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81. 发明申请

US20110039294A1 SYSTEM AND METHOD FOR MONITORING CARDIOMYOCYTE BEATING, VIABILITY AND MORPHOLOGY AND FOR SCREENING FOR PHARMACOLOGICAL AGENTS WHICH MAY INDUCE CARDIOTOXICITY OR MODULATE CARDIOMYOCYTE FUNCTION 审中-公开
标题翻译：用于监测心脏病发作，病变和形态学以及可能引起心脏病毒或调节心肌细胞功能的药物代谢筛选的系统和方法
公开(公告)号：US20110039294A1
公开(公告)日：2011-02-17
申请号：US12774709
申请日：2010-05-05
申请人： Xiaobo Wang , Wei Ouyang , Nan Li , Biao Xi , Yama A. Abassi , Xiao Xu
发明人： Xiaobo Wang , Wei Ouyang , Nan Li , Biao Xi , Yama A. Abassi , Xiao Xu
IPC分类号： C12Q1/02 , C12M1/34
CPC分类号： G01N33/48735
摘要： Devices and methods for performing extracellular recording of cells, such as excitable cells, cardiomyocytes, and cardiomyocyte precursor cells is provided. An exemplary device includes a nonconductive substrate forming or provided as a base of one or more wells; a recording electrode positioned on the substrate within the well, wherein the recording electrode is accessible to cells when a cell sample is added to the device; and a reference electrode positioned within the well in a cell-free zone, the cell-free zone characterized as free from contact with cells when the cell sample is added to the device, thereby preventing contact between cells and the reference electrode.
摘要翻译：提供了用于进行细胞的细胞外记录的装置和方法，例如可兴奋细胞，心肌细胞和心肌细胞前体细胞。示例性装置包括形成或提供为一个或多个孔的基底的非导电基底; 记录电极，其位于所述阱内的所述衬底上，其中当将细胞样品添加到所述装置时，所述记录电极可接近细胞; 以及位于无细胞区域内的阱内的参比电极，当将细胞样品添加到器件时，无细胞区域表征为不与细胞接触，从而防止细胞与参比电极之间的接触。

82. 发明申请

US20100088371A1 METHOD FOR OBTAINING DEVICE INFORMATION OF USER TERMINALS AND COMMUNICATION SERVICE FUNCTION ENTITY 有权
标题翻译：用于获取用户终端和通信服务功能实体的设备信息的方法
公开(公告)号：US20100088371A1
公开(公告)日：2010-04-08
申请号：US12635452
申请日：2009-12-10
申请人： Guojun Xu , Lunjian Mu , Jue Wang , Gang Liang , Xiaobo Wang , Cheng Huang
发明人： Guojun Xu , Lunjian Mu , Jue Wang , Gang Liang , Xiaobo Wang , Cheng Huang
IPC分类号： G06F15/16
CPC分类号： H04L67/303 , H04L67/04 , H04L67/14 , H04W8/22
摘要： A method for obtaining device information of user terminals and a communication service function thereof are disclosed to enable a user to obtain terminal device information. The method for obtaining device information of user terminals in a communication system includes that a communication service function sends device information of a target user to a requesting terminal according to the target user ID carried in a device information obtaining request or a device information publish service setting. The communication service function includes: a receiving unit, adapted to receive a device information obtaining request or a device information publish service setting; a sending unit, adapted to send the stored device information of the target user to the requesting terminal according to the target user ID carried in the device information obtaining request or device information publish service setting.
摘要翻译：公开了一种用于获取用户终端的设备信息和通信服务功能的方法，以使用户能够获得终端设备信息。用于获取通信系统中的用户终端的设备信息的方法包括：通信服务功能根据设备信息获取请求中携带的目标用户ID或设备信息发布服务设置向目标用户发送目标用户的设备信息。通信服务功能包括：接收单元，用于接收设备信息获取请求或设备信息发布服务设置; 发送单元，用于根据在设备信息获取请求或设备信息发布服务设置中携带的目标用户ID将目标用户存储的设备信息发送到请求终端。

