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81. 发明授权

US09468488B2 Thermo-chemical medical device for manipulation of tissue 有权
标题翻译：用于操作组织的热化学医疗装置
公开(公告)号：US09468488B2
公开(公告)日：2016-10-18
申请号：US13581386
申请日：2011-02-28
申请人： Brian L. Bates , Jeffry S. Melsheimer
发明人： Brian L. Bates , Jeffry S. Melsheimer
IPC分类号： A61B18/06 , A61B18/00
CPC分类号： A61B18/06 , A61B2018/00023
摘要： The present invention provides a medical device for manipulation of tissue of a patient. The medical device comprises a shaft having a proximal section extending to a distal section that has a closed distal end portion. The shaft has a plurality of lumens formed therein including a first lumen and a second lumen. The first lumen is for distally advancing a first reactant through the proximal section. The second lumen is for distally advancing a second reactant through the proximal section. Positioned longitudinally within the shaft and distally from the first and second lumens is a mixing element. The mixing element is in fluid communication with the first and second lumens. The mixing element has a series of baffles for mixing the first and second reactants together producing a reaction product to heat the closed distal end portion of the shaft for manipulation of the tissue.
摘要翻译：本发明提供了一种用于操纵患者组织的医疗装置。医疗装置包括轴，该轴具有延伸到具有封闭的远端部分的远侧部分的近端部分。轴具有形成在其中的多个腔，其包括第一腔和第二腔。第一管腔用于通过近端部分远端推进第一反应物。第二腔用于通过近端部分远端推进第二反应物。一个混合元件纵向定位在轴内并远离第一和第二管腔。混合元件与第一和第二内腔流体连通。混合元件具有一系列用于将第一和第二反应物混合在一起的挡板，产生反应产物以加热用于组织的操作的轴的封闭的远端部分。

82. 发明申请

US20140276716A1 CATALYZED EXOTHERMIC ABLATION DEVICE 有权
标题翻译：催化灭菌装置
公开(公告)号：US20140276716A1
公开(公告)日：2014-09-18
申请号：US14202956
申请日：2014-03-10
申请人： Jeffry S. Melsheimer
发明人： Jeffry S. Melsheimer
IPC分类号： A61B18/06
CPC分类号： A61B18/06 , A61B2018/00333 , A61B2018/00446 , A61B2018/00494 , A61B2018/005 , A61B2018/00529 , A61B2018/00535 , A61B2018/00541 , A61B2018/00565 , A61B2018/00577 , A61B2018/066
摘要： The invention relates to devices, systems, and methods for heating tissue, including ablating a tumor, using the catalyzed heat of decomposition of hydrogen peroxide solutions. A hydrogen peroxide solution is contacted with a catalyst to decompose the hydrogen peroxide and heat the distal tip of a catheter to a temperature effective to ablate a target tissue.
摘要翻译：本发明涉及使用催化的过氧化氢溶液分解热来加热组织的装置，系统和方法，包括烧蚀肿瘤。过氧化氢溶液与催化剂接触以分解过氧化氢并将导管的远端加热到有效消融靶组织的温度。

83. 发明授权

US08795288B2 Access device 有权
标题翻译：访问设备
公开(公告)号：US08795288B2
公开(公告)日：2014-08-05
申请号：US11874444
申请日：2007-10-18
申请人： Jeffry S. Melsheimer , Darin G. Schaeffer
发明人： Jeffry S. Melsheimer , Darin G. Schaeffer
IPC分类号： A61F11/00
CPC分类号： A61M25/0662 , A61B17/3415 , A61B2017/00243 , A61F2/95
摘要： A device for providing access to a treatment site within the body of a patient includes a tubular member having a first, generally elongated configuration for introduction into the body of the patient, and deployable therein to a second configuration. The second configuration includes an axially displaced segment along the distal portion of the tubular member. The tubular member includes a side port oriented along the axially displaced segment, and further includes a lumen communicating with the side port. The lumen and side port are sized for passage therethrough of an interventional device for delivery to the treatment site.
摘要翻译：用于提供对患者体内的治疗部位的通路的装置包括管状构件，其具有用于引入患者体内的第一大体上细长的构造，并且可部署到第二构造中。第二构造包括沿着管状构件的远端部分的轴向移位的段。管状构件包括沿轴向移位的段定向的侧端口，并且还包括与侧端口连通的管腔。管腔和侧端口的尺寸设置成用于通过其介入装置，用于输送到治疗部位。

