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81. 发明授权

EP2989197B1 METHOD OF PRODUCING PARTIALLY PURIFIED EXTRACELLULAR METABOLITE PRODUCTS FROM BACILLUS COAGULANS AND BIOLOGICAL APPLICATIONS THEREOF 有权
公开(公告)号：EP2989197B1
公开(公告)日：2018-08-29
申请号：EP14873856.0
申请日：2014-12-24
申请人： Majeed, Muhammed
发明人： NAGABHUSHANAM, Kalyanam , ARUMUGAM, Sivakumar , ALI, Furqan
IPC分类号： C12N1/20 , A01N63/02 , A01N37/12 , A01N31/08 , A01N65/08 , A01P1/00 , A01P3/00
CPC分类号： A01N63/02 , A01N31/08 , A01N37/12 , C12N1/20 , C12R1/07 , C12R1/085 , C12R1/19 , C12R1/385 , C12R1/42 , C12R1/445 , C12R1/45 , C12R1/46 , A01N65/08
摘要： Method of extracting a partially purified extracellular metabolite composition from Bacillus coagulans MTCC 5856 and its antimicrobial effects thereof are described.

82. 发明公开

EP2989197A1 METHOD OF PRODUCING PARTIALLY PURIFIED EXTRACELLULAR METABOLITE PRODUCTS FROM BACILLUS COAGULANS AND BIOLOGICAL APPLICATIONS THEREOF 有权
标题翻译：用于生产部分纯化的胞外METABOLITPRODUKTEN从凝结芽孢杆菌与生物它们的应用
公开(公告)号：EP2989197A1
公开(公告)日：2016-03-02
申请号：EP14873856.0
申请日：2014-12-24
申请人： Majeed, Muhammed
发明人： NAGABHUSHANAM, Kalyanam , ARUMUGAM, Sivakumar , ALI, Furqan
IPC分类号： C12N1/20
CPC分类号： A01N63/02 , A01N31/08 , A01N37/12 , C12N1/20 , C12R1/07 , C12R1/085 , C12R1/19 , C12R1/385 , C12R1/42 , C12R1/445 , C12R1/45 , C12R1/46 , A01N65/08
摘要： Disclosed is a method for producing partially purified extracellular metabolite preparation from the probiotic bacterial strain Bacillus coagulans SBC-37 (Deposited in the Microbial Type Culture Collection and Gene Bank as strain number MTCC 5856) exhibiting 99% genetic homology with the known bacterial strains Bacillus coagulans ATCC 31284, Bacillus coagulans NBRC 3887 and Bacillus coagulans ATCC 7050. Also disclosed is the anti-microbial profile of said extracellular metabolite preparation against a panel of microbial pathogens, including synergistic anti-microbial effects of preparation when combined with a synergistic preservative blend comprising from about 61% w/w of thymol, about 38% of monolaurin and about 1% w/w of magnolol obtained from supercritical fluid extracts of Magnolia officinalis. The extracellular metabolite preparation alone or the combination of said extracellular metabolite preparation and preservative blend also inhibits microbial biofilm formation in a synergistic manner.
摘要翻译：公开了一种用于从益生菌菌株凝结芽孢杆菌SBC-37（在微生物典型培养物保藏中心和基因库保藏为菌株号MTCC 5856）参展99％的遗传同源性与已知的细菌菌株凝结芽孢杆菌生产的部分纯化的细胞外代谢物制备方法 ATCC 31284，凝结芽孢杆菌NBRC 3887和凝结芽孢杆菌ATCC 7050所以盘游离缺失是针对微生物病原体，包括准备的协同抗微生物作用时具有协同防腐剂共混物由包含组合的面板。所述胞外代谢物制剂的抗微生物轮廓约61％w / w的百里酚，单月桂酸甘油酯的约38％至约1％w / w的厚朴酚从厚朴超临界流体提取物中得到。所以单独的胞外代谢物制剂或所述胞外代谢物的制备和防腐剂共混物的组合抑制以协同方式微生物生物膜的形成。

