1 -C 3烷硫基,烯丙氧基,炔丙氧基,烯丙硫基,炔丙硫基,卤代烯氧基,卤代烯硫基,氰基和硝基。 R是氢,C 1 -C 6烷基,苯基-C 1 -C 4烷基,C 3 -C 6环烷基,C 2 -C 6烯基或C 2 -C 6炔基; 和X是以游离形式或盐形式的N-NO 2或N-CN,如果适当的互变异构体,以游离形式或盐形式,以及根据本发明提及的一种或多种化合物(I至CLXXXIV) 和至少一个辅助物。 描述了控制害虫的方法,用于制备组合物的方法,其使用和植物繁殖材料的处理方法以及式(A)化合物用于制备组合物的用途。
    • 85. 发明申请
    • DINUCLEOTIDE AND OLIGONUCLEOTIDE ANALOGUES
    • 胆固醇和寡核苷酸类似物
    • WO1997035869A1
    • 1997-10-02
    • PCT/GB1997000651
    • 1997-03-11
    • NOVARTIS AGBAXTER, Anthony, DavidBAYLIS, Eric, KeithCOLLINGWOOD, Stephen, PaulFAIRHURST, Robin, AlecTAYLOR, Roger, John
    • NOVARTIS AG
    • C07H21/00
    • C07H19/06C07H21/00Y02P20/55
    • A compound which is a dinucleotide analogue of formula (I) or a salt thereof, where B an B are each independently a monovalent nucleoside base radical, R is hydrogen or Y , R and R are each independently hydrogen, halogen, hydroxy or -OY , R is hydrogen, halogen, hydroxy, -OY or R , R is hydrogen, halogen or R , R is hydrogen, Y or a phosphoramidyl group, Z is a group of formula (II), (III) or (IV), where R is hydrogen, halogen, hydroxy, -OY or R , R is hydrogen, halogen or R , R is hydroxy, R or -OR where R is a C1 to C10 aliphatic group, a C3 to C8 cycloaliphatic group, a C6 to C10 aromatic group or a C7 to C13 araliphatic group, and R is hydrogen, R a or -OCOR a where R a is C1 to C10 aliphatic, a C3 to C8 cycloaliphatic group, a C6 to C10 aromatic group or a C7 to C13 araliphatic group, Y , Y , Y , Y , and Y are each independently a hydroxy-protecting group, and R , R , R , R are each independently a C1 to C10 aliphatic group, a C3 to C8 cycloaliphatic group, a C6 to C10 aromatic group or a C7 to C13 araliphatic group.
    • 作为式(I)的二核苷酸类似物或其盐的化合物,其中B 1和B 2各自独立地为一价核苷碱基,R 1为氢或Y 1, 2>和R 3各自独立地为氢,卤素,羟基或-OY 2,R 4为氢,卤素,羟基,-OY 3或R 7,R 5为氢 ,卤素或R 8,R 6为氢,Y 4或亚磷酰基,Z为式(II),(III)或(IV)的基团,其中R 9为氢, 卤素,羟基,-OY 5或R 13,R 10是氢,卤素或R 14,R 11是羟基,R 15或-OR 15,其中R 15 >为C1至C10脂族基团,C3至C8脂环族基团,C6至C10芳族基团或C7至C13芳脂族基团,R12为氢,R12a或-OCOR12 其中R 12是C 1至C 10脂族基,C 3至C 8脂环族基团,C 6至C 10芳族基团或C 7至C 13芳脂基基团,Y 1,Y 2,Y 3, 4>和Y 5各自独立地为羟基保护基,R 7,R 8,R 13,R 14,Ar 各自独立地为C1至C10脂族基团,C3至C8脂环族基团,C6至C10芳族基团或C7至C13芳脂肪族基团。
    • 88. 发明申请
    • PYRIMIDIN-4-ONE DERIVATIVES AS PESTICIDE
    • PYRIMIDIN-4-ONE衍生物作为杀菌剂
    • WO1997033890A1
    • 1997-09-18
    • PCT/EP1997001056
    • 1997-03-03
    • NOVARTIS AGWALTER, Harald
    • NOVARTIS AG
    • C07D495/04
    • C07D487/04A01N43/90C07D491/04C07D495/04C07D513/04
