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81. 发明专利

CA2509239A1 CARBOXYLIC ACID, PHOSPHATE OR PHOSPHONATE SUBSTITUTED QUINAZOLIN-4-YLAMINE ANALOGUES AS CAPSAICIN RECEPTOR MODULATORS 未知
公开(公告)号：CA2509239A1
公开(公告)日：2004-07-01
申请号：CA2509239
申请日：2003-12-12
申请人： NEUROGEN CORP
发明人： BRIELMANN HARRY , BLUM CHARLES A , DE LOMBAERT STEPHANE , HODGETTS KEVIN J , BAKTHAVATCHALAM RAJAGOPAL , ZHENG XIAOZHANG , CALDWELL TIMOTHY M
IPC分类号： C07D239/94 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14 , C07D471/04 , C07D491/10 , C07D519/00 , C07F9/6512 , C07F9/6558 , C07F9/6561 , C07F9/09 , C07F9/38
摘要： Acid-substituted quinazolin-4-ylamine analogues are provided. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using them to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

82. 发明专利

DOP2003000789A ANALOGOS DE 2-QUINAZOLINA SUSTITUIDA-4-YLAMINA 未知
公开(公告)号：DOP2003000789A
公开(公告)日：2004-06-15
申请号：DO2003000789
申请日：2003-12-12
申请人： NEUROGEN CORP
发明人： BAKTHAVATCHALAM RAJAGOPAL , BLUM CHARLES A , BRIELMANN HARRY , CALDWELL TIMOTHY M , LOMBAERT STEPHANE DE , HODGETTS KEVIN J , ZHENG XIAOZHANG
摘要： Certain 2-substituted quinazolin-4-ylamine analogues are provided. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using them to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

83. 发明专利

CA2660957C 2-PHENOXY PYRIMIDINONE ANALOGUES 未知
公开(公告)号：CA2660957C
公开(公告)日：2016-10-11
申请号：CA2660957
申请日：2007-08-22
申请人： NEUROGEN CORP
发明人： BAKTHAVATCHALAM RAJAGOPAL , CAPITOSTI SCOTT MICHAEL , XU JIANJUN , CHENARD BERTRAND L , GHOSH MANUKA , BLUM CHARLES A
IPC分类号： C07D473/30 , A61K31/519 , A61K31/522 , C07D471/04 , C07D495/04 , C07D513/04 , G01N33/566
摘要： 2-Phenoxy pyrimidinone analogues are provided, of the Formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

84. 发明专利

ES2399928T3 Análogos de 2-fenoxipirimidinona 未知
公开(公告)号：ES2399928T3
公开(公告)日：2013-04-04
申请号：ES07811503
申请日：2007-08-22
申请人： NEUROGEN CORP
发明人： BAKTHAVATCHALAM RAJAGOPAL , CAPITOSTI SCOTT , XU JIANJUN , CHENARD BERTRAND , GHOSH MANUKA , BLUM CHARLES
IPC分类号： C07D471/04 , A61K31/519 , A61K31/522 , A61P3/04 , A61P11/14 , A61P25/02 , A61P25/06 , A61P35/04 , C07D473/30 , C07D513/04
摘要： Un compuesto de la fórmula o una sal farmacéuticamente aceptable o hidrato del mismo, en la que: representa un heteroarilo de 5 ó 6 miembros condensado que contiene 1, 2 ó 3 heteroátomos seleccionadosindependientemente de O, N y S, siendo los átomos anulares restantes carbono, en el que el heteroarilocondensado está opcionalmente sustituido con de 0 a 3 sustituyentes seleccionados independientemente deamino, hidroxi, alquilo de C1-C6, hidroxialquilo de C1-C6, (cicloalquil C3-C7)-alquilo de C0-C2, haloalquilo de C1-C6, alcoxi de C1-C6, alquil C2-C6-éter, alcanoil C1-C6 oxi, alquil C1-C6-sulfonilamino, alcanoil C1-C6-amino, ymono- o di-(alquil C1-C6)amino; Ar es fenilo o un heteroarilo de 5 ó 6 miembros, cada uno de los cuales está sustituido con de 0 a 4sustituyentes que se seleccionan independientemente de halógeno, ciano, amino, nitro, alquilo de C1-C6,alquenilo de C2-C6, alquinilo de C2-C6, haloalquilo de C1-C6, hidroxialquilo de C1-C6, alcoxi de C1-C6,haloalcoxi de C1-C6, (cicloalquil C3-C7)-alquilo de C0-C4, y mono- o di-(alquil C1-C6)amino; y R3 representa de 0 a 4 sustituyentes, los cuales se seleccionan de forma independiente de halógeno, hidroxi,ciano, amino, nitro, alquilo de C1-C6, alquenilo de C2-C6, alquinilo de C2-C6, haloalquilo de C1-C6,hidroxialquilo de C1-C6, alcoxi de C1-C6, haloalcoxi de C1-C6, (cicloalquil C3-C7)-alquilo de C0-C4, mono- o di-(alquil C1-C6)amino, y mono- o di-(alquil C1-C6)aminosulfonilo, en el que el compuestso está opcionalmenteradiomarcado.