83. 发明授权

EP3108935B1 COMPOSITION COMPRISING SCIRPUSIN A AND SCIRPUSIN B AND ANTI-OBESITY POTENTIAL THEREOF 有权
公开(公告)号：EP3108935B1
公开(公告)日：2020-04-22
申请号：EP16184143.2
申请日：2013-07-17
申请人： Majeed, Muhammed
发明人： MAJEED, Muhammed , NAGABHUSHANAM, Kalyanam , KALMAN, Douglas , BHAT, Beena , VAIDYANATHAN, Priti , BANI, Sarang , PANDEY, Anjali
IPC分类号： A61P3/04 , A61K8/97 , A61K31/343 , A61K36/8905

84. 发明公开

EP3614846A1 GARCINOL COMPOSITIONS FOR THERAPEUTIC MANAGEMENT OF ENDOPLASMIC RETICULUM STRESS 审中-公开
公开(公告)号：EP3614846A1
公开(公告)日：2020-03-04
申请号：EP18821067.8
申请日：2018-06-22
申请人： Majeed, Muhammed , Mundkur, Lakshmi , Sami Labs Limited
发明人： MAJEED, Muhammed , MUNDKUR, Lakshmi , NAGABHUSHANAM, Kalyanam
IPC分类号： A01N59/08 , A61P1/02 , A61P3/00 , A61P3/04 , A61K31/352 , A61P7/00 , A61P9/00

85. 发明授权

EP2744571B1 SCIRPUSIN A AND SCIRPUSIN B AND ANTI-OBESITY POTENTIAL THEREOF 无效转让
公开(公告)号：EP2744571B1
公开(公告)日：2019-10-16
申请号：EP13819890.8
申请日：2013-07-17
申请人： Majeed, Muhammed
发明人： KALMAN, Douglas , BHAT, Beena , VAIDYANATHAN, Priti , BANI, Sarang , PANDEY, Anjali , MAJEED, Muhammed , NAGABHUSHANAM, Kalyanam
IPC分类号： A61P3/04 , A61K8/97 , A61K31/343 , A61K36/8905

86. 发明授权

EP2461786B1 PROTECTIVE COMPOSITIONS FOR DERMAL PAPILLA CELLS 有权
标题翻译：保护剂毛乳头细胞
公开(公告)号：EP2461786B1
公开(公告)日：2016-04-20
申请号：EP10834886.3
申请日：2010-08-07
申请人： Sami Labs Limited , Majeed, Muhammed
发明人： MAJEED, Muhammed , NAGABHUSHANAM, Kalyanam , BHAT, Beena , KANHANGAD GANGADHARAN, Geetha , TATHAPUDI ANAND, Susmitha , PALIWAL, Pritee
IPC分类号： A61K8/00 , A61K8/18 , A61Q17/04 , A61K36/889
CPC分类号： A61Q7/00 , A61K8/37 , A61K8/4973 , A61K8/60 , A61K8/97 , A61K9/0014 , A61K9/08 , A61K31/235 , A61K31/365 , A61K31/366 , A61K31/7024 , A61K36/889 , A61K47/10 , A61K2800/592 , A61K2300/00

87. 发明申请

WO2020146635A1 WATER-SOLUBLE MINERAL FERULATES AND THEIR METHOD OF PREPARATION 审中-公开
公开(公告)号：WO2020146635A1
公开(公告)日：2020-07-16
申请号：PCT/US2020/012937
申请日：2020-01-09
申请人： MAJEED, Muhammed
发明人： MAJEED, Muhammed , NAGABHUSHANAM, Kalyanam , MANOHARAN, Samuel, Thomas , MUNDKUR, Lakshmi
IPC分类号： A61K31/216 , A61K9/08 , A61P9/10
摘要： The present invention discloses novel water-soluble mineral ferulates and mineral dihydroferulates, for use as a mineral and ferulic acid supplement. More specifically, the invention discloses a composition comprising water soluble calcium ferulate dihydrate or magnesium ferulate or calcium/magnesium dihydro ferulate for use as a calcium/magnesium and ferulic acid / dihydroferulic acid supplement and the method of their preparation.

