专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

81. 发明申请

US20110229508A1 POLYPEPTIDES FOR INDUCING A PROTECTIVE IMMUNE RESPONSE AGAINST STAPHYLOCOCCUS AUREUS 审中-公开
标题翻译：诱导针对维生素A的保护性免疫应答的多肽
公开(公告)号：US20110229508A1
公开(公告)日：2011-09-22
申请号：US13130964
申请日：2009-11-18
申请人： Tessie B. McNeely , Leslie D. Cope , Mark A. Miller , Loren D. Schultz , Xinmin Wang
发明人： Tessie B. McNeely , Leslie D. Cope , Mark A. Miller , Loren D. Schultz , Xinmin Wang
IPC分类号： A61K39/085 , C07K14/31 , C07H21/04 , C12N15/63 , C12N1/21 , C12P21/02 , A61P31/04
CPC分类号： C07K14/31 , A61K39/085 , A61K2039/55505
摘要： The present invention features polypeptides comprising an amino acid sequence structurally related to SEQ ID NO: 1 and uses of such polypeptides and compositions thereof. SEQ ID NO: 1 is a full length S. aureus sequence. A derivative of SEQ ID NO: 1 containing an amino terminus his-tag was found to produce a protective immune response against S. aureus.
摘要翻译：本发明的特征在于包含与SEQ ID NO：1结构相关的氨基酸序列的多肽及其多肽及其组合物的用途。 SEQ ID NO：1是全长金黄色葡萄球菌序列。发现含有氨基末端his标签的SEQ ID NO：1的衍生物产生针对金黄色葡萄球菌的保护性免疫应答。

82. 发明申请

US20110124553A1 INSULIN-OLIGOMER CONJUGATES, FORMULATIONS AND USES THEREOF 审中-公开
标题翻译：胰岛素寡聚体结合体，其制剂及其用途
公开(公告)号：US20110124553A1
公开(公告)日：2011-05-26
申请号：US13008094
申请日：2011-01-18
申请人： Balasingam Radhakrishnan , Diti Aggarwal , Michelle Ferro , Kenneth D. James , Navdeep B. Malkar , Mark A. Miller , Monica Puskas , Nnochiri N. Ekwuribe
发明人： Balasingam Radhakrishnan , Diti Aggarwal , Michelle Ferro , Kenneth D. James , Navdeep B. Malkar , Mark A. Miller , Monica Puskas , Nnochiri N. Ekwuribe
IPC分类号： A61K38/28 , C07K14/62 , A61P3/10
CPC分类号： C07K14/62 , A61K9/0095 , A61K9/2013 , A61K9/2018 , A61K33/30 , A61K38/00 , A61K38/28 , A61K45/06 , A61K47/60 , A61K47/69 , A61K2300/00
摘要： An insulin compound coupled to a modifying moiety having a formula: —X—R1—Y—PAG-Z—R2 (Formula VI) where, X, Y and Z are independently selected linking groups and each is optionally present, and X, when present, is coupled to the insulin compound by a covalent bond, either R1 or R2 is a lower alkyl, optionally including a carbonyl group, and when R1 is a lower alkyl, R2 is a capping group, and PAG is a linear or branched carbon chain incorporating one or more alkalene glycol moieties, and optionally incorporating one or more additional moieties selected from the group consisting of —S—, —O—, —N—, and —C(O)—.
摘要翻译：与具有下式的-X-R1-Y-PAG-Z-R2（式VI）的修饰部分偶联的胰岛素化合物，其中X，Y和Z独立选择连接基团，并且各自任选存在，X，当存在的通过共价键与胰岛素化合物偶联，R 1或R 2是任选地包括羰基的低级烷基，当R 1是低级烷基时，R 2是封端基，PAG是直链或支链碳含有一个或多个碱金属二醇部分，以及任选地引入一个或多个选自-S-，-O-，-N-和-C（O） - 的其它部分的链。