85. 发明专利

ZA200901163B 2-Phenoxy pyrimidinone analogues 未知
公开(公告)号：ZA200901163B
公开(公告)日：2010-08-25
申请号：ZA200901163
申请日：2007-08-22
申请人： NEUROGEN CORP
发明人： BAKTHAVATCHALAM RAJAGOPAL , CAPITOSTI SCOTT MICHAEL , XU JIANJUN , CHENARD BERTRAND L , GHOSH MANUKA , BLUM CHARLES A
IPC分类号： A61K20060101 , A61P20060101 , C07D20060101
摘要： 2-Phenoxy pyrimidinone analogues are provided, of the Formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

86. 发明专利

AU2005295091A1 Substituted biaryl quinolin-4-ylamine analogues 未知
公开(公告)号：AU2005295091A1
公开(公告)日：2006-04-20
申请号：AU2005295091
申请日：2005-10-12
申请人： NEUROGEN CORP
发明人： CALDWELL TIMOTHY M , HODGETTS KEVIN J , CAPITOSTI SCOTT MICHAEL , BAKTHAVATCHALAM RAJAGOPAL , CHENARD BERTRAND L
IPC分类号： A01N43/64 , A01N43/42 , A01N43/54 , A01N43/58 , A61K31/44 , A61K31/47 , A61K31/4745 , A61K31/495 , A61K31/496 , A61K31/4965 , A61K31/497 , A61K31/498 , A61K31/50 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/5377 , C07D239/42 , C07D471/02 , C07D487/02
摘要： Substituted biaryl quinolin-4-ylamine analogues of Formula I are provided. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

87. 发明专利

DE60115092T2 未知
公开(公告)号：DE60115092T2
公开(公告)日：2006-03-30
申请号：DE60115092
申请日：2001-12-11
申请人： NEUROGEN CORP , PFIZER
发明人： BAKTHAVATCHALAM RAJAGOPAL , BLUM A , BRIELMANN L , DARROW WILLIAM , DE LOMBAERT STEPHANE , HUTCHISON ALAN , TRAN JENNIFER , ZHENG XIAOZHANG , ELLIOTT LOUIS , HAMMOND MARLYS
IPC分类号： C07D491/10 , C07D491/107 , A61K31/438 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K31/506 , A61K31/517 , A61K31/519 , A61K51/00 , A61P3/04 , A61P3/10 , A61P9/00 , A61P25/00 , A61P25/18 , A61P25/24 , A61P43/00 , C07D487/04 , C07D487/10 , C07D519/00
摘要： Substituted spiro[isobenzofuran-1,4'-piperidin]-3-ones and 3H-spiroisobenzofuran-1,4'-piperidines capable of modulating NPY5 receptor activity are provided. Such compounds may be used to modulate ligand binding to NPY5 receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of disorders (e.g., eating disorders such as obesity or bulimia, psychiatric disorders, diabetes and cardiovascular disorders such as hypertension) in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such compounds for detecting NPY5 receptors.

88. 发明专利

BR0317168A 未知
公开(公告)号：BR0317168A
公开(公告)日：2005-11-01
申请号：BR0317168
申请日：2003-12-12
申请人： NEUROGEN CORP
发明人： BAKTHAVATCHALAM RAJAGOPAL , BLUM CHARLES A , BRIELMANN HARRY , CALDWELL TIMOTHY M , DELOMBAERT STEPHANE , HODGETTS KEVIN J , ZHENG XIAOZHANG
IPC分类号： C07D239/94 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14 , C07D471/04 , C07D491/10 , C07D519/00 , C07F9/6512 , C07F9/6558 , C07F9/6561
摘要： Acid-substituted quinazolin-4-ylamine analogues are provided. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using them to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

89. 发明专利

AU2005218655A1 Aryl substituted purine analogues 未知
公开(公告)号：AU2005218655A1
公开(公告)日：2005-09-15
申请号：AU2005218655
申请日：2005-03-02
申请人： NEUROGEN CORP
发明人： LOMBAERT STEPHANE DE , BAKTHAVATCHALAM RAJAGOPAL
IPC分类号： C07D217/22
摘要： Aryl-substituted purine analogues are provided, of the formula: (I) wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

90. 发明专利

AU2004270740A1 4 - heterobicyclyamino - substituted quinazolines and analogues therof as capsaicin - antagonists 未知
公开(公告)号：AU2004270740A1
公开(公告)日：2005-03-17
申请号：AU2004270740
申请日：2004-09-09
申请人： NEUROGEN CORP
发明人： CHENARD BERTRAND L , BLUM CHARLES A , BAKTHAVATCHALAM RAJAGOPAL
IPC分类号： C07D471/04 , A61K31/435 , A61P25/00 , C07D401/12 , C07D401/14 , C07D413/14 , C07D417/14 , C07D487/04
摘要： Substituted bicyclic quinazolin-4-ylamine derivatives are provided. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using them to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

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