84. 发明授权

US08764813B2 Gradually self-expanding stent 有权
标题翻译：逐渐自扩张支架
公开(公告)号：US08764813B2
公开(公告)日：2014-07-01
申请号：US12342302
申请日：2008-12-23
申请人： Alexandra E. Jantzen , Nathaniel A. Irwin , Jeffry S. Melsheimer
发明人： Alexandra E. Jantzen , Nathaniel A. Irwin , Jeffry S. Melsheimer
IPC分类号： A61F2/06
CPC分类号： A61F2/90 , A61F2/07 , A61F2/91 , A61F2/915 , A61F2002/823 , A61F2002/91558 , A61F2210/0076 , A61F2230/0078 , A61F2230/008 , A61L31/148 , A61L31/16
摘要： A gradually self-expanding stent includes a first plurality of stent cells including a first plurality of circumferentially adjacent structural members in mechanical communication with each other. The stent also includes a second plurality of stent cells including a second plurality of circumferentially adjacent structural members in mechanical communication with each other. The circumferentially adjacent structural members of the first and second plurality of stent cells have a compressed configuration and an expanded configuration. A restraining material is attached to each of the circumferentially adjacent structural members defining each of the second plurality of stent cells such that it substantially covers an entirety of each of the second plurality of stent cells in the compressed configuration. Over time, the restraining material releases the structural members defining each of the second plurality of stent cells, thereby allowing the second plurality of stent cells to assume the expanded configuration.
摘要翻译：逐渐自扩张支架包括第一多个支架单元，其包括彼此机械连通的第一多个周向相邻的结构构件。支架还包括第二多个支架电池，其包括彼此机械连通的第二多个周向相邻的结构构件。第一和第二多个支架电池的周向相邻的结构构件具有压缩构型和扩张构型。约束材料连接到限定每个第二多个支架细胞的每个周向相邻的结构构件，使得其基本上覆盖处于压缩构型的每个第二多个支架细胞的整体。随着时间的推移，约束材料释放限定第二多个支架细胞中的每一个的结构构件，从而允许第二多个支架细胞呈现膨胀的构型。

85. 发明授权

US08764712B2 Micro-needle array and method of use thereof 有权
标题翻译：微针阵列及其使用方法
公开(公告)号：US08764712B2
公开(公告)日：2014-07-01
申请号：US12535314
申请日：2009-08-04
申请人： Jeffry S. Melsheimer
发明人： Jeffry S. Melsheimer
IPC分类号： A61M5/00
CPC分类号： A61K9/0021 , A61M37/0015 , A61M2025/1086 , A61M2037/003 , A61M2037/0038 , A61M2037/0053 , B33Y80/00
摘要： A micro-needle array is provided that may be used to deliver a bioactive agent to a therapeutic target. The micro-needle array preferably includes a substrate, a plurality of micro-needles integral with the substrate, and a bioactive agent. At least one micro-needle preferably includes a top surface, a bottom surface, a side surface, and a cavity defined by an inner surface. The bioactive agent may be disposed on the substrate and the plurality of micro-needles. The at least one micro-needle may further include a slit connecting the cavity to an aperture, the slit extending from the top surface to the bottom surface.
摘要翻译：提供了可用于将生物活性剂递送至治疗靶的微针阵列。微针阵列优选地包括基底，与基底一体的多个微针和生物活性剂。至少一个微针优选地包括顶表面，底表面，侧表面和由内表面限定的空腔。生物活性剂可以设置在基材和多个微针上。所述至少一个微针还可以包括将腔连接到孔的狭缝，狭缝从顶表面延伸到底表面。

86. 发明授权

US08585680B2 Endovascular device tip assembly incorporating a marker device and method for making the same 有权
标题翻译：包括标记装置的血管内装置尖端装置及其制造方法
公开(公告)号：US08585680B2
公开(公告)日：2013-11-19
申请号：US11787626
申请日：2007-04-17
申请人： Mark A. Magnuson , Jeffry S. Melsheimer
发明人： Mark A. Magnuson , Jeffry S. Melsheimer
IPC分类号： A61M25/098 , B21D39/00 , B23P11/00 , B23P13/04
CPC分类号： A61M25/0068 , A61M25/001 , A61M25/0012 , A61M25/0069 , A61M25/0108
摘要： An endovascular device tip assembly and method of making the same, incorporating a radiopaque marker usable with catheters and other suitable endovascular devices is provided. The tip assembly incorporates a radiopaque marker device by providing a counterbore within a primary bore of a tubular tip of an endovascular device. The marker device is fitted securely within the counterbore and the tubular tip is further deformed distally of the marker in order to secure the marker within the device.
摘要翻译：提供了一种血管内装置尖端组件及其制造方法，其包括可用于导管和其它合适的血管内装置的不透射线的标记。尖端组件通过在血管内装置的管状尖端的主孔内提供沉孔而组合不透射线的标记装置。标记装置牢固地装配在沉孔内，并且管状尖端进一步沿标记的远端变形，以便将标记固定在装置内。