83. 发明申请

US20100084273A1 Method and Apparatus for Programmable Fluidic Processing 有权
标题翻译：用于可编程流体处理的方法和装置
公开(公告)号：US20100084273A1
公开(公告)日：2010-04-08
申请号：US12622775
申请日：2009-11-20
申请人： Frederick F. Becker , Peter Gascoyne , Xiaobo Wang , Jody Valentine Vykoukal , Giovanni De Gasperis
发明人： Frederick F. Becker , Peter Gascoyne , Xiaobo Wang , Jody Valentine Vykoukal , Giovanni De Gasperis
IPC分类号： B01J8/42
CPC分类号： G01N27/44773 , B01F13/0076 , B01F2215/0404 , B01L3/502715 , B01L3/502761 , B01L3/502792 , B01L2200/143 , B01L2300/089 , B01L2400/0421 , B01L2400/0424 , B01L2400/0454 , B03C5/005 , B03C5/024 , B03C5/026 , B03C5/028 , G01N27/447
摘要： A method and apparatus for microfluidic processing by programmably manipulating a packet. A material is introduced onto a reaction surface and compartmentalized to form a packet. A position of the packet is sensed with a position sensor. A programmable manipulation force is applied to the packet at the position. The programmable manipulation force is adjustable according to packet position by a controller. The packet is programmably moved according to the programmable manipulation force along arbitrarily chosen paths.
摘要翻译：用于通过可编程地操纵分组的微流体处理的方法和装置。将材料引入反应表面并分隔成形成包装。用位置传感器检测分组的位置。可编程操纵力被施加到该位置处的分组。可编程操纵力可根据控制器的分组位置进行调节。根据可编程操纵力沿着任意选择的路径可编程地移动分组。

84. 发明授权

US07641779B2 Method and apparatus for programmable fluidic processing 有权
标题翻译：用于可编程流体处理的方法和装置
公开(公告)号：US07641779B2
公开(公告)日：2010-01-05
申请号：US11135615
申请日：2005-05-23
申请人： Frederick F. Becker , Peter Gascoyne , Xiaobo Wang , Jody Valentine Vykoukal , Giovanni De Gasperis
发明人： Frederick F. Becker , Peter Gascoyne , Xiaobo Wang , Jody Valentine Vykoukal , Giovanni De Gasperis
IPC分类号： G01N27/447 , G01N27/453
CPC分类号： G01N27/44773 , B01F13/0076 , B01F2215/0404 , B01L3/502715 , B01L3/502761 , B01L3/502792 , B01L2200/143 , B01L2300/089 , B01L2400/0421 , B01L2400/0424 , B01L2400/0454 , B03C5/005 , B03C5/024 , B03C5/026 , B03C5/028 , G01N27/447
摘要： A method and apparatus for microfluidic processing by programmably manipulating a packet. A material is introduced onto a reaction surface and compartmentalized to form a packet. A position of the packet is sensed with a position sensor. A programmable manipulation force is applied to the packet at the position. The programmable manipulation force is adjustable according to packet position by a controller. The packet is programmably moved according to the programmable manipulation force along arbitrarily chosen paths.
摘要翻译：用于通过可编程地操纵分组的微流体处理的方法和装置。将材料引入反应表面并分隔成形成包装。用位置传感器检测分组的位置。可编程操纵力被施加到该位置处的分组。可编程操纵力可根据控制器的分组位置进行调节。根据可编程操纵力沿着任意选择的路径可编程地移动分组。

85. 发明申请

US20090192146A1 SUBSTITUTED ORGANOSULFUR COMPOUNDS AND METHODS OF USING THEREOF 有权
标题翻译：取代的有机骨架化合物及其使用方法
公开(公告)号：US20090192146A1
公开(公告)日：2009-07-30
申请号：US12368206
申请日：2009-02-09
申请人： Xiao XU , Haoyun An , Xiaobo Wang
发明人： Xiao XU , Haoyun An , Xiaobo Wang
IPC分类号： A61K31/549 , A61K31/522 , A61K31/506 , A61K31/497 , A61K31/498
CPC分类号： C07C323/07 , C07C321/20 , C07C323/16 , C07C323/20
摘要： The present invention provides substituted di-, tri-, tetra- and penta-sulfide compounds and compositions, and methods of using the same for the treatment and/or prevention of a cell proliferative disorder. The present invention also provides methods for preparing trisulfide compounds and compositions.
摘要翻译：本发明提供取代的二，三，四和五硫化物化合物和组合物，及其用于治疗和/或预防细胞增殖性疾病的方法。本发明还提供了制备三硫化物和组合物的方法。