83. 发明申请

US20100311502A1 ELECTRICAL TRANSMISSION AMONG INTERCONNECTED GAMING SYSTEMS 有权
标题翻译：互连游戏系统中的电气传输
公开(公告)号：US20100311502A1
公开(公告)日：2010-12-09
申请号：US12479997
申请日：2009-06-08
申请人： Mark A. Miller , Dean P. Alderucci , Thomas D. Bradshaw
发明人： Mark A. Miller , Dean P. Alderucci , Thomas D. Bradshaw
IPC分类号： A63F13/00
CPC分类号： A63F1/02 , G07F17/3293
摘要： Various card devices and methods involving card devices are described. Other embodiments are also described.
摘要翻译：描述了涉及卡装置的各种卡装置和方法。还描述了其它实施例。

84. 发明申请

US20100311490A1 PORTABLE ELECTRONIC CHARGE DEVICE FOR CARD DEVICES 有权
标题翻译：用于卡设备的便携式电子充电装置
公开(公告)号：US20100311490A1
公开(公告)日：2010-12-09
申请号：US12479987
申请日：2009-06-08
申请人： Mark A. Miller , Dean P. Alderucci , Thomas D. Bradshaw
发明人： Mark A. Miller , Dean P. Alderucci , Thomas D. Bradshaw
IPC分类号： A63F9/24
CPC分类号： A63F1/18 , A63F2009/2494 , G07F17/32 , G07F17/322 , G07F17/3232 , G07F17/3293
摘要： Various card devices and methods involving card devices are described. Other embodiments are also described.
摘要翻译：描述了涉及卡装置的各种卡装置和方法。还描述了其它实施例。

85. 发明申请

US20100150954A1 VACCINES AGAINST INFLUENZA VIRUS 失效
标题翻译：疫苗对流感病毒
公开(公告)号：US20100150954A1
公开(公告)日：2010-06-17
申请号：US12541804
申请日：2009-08-14
申请人： Mark A. Miller , Rachel Schneerson , Joanna Kubler-Kielb , John B. Robbins , Zuzana Biesova , Jerry Keith
发明人： Mark A. Miller , Rachel Schneerson , Joanna Kubler-Kielb , John B. Robbins , Zuzana Biesova , Jerry Keith
IPC分类号： A61K39/385 , A61P31/16 , C07K17/06
CPC分类号： C07K17/06 , A61K39/00 , A61K39/12 , A61K39/145 , A61K2039/5252 , A61K2039/55505 , A61K2039/6037 , C07K14/005 , C07K14/34 , C12N2760/16122 , C12N2760/16134
摘要： Disclosed are immunogenic conjugates having the general formula: M2e-Cys-S—CH2—C(O)—NH—CH2—CH2-C(O—)NH-Lys-Pr, were M2e is the influenza M2 ectodomain (M2e) peptide; Cys is a cysteine amino acid residue present in the M2e peptide; S the sulfur present in the cysteine amino acid residue; CH2-CO—NH—CH2-CH2-CO the linking group; NH the amine group present in a lysine residue of the carrier; Lys is a lysine amino acid residue and Pr the carrier protein. Also disclosed are isolated immunogens that include an immunogenic fragment of an influenza HA protein including the polybasic cleavage site, wherein the immunogenic fragment of the influenza HA protein has been modified to remove an N-terminal leader amino acid sequence and a C-terminal transmembrane domain. Also disclosed are methods producing an influenza vaccine specific for an identified influenza strain.
摘要翻译：公开了具有以下通式的免疫原性缀合物：M2e-Cys-S-CH2-C（O）-NH-CH2-CH2-C（O-NH-Lys-Pr），M2e是流感M2胞外域（M2e）肽 ; Cys是存在于M2e肽中的半胱氨酸氨基酸残基; S存在于半胱氨酸氨基酸残基中的硫; CH2-CO-NH-CH2-CH2-CO连接基团; NH存在于载体的赖氨酸残基中的胺基; Lys是赖氨酸氨基酸残基，Pr是载体蛋白。还公开了分离的免疫原，其包括包括多碱性切割位点的流感HA蛋白的免疫原性片段，其中已经修饰了流感HA蛋白的免疫原性片段以除去N-末端前导氨基酸序列和C-末端跨膜结构域。还公开了产生针对所鉴定的流感病毒株特异的流感疫苗的方法。