87. 发明授权

US08585019B2 Loading apparatus and system for expandable intraluminal medical devices 有权
标题翻译：可扩展管腔内医疗器械的装载装置和系统
公开(公告)号：US08585019B2
公开(公告)日：2013-11-19
申请号：US12860422
申请日：2010-08-20
申请人： Jeffry S. Melsheimer , Jessica L. Burke , Sean D. Chambers , Arman Valaie
发明人： Jeffry S. Melsheimer , Jessica L. Burke , Sean D. Chambers , Arman Valaie
IPC分类号： A61F2/84
CPC分类号： A61F2/95 , A61F2/2436 , A61F2/844 , A61F2/92 , A61F2002/9511 , A61F2002/9522 , Y10T29/53843
摘要： Medical device loading apparatuses, systems, methods and kits are described. A loading apparatus comprises a main body having a proximal end defining a proximal opening, a distal end defining a distal opening, and a passageway extending between the proximal and distal openings. The passageway defines a proximal chamber having a first inner diameter, a distal chamber having a second inner diameter, and a transition chamber disposed between the proximal and distal chambers. The transition chamber has an inner diameter that transitions from the larger second inner diameter to the smaller first inner diameter. The main body has a separable connection that divides the main body between proximal and distal portions when disrupted. An expandable intraluminal medical device can be loaded into a delivery catheter using the loading apparatus by placing the device into the passageway such that it is in a radially-expanded configuration; pulling the device along an axial path through the loading apparatus such that the device transitions from the radially-expanded configuration to a radially-compressed configuration; and pushing the radially-compressed device along the axial path into the delivery catheter.
摘要翻译：描述了医疗装置装载装置，系统，方法和试剂盒。装载装置包括主体，其具有限定近端开口的近端，限定远侧开口的远端以及在近端开口和远端开口之间延伸的通道。所述通道限定具有第一内径的近侧腔室，具有第二内径的远侧腔室，以及设置在近端腔室和远端腔室之间的过渡腔室。过渡室具有从较大的第二内径向较小的第一内径转变的内径。主体具有可分离的连接，当中断时将主体分成近端部分和远端部分之间。可扩张的管腔内医疗装置可以通过将装置放置在通道中以使其处于径向展开的构型中而使用装载装置装载到输送导管中; 沿着轴向路径拉动装置通过装载装置，使得装置从径向展开的构型转变成径向压缩的构型; 并将径向压缩的装置沿轴向路径推入输送导管。

88. 发明申请

US20130226237A1 Suture Clamp And Gastrointestinal Suture Anchor Set Device Using Same 有权
标题翻译：缝合夹和胃肠缝合锚定装置使用相同
公开(公告)号：US20130226237A1
公开(公告)日：2013-08-29
申请号：US13405852
申请日：2012-02-27
申请人： Cleon P. Stanley , Jeffry S. Melsheimer
发明人： Cleon P. Stanley , Jeffry S. Melsheimer
IPC分类号： A61B17/04
CPC分类号： A61B17/0401 , A61B17/0469 , A61B17/0487 , A61B2017/00818 , A61B2017/0417 , A61B2017/0479 , A61B2017/06052
摘要： A gastrointestinal suture anchor set device includes a pusher slidably received in a needle. A suture clamp assembly includes an anchor attached to one end of a length of the suture, which is slidably received in a sequence of passages defined by a suture clamp in a high profile sliding configuration. The anchor is received in the distal end of the needle with the suture extending outside of the needle. The clamp includes a series of disks movable to a low profile clamped configuration at which different segments of the suture are clamped between faces of adjacent disks. The series of disks define a sequence of suture passages that are segments of a tortuous pathway through the clamp traversed by the suture.
摘要翻译：胃肠缝合锚固装置包括可滑动地容纳在针中的推动器。缝合线夹具组件包括附接到缝合线长度的一端的锚固件，其以由高剖面滑动构型由缝合线夹具限定的通道可滑动地容纳。锚固体被接收在针的远端，缝合线延伸到针的外部。夹具包括可移动到低轮廓夹紧构造的一系列盘片，缝合线的不同段夹在相邻盘片的表面之间。一系列盘定义了一系列缝合通道，其是通过缝合线穿过的夹具的曲折路径的段。