86. 发明申请

US20080124703A1 Use of impedance-based cytological profiling to classify cellular response profiles upon exposure to biologically active agents 有权
标题翻译：使用基于阻抗的细胞学分析来分类暴露于生物活性剂时的细胞反应谱
公开(公告)号：US20080124703A1
公开(公告)日：2008-05-29
申请号：US11903454
申请日：2007-09-20
申请人： Xiaobo Wang , Yama A. Abassi , Wenfu Zhang , Xiao Xu
发明人： Xiaobo Wang , Yama A. Abassi , Wenfu Zhang , Xiao Xu
IPC分类号： C12Q1/02 , C12Q1/68 , C12Q1/70
CPC分类号： G01N33/502
摘要： The present invention provides methods of multi-dimensional profiling of biologically active agents and determining their effects on biological systems. The methods of the present invention include real-time impedance monitoring of cellular responses to biologically active agents and categorization of cellular kinetic profiles into mechanism specific cellular response profile groups. The grouping of similar cellular response profiles allows the correlation between agent and mechanism, thus allowing for the identification of potential therapeutic applications of agents or further study of cellular responses or mechanisms.
摘要翻译：本发明提供生物活性剂的多维轮廓化方法，并确定其对生物系统的影响。本发明的方法包括对生物活性剂的细胞反应的实时阻抗监测和细胞动力学特征分类到机制特异性细胞应答谱组中。类似的细胞反应谱的分组允许试剂和机制之间的相关性，从而允许鉴定试剂的潜在治疗应用或进一步研究细胞应答或机制。

87. 发明申请

US20060053972A1 Process for producing copper nanoparticles 有权
标题翻译：生产铜纳米粒子的方法
公开(公告)号：US20060053972A1
公开(公告)日：2006-03-16
申请号：US10997220
申请日：2004-11-23
申请人： Weimin Liu , Xiaobo Wang , Singgou Fu
发明人： Weimin Liu , Xiaobo Wang , Singgou Fu
IPC分类号： B22F9/24
CPC分类号： B22F1/0022 , B22F9/24 , B22F2998/00 , B82Y30/00 , C10M125/04 , C10M2201/05 , C10N2210/01 , C10N2220/08 , C10N2220/082 , Y10S977/896
摘要： The present invention provides a process for producing copper nanoparticles, comprising steps of: a) reacting an aqueous solution containing a reductant with an aqueous solution of a copper salt while stirring for 1-8 min, wherein the reductant being one or more selected from a group consisting of hydrazine hydrate, sodium borohydride and sodium hypophosphite; b) adding an apolar organic solution containing the extracting agent and continuing the stirring for 0.5-1.5 hrs, said extracting agent being one or more selected from the group consisting of alkyl dithiocarbonic acid and salts thereof, O,O′-dialkyl dithiophosphoric acid and salts thereof, and dialkylamino dithioformic acid and salts and said apolar organic solution being one selected from the group consisting of benzene, toluene and straight or branched alkanes having 6-12 carbon atoms, wherein the alkyl having 6-20 carbon atoms; and c) post-treating the reaction product to obtain copper nanoparticles.
摘要翻译：本发明提供一种生产铜纳米颗粒的方法，包括以下步骤：a）在搅拌1-8分钟的同时使含有还原剂的水溶液与铜盐水溶液反应，其中还原剂是选自以下的一种或多种：由水合肼，硼氢化钠和次磷酸钠组成的组; b）加入含有提取剂的非极性有机溶液并继续搅拌0.5-1.5小时，所述提取剂是选自烷基二硫代碳酸及其盐，O，O-二烷基二硫代磷酸和其盐和二烷基氨基二硫代甲酸及其盐，所述非极性有机溶液选自苯，甲苯和具有6-12个碳原子的直链或支链烷烃，其中具有6-20个碳原子的烷基; 和c）后处理反应产物以获得铜纳米颗粒。

88. 发明申请

US20050261321A1 Substituted organosulfur compounds and methods of using thereof 有权
标题翻译：取代的有机硫化合物及其使用方法
公开(公告)号：US20050261321A1
公开(公告)日：2005-11-24
申请号：US11110203
申请日：2005-04-20
申请人： Xiao Xu , Haoyun An , Xiaobo Wang
发明人： Xiao Xu , Haoyun An , Xiaobo Wang
IPC分类号： A61K31/095 , A61K31/381 , A61K31/444 , A61K31/513
CPC分类号： C07C323/07 , C07C321/20 , C07C323/16 , C07C323/20
摘要： The present invention provides substituted di-, tri-, tetra- and penta-sulfide compounds and compositions, and methods of using the same for the treatment and/or prevention of a cell proliferative disorder. The present invention also provides methods for preparing trisulfide compounds and compositions.
摘要翻译：本发明提供取代的二，三，四和五硫化物化合物和组合物，及其用于治疗和/或预防细胞增殖性疾病的方法。本发明还提供了制备三硫化物和组合物的方法。

