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    • 85. 发明公开
    • MICRONEEDLES WITH IMPROVED OPEN CHANNEL CROSS-SECTIONAL GEOMETRIES
    • MIKRONADELN MIT VERBESSERTEN OFFENKANAL-QUERSCHNITTSGEETRIEN
    • EP2999510A1
    • 2016-03-30
    • EP14800293.4
    • 2014-05-20
    • Kimberly-Clark Worldwide, Inc.
    • BAKER, Andrew, T.ROSS, Russell, F.RANGANATHAN, Sridhar
    • A61M37/00A61M5/158
    • A61M37/0015A61M2037/0023A61M2037/003A61M2037/0038
    • In one aspect a drug delivery device may include a reservoir containing a liquid drug formulation and a microneedle assembly in fluid communication with the reservoir. The microneedle assembly may include a plurality of microneedles, with each microneedle defining an open channel for receiving a drug formulation. The open channel may have a normalized hydraulic radius ranging from about 0.1 to about 0.8. The open channel may also have a Iiquid-to-solid interfacia! energy and a liquid-to-vapor interfacia! energy when a fixed volume of the drug formulation is received therein. In addition, the drug formulation and a cross-sectional geometry of the open channel may be selected and configured such that the liquid- to-solid energy exceeds the liquid-to-vapor energy as the length of the fixed volume of drug formulation is increased within the open channel.
    • 在一个方面,药物递送装置可以包括容纳液体药物制剂和与储存器流体连通的微针组件的储存器。 微针组件可以包括多个微针,每个微针限定用于接收药物制剂的开放通道。 开放通道可以具有约0.1至约0.8的归一化液压半径。 当容纳固定体积的药物制剂时,开放通道也可以具有液体 - 固体的界面能量和液体至蒸气的界面能量。 此外,可以选择和构造药物制剂和开放通道的横截面几何形状,使得当药物制剂的固定体积的长度增加时,液体 - 固体能量超过液体 - 蒸气能量 在开放频道内。