89. 发明申请

US20130204297A1 RELEASABLE SUTURE CLAMP AND SUTURE ANCHOR ASSEMBLY INCLUDING SAME 有权
标题翻译：可拆卸的固定夹具和固定锚固装置，包括它们
公开(公告)号：US20130204297A1
公开(公告)日：2013-08-08
申请号：US13761571
申请日：2013-02-07
申请人： Jeffry S. Melsheimer , Kristyn Gadlage
发明人： Jeffry S. Melsheimer , Kristyn Gadlage
IPC分类号： A61B17/04
CPC分类号： A61B17/0401 , A61B17/0487 , A61B17/06114 , A61B50/20 , A61B2017/0417 , A61B2017/0488 , A61B2017/0496 , A61B2017/06052
摘要： A suture anchor assembly includes a length of suture having an anchor attached to an end thereof. A releasable suture clamp is disposed in a clamped configuration about the suture. The releasable suture clamp includes a plurality of independent stackable components rotatable about a common axis, which is transverse to opposing faces of the stackable components. Each of the stackable components has a first opening passing through the opposing faces, spaced from the common axis, and sized for receiving the suture therethrough. The releasable suture clamp has an unclamped configuration in which the first openings are aligned relative to an alignment axis and the clamped configuration in which the first openings are misaligned relative to the alignment axis, wherein the alignment axis is parallel to the common axis.
摘要翻译：缝合锚固组件包括具有连接到其一端的锚定物的一段缝合线。可释放的缝线夹以围绕缝合线的夹紧构型设置。可释放的缝合夹具包括多个独立的可叠置部件，可绕公共轴线旋转，该公共轴线横向于可堆叠部件的相对面。每个可堆叠组件具有穿过相对面的第一开口，与公共轴线间隔开，并且其尺寸适于接收穿过其中的缝合线。可释放的缝合夹具具有未夹紧的构造，其中第一开口相对于对准轴线对准，并且夹持构造，其中第一开口相对于对准轴线不对准，其中对准轴线平行于公共轴线。

90. 发明申请

US20130046330A1 MULTI-LAYER FILTRATION DEVICE 有权
标题翻译：多层过滤设备
公开(公告)号：US20130046330A1
公开(公告)日：2013-02-21
申请号：US13211409
申请日：2011-08-17
申请人： Charles L. McIntosh , Shyam Kuppurathanam , Jeffry S. Melsheimer
发明人： Charles L. McIntosh , Shyam Kuppurathanam , Jeffry S. Melsheimer
IPC分类号： A61F2/01
CPC分类号： A61F2/013 , A61F2/82 , A61F2002/016 , A61F2230/0093 , A61F2250/0023
摘要： A filter device assembly and a method of using such a device to capture and remove embolic material from a body lumen or blood vessel is provided. The filter device assembly generally comprises a structure having a collapsed state and an expanded state with first, second, and optionally N additional filter members circumferentially attached thereto. Each filter member forms an annulus chamber with the first filter member having porosity P1; the second filter member circumferentially having porosity P2; and the N additional filter members each having porosity [P3 . . . P(2+N)]. The magnitude of the porosity for the first, second, and N additional filter members follows the relationship P1>[P3> . . . >P(2+N)]>P2. The first, second, and N additional filter portions are configured in the expanded state to allow blood to flow there through and to capture emboli in the annulus chambers.
摘要翻译：提供了一种过滤器装置组件和使用这种装置从体腔或血管捕获和去除栓塞材料的方法。过滤装置组件通常包括具有收缩状态和膨胀状态的结构，其中第一，第二和任选地N个额外的过滤构件周向地附接到其上。每个过滤器构件形成具有孔隙率P1的第一过滤构件的环空室; 周向具有孔P2的第二过滤构件; 并且N个附加的过滤器构件各自具有孔隙率[P3。。。 P（2 + N）]。第一，第二和第N附加过滤器构件的孔隙度的大小遵循关系P1> [P3>。。。 > P（2 + N）]> P2。第一，第二和第N附加过滤器部分被配置为膨胀状态，以允许血液在那里流过并捕获环空室中的栓塞。

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