86. 发明授权

US07718182B2 Polypeptides for inducing a protective immune response against Staphylococcus aureus 有权
标题翻译：用于诱导针对金黄色葡萄球菌的保护性免疫应答的多肽
公开(公告)号：US07718182B2
公开(公告)日：2010-05-18
申请号：US11795538
申请日：2006-01-17
申请人： Rosemarie Kelly , Loren D. Schultz , Mark A. Miller , Mark D. Yeager , Tessie McNeely
发明人： Rosemarie Kelly , Loren D. Schultz , Mark A. Miller , Mark D. Yeager , Tessie McNeely
IPC分类号： A61K39/085 , C12P21/04 , C07H21/02 , C07H21/04 , C07K14/31
CPC分类号： C07K14/31 , A61K39/00
摘要： The present invention features polypeptides comprising an amino acid sequence structurally related to SEQ ID NO: 1 or a fragment thereof, S. aureus AhpC-AhpF compositions, and uses of such polypeptides and compositions. SEQ ID NO: 1 has a full length S. aureus AhpC sequence. A derivative of SEQ ID NO: 1 containing an amino His-tag and three additional carboxyl amino acids was found to produce a protective immune response against S. aureus. MGHHHHHHHHHHSSGHIEGRHMSLINKEILPFTAQAFDPKKDQFKEVTQE DLKGSWSVVCFYPADFSFVCPTELEDLQNQYEELQKLGVNVFSVSTDTHF VHKAWHDHSDAISKITYTMIGDPSQTITRNDVLDEATGLAQRGTFIIDPD GVVQASEINADGIGRDASTLAHKIKAAQYVRKNPGEVCPAKWEEGAKTLQ PGLDLVGKIAEQ
摘要翻译：本发明的特征在于包含与SEQ ID NO：1结构相关的氨基酸序列或其片段，金黄色葡萄球菌AhpC-AhpF组合物以及这些多肽和组合物的用途的多肽。 SEQ ID NO：1具有全长金黄色葡萄球菌AhpC序列。发现含有氨基His标签和三个另外的羧基氨基酸的SEQ ID NO：1的衍生物产生针对金黄色葡萄球菌的保护性免疫应答。 Q Q H HI R H INK INK S HI Q Q Q Q

87. 发明申请

US20100105465A1 DETERMINATION OF RESTORATION EVENT 有权
标题翻译：恢复活动的确定
公开(公告)号：US20100105465A1
公开(公告)日：2010-04-29
申请号：US12259325
申请日：2008-10-28
申请人： Mark A. Miller
发明人： Mark A. Miller
IPC分类号： A63F9/24
CPC分类号： G07F17/32
摘要： Example methods and devices are set forth for playing a game. In some embodiments, an inventory of game indicia is arranged in a random but established, serial order. In some embodiments, for each hand of play the player makes a wager and game indicia are displayed in order from the inventory to define a winning or losing outcome. In some embodiments, a display, as hands are played, displays the remaining constituency of the inventory and the player, before any game, can order re-shuffling and re-constitute of the inventory. Other embodiments are described.
摘要翻译：规定了玩游戏的方法和设备。在一些实施例中，游戏标记的清单以随机但已建立的串行顺序排列。在一些实施例中，对于玩家的每一只手，玩家进行下注，并且从库存中顺序显示游戏标记以定义获胜或失败的结果。在一些实施例中，作为手的播放的显示器在任何游戏之前显示库存的剩余选区，并且玩家可以订购重新洗牌和重新组合库存。描述其他实施例。