    • Novel pyrimidin-4-one derivatives of formula (I), wherein: R1=C1-C8alkyl, C2-C8alkenyl, C2-C8alkynyl, C3-C6cycloalkyl, each of which is unsubstituted or substituted by halogen, O-C1-C4alkyl, O-C1-C4haloalky, O-C1-C4alkoxy, S-C1-C4alkyl, SO-C1-C4alkyl, SO2-C1-C4alkyl, CO-C1C4alkyl, N=C1-C4alkyl, NH-C1-C4alkyl, N(C1-C4alkyl)2, COO-C1-C4alkyl, COO-aryl, cyano, nitro, Si-(C1-C4alkyl)3, phenyl, halophenyl, phenoxyphenyl, halophenoxyphenyl, naphthyl; R2=OR5, SR6, NR7R8; R3 and R4 are each independently of the other hydrogen, halogen, C1-C4alkyl, C1-C4haloalkyl, C2-C4alkenyl, C2-C4haloalkenyl, C2-C4alkynyl, C2-C4haloalkynyl, Si-(C1-C6alkyl)3, COO-C1-C4alkyl, COO-aryl, COOH, CH=N-C1-C4alkyl, C(CH3)=N-C1-C4alkyl, SO-C1-C4alkyl, SO2-C1-C4alkyl, OR5, SR6, NR7R8, COR9; R9=hydrogen, C1-C4alkyl, phenyl, benzyl; R5 and R6 are each independently of the other C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C3-C6cycloalkyl, each of which is unsubstituted or substituted by halogen, O-C1-C4alkyl, O-C1-C4haloalkyl, O-C1-C4alkoxy, S-C1-C4alkyl, SO-C1-C4alkyl, SO2-C1-C4alkyl, CO-C1-C4alkyl, N=C1-C4alkyl, NH-C1-C4alkyl, N(C1-C4alkyl)2, COO-C1-C4alkyl, COO-aryl, cyano, nitro, Si-(C1-C4alkyl)3, phenyl, halophenyl, phenoxyphenyl, halophenoxyphenyl, naphthyl; R7 and R8 are each independently of the other C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C3-C6cycloalkyl, each of which is unsubstituted or substituted by halogen, O-C1-C4alkyl, O-C1-C4haloalkyl, O-C1-C4alkoxy, S-C1-C4alkyl, SO-C1-C4alkyl, SO2-C1-C4alkyl, CO-C1-C4-alkyl, N=C1-C4alkyl, NH-C1-C4alkyl, N(C1-C4alkyl)2, COO-C1-C4alkyl, COO-aryl, cyano, nitro, Si-(C1-C4alkyl)3, phenyl, halophenyl, phenoxyphenyl, halophenoxyphenyl, naphthyl; A = is a 5-membered heterocyclic ring which may be saturated or unsaturated, aromatic or non-aromatic and which may contain one or two hetero atoms O, S and/or N, each in the free form or in salt form. The novel compounds have plant-protective properties and are suitable for protecting plants against infestation by phytopathogenic micro-organisms, in particular fungi.
    • 式(I)的新型嘧啶-4-酮衍生物,其中:R1 = C1-C8烷基,C2-C8链烯基,C2-C8炔基,C3-C6环烷基,其各自为未取代或被卤素,O-C1-C4烷基,O C 1 -C 4卤代烷基,O-C 1 -C 4烷氧基,S-C 1 -C 4烷基,SO-C 1 -C 4烷基,SO 2 -C 1 -C 4烷基,CO-C 1 -C 4烷基,N = C 1 -C 4烷基,NH-C 1 -C 4烷基, )2,COO-C 1 -C 4烷基,COO-芳基,氰基,硝基,Si-(C 1 -C 4烷基)3,苯基,卤代苯基,苯氧基苯基,卤代苯氧基苯基, R2 = OR5,SR6,NR7R8; R3和R4分别独立地为氢,卤素,C1-C4烷基,C1-C4卤代烷基,C2-C4链烯基,C2-C4卤代烯基,C2-C4炔基,C2-C4卤代炔基,Si-(C1-C6烷基)3,COO-C1- C4烷基,COO-芳基,COOH,CH = N-C1-C4烷基,C(CH3)= N-C1-C4烷基,SO-C1-C4烷基,SO2-C1-C4烷基,OR5,SR6,NR7R8,COR9; R9 =氢,C1-C4烷基,苯基,苄基; R 5和R 6各自独立地为C 1 -C 6烷基,C 2 -C 6烯基,C 2 -C 6炔基,C 3 -C 6环烷基,其各自未被取代或被卤素,O-C 1 -C 4烷基,O-C 1 -C 4卤代烷基,O-C 1 C 1-4烷氧基,S-C 1 -C 4烷基,SO-C 1 -C 4烷基,SO 2 -C 