89. 发明申请

US20050213374A1 Real time electronic cell sensing system and applications for cytoxicity profiling and compound assays 有权
标题翻译：实时电子细胞感测系统和细胞毒性分析和化合物分析的应用
公开(公告)号：US20050213374A1
公开(公告)日：2005-09-29
申请号：US11055639
申请日：2005-02-09
申请人： Xiao Xu , Yama Abassi , Xiaobo Wang
发明人： Xiao Xu , Yama Abassi , Xiaobo Wang
IPC分类号： G11C11/00
CPC分类号： C12Q1/025 , C12Q1/002 , G01N27/02 , G01N33/4836 , G01N33/5014 , G01N33/5438
摘要： The present invention includes devices, systems, and methods for assaying cells using cell-substrate impedance monitoring. In one aspect, the invention provides cell-substrate impedance monitoring devices that comprise electrode arrays on a nonconducting substrate, in which each of the arrays has an approximately uniform electrode resistance across the entire array. In another aspect, the invention provides cell-substrate monitoring systems comprising one or more cell-substrate monitoring devices comprising multiple wells each having an electrode array, an impedance analyzer, a device station that connects arrays of individual wells to the impedance analyzer, and software for controlling the device station and impedance analyzer. In another aspect, the invention provides cellular assays that use impedance monitoring to detect changes in cell behavior or state. The methods can be used to test the effects of compounds on cells, such as in cytotoxicity assays. Methods of cytotoxicity profiling of compounds are also provided.
摘要翻译：本发明包括使用细胞 - 基底阻抗监测来测定细胞的装置，系统和方法。在一个方面，本发明提供了包括非导电衬底上的电极阵列的电池衬底阻抗监测装置，其中每个阵列在整个阵列上具有大致均匀的电极电阻。在另一方面，本发明提供了一种电池衬底监测系统，其包括一个或多个电池衬底监测装置，其中每个电池衬底监测装置包括各自具有电极阵列的多个阱，阻抗分析器，将各个阱的阵列连接到阻抗分析仪的装置站以及软件用于控制设备站和阻抗分析仪。在另一方面，本发明提供了使用阻抗监测来检测细胞行为或状态的变化的细胞测定。该方法可用于测试化合物对细胞的影响，例如细胞毒性测定。还提供了化合物的细胞毒性分析方法。

90. 发明申请

US20050153425A1 Real time electronic cell sensing systems and applications for cell-based assays 有权
标题翻译：实时电子传感系统和基于细胞的测定的应用
公开(公告)号：US20050153425A1
公开(公告)日：2005-07-14
申请号：US10987732
申请日：2004-11-12
申请人： Xiao Xu , Yama Abassi , Xiaobo Wang , Jiangbo Gan
发明人： Xiao Xu , Yama Abassi , Xiaobo Wang , Jiangbo Gan
IPC分类号： C12M1/34 , C12M1/42 , C12N20060101 , G01N33/487 , H01M4/50
CPC分类号： G01N33/6854 , C12M25/08 , C12M41/36 , G01N33/4836 , G01N33/5005 , G01N2500/10
摘要： The present invention includes devices, systems, and methods for assaying cells using cell-substrate impedance monitoring. In one aspect, the invention provides cell-substrate impedance monitoring devices that comprise electrode arrays on a nonconducting substrate, in which each of the arrays has an approximately uniform electrode resistance across the entire array. In another aspect, the invention provides cell-substrate monitoring systems comprising one or more cell-substrate monitoring devices comprising multiple wells each having an electrode array, an impedance analyzer, a device station that connects arrays of individual wells to the impedance analyzer, and software for controlling the device station and impedance analyzer. In another aspect, the invention provides cellular assays that use impedance monitoring to detect changes in cell behavior or state. In some preferred aspects, the assays are designed to investigate the affects of compounds on cells, such as cytotoxicity assays. In other preferred aspects, the assays are designed to investigate the compounds that effect IgE-mediated responses of cells to antigens.
摘要翻译：本发明包括使用细胞 - 基底阻抗监测来测定细胞的装置，系统和方法。在一个方面，本发明提供了包括非导电衬底上的电极阵列的电池衬底阻抗监测装置，其中每个阵列在整个阵列上具有大致均匀的电极电阻。在另一方面，本发明提供了一种电池衬底监测系统，其包括一个或多个电池衬底监测装置，其中每个电池衬底监测装置包括各自具有电极阵列的多个阱，阻抗分析器，将各个阱的阵列连接到阻抗分析仪的装置站以及软件用于控制设备站和阻抗分析仪。在另一方面，本发明提供了使用阻抗监测来检测细胞行为或状态的变化的细胞测定。在一些优选的方面，设计测定法以研究化合物对细胞的影响，例如细胞毒性测定。在其它优选方面，设计这些测定法来研究影响细胞对抗原的IgE介导的反应的化合物。

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