88. 发明申请

US20100105459A1 RESHUFFLE TIMING 有权
标题翻译：恢复时间
公开(公告)号：US20100105459A1
公开(公告)日：2010-04-29
申请号：US12259330
申请日：2008-10-28
申请人： Mark A. Miller
发明人： Mark A. Miller
IPC分类号： A63F9/24
CPC分类号： G07F17/32 , G07F17/3293
摘要： A method and/or device is set forth for playing a game. In some embodiments, an inventory of data representing playing cards is arranged in a random but established, serial order. In some embodiments, for each hand of play the player makes a wager and cards are displayed, according to the rules of the game, in order from the inventory to define a winning or losing outcome. In some embodiments, a display, as hands are played, displays the remaining constituency of the inventory and the player, before any hand, can order re-shuffling and re-constitute of the inventory. In some embodiments, re-shuffling may be triggered by a card or hand count or certain pre-defined triggers. Other embodiments are described.
摘要翻译：阐述了玩游戏的方法和/或设备。在一些实施例中，代表扑克牌的数据的清单以随机但已建立的串行顺序排列。在一些实施例中，对于玩家的每一只手，根据游戏的规则，玩家根据游戏的顺序从玩家进行下注并显示牌，以便定义获胜或失败的结果。在一些实施例中，作为手播放的显示器显示库存的剩余选区，并且玩家在任何手之前可以订购重新洗牌和重新组合库存。在一些实施例中，重新洗牌可以由卡或手数或某些预定义的触发来触发。描述其他实施例。

89. 发明申请

US20100099481A1 TWO STAGE CARD SELECT 有权
标题翻译：两级卡选择
公开(公告)号：US20100099481A1
公开(公告)日：2010-04-22
申请号：US12254485
申请日：2008-10-20
申请人： Dean P. Alderucci , Mark A. Miller
发明人： Dean P. Alderucci , Mark A. Miller
IPC分类号： A63F9/24 , A63F13/00
CPC分类号： A63F1/00 , G07F17/3293
摘要： A method and/or device is set forth for playing a game. In some embodiments, an inventory of data representing playing cards is arranged in a random but established, serial order. In some embodiments, for each hand of play the player makes a wager and cards are displayed, according to the rules of the game, in order from the inventory to define a winning or losing outcome. In some embodiments, a display, as hands are played, displays the remaining constituency of the inventory and the player, before any hand, can order re-shuffling and re-constitute of the inventory. In some embodiments, re-shuffling may be triggered by a card or hand count or certain pre-defined triggers. Other embodiments are described.
摘要翻译：阐述了玩游戏的方法和/或设备。在一些实施例中，代表扑克牌的数据的清单以随机但已建立的串行顺序排列。在一些实施例中，对于玩家的每一只手，根据游戏的规则，玩家根据游戏的顺序从玩家进行下注并显示牌，以便定义获胜或失败的结果。在一些实施例中，作为手播放的显示器显示库存的剩余选区，并且玩家在任何手之前可以订购重新洗牌和重新组合库存。在一些实施例中，重新洗牌可以由卡或手数或某些预定义的触发来触发。描述其他实施例。

90. 发明申请

US20100099477A1 CARD SELECTION 有权
标题翻译：卡片选择
公开(公告)号：US20100099477A1
公开(公告)日：2010-04-22
申请号：US12253343
申请日：2008-10-17
申请人： Dean P. Alderucci , Mark A. Miller
发明人： Dean P. Alderucci , Mark A. Miller
IPC分类号： A63F9/24 , A63F13/00
CPC分类号： G07F17/3227 , A63F3/00157 , A63F2001/003 , G07F17/3286 , G07F17/3293 , G07F17/34
摘要： Example methods and devices are set forth for playing a game. In some embodiments, an inventory of game indicia is arranged in a random but established, serial order. In some embodiments, for each hand of play the player makes a wager and game indicia are displayed in order from the inventory to define a winning or losing outcome. In some embodiments, a display, as hands are played, displays the remaining constituency of the inventory and the player, before any game, can order re-shuffling and re-constitute of the inventory. Other embodiments are described.
摘要翻译：规定了玩游戏的方法和设备。在一些实施例中，游戏标记的清单以随机但已建立的串行顺序排列。在一些实施例中，对于玩家的每一只手，玩家进行下注，并且从库存中顺序显示游戏标记以定义获胜或失败的结果。在一些实施例中，作为手的播放的显示器在任何游戏之前显示库存的剩余选区和玩家可以订购重新洗牌和重新组合库存。描述其他实施例。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式