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    • 83. 发明授权
    • 4,5-dihydronaphtho[1,2-b]thiophene derivative
    • 4,5-二氢萘并[1,2-b]噻吩衍生物
    • US07384974B2
    • 2008-06-10
    • US10566572
    • 2004-07-30
    • Minoru TaguchiRyo SuzukiAyako Mikami
    • Minoru TaguchiRyo SuzukiAyako Mikami
    • A61K31/381C07D333/74C07D495/14
    • C07D333/74C07D319/18C07D495/04
    • A 4,5-dihydronaphtho[1,2-b]thiophene derivative expressed by the formula: (wherein R1 is a C1 to C10 1-hydroxyalkyl group or a C1 to C10 acyl group, and R2 and R3 separately substitute in the 6-, 7-, 8-, or 9-positions, and are each independently a hydrogen atom, a halogen atom, a C1 to C10 alkyl group, a hydroxy group, a C1 to C10 alkoxy group, a C1 to C5 alkenyloxy group, a C1 to C5 alkynyloxy group, a benzyloxy group, or the like, provided that when R1 is an acyl group and R2 is a hydrogen atom, then R3 is neither a hydrogen atom nor an acetyl group), or a pharmaceutically acceptable salt thereof This is a novel compound that is effective in reducing triglyceride levels in the liver and reducing blood glucose levels.
    • 由下式表示的4,5-二氢萘并[1,2-b]噻吩衍生物(其中R 1是C 1至C 10 - SUB- 1-羟基烷基或C 1〜C 10酰基,R 2和R 3, 分别代替6-,7-,8-或9-位,并且各自独立地为氢原子,卤素原子,C 1至C 10 - 烷基,羟基,C 1〜C 10烷氧基,C 1〜C 5烷基,C 1〜 烯氧基,C 1〜C 5炔氧基,苄氧基等,条件是当R 1是酰基时, 和R 2是氢原子,则R 3不是氢原子也不是乙酰基)或其药学上可接受的盐这是有效的新化合物 在减少肝脏中的甘油三酯水平并降低血糖水平。