88. 发明申请

WO2015105501A1 COMPOSITION AND METHOD FOR THE PROTECTION OF ARTICULAR CARTILAGE 审中-公开
标题翻译：用于保护纸张的组合物和方法
公开(公告)号：WO2015105501A1
公开(公告)日：2015-07-16
申请号：PCT/US2014/010993
申请日：2014-01-10
申请人： MAJEED, Muhammed
发明人： MAJEED, Muhammed , BANI, Sarang , PANDEY, Anjali , NAGABHUSHANAM, Kalyanam
IPC分类号： A61K31/216 , A61K31/05
CPC分类号： A61K31/216
摘要： The novel therapeutic potential of Calebin A and compositions thereof to prevent pathological damage to mammalian articular cartilage is disclosed. Specifically a method has been provided for protecting mammalian articular cartilage from pathological damage, said method comprising the step of administering effective dose of Calebin A to mammals in need of said protection.
摘要翻译：公开了Calebin A及其组合物用于预防哺乳动物关节软骨病理损伤的新颖治疗潜力。具体地说，提供了一种保护哺乳动物关节软骨免受病理损伤的方法，所述方法包括对需要所述保护的哺乳动物施用有效剂量的Calebin A的步骤。

89. 发明申请

WO2015100405A1 METHOD OF PRODUCING PARTIALLY PURIFIED EXTRACELLULAR METABOLITE PRODUCTS FROM BACILLUS COAGULANS AND BIOLOGICAL APPLICATIONS THEREOF 审中-公开
标题翻译：生产部分纯化的细菌性代谢产物的方法及其生物应用
公开(公告)号：WO2015100405A1
公开(公告)日：2015-07-02
申请号：PCT/US2014/072331
申请日：2014-12-24
申请人： MAJEED, Muhammed
发明人： MAJEED, Muhammed , NAGABHUSHANAM, Kalyanam , ARUMUGAM, Sivakumar , ALI, Furqan
IPC分类号： C12N1/20
CPC分类号： A01N63/02 , A01N31/08 , A01N37/12 , C12N1/20 , C12R1/07 , C12R1/085 , C12R1/19 , C12R1/385 , C12R1/42 , C12R1/445 , C12R1/45 , C12R1/46 , A01N65/08
摘要： Disclosed is a method for producing partially purified extracellular metabolite preparation from the probiotic bacterial strain Bacillus coagulans SBC-37 (Deposited in the Microbial Type Culture Collection and Gene Bank as strain number MTCC 5856) exhibiting 99% genetic homology with the known bacterial strains Bacillus coagulans ATCC 31284, Bacillus coagulans NBRC 3887 and Bacillus coagulans ATCC 7050. Also disclosed is the anti-microbial profile of said extracellular metabolite preparation against a panel of microbial pathogens, including synergistic anti-microbial effects of preparation when combined with a synergistic preservative blend comprising from about 61% w/w of thymol, about 38% of monolaurin and about 1% w/w of magnolol obtained from supercritical fluid extracts of Magnolia officinalis. The extracellular metabolite preparation alone or the combination of said extracellular metabolite preparation and preservative blend also inhibits microbial biofilm formation in a synergistic manner.
摘要翻译：公开了一种从已知菌株凝结芽孢杆菌（Bacillus coagulans）显示出99％的遗传同源性的益生菌菌株凝结芽孢杆菌凝结芽孢杆菌SBC-37（沉积在微生物型培养物收集和基因库中的菌株号MTCC 5856）的部分纯化细胞外代谢物制剂的方法 ATCC 31284，凝结芽孢杆菌NBRC 3887和凝结芽孢杆菌ATCC 7050.还公开了所述细胞外代谢产物针对一组微生物病原体的抗微生物特征，包括与协同防腐混合物组合时的制备的协同抗微生物作用，约61％w / w的百里酚，约38％的单月桂酸和约1％w / w的从木兰超临界流体提取物获得的厚朴酚。单独的胞外代谢物制剂或所述细胞外代谢物制剂和防腐剂混合物的组合也以协同方式抑制微生物生物膜形成。

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