1 -C 4烷基,CO-C 1 -C 4烷基,N = C 1 -C 4烷基,NH-C 1 -C 4烷基,N(C 1 -C 4烷基)2,COO- -C 1-4烷基,COO-芳基,氰基,硝基,Si-(C 1 -C 4烷基)3,苯基,卤代苯基,苯氧基苯基,卤代苯氧基苯基,萘基; R 1和R 2各自独立地为C 1 -C 6烷基,C 2 -C 6烯基,C 2 -C 6炔基,C 3 -C 6环烷基,其各自未被取代或被卤素,O-C 1 -C 4烷基,O-C 1 -C 4卤代烷基,O-C 1 C 1-4烷氧基,S-C 1 -C 4烷基,SO-C 1 -C 4烷基,SO 2 -C 1 -C 4烷基,CO-C 1 -C 4烷基,N = C 1 -C 4烷基,NH-C 1 -C 4烷基,N(C 1 -C 4烷基)2,COO C 1 -C 4烷基,COO-芳基,氰基,硝基,Si-(C 1 -C 4烷基)3,苯基,卤代苯基,苯氧基苯基,卤代苯氧基苯基,萘基; A =是可以是饱和或不饱和的,芳族或非芳族的5元杂环,并且可以含有一个或两个以游离形式或盐形式的一个或两个杂原子O,S和/或N。 新化合物具有植物保护性质,并且适合于保护植物免受植物病原微生物特别是真菌的侵袭。
    • 90. 发明申请
    • TESTING SYSTEM FOR CHEMICAL SUBSTANCES OR MIXTURES
    • 测试系统化学物质或含有
    • WO1997033179A1
    • 1997-09-12
    • PCT/EP1997000985
    • 1997-02-28
    • NOVARTIS AGDANIGEL, HaraldKESSMANN, HelmutKLOKOW, GerhardMENTZEN, JörgOBERGFELL, Peter
    • NOVARTIS AG
    • G01N35/00
    • G01N35/00B01J2219/00585B01J2219/00707G01N2001/317Y10T436/11Y10T436/119163Y10T436/163333Y10T436/25Y10T436/2575
    • In a testing system for chemical substances or mixtures, especially for potential plant protection agents, the chemical substance or mixture is applied to a test sample, especially plants or parts of plants. After a predetermined time, the test sample is examined for the effectiveness of the substance or mixture. To this end, a type of a test sample is selected from a stock of such samples and the substances to be tested are selected from a stock thereof. The selected type of test sample and the selected substances are identified (BC1, BC2) by a machine-readable code, which is transmitted to a storage unit (12). The test samples are prepared in a supporting plate (30), for which purpose the test samples or a section (BR) thereof are laid in a depression (300) in the supporting plate (30) partly filled with a nutrient solution (301). Then a spraying device (150, 151) is inserted into the depression (300) in the supporting plate (30) and sprays the test sample therein with the selected substance and is then removed from the depression (300) or the spray device is placed immediately above the depression (300) in the supporting plate (30) and sprays the test sample therein with the selected substance.
    • 在一个测试系统的化学物质或物质的混合物,尤其是对潜在的作物保护剂,该化学物质将被测试或待测试物质混合物施加到测试样本,尤其是植物或植物的部分。 在预定的时间段之后,将标本检查所述物质或组合物出的活性。 为此,一个类型的试验片的是第一选自和选择将被从测试材料的供给所测试的物质的样品的供给。 通过的机器可读代码装置,所选择的类型试样,并确定所选择的物质(BC1,BC2),并提供一个存储器单元(12),这些代码。 在支撑板(30),存储到的样品,或在所述载体板(30)在每种情况下设置在一个样品的截面(BR),并用在营养液(301)部分地填充凹部(300)被设置在标本。 在载体板(30)的凹部(300)随后浸入喷射装置(150,151),并喷洒在与所选择的织物测试的存储在那里,并浸入从所述凹部(300)之后背出的或立即喷雾高于 凹部(300)定位所述支撑板(30)并喷射与所选择的物质沉积在其中的试样。